4.5 Review

Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns

Related references

Note: Only part of the references are listed.
Article Cell Biology

Bone marrow-derived extracellular vesicles carry the TGF-β signal transducer Smad2 to preserve hematopoietic stem cells in mice

Flavie Gautheron et al.

Summary: Extracellular vesicles (EVs) released by cells in the bone marrow (BM) play an important role in regulating hematopoietic stem cells (HSC) through the transport of bioactive phosphorylated Smad2 (p-Smad2). We found that the EV inhibitor Calpeptin significantly affected the production of p-Smad2-carrying EVs in mouse BM, leading to alterations in HSC quiescence and maintenance. Our study also revealed that p-Smad2 is necessary for the ex vivo maintenance of HSC, as EVs lacking p-Smad2 failed to support HSC survival.

CELL DEATH DISCOVERY (2023)

Article Clinical Neurology

Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules

Zaquer Suzana Munhoz Costa-Ferro et al.

Summary: BMMC transplantation can prevent the development of depression and anxiety-like behavior triggered by chronic mild stress. It has anti-inflammatory effects and affects neurogenic molecules, providing a new perspective for depression and mood disorder research and treatment.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2022)

Review Pharmacology & Pharmacy

Extracellular Vesicle-Based Therapeutics in Neurological Disorders

Yiwen Yuan et al.

Summary: Extracellular vesicles have shown potential in treating neurological disorders, but face challenges in clinical application.

PHARMACEUTICS (2022)

Review Cell & Tissue Engineering

Mesenchymal Stromal Cell Mitochondrial Transfer as a Cell Rescue Strategy in Regenerative Medicine: A Review of Evidence in Preclinical Models

Yu Ling Tan et al.

Summary: Mesenchymal stromal cells (MSC) have the potential to treat damaged cells through mitochondrial transfer. However, the mechanisms of mitochondrial transfer and factors contributing to mitochondrial bioenergetics recovery need further investigation.

STEM CELLS TRANSLATIONAL MEDICINE (2022)

Review Neurosciences

Extracellular vesicles through the blood-brain barrier: a review

Hector M. Ramos-Zaldivar et al.

Summary: Extracellular vesicles (EVs) are non-replicative particles released from cells. The mechanism of bidirectional EVs transport across the blood-brain barrier (BBB) is poorly understood. Current research lacks direct visualization of EVs transcytosis through the BBB in mammals, with most studies relying on in vitro models that do not consider the combined effect of all cellular layers constituting the BBB. Further research using in vitro and in vivo methodologies is needed to clarify these issues.

FLUIDS AND BARRIERS OF THE CNS (2022)

Article Neurosciences

Exosomes derived from bone marrow mesenchymal stem cells attenuate neurological damage in traumatic brain injury by alleviating glutamate-mediated excitotoxicity

Zerui Zhuang et al.

Summary: BMSCs-Exos alleviate glutamate excitotoxicity post-TBI by upregulating GLT-1 level and downregulating p-p38 MAPK level in astrocytes, reducing glutamate levels and attenuating neuronal apoptosis. They demonstrate significant neuroprotective effects in experimental and animal models, reducing cortical lesion volume and improving cognitive function after TBI.

EXPERIMENTAL NEUROLOGY (2022)

Review Biochemistry & Molecular Biology

Stem cell-based therapy for human diseases

Duc M. Hoang et al.

Summary: Recent advancements in stem cell technology have provided new treatment options for patients with untreatable diseases and disorders. Human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs) have emerged as important players in regenerative medicine. Clinical applications of hPSCs and MSCs derived from different tissues, such as bone marrow, adipose tissue, and umbilical cord, have shown promising results in treating neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related diseases, reproductive disorders, skin burns, and cardiovascular conditions. The mechanisms underlying the therapeutic effects of these stem cells vary depending on their tissue origin.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Review Clinical Neurology

Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient

Jose De Andres et al.

Summary: Advancements in understanding the biology of spinal systems have led to a focus on therapeutic approaches targeted at the extracranial neuraxial space, particularly through the use of intrathecal drug delivery systems. These systems are effective for treating chronic pain and severe spasticity, but require careful consideration of risks and safety when implementing therapy.

FRONTIERS IN PAIN RESEARCH (2022)

Article Cell & Tissue Engineering

Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder

Liem Nguyen Thanh et al.

