4.6 Article

Tumor-suppressive role of miR-139-5p in angiogenesis and tumorigenesis of ovarian cancer: Based on GEO microarray analysis and experimental validation

Related references

Note: Only part of the references are listed.
Article Cell Biology

METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA

Liping Meng et al.

Summary: This study reveals the important role of METTL14-mediated m6A methylation and lncRNA regulation in pyroptosis and DCM. The results show that METTL14 suppresses pyroptosis and DCM by downregulating lncRNA TINCR, and the underlying mechanisms involve m6A methylation and RNA degradation.

CELL DEATH & DISEASE (2022)

Article Health Care Sciences & Services

miR-139-5p Suppresses Proliferation and Angiogenesis of Intracranial Aneurysm via FGB

Tao Jin et al.

Summary: This study confirms that miR-139-5p targets FGB and regulates the progression of intracranial aneurysm. In addition, suppressing FGB expression inhibits cell proliferation and angiogenesis.

JOURNAL OF HEALTHCARE ENGINEERING (2022)

Article Cell Biology

Tumor-associated macrophages improve hypoxia-induced endoplasmic reticulum stress response in colorectal cancer cells by regulating TGF-β1/SOX4

Yuqing Kang et al.

Summary: This study reveals that tumor-associated macrophages (TAMs) can alleviate endoplasmic reticulum stress (ERS) in colorectal cancer (CRC) cells under hypoxic conditions by secreting TGF-I31. TGF-I31 stimulates cell growth and inhibits apoptosis in CRC cells, and its mechanism involves the activation of the SOX4-TMEM2 axis.

CELLULAR SIGNALLING (2022)

Article Biochemistry & Molecular Biology

The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors

Sumeda Nandadasa et al.

Summary: The study reveals that versican and hyaluronan are associated with the formation of early cell lineages in the embryo, with the versican-hyaluronan ECM playing a crucial role in vasculogenesis and primitive hematopoiesis. Inactivation of versican can lead to reduced vascular endothelial and hematopoietic differentiation, while hyaluronan-deficient mouse embryos also show vasculogenic suppression.

MATRIX BIOLOGY (2021)

Article Oncology

lncRNA SNHG3 acts as oncogene in ovarian cancer through miR-139-5p and Notch1

Li Zhang et al.

Summary: The study revealed that SNHG3 accelerates the proliferation and migration of ovarian cancer cells by regulating miR-139-5p and Notch1.

ONCOLOGY LETTERS (2021)

Article Oncology

miRNA-214-5p inhibits prostate cancer cell proliferation by targeting SOX4

Guangchi Xu et al.

Summary: miRNA-214-5p specifically targets SOX4 to inhibit the proliferation of prostate cancer cells and the expression of downstream growth factors in this pathway. Experimental results confirm the significant inhibitory effect of miRNA-214-5p on the proliferation of prostate cancer cells.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2021)

Article Cell Biology

Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation

Yuhao Luo et al.

Summary: Recent studies have shown that lncRNA EIF3J-DT is highly expressed in drug-resistant gastric cancer cells, contributing to chemoresistance by activating autophagy through targeting ATG14. This regulatory mechanism by EIF3J-DT may serve as a potential new target for enhancing chemosensitivity and improving prognosis in gastric cancer patients.

AUTOPHAGY (2021)

Article Medicine, Research & Experimental

KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1

Wenxue Liu et al.

Summary: The study reveals that KAT6A is upregulated in ovarian cancer and correlates with patient survival. Downregulation of KAT6A inhibits proliferation and migration of ovarian cancer cells, induces apoptosis, and enhances sensitivity to cisplatin. Additionally, KAT6A interaction with COP1 leads to impaired function, accumulation, and enhanced activity of beta-catenin, suggesting a critical role of the KAT6A/COP1/beta-catenin signaling axis in ovarian cancer progression. Targeting this signaling axis could be a novel strategy for ovarian cancer treatment.

THERANOSTICS (2021)

Article Oncology

TheU2AF2/circRNA ARF1/miR-342-3p/ISL2feedback loop regulates angiogenesis in glioma stem cells

Yang Jiang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Biochemistry & Molecular Biology

miR-590-3p Targets Cyclin G2 and FOXO3 to Promote Ovarian Cancer Cell Proliferation, Invasion, and Spheroid Formation

Mohamed Salem et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

The role of microRNAs involved in PI3-kinase signaling pathway in colorectal cancer

Saeed Noorolyai et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Multidisciplinary Sciences

MiR-139-5p as a novel serum biomarker for recurrence and metastasis in colorectal cancer

Jinsei Miyoshi et al.

SCIENTIFIC REPORTS (2017)

Article Cell Biology

Membranous and Cytoplasmic Expression of PD-L1 in Ovarian Cancer Cells

Qiu-Xia Qu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

Review Oncology

SOX4: Joining the Master Regulators of Epithelial-to-Mesenchymal Transition?

Ana Rita Lourenco et al.

TRENDS IN CANCER (2017)

Article Cell Biology

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

Jessica E. De Angelis et al.

DEVELOPMENTAL CELL (2017)

Article Medicine, Research & Experimental

Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer

Mingzhu Yin et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Biochemistry & Molecular Biology

MiR-139-5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel

He-da Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

miR-139-5p inhibits epithelial-mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2

Gongcai Qiu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Oncology

MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1

Yu-Ming Yeh et al.

INTERNATIONAL JOURNAL OF CANCER (2013)

Article Biochemistry & Molecular Biology

miR-139-5p is a regulator of metastatic pathways in breast cancer

Keerthana Krishnan et al.

Article Multidisciplinary Sciences

Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps

Sung Wook Chi et al.

NATURE (2009)

Review Biochemistry & Molecular Biology

The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins

M. Stros et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)