Outcomes of European Society of Cardiology 0/1-h algorithm with high-sensitivity cardiac troponin T among patients with coronary artery disease

Article Cardiac & Cardiovascular Systems

Aplicación del algoritmo 0 h/1 h de troponina de alta sensibilidad de la ESC para la toma de decisiones en el servicio de urgencias

Maria Rubini Gimenez et al.

REVISTA ESPANOLA DE CARDIOLOGIA (2023)

Article Cardiac & Cardiovascular Systems

Performance of the European Society of Cardiology 0/1-Hour Algorithm With High-Sensitivity Cardiac Troponin T Among Patients With Known Coronary Artery Disease

Nicklaus P. Ashburn et al.

Summary: The ESC 0/1-hour algorithm is effective in diagnosing acute coronary syndrome, but limited data is available for patients with known coronary artery disease. This study evaluated and compared the diagnostic performance of the algorithm for cardiac death or myocardial infarction in patients with and without known CAD, and assessed its ability to achieve a negative predictive value of 99% or higher.

JAMA CARDIOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Diagnostic accuracy of a high-sensitivity troponin I assay and external validation of 0/3 h rule out strategies

Patricia van den Berg et al.

Summary: This study evaluated the diagnostic accuracy of a high-sensitivity cardiac troponin I assay in the Emergency Department. Absolute delta criteria showed superior accuracy compared to relative criteria. Using the Siemens TNIH assay in combination with validated algorithms incorporating specific cutoff values and absolute delta criteria can improve sensitivity in diagnosing acute myocardial infarction.

EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE (2022)

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Article Cardiac & Cardiovascular Systems

Rapid Exclusion of Acute Myocardial Injury and Infarction With a Single High-Sensitivity Cardiac Troponin T in the Emergency Department: A Multicenter United States Evaluation

Yader Sandoval et al.

Summary: Using a single hs-cTnT below the limit of quantitation of 6 ng/L is a safe and rapid method to identify a substantial number of patients at very low risk for acute myocardial injury and infarction.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Diagnostic Performance of High-Sensitivity Cardiac Troponin T Strategies and Clinical Variables in a Multisite US Cohort

Brandon R. Allen et al.

Summary: In a prospective multisite US cohort, an initial hs-cTnT below the LOQ combined with a low-risk HEART score has a 99% NPV for 30-day MACEs. The 0/1-h hs-cTnT algorithm did not achieve an NPV >99% for 30-day MACEs when used alone or with a HEART score.

CIRCULATION (2021)

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Article Medical Laboratory Technology

Diagnostic Validation of a High-Sensitivity Cardiac Troponin I Assay

Nils A. Soerensen et al.

Summary: This study assessed the diagnostic accuracy of a high-sensitivity cardiac troponin I assay in patients with suspected acute MI, developing and validating a 0/1 hour diagnostic algorithm. The algorithm showed high negative predictive value and sensitivity, making it suitable for rapid diagnostic stratification of patients with suspected MI.

CLINICAL CHEMISTRY (2021)

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Review Cardiac & Cardiovascular Systems

Acute coronary syndrome treatment delay in low to middle-income countries: A systematic review

Lemlem Beza et al.

Summary: Morbidity and mortality rates for acute coronary syndrome (ACS) are decreasing in high-income countries but rising at an alarming pace in low to middle income countries (LMICs). Factors contributing to poor clinical outcomes in LMICs include prehospital treatment delays, with older age, female gender, illiteracy, rural residence, and financial limitations associated with longer delays. Lack of developed emergency transportation systems and poor communication between community and interventional facilities are also major contributors to delays in ACS treatment.

IJC HEART & VASCULATURE (2021)

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Article Emergency Medicine