Summary: This study evaluated the safety and efficacy of autologous bone marrow mononuclear cell transplantation combined with educational intervention for children with autism spectrum disorder. The findings showed a significant reduction in the severity of ASD symptoms, an increase in adaptive capacity, and improvements in social communication, language, and daily skills after transplantation.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Article Critical Care Medicine

Bone Marrow-Derived Mononuclear Cell Transplantation Can Reduce Systemic Inflammation and Endothelial Glycocalyx Damage in Sepsis

Tsunehiro Matsubara et al.

Summary: This study demonstrated that BMMNC transplantation can reduce systemic inflammation and endothelial glycocalyx damage in sepsis, significantly improving the survival of rats. These findings offer insights for potential therapeutic strategies against sepsis.

SHOCK (2021)

Review Chemistry, Multidisciplinary

Mesenchymal Stem Cells for Neurological Disorders

Anna Andrzejewska et al.

Summary: Neurological disorders pose a growing burden as society ages, with stem cell-based regenerative medicine offering a promising approach. Researchers are studying the application of MSCs to various neurological diseases and focusing on the delivery of stem cells to the brain as an essential and understudied challenge.

ADVANCED SCIENCE (2021)

Review Biotechnology & Applied Microbiology

Extracellular vesicles in neuroinflammation: Pathogenesis, diagnosis, and therapy

Jing Ruan et al.

Summary: Extracellular vesicles play a crucial role in intercellular communication in the central nervous system, influencing the pathogenesis and treatment of neuroinflammatory diseases.

MOLECULAR THERAPY (2021)

Review Surgery

Management of Acute Traumatic Spinal Cord Injury: A Review of the Literature

Timothy Y. Wang et al.

Summary: Traumatic spinal cord injury is a debilitating disease that presents significant functional and economic burdens. Prognosis depends on the extent of injury and severity of dysfunction, with rapid treatment crucial to prevent further damage. Managing TSCI patients involves various factors, from initial assessment to long-term care for optimal recovery.

FRONTIERS IN SURGERY (2021)

Letter Cell & Tissue Engineering

Invasive therapy for children with autism is not justified

Heather Finlay-Morreale

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Article Neurosciences

Bone Marrow Mononuclear Cells Transplantation and Training Increased Transplantation of Energy Source Transporters in Chronic Stroke

Yuko Ogawa et al.

Summary: The study showed that BM-MNC transplantation combined with training can activate transcriptional activation of metabolism-related genes in the brain during chronic stroke, leading to improved motor function. The combination therapy has demonstrated significant therapeutic efficacy in treating chronic stroke.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

Review Neurosciences

Extracellular vesicles in the treatment of neurological disorders

Samantha L. Reed et al.

Summary: Extracellular vesicles (EVs) are cell-derived membranous particles that contain various molecules and play important roles in intercellular communication. They have shown efficacy in models of neurological disorders by reducing symptoms and providing benefits, making them a promising avenue for future research and clinical applications.

NEUROBIOLOGY OF DISEASE (2021)

Article Cell & Tissue Engineering

Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells

Liem Thanh Nguyen et al.

Summary: The study suggests that autologous administration of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) is safe in patients with type 2 diabetes mellitus (T2DM), with treatment efficacy dependent on the quality of the stem cell population and administration routes. Short-term therapeutic effects were observed in patients with shorter T2DM duration and lower body weight.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Review Clinical Neurology

Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease

Agata Matejuk et al.

Summary: The immune system plays a crucial role in maintaining tissue homeostasis and integrity, beyond self-recognition, from early development to ensure proper organ function later in life. Recent research shows that immune cells in the blood can support the CNS through neuroimmune communication, challenging the traditional view of peripheral immunity being detrimental to the nervous system. Understanding the cross-talk between the CNS and the immune system is essential to uncover neurodestructive and neuroprotective immune mechanisms for more effective therapeutic strategies in health and disease.

FRONTIERS IN NEUROLOGY (2021)

Review Multidisciplinary Sciences

Contribution of extracellular vesicles in normal hematopoiesis and hematological malignancies

Soudeh Ghafouri-Fard et al.

Summary: Extracellular vesicles, such as exosomes and microvesicles, play crucial roles in intercellular communication by modulating the bone marrow microenvironment and influencing the differentiation and expansion of hematopoietic cells. Understanding the specific targets, transferred biomolecules, and molecular mechanisms of EVs is essential for targeted therapeutic approaches in transfusion medicine. Additionally, EVs are implicated in the pathogenesis and progression of hematological malignancies, highlighting their potential as important players in both normal hematopoiesis and cancer development.

HELIYON (2021)

Article Multidisciplinary Sciences

Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis

Toru Yamashita et al.

SCIENTIFIC REPORTS (2020)

Review Cell & Tissue Engineering

Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation

Pedro Norat et al.

