Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 8, Pages 1528-1531Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08900f
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Funding
- Natural Science Foundation of Jiangsu Province [BK20131160]
- Natural Science Foundation of the Jiangsu Higher Education Institutions [10KJA150049, 11KJB150014]
- Priority Academic Project Development of the Jiangsu Higher Education Institutions
- foundation of the Key Laboratory of Organic Synthesis of Jiangsu Province [JSK 1210]
- Jiangsu College Graduate Research and Innovation Project of the Jiangsu Province Department of Education [KYZZ_0336]
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Two series of novel functionalized polyhydroisoquinoline derivatives have been synthesized via the three-component domino reaction of glutaraldehyde and malononitrile with a series of beta-ketoamides under microwave irradiation conditions in the presence of a catalytic amount of Et3N (10 mol%). This reaction represents the first reported process for the facile conversion of a beta-ketoamide to a hydroiso-quinoline via a C-N bond cleavage reaction without the need for a multistep reaction process.
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