Journal
CELL CALCIUM
Volume 113, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2023.102759
Keywords
Apoptosis; Bcl2; Endoplasmic reticulum; immunogenic cell; death; Lysosomes; MPT-driven necrosis
Categories
Ask authors/readers for more resources
Multiple forms of regulated cell death (RCD) are associated with the activation of specific molecular mechanisms. Ca2+ ions can physically interact and regulate various components of the RCD machinery, leading to organellar dysfunction and increased sensitivity to cell death induced by other stressors.
Multiple forms of regulated cell death (RCD) have been characterized, each of which originates from the activation of a dedicated molecular machinery. RCD can occur in purely physiological settings or upon failing cellular adaptation to stress. Ca2+ions have been shown to physically interact with - and hence regulate - various components of the RCD machinery. Moreover, intracellular Ca2+ accumulation can promote organellar dysfunction to degree that can be overtly cytotoxic or sensitize cells to RCD elicited by other stressors. Here, we provide an overview of the main links between Ca2+and different forms of RCD, including apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, lysosome-dependent cell death, and parthanatos.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available