LncRNA MEG3 regulates ASK1/JNK axis-mediated apoptosis and autophagy via sponging miR-23a in granulosa cells of yak tertiary follicles

Article Cell Biology

Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1

Tong Shao et al.

Summary: Autophagy regulates the differentiation of ovarian granulosa cells (GCs) by degrading the transcription factor WT1, and insufficient autophagy might be involved in ovarian dysfunction.

AUTOPHAGY (2022)

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Review Cell Biology

microRNAs and long non-coding RNAs as biomarkers for polycystic ovary syndrome

Mona Tamaddon et al.

Summary: This review discusses the research on miRNAs and lncRNAs associated with PCOS, highlighting their potential as molecular biomarkers and RNA therapy agents. The pros and cons of different research methodologies are compared, and recommendations are made for future research to prevent error propagation.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Review Cell Biology

Role of autophagy in follicular development and maintenance of primordial follicular pool in the ovary

Jitender K. Bhardwaj et al.

Summary: Follicular development and maintenance of the primordial follicle pool play a crucial role in the reproductive lifespan of an organism, with autophagy serving as a key regulatory mechanism. Dysregulation or mutation of autophagy-related genes can significantly impact follicular development and, consequently, female reproductive health. Various signaling pathways are involved in regulating autophagy in granulosa and oocytes, with mTOR signaling being a primary mechanism.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Article Obstetrics & Gynecology

Exosomal lncRNA and mRNA profiles in polycystic ovary syndrome: bioinformatic analysis reveals disease-related networks

Weidong Zhou et al.

Summary: This study analyzed the role of exosomal lncRNAs and mRNAs in regulating the development of polycystic ovary syndrome (PCOS). Results identified differentially expressed exosomal lncRNAs and mRNAs, and indicated PCOS-related biological processes and regulatory networks. This suggests that exosomal components may play important roles in the follicular development of PCOS.

REPRODUCTIVE BIOMEDICINE ONLINE (2022)

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Article Biotechnology & Applied Microbiology

Translation regulatory long non-coding RNA 1 (TRERNA1) sponges microRNA-23a to suppress granulosa cell apoptosis in premature ovarian failure

Lili Zhang et al.

Summary: This study suggests that TRERNA1 may suppress granulosa cell apoptosis in POF by directly interacting with miR-23a.

BIOENGINEERED (2022)

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Article Cell Biology

LncRNA MEG3 regulates autophagy and pyroptosis via FOXO1 in pancreatic ?-cells

Xiudan Li et al.

Summary: The study shows that MEG3 can regulate autophagy and pyroptosis through FOXO1 in pancreatic β-cells. Inhibiting autophagy may promote pyroptosis in high-glucose induced cells.

CELLULAR SIGNALLING (2022)

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Article Medicine, Research & Experimental

MAP kinase-dependent autophagy controls phorbol myristate acetate-induced macrophage differentiation of HL-60 leukemia cells

Milos Mandic et al.

Summary: In this study, we investigated the mechanisms and role of autophagy in the differentiation of HL-60 human acute myeloid leukemia cells induced by the protein kinase C (PKC) activator phorbol myristate acetate (PMA). We found that MAP kinases ERK and JNK control PMA-induced macrophage differentiation of HL-60 cells through TFEB/FOXO-mediated transcriptional activation and beclin-1-dependent post-translational activation of autophagy.

LIFE SCIENCES (2022)

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Article Oncology

Role of metformin in functional endometrial hyperplasia and polycystic ovary syndrome involves the regulation of MEG3/miR-223/GLUT4 and SNHG20/miR-4486/GLUT4 signaling

Jie Liu et al.

Summary: This study confirms the effectiveness of MET in treating functional EH and PCOS. MET treatment can inhibit EH and regulate the expression of GLUT4 in PCOS rats. Additionally, MET treatment can restore the decreased expression of lncRNA-MEG3 and lncRNA-SNHG20 in PCOS rats.

MOLECULAR MEDICINE REPORTS (2022)

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Article Biochemistry & Molecular Biology

Macrophage migration inhibitory factor protects bone marrow mesenchymal stem cells from hypoxia/ischemia-induced apoptosis by regulating lncRNA MEG3

Zhibiao Bai et al.

