Mismatch negativity as a marker of auditory pattern separation

To what extent does incidental encoding of auditory stimuli influence subsequent episodic memory for the same stimuli? We examined whether the mismatch negativity (MMN), an event-related potential generated by auditory change detection, is correlated with participants' ability to discriminate those stimuli (i.e. targets) from highly similar lures and from dissimilar foils. We measured the MMN in 30 young adults (18-32 years, 18 females) using a passive auditory oddball task with standard and deviant 5-tone sequences differing in pitch contour. After exposure, all participants completed an incidental memory test for old targets, lures, and foils. As expected, participants at test exhibited high sensitivity in recognizing target items relative to foils and lower sensitivity in recognizing target items relative to lures. Notably, we found a significant correlation between MMN amplitude and lure discrimination, but not foil discrimination. Our investigation shows that our capacity to discriminate sensory inputs at encoding, as measured by the MMN, translates into precision in memory for those inputs.

Automated summary

This study examined the extent to which incidental encoding of auditory stimuli influences subsequent episodic memory for the same stimuli. By correlating the mismatch negativity (MMN), an event-related potential generated by auditory change detection, with participants' ability to discriminate the stimuli, the researchers found a significant correlation between MMN amplitude and lure discrimination. The findings indicate that our ability to discriminate sensory inputs at encoding translates into precision in memory for those inputs.