☆ 4.7 Article

Autophagy and cancer drug resistance in dialogue: Pre-clinical and clinical evidence

CANCER LETTERS (2023)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

Xanthine oxidoreductase mediates genotoxic drug-induced autophagy and apoptosis resistance by uric acid accumulation and TGF-β-activated kinase 1 (TAK1) activation

Jingxiang Wang et al.

Summary: Autophagy plays a crucial role in the efficacy of genotoxic chemotherapeutic drugs. This study reveals that XOR, an enzyme involved in purine catabolism, can activate TAK1 through uric acid generation, leading to autophagy and apoptosis resistance induced by genotoxic drugs. Inhibition of TAK1 and its downstream kinases AMPK and JNK can enhance genotoxic drug-induced apoptosis. This finding has important implications for the development of novel therapeutic strategies for cancer treatment.

FASEB JOURNAL (2023)

Add to Collection

Article Medicine, Research & Experimental

M2 tumor-associated macrophage mediates the maintenance of stemness to promote cisplatin resistance by secreting TGF-beta 1 in esophageal squamous cell carcinoma

Kaige Yang et al.

Summary: This study found that M2 tumor-associated macrophages (M2-TAMs) promote stemness characteristics and induce cisplatin resistance in esophageal squamous cell carcinoma (ESCC) cells by secreting TGF-beta 1. This finding helps to understand the mechanism of chemotherapy resistance in ESCC.

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Icaritin Derivative IC2 Induces Cytoprotective Autophagy of Breast Cancer Cells via SCD1 Inhibition

Yi-Xuan Wang et al.

Summary: Icaritin (ICT), a derivative of Epimedium Genus, can inhibit the proliferation and stemness of breast cancer cells. This study found that IC2, a derivative of ICT, induced apoptosis in breast cancer cells by inhibiting SCD1 and also stimulated autophagy through AMPK and MAPK signaling pathways. The combination of autophagy inhibitor enhanced the anticancer activity of IC2, suggesting the potential of IC2 in combination therapy for breast cancer.

MOLECULES (2023)

Add to Collection

Article Cell Biology

Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis

Jingru Bai et al.

Summary: This study reveals that autophagy deficiency in cancer-associated fibroblasts inhibits their activation by impeding proline biosynthesis and collagen production. Autophagy promotes proline biosynthesis through mitophagy-mediated regulation of NADK2. Inhibiting mitophagy can reduce tumor weight in pancreatic ductal adenocarcinoma.

AUTOPHAGY (2023)

Add to Collection

Article Pharmacology & Pharmacy

Oncogenic lncRNA MALAT-1 recruits E2F1 to upregulate RAD51 expression and thus promotes cell autophagy and tumor growth in non-small cell lung cancer

Rui Xin et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2023)

Add to Collection

Article Multidisciplinary Sciences

FGF19 promotes cell autophagy and cisplatin chemoresistance by activating MAPK signaling in ovarian cancer

Wei Zhu et al.

Summary: This study found that FGF19 promotes cisplatin resistance in ovarian cancer cells by inducing autophagy. NGS analysis of 62 cases of high grade serous ovarian cancer identified a significantly amplified gene, FGF19. Furthermore, the expression level of FGF19 in ovarian cancer samples was higher than that in normal samples.

PEERJ (2023)

Add to Collection

Article Oncology

P38 Mediates Tumor Suppression through Reduced Autophagy and Actin Cytoskeleton Changes in NRAS-Mutant Melanoma

Ishani Banik et al.

Summary: NRAS mutations are common in melanoma but lack targeted therapies. This study demonstrates that p38 acts as a tumor suppressor in NRAS mutant melanoma by regulating mTOR phosphorylation, autophagy, and actin remodeling. Pharmacologically available small molecules can modulate p38 and its downstream targets, providing a potential strategy for treating NRAS mutant melanoma. Combining these compounds with FDA-approved drugs like MEK inhibitors may offer a novel approach for targeting NRAS-mutant melanoma.

CANCERS (2023)

Add to Collection

Article Microbiology

Chloroquine Inhibition of Autophagy Enhanced the Anticancer Effects of Listeria monocytogenes in Melanoma

Zuhua Yu et al.

Summary: This study demonstrated that Listeria monocytogenes (LM) exhibits antitumor effects by inducing autophagy, and the combination of LM and the autophagy inhibitor chloroquine (CQ) enhances the antitumor activity of LM both in vitro and in vivo.

MICROORGANISMS (2023)

Add to Collection

Article Chemistry, Medicinal

Ciclopirox Olamine Induces Proliferation Inhibition and Protective Autophagy in Hepatocellular Carcinoma

Xinyan Wan et al.

Summary: Hepatocellular carcinoma is a prevalent and deadly cancer, but early identification and diagnosis remain challenging. The synthetic antifungal agent, Ciclopirox olamine (CPX), has shown potential as an anti-cancer drug for hepatocellular carcinoma, although its specific mechanisms of action have not been fully elucidated. This study demonstrates that CPX inhibits HCC cell proliferation by arresting the cell cycle, while also triggering ROS accumulation and downregulating DJ-1. CPX also induces complete autophagic flux, although this can mitigate its anti-cancer effects, and it induces glycogen clustering in HCC cells. Overall, this research provides new insights into the molecular mechanisms of CPX as an anti-cancer therapy for hepatocellular carcinoma.

PHARMACEUTICALS (2023)

Add to Collection

Article Oncology

LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy

Bensong Duan et al.

Summary: In this study, the researchers found that long intergenic noncoding RNA-1871 (LINC01871) regulates chemoresistance in colorectal cancer (CRC) by inducing autophagy. LINC01871 was found to be low-expressed in CRC tissues and cells, and patients with low expression had a significantly lower survival rate. LINC01871's regulatory role was mediated through its interaction with miR-142-3p and subsequent modulation of ZYG11B expression. This finding is important for understanding the mechanism of chemoresistance in CRC.

ANTI-CANCER DRUGS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

An ATG4B inhibitor blocks autophagy and sensitizes Sorafenib inhibition activities in HCC tumor cells

Yanqiu Xie et al.

Summary: ATG4B regulates autophagy and is closely related to cancer cell growth and drug resistance. A new ATG4B inhibitor called DC-ATG4in has been identified, which directly binds to ATG4B and inhibits its enzyme activity. The inhibitor can enhance the autophagy inhibition effect induced by Sorafenib in hepatocellular carcinoma cells. Therefore, ATG4B inhibition may be a promising strategy to sensitize existing targeted therapy in the future.

BIOORGANIC & MEDICINAL CHEMISTRY (2023)

Add to Collection

Article Oncology

RANKL Promotes Chemotherapy Resistance in Breast Cancer Cells Through STAT3 Mediated Autophagy Induction

Zhen-ning Tang et al.

Summary: This study reveals that RANKL/RANK induces autophagy and mediates chemoresistance in breast cancer cells through the activation of the STAT3 signaling pathway. Targeting RANKL/RANK and STAT3 may be a potential therapeutic strategy against chemoresistance in breast cancer.

CLINICAL BREAST CANCER (2023)

Add to Collection

Article Immunology

KLF5-mediated aquaporin 3 activated autophagy to facilitate cisplatin resistance of gastric cancer

Xudong Dai et al.

Summary: This study found that AQP3 is highly expressed in gastric cancer cells, especially in drug-resistant gastric cancer cells. Inhibiting AQP3 reduces the viability, autophagy, and epithelial-mesenchymal transition of drug-resistant cells. KLF5 positively regulates the expression of AQP3 and affects the function and phenotype of drug-resistant cells by modulating AQP3.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Lactobacillus plantarum Metabolites Elicit Anticancer Effects by Inhibiting Autophagy-Related Responses

Sihyun Jeong et al.

Summary: In this study, the potential mechanisms underlying the anticancer effect of Lactobacillus plantarum metabolites were investigated. The results showed that the metabolites had a synergistic effect with chloroquine, reducing cell viability and downregulating the expression of autophagy-related proteins in Caco-2 cells. This study provides new insights into new therapeutic methods via inhibiting autophagy.

MOLECULES (2023)

Add to Collection

Article Cell Biology

Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/DvI2/Wnt/β-catenin axis

Yuan Chen et al.

