☆ 4.8 Article

Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma

CANCER RESEARCH (2023)

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer

Maria Chiara De Santis et al.

Summary: This study reveals that loss of PI3K-C2 gamma in pancreatic ductal adenocarcinoma (PDAC) leads to hyperactivation of mTORC1 pathway and rewiring of glutamine metabolism, increasing tumor aggressiveness. Furthermore, PI3K-C2 gamma knockout tumors fail to adapt to metabolic stress induced by glutamine depletion, resulting in cell death. These findings suggest that targeting mTORC1 and glutamine metabolism may be a potential strategy for personalized treatment in PDAC with PI3K-C2 gamma loss.

GUT (2023)

Add to Collection
Article Medicine, Research & Experimental

Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models

Xu Han et al.

Summary: Myeloproliferative neoplasms (MPNs) are characterized by the activated JAK2/STAT pathway. Pleckstrin-2 (Plek2) is a downstream target of the JAK2/STAT5 pathway and is overexpressed in patients with MPNs. Plek2-specific small molecule inhibitors show potent inhibitory effects on cell proliferation.

JOURNAL OF CLINICAL INVESTIGATION (2023)

Add to Collection
Review Oncology

Expanding the Reach of Precision Oncology by Drugging All KRAS Mutants

Marco H. Hofmann et al.

Summary: KRAS is a frequently mutated oncogene, and there is a need for both allele-specific and pan-KRAS drugs to target a wide range of KRAS mutations and conquer KRAS-driven cancers.

CANCER DISCOVERY (2022)

Add to Collection
Review Cell Biology

Biogenesis and Regulatory Roles of Circular RNAs

Li Yang et al.

Summary: Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes as well as from the processing of cellular RNAs. Recent studies have revealed that many protein-coding genes can undergo backsplicing, leading to widespread expression of circular RNAs (circRNAs) in eukaryotic cells. circRNAs play various roles in gene regulation, acting as noncoding RNAs or encoding functional peptides. They are involved in physiological processes including early development, immune responses, neurogenesis, and tumorigenesis.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Circular RNAs: Characterization, cellular roles, and applications

Chu-Xiao Liu et al.

Summary: In this review, we discuss the methods used in circular RNA studies and the current understanding of their regulatory roles and potential applications. Circular RNAs can modulate transcription and splicing, regulate the stability and translation of mRNAs, interfere with signaling pathways, and play important roles in cellular processes and immune responses.

CELL (2022)

Add to Collection
Letter Oncology

Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer

Yang Zhang et al.

Summary: IL1RAP is an important regulator in the development of pancreatic cancer and its overexpression is associated with poor prognosis in pancreatic cancer patients. Silencing IL1RAP and inhibiting its downstream IRAK4 can reduce the growth and invasive ability of pancreatic cancer cells.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Add to Collection
Correction Biochemistry & Molecular Biology

CircRNA perspective: new strategies for RNA therapy (vol 28, pg 343, 2022)

Nan Wu et al.

TRENDS IN MOLECULAR MEDICINE (2022)

Add to Collection
Review Cell Biology

The Quaking RNA-binding proteins as regulators of cell differentiation

Daniel P. Neumann et al.

Summary: The RNA-binding protein Quaking (QKI) plays an important role in cellular differentiation, with different isoforms affecting neuronal, vascular, muscle, and monocyte cell differentiation as well as epithelial-mesenchymal transition in cancer progression. QKI isoforms control cell differentiation through regulating alternative splicing, mRNA stability and translation, and also have activities in gene transcription. These diverse functions of the QKI isoforms contribute to their broad influences on RNA metabolism and cellular differentiation.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia

Chao Zhou et al.

Summary: The study found that knockout mice of miR-15a/16-1 exhibited fewer cognitive and sensorimotor deficits after VCID. The deficiency of miR-15a/16-1 also reduced myelin degeneration, axonal injury, and neuronal loss in VCID mice. The miR-15a/16-1-IL/10RA/AKT3 axis played a critical role in regulating vascular brain damage and cognitive decline after VCID. Targeting miR-15a/16-1 could be a novel therapeutic approach for the treatment of VCID.

ADVANCED SCIENCE (2022)

Add to Collection
Article Cardiac & Cardiovascular Systems

A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity

Dongchao Lu et al.

