Journal
CARBOHYDRATE POLYMERS
Volume 324, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2023.121526
Keywords
Hydrogel microparticles; Hydrogel; Natural cross -linker; Wound healing; BBD; Spray drying; Silver nanoparticles
Categories
Ask authors/readers for more resources
Interactive wound dressings combining healing and antimicrobial potentials, utilizing a three-dimensional structured matrix constructed with natural bio-macromolecules, demonstrated significant wound healing effects and antimicrobial activity. Injured rat experiments confirmed its excellent wound healing ability and minimal oxidative stress.
Interactive wound dressings combining healing and antimicrobial potentials, besides ensuring patient compliance with a recognized wound care service gained considerable interest recently. Both hydrogel spray dried microparticles (HMP) and soft hydrogel (G) were prepared. The bio-inspired combinatory platform included natural bio-macromolecules namely: chitosan (CS) and collagen (COL) with wound healing enhancement and connective tissue building capabilities cross linked with the natural genipin (GN) to build a three dimensional structured matrix. The optimized plain hydrogel obtained by a box behnken design (BBD) program (G) scored maximum swelling and porosity. The network was hosted with green synthesized cefotaxime sodium (cef.Na) AgNPs reduced by the anabolic folic acid (FA). Both hydrogels exhibited good antimicrobial activity against gram +ve and -ve bacteria. The wound healing activity, evaluated in injured rats, showed >98 % and complete wound closure after two and three weeks respectively. Oxidative stress minimization was proved by the estimation of biochemical markers malondialdehyde (MDA) and superoxide dismutase (SOD) levels at the wound site.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available