Summary: This study highlights the promotive role of exosomal circ_0091741 in autophagy and chemoresistance of gastric cancer cells. By obstructing the binding of miR-330-3p to TRIM14 and increasing the expression of TRIM14, circ_0091741 enhances the activation of the Wnt/beta-catenin signaling pathway, thereby augmenting autophagy and chemoresistance in gastric cancer cells.

HUMAN CELL (2023)

Add to Collection

Article Geriatrics & Gerontology

Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer

Balazs Gyorffy

Summary: Progress in the treatment of ovarian cancer is behind other tumor types. A large-scale transcriptomic database was established to identify survival-associated genes. The database includes 1816 samples, with 2468 genes correlated to progression-free survival (PFS) and 704 genes correlated with overall survival (OS).

GEROSCIENCE (2023)

Add to Collection

Article Pharmacology & Pharmacy

SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex

Ping Huang et al.

Summary: This study found that SIRT3 regulates autophagy by phosphorylation of AMPK, and promotes ferroptosis by inducing the formation of BECN1-SLC7A11 complexes. This discovery has potential therapeutic value for treating breast cancer.

BIOCHEMICAL PHARMACOLOGY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Hesperetin Induces Autophagy and Delayed Apoptosis by Modulating the AMPK/Akt/mTOR Pathway in Human Leukemia Cells In Vitro

Ching-Yeh Lin et al.

Summary: The study evaluated the mechanisms of hesperetin in leukemia cells and found that hesperetin can promote cell death in U937 cells through inducing slight apoptosis, cell cycle arrest, and autophagy. This suggests that hesperetin may serve as an adjuvant to antileukemia therapy and can be combined with other chemotherapeutic drugs to reduce chemoresistance and side effects.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2023)

Add to Collection

Article Cell Biology

Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway

Yanhong Xing et al.

Summary: The study shows that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis through the ROS-mediated TP53/p53 pathway, by inhibiting cell migration, invasion, and inducing accumulation of damaged mitochondria followed by ROS release. The elevated ROS levels trigger TP53 activity which modulates downstream targets involved in the metastatic cascade, such as MMP members and TWIST, to suppress metastasis.

AUTOPHAGY (2022)

Add to Collection

Article Cell Biology

Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers

Shaoyang Zhang et al.

Summary: The study shows that the protein SH3BGRL is elevated in breast cancer patients and is associated with relapse and poor prognosis. The upregulation of SH3BGRL enhances chemoresistance by promoting macroautophagic/autophagic protection in breast cancer cells, suggesting that targeting SH3BGRL could be a potential therapeutic strategy.

AUTOPHAGY (2022)

Add to Collection

Article Oncology

A combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer

Yinghui Zhao et al.

Summary: Melatonin and andrographis were found to have a synergistic therapeutic effect in the treatment of colorectal cancer (CRC) by inducing autophagy-associated pathways and apoptotic activation. This combination therapy shows promise as a potential treatment option for CRC patients.

CARCINOGENESIS (2022)

Add to Collection

Article Cell Biology

MiR-1298-5p level downregulation induced by Helicobacter pylori infection inhibits autophagy and promotes gastric cancer development by MAP2K6

Xiao Li et al.

Summary: This study identified that Helicobacter pylori infection inhibited autophagy in the gastric mucosa and decreased miR-1298-5p levels. The downregulation of miR-1298-5p inhibited autophagy and increased intracellular H. pylori load. Furthermore, it was found that the miR-1298-5p/MAP2K6/p38 MAPK axis played a role in H. pylori infection and gastric cancer cell proliferation, migration, and invasion.

CELLULAR SIGNALLING (2022)

Add to Collection

Article Medicine, General & Internal

MiR-25 enhances autophagy and promotes sorafenib resistance of hepatocellular carcinoma via targeting FBXW7

Xiaoning Feng et al.

Summary: MiR-25 increases sorafenib resistance of HCC cells by inducing autophagy and is associated with tumor pathological grade, clinic staging, and lymphatic metastasis, making it a potential novel therapeutic target for HCC treatment.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2022)

Add to Collection

Article Oncology

Cx32 promotes autophagy and produces resistance to SN-induced apoptosis via activation of AMPK signalling in cervical cancer

Li-Xia Fan et al.

Summary: This study investigates the role of gap junctions and connexins in the autophagy of cervical cancer cells. It is found that connexin 32 promotes autophagy by activating the AMP-activated protein kinase pathway, leading to the inhibition of apoptosis in cervical cancer cells.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

Add to Collection

Article Engineering, Biomedical

Co-delivery of the autophagy inhibitor si-Beclin1 and the doxorubicin nano-delivery system for advanced prostate cancer treatment

Chuling Hu et al.

Summary: Resistance to apoptosis in cancer cells can be overcome by inhibiting autophagy, as demonstrated in this study through the delivery of DOX-EMCH and si-Beclin1 using Co-PMs. The Co-PMs not only enhanced the cytotoxicity and proapoptotic ability in prostate cancer cells, but also showed passive targeting to tumor tissues, resulting in a significant antiproliferative effect in vivo. This suggests that the developed Co-PMs have the potential to combine autophagy inhibition and chemotherapy for effective cancer treatment, particularly in prostate cancer.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

Add to Collection

Article Reproductive Biology

MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in ovarian cancer via regulating DNMT3B-mediated DNA methylation of RBP1

Hui Li et al.

Summary: In this study, researchers investigated the role of miR-20a-5p in modulating autophagy and cisplatin resistance in ovarian cancer. They found that miR-20a-5p suppresses malignant phenotypes and autophagy in cisplatin-resistant ovarian cancer cells. Furthermore, they demonstrated that DNMT3B mediates DNA methylation of RBP1, impairing its promoting effects on carcinogenesis and autophagy in ovarian cancer. Overall, the study highlights the importance of miR-20a-5p in the regulation of autophagy and cisplatin resistance in ovarian cancer.

REPRODUCTIVE TOXICOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Insulin-like growth factor 2 mRNA-binding protein 2-stabilized long non-coding RNA Taurine up-regulated gene 1 (TUG1) promotes cisplatin-resistance of colorectal cancer via modulating autophagy

Cuifeng Xia et al.

Summary: This study reveals that long non-coding RNA TUG1 enhances the resistance of colorectal cancer cells to cisplatin through the regulation of autophagy and the activation of the miR-195-5p/HDGF/DDX5/β-catenin axis.

BIOENGINEERED (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis

Xinxing Duan et al.

Summary: The study identified that circ_0001658 was aberrantly expressed in GC tissues and could affect GC cell viability, autophagy, and apoptosis by regulating miR-182 and RAB10. This suggests that circ_0001658 may be a potential therapeutic target for GC.

BIOENGINEERED (2022)

Add to Collection

Article Oncology

Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2-mediated autophagy

Lang Fang et al.

Summary: This study reveals the crucial role of circCPM in regulating gastric cancer autophagy and 5-FU resistance by targeting PRKAA2. High expression of circCPM is positively associated with poor survival, and silencing circCPM significantly improves chemosensitivity.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

HMGB1-mediated autophagy promotes gefitinib resistance in human non-small cell lung cancer

Tianyao Lei et al.

Summary: In this study, the researchers discovered that high mobility group box 1 (HMGB1) contributes to gefitinib resistance in non-small cell lung cancer (NSCLC) by activating autophagy. These findings provide important insights into the resistance mechanisms and potential therapeutic strategies for NSCLC.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2022)

Add to Collection

Article Chemistry, Medicinal

Overexpression of ARHI increases the sensitivity of cervical cancer cells to paclitaxel through inducing apoptosis and autophagy

Yang Wang et al.

Summary: This study investigated the role of ARHI in cervical cancer and found that high expression of ARHI can decrease MDR1 expression, promote apoptosis and activate autophagy, thus increasing sensitivity to paclitaxel in a pathway dependent on AKT/mTOR inactivation.

DRUG DEVELOPMENT RESEARCH (2022)

Add to Collection

Article Cell Biology

TFEB- and TFE3-dependent autophagy activation supports cancer proliferation in the absence of centrosomes

Chien-Han Kao et al.

Summary: The combination of centrosome depletion and inhibition of the TFEB-TFE3 autophagy-lysosome pathway has strong anti-proliferative effects on cancer cells.

AUTOPHAGY (2022)

Add to Collection

Article Medicine, Research & Experimental

Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling

Maliheh Entezari et al.