Summary: This study identified a circular RNA called Circ-INSR, which is down-regulated during cardiac toxicity and remodeling. The researchers found that overexpression of Circ-INSR can prevent and reverse doxorubicin-induced cardiomyocyte death, and improve cardiac function.

EUROPEAN HEART JOURNAL (2022)

Add to Collection
Review Oncology

Moving the Needle on Precision Medicine in Pancreatic Cancer

Grainne M. O'Kane et al.

Summary: Managing pancreatic ductal adenocarcinoma (PDAC) has been a challenge, but a deeper understanding of its biology has provided guidance for precision treatment. Specific PDAC subgroups and KRAS wild-type PDAC can be targeted for treatment, and genomic- and transcriptomic-based classifiers can be used in clinical trials.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Add to Collection
Review Immunology

Splicing dysregulation in human hematologic malignancies: beyond splicing mutations

Jonas De Kesel et al.

Summary: This article provides an overview of the emerging mechanisms of aberrant splicing, its contribution to oncogenesis, and its clinical potential in the treatment of blood cancers.

TRENDS IN IMMUNOLOGY (2022)

Add to Collection
Review Medicine, Research & Experimental

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Javeria Qadir et al.

Summary: This review examines the interplay between the Hippo signaling pathway and circular RNAs (circRNAs) in various forms of cancer. It discusses how circRNAs can function as either tumor suppressors or oncogenes in cancer by interacting with miRNAs or proteins. The review also highlights the limitations and constraints in studying circRNA mechanisms, and raises questions about the role of circRNAs associated with the Hippo-YAP pathway in cancer. Finally, it explores the potential of circRNAs as diagnostic and prognostic biomarkers, as well as molecular targets for cancer therapy.

THERANOSTICS (2022)

Add to Collection
Review Oncology

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data

Ashton A. Connor et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest epithelial malignancies, with increasing research over several decades leading to a better understanding of its carcinogenesis and significant progress in genomics and transcriptomics. The inclusion of PDAC data in international pan-cancer analyses has provided further insights, and the study of PDAC evolution and heterogeneity has led to the proposal of an evolutionary model based on genomics studies of human PDAC.

NATURE REVIEWS CANCER (2022)

Add to Collection
Article Multidisciplinary Sciences

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function

Xinyun Chen et al.

Summary: The RNA-binding protein Quaking (QKI) plays a crucial role in cardiac development and contractile physiology through its regulation of alternative splicing in genes involved in Z-disc formation and contractile physiology. Deficiency of QKI results in the failure of cardiomyocytes to mature into functional cells, highlighting its importance in cardiac pathophysiology.

NATURE COMMUNICATIONS (2021)

Add to Collection
Article Cell Biology

Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas

Stefan R. Sweha et al.

Summary: High-grade gliomas with H3.3G34R/V mutations have poor prognosis and current treatments are not curative. Epigenetic analysis revealed the LIF/STAT3 pathway as a key vulnerability in H3.3G34R/V gliomas, suggesting potential for targeted therapies.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection
Article Multidisciplinary Sciences

Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain

Kristina Sakers et al.

Summary: The study defines the targets of QKI in the mouse brain and shows that loss of QKI disrupts the expression of cell maturation-associated genes in astrocytes in vivo.

NATURE COMMUNICATIONS (2021)

Add to Collection
Article Multidisciplinary Sciences

A KRAS-responsive long non-coding RNA controls microRNA processing

Lei Shi et al.

Summary: This study reveals the role of KIMAT1 in maintaining KRAS signaling in lung cancer progression, suggesting that targeting it may be a strategy to prevent KRAS-induced tumorigenesis.

NATURE COMMUNICATIONS (2021)

Add to Collection
Review Medicine, General & Internal

Pancreatic Cancer: A Review

Wungki Park et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer with increasing incidence each year, resulting in a high percentage of patients being diagnosed with advanced disease. Current cytotoxic therapies for PDAC are moderately effective, emphasizing the importance of multidisciplinary management, comprehensive germline testing, and integrated supportive care for all patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection
Review Biochemistry & Molecular Biology

KRAS mutation: from undruggable to druggable in cancer

Lamei Huang et al.

