Menstrually-related migraine shapes the structural similarity network integration of brain

Menstrually-related migraine (MM) is a primary migraine in women of reproductive age. The underlying neural mechanism of MM was still unclear. In this study, we aimed to reveal the case-control differences in network integration and segregation for the morphometric similarity network of MM. Thirty-six patients with MM and 29 healthy females were recruited and underwent MRI scanning. The morphometric features were extracted in each region to construct the single-subject interareal cortical connection using morphometric similarity. The network topology characteristics, in terms of integration and segregation, were analyzed. Our results revealed that, in the absence of morphology differences, disrupted cortical network integration was found in MM patients compared to controls. The patients with MM showed a decreased global efficiency and increased characteristic path length compared to healthy controls. Regional efficiency analysis revealed the decreased efficiency in the left precentral gyrus and bilateral superior temporal gyrus contributed to the decreased network integration. The increased nodal degree centrality in the right pars triangularis was positively associated with the attack frequency in MM. Our results suggested MM would reorganize the morphology in the pain-related brain regions and reduce the parallel information processing capacity of the brain.

Automated summary

Menstrually-related migraine (MM) is a primary migraine that affects women of reproductive age. In this study, we investigated the differences in network integration and segregation in the cortical connections of MM patients using morphometric similarity analysis. We found disrupted cortical network integration and decreased efficiency in pain-related brain regions in MM patients compared to healthy controls. The results suggest that MM reorganizes brain morphology and reduces the brain's capacity for parallel information processing.