cGAS-STING signaling in the tumor microenvironment

The cGAS-STING signaling is an important pathway involved in the regulation of tumor microenvironment, which affects many cellular functions including immune activation. Its role in combating tumor progression is widely recognized, especially with its function in inducing innate and adaptive immune responses, on which many immunotherapies have been developed. However, a growing number of findings also suggest a diversity of its roles in shaping tumor microenvironment, including functions that promote tumor progression. Here, we summarize the functions of the cGAS-STING signaling in tumor microenvironment to maintain tumor survival and proliferation through facilitating the forming of an immunosuppressive tumor microenvironment and discuss the current advances of STING-related immunotherapies.

Automated summary

The cGAS-STING signaling pathway plays a critical role in regulating the tumor microenvironment by affecting immune activation. It has been widely recognized for its ability to combat tumor progression and induce immune responses, leading to the development of immunotherapies. However, recent findings also suggest its diverse roles in shaping the tumor microenvironment, including functions that promote tumor progression.