Summary: This review focuses on lncRNAs and exosomal lncRNAs in lung cancer, highlighting their roles in regulating proliferation and metastasis. LncRNAs play a significant role in the development of lung cancer through various molecular mechanisms, and have the potential to serve as biomarkers and diagnostic tools.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Article Oncology

ATF4-mediated microRNA-145/HDAC4/p53 axis affects resistance of colorectal cancer cells to 5-fluorouracil by regulating autophagy

Lin Zhao et al.

Summary: This study revealed the clinical significance of the ATF4-mediated miR-145/HDAC4/p53 axis in colorectal cancer (CRC). The axis promotes autophagy and chemoresistance in CRC cells by inhibiting miR-145 expression and activating the HDAC4/p53 pathway.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2022)

Add to Collection

Article Oncology

TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis

Yucheng Liu et al.

Summary: This study reveals the mechanism by which TRPML1 inhibits autophagy to regulate apoptosis, involving disrupted mitochondrial turnover, elevated ROS, DNA damage, and p53 activation. These findings have potential clinical implications for treating melanoma and glioblastoma.

CANCER LETTERS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells

Jian Sheng Loh et al.

Summary: In this study, it was found that the combination of doxorubicin and ixazomib induced autophagy in breast cancer cells, which had a cytoprotective role. Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhanced the cytotoxicity of doxorubicin.

CELL BIOCHEMISTRY AND FUNCTION (2022)

Add to Collection

Article Pharmacology & Pharmacy

Solamargine induces autophagy-mediated apoptosis and enhances bortezomib activity in multiple myeloma

Qiaoyan Han et al.

Summary: The study demonstrates that solamargine (SM) exhibits promising anti-multiple myeloma (MM) activity by suppressing MM cell viability through activating cell autophagy and inducing apoptosis. Additionally, a synergistic effect between SM and the common chemotherapeutic agent bortezomib (BTZ) is observed, suggesting a potential therapeutic strategy for treating MM.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Long noncoding RNAs (lncRNAs) in pancreatic cancer progression

Milad Ashrafizaden et al.

Summary: Long noncoding RNAs (lncRNAs) play a role in gene regulation in pancreatic cancer cells, affecting apoptosis, autophagy, proliferation, metastasis, and drug resistance.

DRUG DISCOVERY TODAY (2022)

Add to Collection

Article Oncology

Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer

Feikai Lin et al.

Summary: This study found that STC1 is significantly enhanced in ovarian cancer tissues, especially in peritoneal metastasis tissues. STC1 promotes metastasis, lipid metabolism, and cisplatin chemoresistance in ovarian cancer through the FOXC2/ITGB6 signaling pathway. Therefore, STC1 may serve as a prognostic indicator for metastatic ovarian cancer and a potential therapeutic target for patients with cisplatin resistance.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Oncology

Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma

Danyang Li et al.

Summary: High expression of the cholesterol sensor SCAP is associated with sorafenib resistance in HCC, and inhibition of SCAP can improve sorafenib sensitivity. SCAP-mediated sorafenib resistance is related to decreased autophagy and decreased AMPK activity. Lycorine, a specific SCAP inhibitor, can reverse acquired resistance to sorafenib.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Review Oncology

Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

Milad Ashrafizadeh et al.

Summary: This review discusses the role and regulatory mechanisms of autophagy in prostate cancer. Autophagy can impact cancer cell proliferation, survival, and metastasis, as well as the response to therapy. Targeting autophagic genes and utilizing nanotherapeutics show promise in improving patient prognosis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Methylation-mediated silencing of miR-125a-5p facilitates breast cancer progression by inducing autophagy

Fatemeh Ahmadpour et al.

Summary: The promoter hypermethylation of miR-125a leads to its decreased expression in breast cancer, while overexpression of miR-125a can reduce autophagy. These findings provide a new therapeutic approach for the treatment of breast cancer.

MOLECULAR BIOLOGY REPORTS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

P2x4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition

Stephanie Chadet et al.

Summary: The P2X4 purinergic receptor is upregulated in breast cancer patients and primarily localised in endolysosomes. It promotes breast cancer invasion, tumour growth, and metastasis by regulating lysosome acidity, promoting autophagy and cell survival. It is also associated with epithelial-to-mesenchymal transition and plays a more significant role under metabolic challenges.

ONCOGENE (2022)

Add to Collection

Article Cell Biology

Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer

Tingjia Zhu et al.

Summary: This study identified the overexpression of circTICRR in cervical cancer. CircTICRR interacts with HuR protein, stabilizes GLUD1 mRNA, and promotes cell apoptosis and inhibits proliferation through autophagy activation.

CELL DEATH & DISEASE (2022)

Add to Collection

Article Pharmacology & Pharmacy

Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells

Ming Xin et al.

Summary: The study found that methylseleninic acid (MSA) effectively inhibits the proliferation of lung adenocarcinoma cells and counteracts cisplatin resistance by promoting apoptosis. The mitochondrial damage caused by MSA treatment can be degraded through the induction of autophagy, providing self-protection for tumor cells. Mechanistically, MSA inhibits cell proliferation, promotes apoptosis, and induces autophagy in lung adenocarcinoma cells by inhibiting the Akt/mTOR pathway. Combination with autophagy inhibitors enhances the anti-tumor effect of MSA on cisplatin-resistant lung adenocarcinoma cells.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

NRBF2 regulates the chemoresistance of small cell lung cancer by interacting with the P62 protein in the autophagy process

Weitao Shen et al.

Summary: This study investigated the underlying mechanisms of nuclear receptor binding factor 2 (NRBF2) in chemotherapy resistance in small cell lung cancer (SCLC). It was found that NRBF2 positively regulated autophagy, leading to drug resistance in SCLC. Additionally, NRBF2 was directly modulated by the transcription factor XRCC6. These findings suggest that NRBF2 may serve as a potential therapeutic target in SCLC.

ISCIENCE (2022)

Add to Collection

Article Cell Biology

Protective autophagy decreases lorlatinib cytotoxicity through Foxo3a-dependent inhibition of apoptosis in NSCLC

Conghua Lu et al.

Summary: Lorlatinib induces apoptosis and protective autophagy in ALK-positive NSCLC cells, but the combination with CQ inhibits autophagy and promotes apoptosis, sensitizing cells to lorlatinib by dephosphorylating Foxo3a and activating the Foxo3a/Bim axis. Inhibition of protective autophagy may be a therapeutic target to delay acquired resistance to lorlatinib in ALK-positive NSCLC patients.

CELL DEATH DISCOVERY (2022)

Add to Collection

Article Engineering, Biomedical

Engineering dual catalytic nanomedicine for autophagy-augmented and ferroptosis-involved cancer nanotherapy

Zhifang Li et al.

Summary: In this study, a liposomal nanosystem was constructed to achieve autophagy-enhanced and ferroptosis-involved cancer cell death using a Cu-based dual catalytic strategy. The results demonstrated the significant therapeutic efficacy of this system and provided a potential approach for suppressing tumor growth.

BIOMATERIALS (2022)

Add to Collection

Article Oncology

CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization

Xiaohong Hong et al.

Summary: In this study, circIPO7 was found to be specifically overexpressed in NPC patients with distant metastasis and its knockdown suppressed metastasis and increased sensitivity to cisplatin treatment. Mechanistically, circIPO7 binds to YBX1 protein and facilitates the activation of transcription factors. Higher circIPO7 expression indicated unfavorable distant metastasis-free survival in NPC patients given cisplatin-based chemotherapy.

CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis

Yi Yang et al.

Summary: Autophagy is a fundamental mechanism for cell survival and tissue homeostasis, and TRIM27 has been identified as a negative regulator of the FIP200-ATG13-ULK1 complex. TRIM27 controls the amplitude and duration of autophagy by ubiquitinating ULK1, and the ubiquitination of STK38L kinase plays a key role in ULK1 activation and phosphorylation.

EMBO JOURNAL (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance

Changduo Wang et al.

Summary: The development of a targeted gene/drug co-delivery nano system provides a potential strategy to combat multidrug resistance by suppressing drug efflux pumps and modulating autophagy.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Add to Collection

Review Oncology

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Mahshid Deldar Abad Paskeh et al.