NPJ REGENERATIVE MEDICINE (2020)

Review Geriatrics & Gerontology

Neuroprotective Properties and Therapeutic Potential of Bone Marrow-Derived Microglia in Alzheimer's Disease

Chang Li et al.

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2020)

Article Veterinary Sciences

Efficacy of autologous bone marrow mononuclear cell transplantation in dogs with chronic spinal cord injury

Katsutoshi Tamura et al.

OPEN VETERINARY JOURNAL (2020)

Editorial Material Clinical Neurology

Editorial: New Advances in Neurorehabilitation

Stefano Tamburin et al.

FRONTIERS IN NEUROLOGY (2019)

Review Medicine, General & Internal

Vascular endothelial growth factor biology for regenerative angiogenesis

Andrea Uccelli et al.

SWISS MEDICAL WEEKLY (2019)

Review Pediatrics

Cellular therapy for traumatic neurological injury

Charles S. Cox

PEDIATRIC RESEARCH (2018)

Article Health Care Sciences & Services

The effects of bone marrow mononuclear cell transplantation on the quality of life of children with cerebral palsy

Nguyen Thanh Liem et al.

HEALTH AND QUALITY OF LIFE OUTCOMES (2018)

Article Cell & Tissue Engineering

Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells

Charles S. Cox et al.

STEM CELLS (2017)

Review Immunology

Myeloid Cells in the Central Nervous System

Jasmin Herz et al.

IMMUNITY (2017)

Review Pediatrics

Autism Spectrum Disorders - Diagnosis and Management

Sharmila Banerjee Mukherjee

INDIAN JOURNAL OF PEDIATRICS (2017)

Article Medicine, General & Internal

Bone Marrow Mononuclear Cells Transplantation in Treatment of Established Bronchopulmonary Dysplasia: A Case Report

Nguyen Thanh Liem et al.

AMERICAN JOURNAL OF CASE REPORTS (2017)

Article Engineering, Biomedical

Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

Dongfen Yuan et al.

BIOMATERIALS (2017)

Article Multidisciplinary Sciences

Chromatographically isolated CD63+ CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

Dong-ki Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biotechnology & Applied Microbiology

Safety and seizure control in patients with mesial temporal lobe epilepsy treated with regional superselective intra-arterial injection of autologous bone marrow mononuclear cells

Jaderson C. DaCosta et al.

Journal of Tissue Engineering and Regenerative Medicine (2016)

Article Clinical Neurology

Managing drug-resistant epilepsy: challenges and solutions

Linda Dalic et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2016)

Article Peripheral Vascular Disease

Paracrine Mechanisms of Intravenous Bone Marrow-Derived Mononuclear Stem Cells in Chronic Ischemic Stroke

Ashu Bhasin et al.

CEREBROVASCULAR DISEASES EXTRA (2016)

Review Biochemistry & Molecular Biology

The dynamic blood-brain barrier

James Keaney et al.

FEBS JOURNAL (2015)

Article Critical Care Medicine

Autologous Bone Marrow Mononuclear Cells Reduce Therapeutic Intensity for Severe Traumatic Brain Injury in Children

George P. Liao et al.

PEDIATRIC CRITICAL CARE MEDICINE (2015)

Article Cell & Tissue Engineering

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

Thorsten R. Doeppner et al.

STEM CELLS TRANSLATIONAL MEDICINE (2015)

Article Cell & Tissue Engineering

A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier

Alok Sharma et al.

STEM CELLS INTERNATIONAL (2015)

Article Zoology

Migration of Bone Marrow-Derived Cells Into the Central Nervous System in Models of Neurodegeneration

Antoine Lampron et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2015)

Article Cell Biology

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Oscar P. B. Wiklander et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Article Medicine, General & Internal

Cerebral palsy

Allan Colver et al.

LANCET (2014)

Article Cell & Tissue Engineering

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

Bin Zhang et al.

STEM CELLS AND DEVELOPMENT (2014)

Article Peripheral Vascular Disease

Autologous Bone Marrow Mononuclear Cells Intrathecal Transplantation in Chronic Stroke

Alok Sharma et al.

STROKE RESEARCH AND TREATMENT (2014)

Article Neurosciences

Bone marrow-derived mononuclear cell transplantation in spinal cord injury patients by lumbar puncture

Yoshihisa Suzuki et al.