Summary: This research investigated the impact of macrophage migration inhibitory factor (MIF) on the apoptosis of bone marrow mesenchymal stem cells (BMSCs) in ischemia and hypoxia environments. The study found that MIF can protect BMSCs from apoptosis induced by ischemia and hypoxia by downregulating the lncRNA MEG3/p53 signaling pathway, activating the Wnt/beta-catenin signaling pathway, and decreasing reactive oxygen species (ROS) levels.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2022)

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Article Biotechnology & Applied Microbiology

Integrated analysis of the expression profiles of the lncRNA-miRNA-mRNA ceRNA network in granulosa and cumulus cells from yak ovaries

Ling Zhao et al.

Summary: A comprehensive whole-transcriptome analysis was conducted to understand the proliferation and differentiation of granulosa cells (GCs) and cumulus cells (CCs) in yaks. The study identified differentially expressed long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) that play important roles in cell adhesion, cell differentiation, oocyte development, and other biological processes. These RNAs are involved in various signaling pathways and molecular interactions. The findings contribute to the understanding of oocyte development and provide a theoretical basis for future research.

BMC GENOMICS (2022)

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Article Neurosciences

Quinolinic Acid Induces Alterations in Neuronal Subcellular Compartments, Blocks Autophagy Flux and Activates Necroptosis and Apoptosis in Rat Striatum

Carlos Alfredo Silva-Islas et al.

Summary: In this study, the authors investigated the activation and status of autophagy, necroptosis, and apoptosis in the striatum of rats administered with Quinolinic acid (QUIN). Their findings suggest that QUIN initially activates autophagy but on day 7, the autophagy pathway becomes blocked. This blockade leads to organelle and cellular damage, neurodegeneration, and behavioral changes that may be caused by the activation of necroptosis and apoptosis.

MOLECULAR NEUROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

HB-EGF induces mitochondria) dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca2+-FOXO1 pathway

Ji-Cheng Huang et al.

Summary: This study found that HB-EGF is abundant in PCOS patients and may induce excessive estrogen secretion, mitochondrial dysfunction, and granulosa cell apoptosis. The results reveal the important role of HB-EGF in the pathogenesis of PCOS.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Role of Autophagy in Lysophosphatidylcholine-Induced Apoptosis of Mouse Ovarian Granulosa Cells

Si Yang et al.

Summary: LPC has been found to inhibit cell viability and induce apoptosis and autophagy in mouse ovarian granulosa cells, with the involvement of oxidative stress and autophagy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers

Tetsushi Kataura et al.

Summary: Autophagy is essential in the pathogenesis of human diseases, and chemical autophagy inducers are being explored as potential disease-modifying agents. Through chemical genomic analyses, it was found that certain compounds can induce autophagy by activating endoplasmic reticulum stress responses. These autophagy inducers were also shown to enhance the clearance of protein aggregates in cellular models of neurodegenerative diseases.

AUTOPHAGY (2021)

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Article Medicine, Research & Experimental

Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3

Xiaohong Chen et al.

Summary: Acupuncture can improve ovulation dysfunction and abnormal follicular development in patients with polycystic ovary syndrome by down-regulating LncMEG3 expression, inhibiting the PI3K/AKT/mTOR pathway, reducing granulosa cell autophagy, and ultimately normalizing their proliferation, suggesting its clinical potential as a safe treatment for PCOS ovulatory dysfunction.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Cell Biology

Long non-coding RNA MEG3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via PTEN up-regulation by binding to microRNA-21

Liqiang Lin et al.

Summary: The study shows that MEG3 promotes autophagy and apoptosis in NPC cells by binding to miR-21, leading to enhanced PTEN expression. Overexpression of MEG3 in HK-1 cells can inhibit tumour formation.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Agriculture, Dairy & Animal Science

High doses of FSH induce autophagy in bovine ovarian granulosa cells via the AKT/mTOR pathway

Xiaorong Tang et al.

Summary: This study shows that higher doses of FSH (10 and 100 ng/ml) induce BGC autophagy via the AKT/mTOR signaling pathway, particularly by increasing the expression of a series of related genes.

REPRODUCTION IN DOMESTIC ANIMALS (2021)

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Article Environmental Sciences

Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK/mTOR/ULK1 signalling pathway

Miaoling Lin et al.

Summary: This study demonstrated that BPA exposure could significantly decrease human ovarian functions and lead to abnormal folliculogenesis by activating autophagy in GCs through the AMPK/mTOR/ULK1 pathway.

ENVIRONMENT INTERNATIONAL (2021)

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Article Environmental Sciences

Bisphenol AF induces apoptosis via estrogen receptor beta (ERb) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN

Mingquan Huang et al.