Summary: This review discusses the role of exosomes in cancer progression, therapy, and regulation of the tumor microenvironment. The study found that exosomes can influence cancer cell proliferation and migration rates by modulating components of the tumor microenvironment. Depending on their cargo, exosomes can promote or suppress tumor cell progression and enhance or reduce the response to radiotherapy and chemotherapy. Additionally, exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by transferring RNA and modulating molecular signaling pathways. Moreover, exosomes can serve as carriers of anti-tumor agents and genetic tools to control cancer progression. Finally, exosomes are valuable diagnostic and prognostic tools in the treatment of cancer patients.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Bisdemethoxycurcumin sensitizes the response of cisplatin resistant non-small cell lung carcinoma cell lines by activating apoptosis and autophagy

Verena Klingseisen et al.

Summary: This study analyzed the influence of bisdemethoxycurcumin (BDMC) on non-small cell lung carcinoma (NSCLC) cells and found that BDMC had significant cytotoxic effects, especially on cisplatin-resistant cells. BDMC induced apoptosis and autophagy, inhibited cell cycle progression, and suppressed the growth and motility of cisplatin-resistant cells.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

Add to Collection

Article Oncology

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma

Hongyi Wang et al.

Summary: Metastasis and drug resistance are the main reasons for poor prognosis in osteosarcoma patients. Autophagy is highly activated in metastatic osteosarcoma and is closely related to unfavorable prognosis. Inhibiting autophagy-related genes and specific signaling pathways may improve the therapeutic outcome of osteosarcoma.

FRONTIERS OF MEDICINE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Curcumol Synergizes with Cisplatin in Osteosarcoma by Inhibiting M2-like Polarization of Tumor-Associated Macrophages

Jincheng Wang et al.

Summary: Curcumol enhances cisplatin-induced apoptosis in osteosarcoma cells and inhibits cell migration. Curcumol and cisplatin combination therapy shows stronger tumor-growth suppression in orthotopic transplantation. Additionally, curcumol reverses the expression of drug-resistant genes induced by cisplatin and inhibits the polarization of M2-like macrophages.

MOLECULES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of Autophagy Promotes the Elimination of Liver Cancer Stem Cells by CD133 Aptamer-Targeted Delivery of Doxorubicin

Wang Yin et al.

Summary: This study aimed to overcome drug resistance in liver cancer caused by cancer stem cells by using a CD133 aptamer for targeted delivery of Doxorubicin and enhancing the treatment efficacy through autophagy inhibition. The results showed that CD133 aptamer-guided delivery of Doxorubicin resulted in a higher concentration of Doxorubicin in liver cancer stem cells. The combinatorial treatment strategy of CD133 aptamer-Doxorubicin conjugates and an autophagy inhibitor showed a significantly higher elimination of liver cancer stem cells in vitro.

BIOMOLECULES (2022)

Add to Collection

Article Cell Biology

Co-loaded lapatinib/PAB by ferritin nanoparticles eliminated ECM-detached cluster cells via modulating EGFR in triple-negative breast cancer

Xinghan Wu et al.

Summary: This study found that inhibition of EGFR can reduce the proportion of CD24(low)CD44(high) cells and the size of tumor spheres in TNBC cells, and promote the expression of LC3B-II through the YAP/mTOR signaling pathway, thus contributing to ferroptosis. Combined treatment with lapatinib and PAB can inhibit the viability of TNBC cells and the formation of tumor spheres, accompanied by increased intracellular ROS levels.

CELL DEATH & DISEASE (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy

Jie Yu et al.

Summary: The high expression of SOCS5 is associated with poor prognosis and resistance to TMZ in GBM. TMZ treatment increases the expression of SOCS5 and induces autophagy, which is mediated by SOCS5. Mechanistically, SOCS5 enhances the transcription of Bcl-2. Knockdown of SOCS5 reduces TMZ chemoresistance in GBM cells by inhibiting Bcl-2-mediated autophagy.

BIOENGINEERED (2022)

Add to Collection

Article Biochemistry & Molecular Biology

ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagy

Hui Fan et al.

Summary: This study found that ciclopirox olamine (CPX) inhibits the proliferation of cervical cancer cells by targeting PARK7. CPX can induce cytoprotective autophagy by downregulating PARK7 to activate PRKAA1 or by accumulating ROS independently of PARK7 to inhibit mTOR signaling. Additionally, CPX treatment increases glycogen clustering and glycophagy in cervical cancer cells.

REDOX BIOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling

Wei Liu et al.

Summary: TRIM22 inhibits the progression of osteosarcoma by promoting proteasomal degradation of NRF2 and activating ROS/AMPK/mTOR/autophagy signaling. Therefore, targeting TRIM22/NRF2 could be a potential therapeutic strategy for treating osteosarcoma.

REDOX BIOLOGY (2022)

Add to Collection

Article Engineering, Biomedical

Engineering mitochondrial uncoupler synergistic photodynamic nanoplatform to harness immunostimulatory pro-death autophagy/ mitophagy

Quanwei Sun et al.

Summary: This study developed a multifunctional metal-organic framework to enhance the efficacy of photodynamic therapy and stimulate antitumor immune responses.

BIOMATERIALS (2022)

Add to Collection

Article Oncology

Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

Qingzhu Shi et al.

Summary: Glucose metabolism plays a role in remodeling the functions of tumor-associated macrophages (TAMs) and promotes cancer metastasis and chemoresistance. This is achieved through the O-GlcNAcylation of Cathepsin B, which is mediated by lysosome-localized O-GlcNAc transferase (OGT) and leads to increased secretion of mature Cathepsin B in the tumor microenvironment.

CANCER CELL (2022)

Add to Collection

Article Oncology

Transient Systemic Autophagy Inhibition Is Selectively and Irreversibly Deleterious to Lung Cancer

Khoosheh Khayati et al.

Summary: Autophagy is an important process in maintaining cellular homeostasis and plays a role in the growth and treatment of lung cancer. Systemic autophagy supports tumor cell metabolism and immune evasion in lung cancer, and the inability of tumors to recover from loss of autophagy provides evidence for the effectiveness of autophagy inhibition in cancer therapy.

CANCER RESEARCH (2022)

Add to Collection

Article Oncology

SAR1A regulates the RhoA/YAP and autophagy signaling pathways to influence osteosarcoma invasion and metastasis

Fangbiao Zhan et al.

Summary: SAR1A and RHOA are upregulated in osteosarcoma and associated with poor metastasis-free survival rates. Knocking down SAR1A or RHOA impairs the invasive and migratory activity of osteosarcoma cells, while RHOA overexpression has the opposite effect. Furthermore, SAR1A knockdown inhibits epithelial-mesenchymal transition, enhances endoplasmic reticulum stress and autophagic activity, and reduces lung metastases.

CANCER SCIENCE (2022)

Add to Collection

Article Cell Biology

LncRNA FGD5-AS1 potentiates autophagy-associated doxorubicin resistance by regulating the miR-154-5p/WNT5A axis in osteosarcoma

Dan Fei et al.

Summary: FGD5-AS1 enhances chemotherapy resistance in osteosarcoma by upregulating WNT5A through sponging miR-154-5p, leading to induced cell autophagy.

CELL BIOLOGY INTERNATIONAL (2022)

Add to Collection

Article Pharmacology & Pharmacy

KIF23 promotes autophagy-induced imatinib resistance in chronic myeloid leukaemia through activating Wnt/β-catenin pathway

Yong Huang et al.

Summary: KIF23 is involved in autophagy and contributes to imatinib resistance in chronic myeloid leukaemia (CML) through activation of the Wnt/beta-catenin pathway.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Hypoxia induces chemoresistance to proteasome inhibitors through orchestrating deSUMOylation and ubiquitination of SRC-3 in multiple myeloma

Jing Guo et al.

Summary: The hypoxic bone marrow microenvironment in multiple myeloma (MM) promotes chemoresistance to proteasome inhibitors (PIs). The expression of steroid receptor coactivator 3 (SRC-3) is increased at the posttranslational level in response to hypoxia stimulus. SENP1, a key modifier of SRC-3 stability, is identified and its depletion or inhibition overcomes chemoresistance to PIs in MM cells.

ONCOGENE (2022)

Add to Collection

Article Multidisciplinary Sciences

Overexpression of LINC00551 promotes autophagy-dependent ferroptosis of lung adenocarcinoma via upregulating DDIT4 by sponging miR-4328

Xiong Peng et al.

