Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction

Diabetic vascular complications (DVCs), including macro- and micro- angiopathy, account for a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial dysfunction is the initial and role step for the pathogenesis of DVCs. Hyperglycemia and lipid metabolism disorders contribute to endothelial dysfunction via direct injury of metabolism products, crosstalk between immunity and inflammation, as well as related interaction network. Although physiological and phenotypic differences support their specified changes in different targeted organs, there are still several common mechanisms underlying DVCs. Also, inhibitors of these common mechanisms may decrease the incidence of DVCs effectively. Thus, this review may provide new insights into the possible measures for the secondary prevention of DM. And we discussed the current limitations of those present preventive measures in DVCs research.AtQqCcZA72cRUWuc-5MhGdVideo Abstract

Automated summary

Diabetic vascular complications (DVCs), including macro- and micro- angiopathy, are major causes of mortality in patients with diabetes mellitus (DM), with endothelial dysfunction playing a key role in their pathogenesis. Hyperglycemia and lipid metabolism disorders contribute to endothelial dysfunction through various mechanisms, and targeting these common mechanisms may be effective in reducing the incidence of DVCs.