RESTORATIVE NEUROLOGY AND NEUROSCIENCE (2014)

Article Biochemistry & Molecular Biology

Ischemic brain injury: A consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction

Colin P. McGuckin et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2013)

Article Biochemical Research Methods

Isolation, culture and evaluation of multilineage-differentiating stress-enduring (Muse) cells

Yasumasa Kuroda et al.

NATURE PROTOCOLS (2013)

Article Cell & Tissue Engineering

Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients

Paulo Henrique Rosado-de-Castro et al.

REGENERATIVE MEDICINE (2013)

Article Gastroenterology & Hepatology

Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses

Qian-Qian Chen et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

Article Cell & Tissue Engineering

Autologous Bone Marrow Mononuclear Cell Therapy for Autism: An Open Label Proof of Concept Study

Alok Sharma et al.

STEM CELLS INTERNATIONAL (2013)

Review Cell & Tissue Engineering

Mesenchymal Stem Cells Migration Homing and Tracking

Abhishek Sohni et al.

STEM CELLS INTERNATIONAL (2013)

Review Immunology

Bone marrow and the control of immunity

Ende Zhao et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2012)

Article Clinical Neurology

Intravenous Autologous Bone Marrow Mononuclear Cells for Ischemic Stroke

Sean I. Savitz et al.

ANNALS OF NEUROLOGY (2011)

Article Medicine, General & Internal

Cardiac cell therapy: where we've been, where we are, and where we should be headed

Konstantinos Malliaras et al.

BRITISH MEDICAL BULLETIN (2011)

Review Clinical Neurology

Clinical diagnosis and management of amyotrophic lateral sclerosis

Orla Hardiman et al.

NATURE REVIEWS NEUROLOGY (2011)

Article Cell & Tissue Engineering

Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke

Valeria Battistella et al.

REGENERATIVE MEDICINE (2011)

Review Cardiac & Cardiovascular Systems

Role of Bone Marrow-Derived Lymphatic Endothelial Progenitor Cells for Lymphatic Neovascularization

Changwon Park et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2011)

Article Neurosciences

Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection

Lea Mirian Barbosa da Fonseca et al.

EXPERIMENTAL NEUROLOGY (2010)

Article Cardiac & Cardiovascular Systems

Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: Combined consequences for cell therapy in older recipients

Yufeng Zhuo et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2010)

Article Cell & Tissue Engineering

Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

Uwe M. Fischer et al.

STEM CELLS AND DEVELOPMENT (2009)

Article Neurosciences

Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study

Carlos Suarez-Monteagudo et al.

RESTORATIVE NEUROLOGY AND NEUROSCIENCE (2009)

Article Cell Biology

Human mesenchymal stem cells stimulated by TNF-α, LPS, or hypoxia produce growth factors by an NFκB- but not JNK-dependent mechanism

Paul R. Crisostomo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Article Pharmacology & Pharmacy

Endothelial progenitor cells in vascular repair and remodeling

Mihail Hristov et al.

PHARMACOLOGICAL RESEARCH (2008)

Article Cell Biology

Age-related BM-MNC dysfunction hampers neovascularization

Shinobu Sugihara et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2007)

Article Neurosciences

Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine model

Akihiko Taguchi et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2007)

Article Neurosciences

Cord blood rescues stroke-induced changes in splenocyte phenotype and function

Martina Vendrame et al.

EXPERIMENTAL NEUROLOGY (2006)

Article Multidisciplinary Sciences

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

M Alvarez-Dolado et al.

NATURE (2003)

Article Cardiac & Cardiovascular Systems

CD117+ stem cells play a key role in therapeutic angiogenesis induced by bone marrow cell implantation

TS Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)

Article Multidisciplinary Sciences

Transplanted bone marrow regenerates liver by cell fusion

G Vassilopoulos et al.

NATURE (2003)

Article Multidisciplinary Sciences

Cell fusion is the principal source of bone-marrow-derived hepatocytes

X Wang et al.

NATURE (2003)

Review Clinical Neurology

Angiogenesis in nervous system disorders

G Zadeh et al.

NEUROSURGERY (2003)

Article Multidisciplinary Sciences

Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

N Terada et al.

NATURE (2002)

Article Medicine, Research & Experimental

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells

KA Jackson et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Article Cell Biology

Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis

M Hellström et al.

JOURNAL OF CELL BIOLOGY (2001)

Article Multidisciplinary Sciences

From marrow to brain: Expression of neuronal phenotypes in adult mice

TR Brazelton et al.

SCIENCE (2000)

Article Neurosciences

Adult bone marrow stromal cells differentiate into neural cells in vitro

J Sanchez-Ramos et al.

EXPERIMENTAL NEUROLOGY (2000)