☆ 4.7 Article

Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer

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Letter Medicine, General & Internal

Evaluation of BRCA1 and BRCA2 as Indicators of Response to Immune Checkpoint Inhibitors

Zhijun Zhou et al.

JAMA NETWORK OPEN (2021)

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Article Cell Biology

microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway

Xiao-Li Yang et al.

Summary: miR-873 can suppress the self-renewal and proliferation of pancreatic cancer stem cells by blocking PLEK2-dependent PI3K/AKT pathway. This study contributes to understanding the role of miR-873 in pancreatic cancer stem cells and its underlying molecular mechanisms to aid in the development of effective pancreatic cancer therapeutics.

CELLULAR SIGNALLING (2021)

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Article Oncology

Memory-like Differentiation Enhances NK Cell Responses to Melanoma

Nancy D. Marin et al.

Summary: The treatment of advanced melanoma is a clinical challenge, and natural killer (NK) cells show promise as a cellular therapy. Cytokine-induced memory-like (ML) differentiation enhances NK-cell responses against blood cancer targets, but its activity against solid tumors like melanoma needs further research. In preclinical studies, ML NK cells from healthy donors and melanoma patients exhibited increased IFN gamma production and cytotoxicity against melanoma targets, with a response partially dependent on activating receptors NKG2D and NKp46. Furthermore, in mouse models, ML NK cells showed better control of melanoma compared to conventional NK cells.

CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways

Zhen Xiang et al.

Summary: The study identified dexamethasone as a potential compound that can suppress T cell exhaustion by decreasing the activity of PD-L1 and IDO1 immune checkpoints, thus increasing sensitivity to immune checkpoint inhibitors. This finding highlights the critical role of dexamethasone in regulating tumor immune evasion.

ONCOGENE (2021)

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Article Gastroenterology & Hepatology

Pleckstrin-2 as a Prognostic Factor and Mediator of Gastric Cancer Progression

Jun Wang et al.

Summary: PLEK2 is significantly upregulated in gastric cancer and patients with higher levels have poor overall survival. It impacts cell proliferation and invasive behavior, promoting tumor development by regulating EMT pathways. PLEK2 may be a novel therapeutic target for gastric cancer.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2021)

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Article Medicine, General & Internal

Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma

Zhencong Chen et al.

Summary: This study reveals high heterogeneity of tumor cells in ESCC and widespread reprogramming across multiple cellular elements within the TME. It identifies potential new markers and therapeutic targets for clinical management of ESCC.

EBIOMEDICINE (2021)

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Article Oncology

PLEK2 mediates metastasis and vascular invasion via the ubiquitin-dependent degradation of SHIP2 in non-small cell lung cancer

Dong-Ming Wu et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Medicine, General & Internal

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Oncology

The cancer-natural killer cell immunity cycle

Nicholas D. Huntington et al.

NATURE REVIEWS CANCER (2020)

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Article Oncology

A C-X-C Chemokine Receptor Type 2-Dominated Cross-talk between Tumor Cells and Macrophages Drives Gastric Cancer Metastasis

Zhijun Zhou et al.

CLINICAL CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity

Laurent Gauthier et al.

CELL (2019)

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Article Oncology

PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway

Hui Shen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Induction of NKG2D ligand expression on tumor cells by CD8+ T-cell engagement-mediated activation of nuclear factor-kappa B and p300/CBP-associated factor

Jiemiao Hu et al.

ONCOGENE (2019)

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Article Medicine, Research & Experimental

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms

Baobing Zhao et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Oncology

Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity

Antoun Al Absi et al.

CANCER RESEARCH (2018)

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Article Oncology

Tumor-Associated Monocytes/Macrophages Impair NK-Cell Function via TGFβ1 in Human Gastric Cancer

Liu-sheng Peng et al.

CANCER IMMUNOLOGY RESEARCH (2017)

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Article Immunology

Tumor MICA status predicts the efficacy of immunotherapy with cytokine-induced killer cells for patients with gastric cancer

Yu Chen et al.

IMMUNOLOGIC RESEARCH (2016)

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Article Oncology

Regulatory T Cells Suppress Natural Killer Cell Immunity in Patients With Human Cervical Carcinoma

Wen-Chun Chang et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2016)

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Article Gastroenterology & Hepatology

Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility

Kensuke Shiraishi et al.

JOURNAL OF GASTROENTEROLOGY (2016)

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Article Oncology

CCL21-CCR7 promotes the lymph node metastasis of esophageal squamous cell carcinoma by up-regulating MUC1

Mo Shi et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2015)

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Review Immunology

The Application of Natural Killer Cell Immunotherapy for the Treatment of Cancer

Katayoun Rezvani et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Review Oncology

NKG2D signaling in cancer immunosurveillance

Alejandro Lopez-Soto et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

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Article Reproductive Biology

Leptin-Promoted Human Extravillous Trophoblast Invasion Is MMP14 Dependent and Requires the Cross Talk Between Notch1 and PI3K/Akt Signaling1

Huayang Wang et al.

BIOLOGY OF REPRODUCTION (2014)

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Article Oncology

Therapeutic potential of highly cytotoxic natural killer cells for gastric cancer

Kousaku Mimura et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

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Article Biochemistry & Molecular Biology

The Tetraspanin CD81 Protein Increases Melanoma Cell Motility by Up-regulating Metalloproteinase MT1-MMP Expression through the Pro-oncogenic Akt-dependent Sp1 Activation Signaling Pathways

In-Kee Hong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Immunology

NK Cells Are the Crucial Antitumor Mediators When STAT3-Mediated Immunosuppression Is Blocked in Hepatocellular Carcinoma

Qiangjun Sui et al.

JOURNAL OF IMMUNOLOGY (2014)

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Review Immunology

Immunobiology and Conflicting Roles of the Human NKG2D Lymphocyte Receptor and Its Ligands in Cancer

Ahmed El-Gazzar et al.

JOURNAL OF IMMUNOLOGY (2013)

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Review Genetics & Heredity

Transcriptional regulation by post-transcriptional modification-Role of phosphorylation in Sp1 transcriptional activity

Shijian Chu

GENE (2012)

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Article Biochemistry & Molecular Biology

Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression

Aneta Kwiatkowska et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

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Article Biotechnology & Applied Microbiology

Natural Killer Cell Cytotoxicity and Immunosuppressive Cytokines (IL-10, TGF-beta 1) in Patients with Gastric Cancer

Andrzej Szkaradkiewicz et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)

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Article Immunology

Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding of MHC Class I Chain-Related Molecule A Independent of A Disintegrin and Metalloproteinases

Gang Liu et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Oncology

EGF-IL-18 fusion protein as a potential anti-tumor reagent by induction of immune response and apoptosis in cancer cells

Jianxin Lu et al.

CANCER LETTERS (2008)

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Article Oncology

Tumor-associated MICA is shed by ADAM proteases

Inja Waldhauer et al.

CANCER RESEARCH (2008)

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Article Oncology

Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells

Xinying Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2008)

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Review Immunology

Functions of natural killer cells

Eric Vivier et al.

NATURE IMMUNOLOGY (2008)

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Article Oncology

Membrane-type 1 matrix metalloproteinase is regulated by Sp1 through the differential activation of AKT, JNK, and ERK pathways in human prostate tumor cells

Isis C. Sroka et al.

NEOPLASIA (2007)

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Article Multidisciplinary Sciences

Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure

S Abouzahr et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Genetics & Heredity

Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene

J Lohi et al.

GENE (2000)

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