Summary: This study provides insight into the molecular mechanism of ferroptosis regulation and highlights LINC00551 as a potential therapeutic target for lung adenocarcinoma (LUAD), utilizing its role as a competing endogenous RNA (ceRNA) to regulate the expression of miR-4328 and DDIT4, promoting autophagy and ferroptosis.

PEERJ (2022)

Add to Collection

Article Oncology

CD13 downregulation mediated by ubenimex inhibits autophagy to overcome 5-FU resistance by disturbing the EMP3/FAK/NF-ΚB pathway in gastric cancer cells

Ting Xiu et al.

Summary: This study found that ubenimex, as a CD13 inhibitor, can reverse drug resistance in gastric cancer cells by affecting autophagy and apoptosis through the CD13/EMP3/FAK/NF-Kappa B pathway.

TRANSLATIONAL CANCER RESEARCH (2022)

Add to Collection

Article Oncology

Hypoxia upregulates the expression of lncRNA H19 in non-small cell lung cancer cells and induces drug resistance

Haiyan Li et al.

Summary: The study revealed that under hypoxic conditions, the expression levels of lncRNA H19, HIF1-alpha, HO-1, MRP1, and P-glycoprotein significantly increased in NSCLC cells, leading to enhanced invasion and migration abilities, increased resistance to cisplatin, reduced cisplatin-induced apoptosis, and chemoresistance induction.

TRANSLATIONAL CANCER RESEARCH (2022)

Add to Collection

Article Chemistry, Medicinal

Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma

Keisuke Okuno et al.

Summary: This study shows that Berberine (BBR) can enhance the chemosensitivity of pancreatic ductal adenocarcinoma (PDAC) cells to Gemcitabine (Gem). Cell culture and patient-derived organoid experiments demonstrate that the combination of BBR and Gem has better anti-cancer effects in Gem-resistant PDAC cells. Furthermore, the study reveals that the Rap1/PI3K-Akt signaling pathway plays a key role in BBR-mediated chemosensitization in PDAC.

PHARMACEUTICALS (2022)

Add to Collection

Article Cell Biology

CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer

Jingxuan Chen et al.

Summary: This study identified a new late-stage autophagy inhibitor called CUR5g, which selectively inhibited autophagosome degradation in cancer cells. CUR5g showed potential for the treatment of non-small-cell lung cancer (NSCLC), particularly when combined with cisplatin, as it enhanced cisplatin sensitivity and effectively inhibited autophagy in tumor tissues.

CELL DEATH DISCOVERY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Weitong Gao et al.

Summary: Immunotherapy has made significant breakthroughs in cancer treatment, but the poor response of some tumors limits its application. Inducing non-apoptotic regulated cell death (RCD) may convert these unresponsive tumors into those that respond to immunotherapy. Autophagy, ferroptosis, pyroptosis, and necroptosis have been found to have both inhibitory and synergistic effects on antitumor immune responses, suggesting that targeted therapies against these processes combined with immunotherapy may be effective even in resistant tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Add to Collection

Article Medicine, Research & Experimental

Drug-induced self-assembled nanovesicles for doxorubicin resistance reversal via autophagy inhibition and delivery synchronism

Juan Wang et al.

Summary: In this study, a pH-responsive drug-induced self-assembled nanovesicle was developed based on an amphiphilic copolymer for the simultaneous delivery of doxorubicin hydrochloride (DOX·HCl) and chloroquine (CQ). The nanovesicle exhibited excellent delivery performance both in vitro and in vivo, and CQ enhanced the efficacy of DOX·HCl by inhibiting autophagy. Therefore, this study provides a promising strategy for precise combination therapy.

THERANOSTICS (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Challenges and Opportunities in Cancer Drug Resistance

Richard A. Ward et al.

Summary: Recent years have seen significant progress in targeted cancer therapies, but drug resistance remains a common challenge. Researchers are exploring new approaches to overcome resistance, such as increasing drug selectivity and potency, using alternative chemical structures, changing mechanisms of action, and targeting allosteric pockets.

CHEMICAL REVIEWS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Astragaloside IV enhanced carboplatin sensitivity in prostate cancer by suppressing AKT/NF-κB signaling pathway

Yi He et al.

Summary: The study demonstrated that astragaloside IV enhances the sensitivity of prostate cancer cell lines to carboplatin, showing significant effects in both in vitro and in vivo experiments. Additionally, it was revealed that AgIV suppresses carboplatin-induced epithelial-mesenchymal transition by inhibiting the AKT/NF-kappa B signaling pathway.

BIOCHEMISTRY AND CELL BIOLOGY (2021)

Add to Collection

Article Cell Biology

Esomeprazole overcomes paclitaxel-resistance and enhances anticancer effects of paclitaxel by inducing autophagy in A549/Taxol cells

Zhaoshi Bai et al.

Summary: The study found that esomeprazole could enhance the efficacy of paclitaxel in NSCLC cells resistant to the drug by reducing intracellular pH, promoting microtubule polymerization, and increasing apoptosis. This offers a promising new strategy for overcoming paclitaxel resistance in NSCLC treatment.

CELL BIOLOGY INTERNATIONAL (2021)

Add to Collection

Article Chemistry, Medicinal

Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1

Shufang Hu et al.

Summary: This study found that TRHDE-AS1 is downregulated in breast cancer patients and is associated with poor outcomes and aggressive tumor biology. ASV can repress breast cancer cell growth and metastasis by increasing TRHDE-AS1 expression, providing new evidence for the use of ASV in breast cancer therapy.

JOURNAL OF NATURAL MEDICINES (2021)

Add to Collection

Article Oncology

WWOX promotes apoptosis and inhibits autophagy in paclitaxel-treated ovarian carcinoma cells

Yan Zhao et al.

Summary: The study demonstrated that WWOX can induce apoptosis, inhibit chemoresistance, and suppress autophagy by downregulating autophagic effectors in EOC cells treated with PTX. This mechanism may be achieved through activation of the mTOR signaling pathway.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection

Article Oncology

CircRNA_100565 contributes to cisplatin resistance of NSCLC cells by regulating proliferation, apoptosis and autophagy via miR-337-3p/ADAM28 axis

Youqing Zhong et al.

Summary: CircRNA_100565 plays a crucial role in NSCLC cisplatin resistance, with its high expression associated with shorter overall survival of patients. Deletion of CircRNA_100565 can alleviate DDP resistance, potentially by regulating cell proliferation, apoptosis, and autophagy via the miR-337-3p/ADAM28 axis.

CANCER BIOMARKERS (2021)

Add to Collection

Article Oncology

Inhibition of chaperone-mediated autophagy reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer

Ying Xuan et al.

Summary: The study found that high expression of lysosome-associated membrane protein 2A (LAMP2A) in colorectal cancer cell lines is associated with resistance to 5-fluorouracil (5-FU) and can enhance PLD2 expression through the activation of the NF-kappa B pathway. Therefore, chaperone-mediated autophagy (CMA) may mediate chemoresistance in patients with colorectal cancer by enhancing resistance.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection

Article Oncology

The Oxygen-Generating Calcium Peroxide-Modified Magnetic Nanoparticles Attenuate Hypoxia-Induced Chemoresistance in Triple-Negative Breast Cancer

Fong-Yu Cheng et al.

Summary: Tumor hypoxia increases chemotherapy resistance in TNBC, but CaO2-MNPs can improve this by promoting apoptosis in TNBC cells and enhancing the efficacy of doxorubicin treatment.

CANCERS (2021)

Add to Collection

Article Cell Biology

Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation

Yuhao Luo et al.

Summary: Recent studies have shown that lncRNA EIF3J-DT is highly expressed in drug-resistant gastric cancer cells, contributing to chemoresistance by activating autophagy through targeting ATG14. This regulatory mechanism by EIF3J-DT may serve as a potential new target for enhancing chemosensitivity and improving prognosis in gastric cancer patients.

AUTOPHAGY (2021)

Add to Collection

Review Chemistry, Applied

Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy

Milad Ashrafizadeh et al.

Summary: Gene therapy using siRNA faces challenges, but chitosan nanoparticles as carriers show promise in overcoming siRNA issues and demonstrating potential in cancer therapy.