Summary: This review provides the latest understanding of fundamental aspects of KRAS, the relationship between KRAS mutations and tumor immune evasion, and new progress in targeting KRAS, particularly KRAS (G12C). The possible mechanisms of resistance to KRAS (G12C) inhibitors and potential combination therapies are also summarized, aiming to offer the best personalized treatment regimen with KRAS (G12C) inhibitors and achieve truly precise treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection
Article Biotechnology & Applied Microbiology

A global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation

Yue Ren et al.

Summary: The study reveals that chromatin-enriched RBPs are versatile factors orchestrating gene expression in different cellular contexts, and identifies QKI5, a classic RBP regulating RNA processing, as a novel transcriptional activator during monocytic differentiation.

GENOME BIOLOGY (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion

Jinbo Chen et al.

EMBO REPORTS (2020)

Add to Collection
Review Gastroenterology & Hepatology

Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer

Louis Buscail et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Add to Collection
Review Cell Biology

Biogenesis and Functions of Circular RNAs Come into Focus

Mei-Sheng Xiao et al.

TRENDS IN CELL BIOLOGY (2020)

Add to Collection
Review Oncology

Roles and mechanisms of alternative splicing in cancer - implications for care

Sophie C. Bonnal et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Add to Collection
Review Cell Biology

The expanding regulatory mechanisms and cellular functions of circular RNAs

Ling-Ling Chen

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Add to Collection
Review Biotechnology & Applied Microbiology

RAS-targeted therapies: is the undruggable drugged?

Amanda R. Moore et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Add to Collection
Review Oncology

Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance

Jiao Li et al.

TRENDS IN CANCER (2020)

Add to Collection
Article Gastroenterology & Hepatology

JAK selectivity for inflammatory bowel disease treatment: does it clinically matter?

Silvio Danese et al.

GUT (2019)

Add to Collection
Article Biochemistry & Molecular Biology

Understanding the binding specificities of mRNA targets by the mammalian Quaking protein

Monika Sharma et al.

NUCLEIC ACIDS RESEARCH (2019)

Add to Collection
Article Medicine, Research & Experimental

Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma

Yan-Jing Zhu et al.

THERANOSTICS (2019)

Add to Collection
Article Oncology

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

Shunsuke Kitajima et al.

CANCER CELL (2018)

Add to Collection
Article Cardiac & Cardiovascular Systems

Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression

Shashi Kumar Gupta et al.

CIRCULATION RESEARCH (2018)

Add to Collection
Review Biochemistry & Molecular Biology

The Biogenesis, Functions, and Challenges of Circular RNAs

Xiang Li et al.

MOLECULAR CELL (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1

Amaresh C. Panda et al.

NUCLEIC ACIDS RESEARCH (2017)

Add to Collection
Article Biochemistry & Molecular Biology

The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs

Ryota Yamagishi et al.

NUCLEIC ACIDS RESEARCH (2016)

Add to Collection
Article Multidisciplinary Sciences

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes

Yongchao Dou et al.

SCIENTIFIC REPORTS (2016)

Add to Collection
Article Biochemistry & Molecular Biology

The RNA Binding Protein Quaking Regulates Formation of circRNAs

Simon J. Conn et al.

CELL (2015)

Add to Collection
Review Medicine, Research & Experimental

Mechanisms of lymphatic metastasis

Sinem Karaman et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Add to Collection
Article Oncology

In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno-Positron Emission Tomography

Viviane Mumprecht et al.

CANCER RESEARCH (2010)

Add to Collection
Article Oncology

Intratumoral Mediated Immunosuppression is Prognostic in Genetically Engineered Murine Models of Glioma and Correlates to Immunotherapeutic Responses

Ling-Yuan Kong et al.

CLINICAL CANCER RESEARCH (2010)

Add to Collection
Article Oncology

New Strategies for Treatment of KRAS Mutant Metastatic Colorectal Cancer

Hans Prenen et al.

CLINICAL CANCER RESEARCH (2010)

Add to Collection
Article Multidisciplinary Sciences

Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein

Lixia Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Add to Collection
Article Oncology

A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells

Ling-Yuan Kong et al.

CLINICAL CANCER RESEARCH (2008)

Add to Collection
Article Multidisciplinary Sciences

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

SC Kent et al.

NATURE (2005)

Add to Collection
Review Biotechnology & Applied Microbiology

The Janus kinases (Jaks)

K Yamaoka et al.

GENOME BIOLOGY (2004)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.