Summary: The study reveals that BPAF can induce apoptosis of KGN cells in a concentration- and time-dependent manner by increasing the expression of pro-apoptotic proteins and decreasing the expression of anti-apoptotic proteins. Additionally, BPAF exposure leads to a significant increase in intracellular ROS levels, which mediates KGN cell apoptosis through the ROS-ASK1-JNK axis.

ENVIRONMENTAL POLLUTION (2021)

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Article Cell Biology

MiR-23a Is Involved in Myocardial Ischemia/Reperfusion Injury by Directly Targeting CX43 and Regulating Mitophagy

Lina Wang et al.

Summary: miR-23a plays a detrimental role in myocardial I/R injury by enhancing mitophagy and inhibiting CX43 mRNA expression.

INFLAMMATION (2021)

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Article Biochemistry & Molecular Biology

Characterization of Long Non-Coding RNA Profiles in Porcine Granulosa Cells of Healthy and Atretic Antral Follicles: Implications for a Potential Role in Apoptosis

Li Meng et al.

Summary: This study identified a large number of lncRNAs in porcine granulosa cells through RNA-seq, with a subset showing differential expression associated with developmental processes, potentially involved in granulosa cell apoptosis and antral follicular atresia. Pathway analysis revealed potential mRNA targets of these DE-lncRNAs enriched in apoptosis related pathways, metabolism, and ovarian steroidogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolism

Lifang Luo et al.

Summary: The study revealed that BCAT1 regulates autophagy through the mTOR signaling pathway, decreasing the sensitivity of cancer cells to cisplatin, while branched-chain amino acids or leucine can reverse this process, enhancing the efficacy of cisplatin.

CELL DEATH & DISEASE (2021)

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Article Environmental Sciences

Microcystin-LR induces ovarian injury and apoptosis in mice via activating apoptosis signal-regulating kinase 1-mediated P38/JNK pathway

Xingde Du et al.

Summary: The research has revealed the significant role of ASK1 in MC-LR-induced ovarian injury and apoptosis. Inhibiting ASK1 expression effectively alleviated MC-LR-induced ovarian cell damage, providing new insights for preventing female reproductive toxicity induced by MCs.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Review Genetics & Heredity

Roles of Noncoding RNA in Reproduction

Chaofan He et al.

Summary: Noncoding RNAs play significant roles in the reproductive system, involved in regulating crucial cellular events such as spermatogenesis and follicular development. Abnormal expression of ncRNAs is closely linked to diseases like testicular germ cell tumors and polycystic ovary syndrome.

FRONTIERS IN GENETICS (2021)

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Article Cell Biology

Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways

Xi Chen et al.

Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.

CELL DEATH & DISEASE (2021)

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Review Cell Biology

Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective

Sanjana Kumariya et al.

Summary: PCOS is a prevalent syndrome among women of fertile age, with the ovary being the prime affected organ. Defective autophagy in follicular cells plays a significant role in PCOS pathogenesis. Although few studies have linked autophagy with PCOS progression, detailed knowledge in this area is lacking.

AUTOPHAGY (2021)

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Article Cell Biology

Ketamine enhances autophagy and endoplasmic reticulum stress in rats and SV-HUC-1 cells via activating IRE1-TRAF2-ASK1-JNK pathway

Yanming Yu et al.

Summary: Ketamine-induced cystitis results in bladder hyperactivity and injury by activating autophagy, apoptosis, and endoplasmic reticulum stress-related markers. Salubrinal can reverse the effects of ketamine on complex formation and related markers. Transfection with shIRE1 can offset the effects of ketamine on cells.

CELL CYCLE (2021)

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Article Environmental Sciences

Cadmium induces apoptosis of human granulosa cell line KGN via mitochondrial dysfunction-mediated pathways

Guofeng Xu et al.

Summary: Cadmium exposure triggers apoptosis in KGN cells by inducing mitochondrial dysfunction, including excessive ROS production and intracellular Ca2+ overload. Activation of downstream signaling pathways following mitochondrial dysfunction may contribute to granulosa cell death and female reproductive toxicity after exposure to Cd.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Reproductive Biology

Differential expression of long non-coding RNA Regulator of reprogramming and its molecular mechanisms in polycystic ovary syndrome

Zhihong Zhang et al.

Summary: In patients with PCOS, the expression levels of lncROR and miR-206 were significantly different compared to the control group, and they were shown to be independent predictors of PCOS. There was a negative correlation between miR-206 and lncROR, and their interaction influenced processes such as cell proliferation and apoptosis.