CARBOHYDRATE POLYMERS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy

Man Zhang et al.

Summary: In this study, GNR multifunctional nanoplatforms were designed and synthesized to target autophagy in OS, improving treatment efficacy and inhibiting metastasis. This research provides a new approach to enhance clinical outcomes for OS.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Article Oncology

Down-regulation of PSMD4 can attenuate autophagy, enhance the accumulation of intracellular ROS, and increase the sensitivity of epithelial ovarian cancer to carboplatin by inhibiting the NF-κB pathway

Ying Li et al.

Summary: PSMD4 was identified as a core molecule in the carboplatin resistance regulatory network of epithelial ovarian cancer (EOC), with its up-regulated expression in carboplatin-resistant EOC tissues and cells. Inhibition of PSMD4 expression was found to increase the sensitivity of EOC to carboplatin.

TRANSLATIONAL CANCER RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology

MiR-15a-5p Confers Chemoresistance in Acute Myeloid Leukemia by Inhibiting Autophagy Induced by Daunorubicin

Emeline Bollaert et al.

Summary: The study found that miR-15a-5p induces chemoresistance in AML cells by inhibiting daunorubicin-induced autophagy, suggesting that this miRNA could be a promising therapeutic target for chemoresistant AML patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Cell Biology

Pre-Clinical and Clinical Applications of Small Interfering RNAs (siRNA) and Co-Delivery Systems for Pancreatic Cancer Therapy

Sepideh Mirzaei et al.

Summary: Pancreatic cancer (PC) is a leading cause of death and the fourth most malignant tumor in men. siRNA can effectively target critical genes in PC progression and enhance the efficacy of chemotherapy and radiotherapy. Loading siRNAs on nanoparticles can protect them from degradation and improve targeted delivery, leading to enhanced therapeutic efficacy in PC treatment.

CELLS (2021)

Add to Collection

Review Cell Biology

Redox Control of the Dormant Cancer Cell Life Cycle

Bowen Li et al.

Summary: After cancer treatment, some cancer cells may survive through dormancy, leading to tumor recurrence and worsened outcomes. Dormancy is when most cancer cells in a tumor population are quiescent with little to no proliferation. Recent research suggests that redox mechanisms control the life cycle of dormant cancer cells, including entrance, long-term dormancy, and metastatic relapse.

CELLS (2021)

Add to Collection

Article Cell Biology

Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy

Alessandra Ferraresi et al.

Summary: The study found that resveratrol (RV) can counteract LPA-induced ovarian cancer malignancy by inhibiting the Hh pathway and restoring autophagy, which supports its inclusion in ovarian cancer therapy for limiting metastasis and chemoresistance.

CELLS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy

Jian Chen et al.

Summary: This study identified SHMT2 as a critical regulator of 5-FU chemoresistance in colorectal cancer (CRC), with SHMT2 inhibiting autophagy and promoting apoptosis under 5-FU treatment. Autophagy inhibitors could reduce 5-FU resistance induced by low SHMT2 levels. Targeting the SHMT2-p53 interaction may present a novel therapeutic strategy to overcome chemoresistance in CRC.

ONCOGENE (2021)

Add to Collection

Review Pharmacology & Pharmacy

Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance

Sepideh Mirzaei et al.

Summary: Nrf2 signaling plays a crucial role in protecting against oxidative damage, but its activation in cancer cells can lead to chemoresistance. Modulating Nrf2 signaling during cisplatin treatment can suppress the development of chemoresistance and alleviate drug toxicity. Activating Nrf2 signaling can help prevent the side effects of cisplatin.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection

Article Cell Biology

LncRNA-HOTAIR activates autophagy and promotes the imatinib resistance of gastrointestinal stromal tumor cells through a mechanism involving the miR-130a/ATG2B pathway

Jinyan Zhang et al.

Summary: This study revealed that HOTAIR targets the ATG2B inhibitor miR-130a to upregulate cell autophagy levels, promoting imatinib resistance in GIST cells.

CELL DEATH & DISEASE (2021)

Add to Collection

Article Cell Biology

Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells

Hsin-Ling Yang et al.

Aging-US (2021)

Add to Collection

Article Biochemistry & Molecular Biology

MKNK2 enhances chemoresistance of ovarian cancer by suppressing autophagy via miR-125b

Jing Wang et al.

Summary: MKNK2 plays a crucial role in chemoresistance in ovarian cancer by modulating autophagy and targeting miR-125b.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Add to Collection

Article Engineering, Biomedical

Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance

Rou Xie et al.

Summary: The study developed a furin-responsive aggregated nanoplatform to address the challenges of insufficient drug accumulation and chemoresistance in cancer chemotherapy. By loading doxorubicin and hydroxychloroquine, the platform enhanced tumor cell sensitivity to chemotherapy drugs and exerted anti-tumor effects through macrophage polarization.

BIOMATERIALS (2021)

Add to Collection

Article Oncology

Long non-coding RNAs in the doxorubicin resistance of cancer cells

Saeed Ashrafizaveh et al.

Summary: Studies have shown that long non-coding RNAs play a significant role in DOX resistance, both activating resistance pathways and increasing sensitivity of cancer cells to DOX.

CANCER LETTERS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Autophagy in major human diseases

Daniel J. Klionsky et al.

Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.

EMBO JOURNAL (2021)

Add to Collection

Review Medicine, Research & Experimental

Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems

Sepideh Mirzaei et al.

Summary: GBM is a serious brain tumor with no cure, requiring new genetic approaches for treatment. The use of siRNA can target and silence genes responsible for disease progression in GBM cells.

LIFE SCIENCES (2021)

Add to Collection

Review Medicine, Research & Experimental

Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy

Sepideh Mirzaei et al.

Summary: siRNA can enhance sensitivity of cancer cells to chemotherapy by down-regulating specific genes, inhibiting cancer stem cell properties and related molecular pathways, as well as promoting cell cycle arrest and increased accumulation of chemotherapy drugs in cancer cells. Carriers such as nanoparticles and biological carriers are important in overcoming siRNA challenges and enhancing its effectiveness in reversing chemotherapy resistance.

LIFE SCIENCES (2021)

Add to Collection

Review Pharmacology & Pharmacy

Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer

Sepideh Mirzaei et al.

Summary: Caffeic acid and caffeic acid phenethyl ester have anti-tumor activity and can impact cancer progression through multiple molecular pathways, as well as enhance the response of cancer cells to chemotherapy.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection

Article Cell Biology

Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

Yao-Xin Lin et al.

Summary: Clinical evidence suggests that restoration of functional PTEN through mRNA delivery by polymeric nanoparticles can effectively induce immune activation in tumor cells, reversing immunosuppressive tumor microenvironment and enhancing sensitivity to immune checkpoint blockade therapy. In vivo results show that PTEN mRNA nanoparticles promote CD8(+) T cell infiltration, increase proinflammatory cytokine expression, and decrease regulatory T cells and myeloid-derived suppressor cells, resulting in potent antitumor effects and immunological memory in cancer models.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Oncology

Hsa_circ_0092276 promotes doxorubicin resistance in breast cancer cells by regulating autophagy via miR-348/ATG7 axis

Qiuli Wang et al.

Summary: The study found that hsa_circ_0092276 promotes autophagy and DOX resistance in breast cancer by modulating the miR-384/ATG7 axis. This research reveals a novel competing endogenous RNA circuitry involved in DOX resistance in breast cancer.

TRANSLATIONAL ONCOLOGY (2021)

Add to Collection

Article Gastroenterology & Hepatology

Zinc oxide nanoparticles reduce the chemoresistance of gastric cancer by inhibiting autophagy

You-Han Miao et al.

Summary: The study found that ZnO-NP can inhibit the proliferation, migration, and invasion of GC cells, induce apoptosis, and alleviate chemotherapy resistance. ZnO-NP regulates chemotherapy resistance in GC cells by inhibiting autophagy, making it a potential candidate for GC treatment.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

FXYD6 Regulates Chemosensitivity by Mediating the Expression of Na plus /K plus -ATPase α1 and Affecting Cell Autophagy and Apoptosis in Colorectal Cancer

Wen Luo et al.

Summary: This study identified that FXYD6 is downregulated in chemoresistant CRC patients and affects chemosensitivity by mediating the expression of Na+/K+-ATPase alpha 1, influencing cell autophagy and apoptosis. FXYD6 functions as a chemosensitivity regulator, potentially predicting the efficacy of chemotherapy in colorectal cancer.

