Prefrontal GABA and glutamate-glutamine levels affect sustained attention

Attention levels fluctuate during the course of daily activities. However, factors underlying sustained attention are still unknown. We investigated mechanisms of sustained attention using psychological, neuroimaging, and neurochemical approaches. Participants were scanned with functional magnetic resonance imaging (fMRI) while performing gradual-onset, continuous performance tasks (gradCPTs). In gradCPTs, narrations or visual scenes gradually changed from one to the next. Participants pressed a button for frequent Go trials as quickly as possible and withheld responses to infrequent No-go trials. Performance was better for the visual gradCPT than for the auditory gradCPT, but the 2 were correlated. The dorsal attention network was activated during intermittent responses, regardless of sensory modality. Reaction-time variability of gradCPTs was correlated with signal changes (SCs) in the left fronto-parietal regions. We also used magnetic resonance spectroscopy (MRS) to measure levels of glutamate-glutamine (Glx) and & gamma;-aminobutyric acid (GABA) in the left prefrontal cortex (PFC). Glx levels were associated with performance under undemanding situations, whereas GABA levels were related to performance under demanding situations. Combined fMRI-MRS results demonstrated that SCs of the left PFC were positively correlated with neurometabolite levels. These findings suggest that a neural balance between excitation and inhibition is involved in attentional fluctuations and brain dynamics.

Automated summary

Attention levels fluctuate during daily activities, and the factors influencing sustained attention are still unknown. This study used psychological, neuroimaging, and neurochemical approaches to investigate mechanisms of sustained attention. Participants performed gradual-onset continuous performance tasks while being scanned with fMRI. The results showed that the dorsal attention network was activated during intermittent responses, and there was a correlation between reaction-time variability and signal changes in the left fronto-parietal regions. MRS measurements also revealed associations between neurometabolite levels and performance under different task demands.