Journal
CELLULAR IMMUNOLOGY
Volume 393, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2023.104771
Keywords
Rheumatoid arthritis; Mesenchymal stromal/stem cell; Immune cell; Immunomodulation; Innate immunity; Adaptive immunity
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This review introduces the potential of mesenchymal stromal/stem cells (MSCs) in treating rheumatoid arthritis (RA), including their immunomodulatory and inhibitory effects. It summarizes the therapeutic effects of MSCs on animal models of arthritis and RA patients, and categorizes their effects on different immune cells. The limitations and future considerations for the use of MSCs as a therapeutic approach in RA patients are also discussed.
Rheumatoid arthritis (RA) is considered to be a degenerative and progressive autoimmune disorder. Although several medicinal regimens are used to treat RA, potential adverse events such as metabolic disorders and increased risk of infection, as well as drug resistance in some patients, make it essential to find an effective and safe therapeutic approach. Mesenchymal stromal/stem cells (MSCs) are a group of non-hematopoietic stromal cells with immunomodulatory and inhibitory potential. These cells exert their regulatory properties through direct cell-to-cell interactions and paracrine effects on various immune and non-immune cells. As conventional therapeutic approaches for RA are limited due to their side effects, and some patients became refractory to the treatment, MSCs are considered as a promising alternative treatment for RA. In this review, we introduced various experimental and clinical studies conducted to evaluate the therapeutic effects of MSCs on animal models of arthritis and RA patients. Then, possible modulatory and suppressive effects of MSCs on different innate and adaptive immune cells, including dendritic cells, neutrophils, macrophages, natural killer cells, B lymphocytes, and various subtypes of T cells, were categorized and summarized. Finally, limitations and future considerations for the efficient application of MSCs as a therapeutic approach in RA patients were presented.
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