BIOMED RESEARCH INTERNATIONAL (2021)

Add to Collection

Article Pharmacology & Pharmacy

Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/β-Catenin/ABCG2 Axis

Mianmian Liao et al.

Summary: Accumulating evidence suggests that the mechanism of chemosensitization by ADQ in breast CSCs involves regulating autophagy, reducing the breast CSC population, and blocking autophagy through beta-catenin/ABCG2 signaling. The study also highlights the role of GRP78 in mediating autophagy-related drug resistance and the chemosensitizing effects of ADQ in breast cancer cells.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Article Oncology

LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 Axis

Hongdan Dai et al.

Summary: The study demonstrated that autophagy is associated with drug resistance in CML cells, and upregulation of OIP5-AS1 enhances autophagy while knockdown of OIP5-AS1 suppresses it and increases sensitivity to IM. OIP5-AS1 regulates ATG12 by competitively binding miR-30e-5p, affecting autophagy-related drug resistance in CML cells.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Surmounting tumor resistance to metallodrugs by co-loading a metal complex and siRNA in nanoparticles

Hongzhi Qiao et al.

Summary: By constructing ATP-responsive nanoparticles containing CTND and siRNA, the release of which in cancer cells can enhance therapeutic efficacy and terminate resistance of B16F10 melanoma cells to CTND.

CHEMICAL SCIENCE (2021)

Add to Collection

Article Oncology

Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma

Linhe Gan et al.

Summary: The study revealed that HVEM-overexpressing MSCs can promote chemoresistance of cholangiocarcinoma cells by secreting IL-6 and activating AMPK/mTOR-dependent autophagy pathway, indicating that ICC-MSC-induced autophagy is the primary cause of chemoresistance in ICC.

ONCOLOGY REPORTS (2021)

Add to Collection

Article Chemistry, Medicinal

Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway

Feng Xiao et al.

DRUG DEVELOPMENT RESEARCH (2020)

Add to Collection

Article Medicine, Research & Experimental

miR-27a ameliorates chemoresistance of breast cancer cells by disruption of reactive oxygen species homeostasis and impairment of autophagy

Shinobu Ueda et al.

LABORATORY INVESTIGATION (2020)

Add to Collection

Article Medicine, Research & Experimental

Propofol facilitates cisplatin sensitivity via lncRNA MALAT1/miR-30e/ATG5 axis through suppressing autophagy in gastric cancer

Yun-Fei Zhang et al.

LIFE SCIENCES (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Berberine Reverses Doxorubicin Resistance by Inhibiting Autophagy Through the PTEN/Akt/mTOR Signaling Pathway in Breast Cancer

Ye Wang et al.

ONCOTARGETS AND THERAPY (2020)

Add to Collection

Article Cell Biology

ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy

Jiao Meng et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Article Cell Biology

LncRNA Sox2OT-V7 promotes doxorubicin-induced autoadagy and chemoresistance in osteosarcoma via tumor-suppressive miR-142/miR-22

Kewei Zhu et al.

AGING-US (2020)

Add to Collection

Editorial Material Cell Biology

Autophagy suppresses breast cancer metastasis by degrading NBR1

Timothy Marsh et al.

AUTOPHAGY (2020)

Add to Collection

Article Oncology

Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p

Li Li et al.

CANCER CELL INTERNATIONAL (2020)

Add to Collection

Article Cell Biology

Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy

Rui Kong

CELL BIOLOGY INTERNATIONAL (2020)

Add to Collection

Review Biochemistry & Molecular Biology

The cellular function of SCAP in metabolic signaling

Sun Hee Lee et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Oncology

PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

Ji Eun Jang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

MicroRNA-375 Targets ATG14 to Inhibit Autophagy and Sensitize Hepatocellular Carcinoma Cells to Sorafenib

Shuo Yang et al.

ONCOTARGETS AND THERAPY (2020)

Add to Collection

Article

Exosome-mediated delivery of miR-30a sensitize cisplatin-resistant variant of oral squamous carcinoma cells via modulating Beclin1 and Bcl2

Bhagyashri Kulkarni et al.

Oncotarget (2020)

Add to Collection

Review Oncology

Targeting apoptosis in cancer therapy

Benedito A. Carneiro et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Add to Collection

Article Oncology

MiR-223 regulates autophagy associated with cisplatin resistance by targeting FBXW7 in human non-small cell lung cancer

Hui Wang et al.

CANCER CELL INTERNATIONAL (2020)

Add to Collection

Article Respiratory System

Astragaloside IV sensitizes non-small cell lung cancer cells to cisplatin by suppressing endoplasmic reticulum stress and autophagy

Song-Tao Lai et al.

JOURNAL OF THORACIC DISEASE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Flavopereirine Inhibits Autophagy via the AKT/p38 MAPK Signaling Pathway in MDA-MB-231 Cells

Ming-Shan Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Oncology

MiTF is Associated with Chemoresistance to Cisplatin in A549 Lung Cancer Cells via Modulating Lysosomal Biogenesis and Autophagy

Wei Li et al.

CANCER MANAGEMENT AND RESEARCH (2020)

Add to Collection

Article Pharmacology & Pharmacy

CD13 Induces Autophagy to Promote Hepatocellular Carcinoma Cell Chemoresistance Through the P38/Hsp27/CREB/ATG7 Pathway

Yan Zhao et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Exploring the mechanism of cisplatin resistance by transcriptome sequencing and reversing the chemoresistance by autophagy inhibition in small cell lung cancer

Kaiyan Ma et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Add to Collection

Article Medicine, Research & Experimental

Mirror siRNAs loading for dual delivery of doxorubicin and autophagy regulation siRNA for multidrug reversing chemotherapy

Bo Yang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Article Oncology

Soft Microenvironments Induce Chemoresistance by Increasing Autophagy Downstream of Integrin-Linked Kinase

Alisya A. Anlas et al.

CANCER RESEARCH (2020)

Add to Collection

Review Chemistry, Applied

Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

Milad Ashrafizadeh et al.

ACS COMBINATORIAL SCIENCE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Role of Nrf2 and mitochondria in cancer stem cells; in carcinogenesis, tumor progression, and chemoresistance

Zahra Payandeh et al.

BIOCHIMIE (2020)

Add to Collection

Article Oncology

Berberine reduces temozolomide resistance by inducing autophagy via the ERK1/2 signaling pathway in glioblastoma

Huiling Qu et al.

CANCER CELL INTERNATIONAL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway

Wei Gao et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Cell Biology

Chloroquine reverses chemoresistance via upregulation of p21WAF1/CIP1 and autophagy inhibition in ovarian cancer

Jae Ryoung Hwang et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Review Biotechnology & Applied Microbiology

Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer

Milad Ashrafizadeh et al.

BIOENGINEERING-BASEL (2020)

Add to Collection

Article Oncology

miR-375 targeting autophagy-related 2B (ATG2B) suppresses autophagy and tumorigenesis in cisplatin-resistant osteosarcoma cells

S. Gao et al.

NEOPLASMA (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Targeting cancer stem cell pathways for cancer therapy

Liqun Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Med19 is involved in chemoresistance by mediating autophagy through HMGB1 in breast cancer

Beibei Liu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Add to Collection

Article Endocrinology & Metabolism

NPRL2 enhances autophagy and the resistance to Everolimus in castration-resistant prostate cancer

Zhixiong Chen et al.

PROSTATE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of -catenin pathway

Satabdi Datta et al.

APOPTOSIS (2019)

Add to Collection

Article Cell Biology

PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma

Hanlin Ma et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy

Hong-Tao Chen et al.

MOLECULAR CANCER (2019)

Add to Collection

Article Oncology

Pantoprazole Affecting Docetaxel Resistance Pathways via Autophagy (PANDORA): Phase II Trial of High Dose Pantoprazole (Autophagy Inhibitor) with Docetaxel in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Aaron R. Hansen et al.

ONCOLOGIST (2019)

Add to Collection

Article Oncology

ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma

Rohit Sachdeva et al.

CANCER RESEARCH (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Past, present, and future of circRNAs

Ines Lucia Patop et al.