JOURNAL OF OVARIAN RESEARCH (2021)

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Article Oncology

The lncRNA-miRNA-mRNA ceRNA network in mural granulosa cells of patients with polycystic ovary syndrome: an analysis of Gene Expression Omnibus data

Hengxi Chen et al.

Summary: This study constructed a novel lncRNA-miRNA-mRNA network in PCOS based on the ceRNA mechanism, identifying some new genes and non-coding RNAs that may be involved in the occurrence and development of PCOS. However, the findings need validation through in vivo and in vitro experiments.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Veterinary Sciences

Whole-Transcriptome Analysis of LncRNAs Mediated ceRNA Regulation in Granulosa Cells Isolated From Healthy and Atresia Follicles of Chinese Buffalo

Yu Pan et al.

Summary: The study found that lncRNAs are dynamically expressed in GCs of healthy and atretic follicles, interacting with target genes in a ceRNA manner, suggesting their critical functions in buffalo follicular development and atresia.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Long non-coding RNA MEG3 promotes cisplatin- induced nephrotoxicity through regulating AKT/TSC/ mTOR-mediated

Xu Jing et al.

Summary: The study found that lncRNA maternally expressed gene 3 (lnc-MEG3) exacerbates DDP-induced nephrotoxicity by negatively regulating miRNA-126 and decreasing autophagy. Paeonol can alleviate DDPIN by inhibiting lnc-MEG3.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Cell Biology

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky et al.

Summary: The guidelines presented in this article aim to assist researchers in selecting and interpreting methods to examine autophagy, as well as to help reviewers provide constructive critiques of reports focused on these processes. It emphasizes that no single assay is perfect for every situation, and multiple techniques may be needed to properly monitor autophagy in different experimental settings. The article also highlights the importance of targeting multiple autophagy-related genes in genetic approaches to block autophagy effectively.

AUTOPHAGY (2021)

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Article Biochemistry & Molecular Biology

FSH prevents porcine granulosa cells from hypoxia-induced apoptosis via activating mitophagy through the HIF-1α-PINK1-Parkin pathway

Chengyu Li et al.

FASEB JOURNAL (2020)

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Necessity for LH in selection and continued growth of the bovine dominant follicle

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A technical review and guide to RNA fluorescence in situ hybridization

Alexander P. Young et al.

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Clinical Value of lncRNA MEG3 in High-Grade Serous Ovarian Cancer

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Granulosa cells provide elimination of apoptotic oocytes through unconventional autophagy-assisted phagocytosis

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Integrated analysis of lncRNA, miRNA and mRNA reveals novel insights into the fertility regulation of large white sows

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Emerging roles for noncoding RNAs in female sex steroids and reproductive disease

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miRNA-21-3p targeting of FGF2 suppresses autophagy of bovine ovarian granulosa cells through AKT/mTOR pathway

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Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

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Effects of nonylphenol induced oxidative stress on apoptosis and autophagy in rat ovarian granulosa cells

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Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway

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Ovarian preantral follicles are responsive to FSH as early as the primary stage of development

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Downregulation of MEG3 promotes neuroblastoma development through FOXO1-mediated autophagy and mTOR-mediated epithelial-mesenchymal transition

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Identification of microRNAs in granulosa cells from patients with different levels of ovarian reserve function and the potential regulatory function of miR-23a in granulosa cell apoptosis

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PKCδ contributes to oxidative stress-induced apoptosis in porcine ovarian granulosa cells via activating JNK

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LncRNA MEG3 inhibits cell proliferation and induces apoptosis in laryngeal cancer via miR-23a/APAF-1 axis

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LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathway

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miR-21-3p inhibits autophagy of bovine granulosa cells by targeting VEGFA via PI3K/AKT signaling

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Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis

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MEG3 modulates TIGIT expression and CD4+T cell activation through absorbing miR-23a

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The IAP family member BRUCE regulates autophagosome-lysosome fusion

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Cyclophosphamide promotes the proliferation inhibition of mouse ovarian granulosa cells and premature ovarian failure by activating the lncRNA-Meg3-p53-p66Shc pathway

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Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population

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Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy

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TGF-β signaling controls FSHR signaling-reduced ovarian granulosa cell apoptosis through the SMAD4/miR-143 axis

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miR-23a and miR-27a Promote Human Granulosa Cell Apoptosis by Targeting SMAD5

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LncRNA MEG3 regulates ASK1/JNK axis-mediated apoptosis and autophagy via sponging miR-23a in granulosa cells of yak tertiary follicles

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