EMBO JOURNAL (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel Therapeutic Targets and Opportunities

Michele Lai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Cell Biology

Knockdown of TRIM65 inhibits autophagy and cisplatin resistance in A549/DDP cells by regulating miR-138-5p/ATG7

Xufeng Pan et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Review Endocrinology & Metabolism

Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists

Rohit A. Sinha et al.

THYROID (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Hsa_circ_0035483 sponges hsa-miR-335 to promote the gemcitabine-resistance of human renal cancer cells by autophagy regulation

Lei Yan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Add to Collection

Article Oncology

GX15-070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma

Sonia Cournoyer et al.

BMC CANCER (2019)

Add to Collection

Article Oncology

MicroRNA-338-5p reverses chemoresistance and inhibits invasion of esophageal squamous cell carcinoma cells by targeting Id-1

Liang Han et al.

CANCER SCIENCE (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Exosomal Transfer Of Cisplatin-Induced miR-425-3p Confers Cisplatin Resistance In NSCLC Through Activating Autophagy

Yuzhu Ma et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Add to Collection

Article Cell Biology

miR-223 overexpression inhibits doxorubicin-induced autophagy by targeting FOXO3a and reverses chemoresistance in hepatocellular carcinoma cells

Yue Zhou et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Article Medicine, General & Internal

circHIPK3 promotes oxaliplatin-resistance in colorectal cancer through autophagy by sponging miR-637

Yanli Zhang et al.

EBIOMEDICINE (2019)

Add to Collection

Article Pharmacology & Pharmacy

A newly synthesized platinum-based compound (PBC-II) increases chemosensitivity of HeLa ovarian cancer cells via inhibition of autophagy

Moureq Rashed Alotaibi et al.

SAUDI PHARMACEUTICAL JOURNAL (2019)

Add to Collection

Article Oncology

Bisdemethoxycurcumin Suppresses Migration and Invasion of Human Cervical Cancer HeLa Cells via Inhibition of NF-kappa B, MMP-2 and-9 Pathways

Ching-Lung Liao et al.

ANTICANCER RESEARCH (2018)

Add to Collection

Article Cell Biology

The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding

Giorgia Benegiamo et al.

CELL METABOLISM (2018)

Add to Collection

Article Gastroenterology & Hepatology

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition

Raymond Wu et al.

HEPATOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

CCL2-SQSTM1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer

Wenxia Xu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Add to Collection

Article Biochemistry & Molecular Biology

MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation

Jun Huang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Add to Collection

Article Medicine, Research & Experimental

TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer

Ke Gong et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Add to Collection

Article Oncology

miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway

Hong Li et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Add to Collection

Review Cell Biology

The coming of age of chaperone-mediated autophagy

Susmita Kaushik et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Add to Collection

Article Oncology

BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells

Chandan Kanta Das et al.

NEOPLASIA (2018)

Add to Collection

Article Cell Biology

Heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to pharmorubicin by promoting autophagy via PI3K/Akt pathway

Lei Pei et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Add to Collection

Article Oncology

Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling

Fei Xu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Add to Collection

Article Pharmacology & Pharmacy

Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB

Ruizhi He et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Add to Collection

Article Oncology

Autophagy Inhibition Promotes Bevacizumab-induced Apoptosis and Proliferation Inhibition in Colorectal Cancer Cells

Zhi Zhao et al.

JOURNAL OF CANCER (2018)

Add to Collection

Article Biochemistry & Molecular Biology

The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells

Yujuan Zhan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Article Medicine, Research & Experimental

Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer

Fuxing Zhou et al.

THERANOSTICS (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular control of chaperone-mediated autophagy

Steve Catarino et al.

SIGNALLING MECHANISMS IN AUTOPHAGY (2017)

Add to Collection

Article Oncology

ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathway

Xin Yin et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

Add to Collection

Review Oncology

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Tsukasa Shibue et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

mAb MDR1-modified chitosan nanoparticles overcome acquired EGFR-TKI resistance through two potential therapeutic targets modulation of MDR1 and autophagy

Yan Zheng et al.

JOURNAL OF NANOBIOTECHNOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

Michele Lai et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Cell Biology

Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer

Nuria Eritja et al.

AUTOPHAGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Bisdemethoxycurcumin sensitizes cisplatin-resistant lung cancer cells to chemotherapy by inhibition of CA916798 and PI3K/AKT signaling

Hai-Jing Wang et al.

APOPTOSIS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Acid Ceramidase in Melanoma EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION

Natalia Realini et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Add to Collection

Article Oncology

Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway

Haopeng Yang et al.

ONCOTARGET (2016)

Add to Collection

Article Pharmacology & Pharmacy

Co-delivery of docetaxel and chloroquine via PEO-PPO-PCL/TPGS micelles for overcoming multidrug resistance

Chunhuan Shi et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Add to Collection

Article Oncology

Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

Jagadish C. Ghosh et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Toward understanding and exploiting tumor heterogeneity

Ash A. Alizadeh et al.

NATURE MEDICINE (2015)

Add to Collection

Article Biotechnology & Applied Microbiology

Co-delivery of Gefitinib and chloroquine by chitosan nanoparticles for overcoming the drug acquired resistance

Liang Zhao et al.

JOURNAL OF NANOBIOTECHNOLOGY (2015)

Add to Collection

Article Oncology

Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

Jagadish C. Ghosh et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

Add to Collection

Article Oncology

Autophagy facilitates multidrug resistance development through inhibition of apoptosis in breast cancer cells

W. L. Sun et al.

NEOPLASMA (2015)

Add to Collection

Article Hematology

A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis

Shuang Chen et al.

BLOOD (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

Hariharan Easwaran et al.

MOLECULAR CELL (2014)

Add to Collection

Article Medicine, Research & Experimental

Sequential Release of Autophagy Inhibitor and Chemotherapeutic Drug with Polymeric Delivery System for Oral Squamous Cell Carcinoma Therapy

Wuliji Saiyin et al.

MOLECULAR PHARMACEUTICS (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Lessons from the Cancer Genome

Levi A. Garraway et al.

CELL (2013)

Add to Collection

Review Multidisciplinary Sciences

The causes and consequences of genetic heterogeneity in cancer evolution

Rebecca A. Burrell et al.

NATURE (2013)

Add to Collection

Review Multidisciplinary Sciences

Cancer Genome Landscapes

Bert Vogelstein et al.

SCIENCE (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

Add to Collection

Review Cell Biology

Chaperone-mediated autophagy: a unique way to enter the lysosome world

Susmita Kaushik et al.

TRENDS IN CELL BIOLOGY (2012)

Add to Collection

Article Cell Biology

C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages

E. Aflaki et al.

CELL DEATH & DISEASE (2012)

Add to Collection

Article Cell Biology

Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development

Wei-Liang Sun et al.

AUTOPHAGY (2011)

Add to Collection

Review Biochemistry & Molecular Biology

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

Inthrani R. Indran et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2011)

Add to Collection

Article Biochemical Research Methods

Jetset: selecting the optimal microarray probe set to represent a gene

Qiyuan Li et al.

BMC BIOINFORMATICS (2011)

Add to Collection

Review Cell Biology

Principles of bioactive lipid signalling: lessons from sphingolipids

Yusuf A. Hannun et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins

L Yin et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)

Add to Collection

Review Biochemistry & Molecular Biology

Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

Y Pommier et al.

ONCOGENE (2004)

Add to Collection

Review Oncology

Biologically active sphingolipids in cancer pathogenesis and treatment

B Ogretmen et al.

NATURE REVIEWS CANCER (2004)

Add to Collection

Review Biochemistry & Molecular Biology

The complex life of simple sphingolipids

AH Futerman et al.

EMBO REPORTS (2004)

Add to Collection

Review Oncology

Dissemination and growth of cancer cells in metastatic sites

AF Chambers et al.

NATURE REVIEWS CANCER (2002)

Add to Collection

Review Biochemistry & Molecular Biology

Can we infer peptide recognition specificity mediated by SH3 domains?

G Cesareni et al.

FEBS LETTERS (2002)

Add to Collection

Review Biochemistry & Molecular Biology

The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport

J Sakai et al.

CURRENT OPINION IN LIPIDOLOGY (2001)

Add to Collection

Article Biochemistry & Molecular Biology

The lipids C2- and C16-ceramide form large stable channels -: Implications for apoptosis

LJ Siskind et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.