4.7 Article

Cholesterol induction in CD8+ T cell exhaustion in colorectal cancer via the regulation of endoplasmic reticulum-mitochondria contact sites

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis

Chuangen Li et al.

Summary: This study reveals that SQLE plays an oncogenic role in colorectal cancer through both cell intrinsic effects and modulation of the gut microbiota-metabolite axis. SQLE can be a potential therapeutic target and prognostic marker for colorectal cancer.
Article Multidisciplinary Sciences

Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes

Shin-ichi Ikeda et al.

Summary: Axial length is the primary determinant of eye size and is elongated in myopia. This study reveals that endoplasmic reticulum (ER) stress in the sclera and the PERK/ATF6 pathway are involved in the axial elongation during myopia development. The researchers also demonstrate that 4-PBA eye drops show promise as a drug for myopia suppression/treatment.

NATURE COMMUNICATIONS (2022)

Article Cell Biology

The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses

Yongquan Hu et al.

Summary: Energy deprivation triggers mitochondrial fission and autophagy, while also increasing the number of mitochondrial-associated ER membranes (MAMs) through AMP-activated protein kinase (AMPK) activity. AMPK translocates to MAMs and interacts with mitofusin 2 (MFN2) during energy stress, regulating autophagy and MAM dynamics. MFN2 plays a critical role in cell survival and function under energy stress, highlighting the importance of the AMPK-MFN2 pathway in cellular stress response.

AUTOPHAGY (2021)

Article Gastroenterology & Hepatology

Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis

Soo Young Jun et al.

Summary: The reduction of SQLE caused by cholesterol accumulation exacerbates CRC progression by activating the beta-catenin oncogenic pathway and deactivating the p53 tumor suppressor pathway. This study provides new insights into the connection between cholesterol and CRC, identifying SQLE as a key regulator in CRC aggressiveness and a prognostic biomarker.

GASTROENTEROLOGY (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Medicine, Research & Experimental

Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects

Yang Xi et al.

Summary: Cholesterol, an important component of cell membranes, plays a crucial role in tumor progression, immune dysregulation, and pathological changes in epigenetic mechanisms. Targeting cholesterol for cancer treatment has sparked increasing interest, with research focusing on its role in mediating immune and epigenetic mechanisms of the tumor microenvironment.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Immunology

Single-Cell Analysis Reveals Characterization of Infiltrating T Cells in Moderately Differentiated Colorectal Cancer

Xi Yang et al.

Summary: This study characterized tumor-infiltrating T cell populations in colorectal cancer using single-cell RNA sequencing data, revealing distinct T cell subgroups in tumor tissue and peripheral blood. Differences in tumor-infiltrating T cell populations between colon cancer and rectal cancer were identified, with changes in gene expression patterns observed in both cancer types.

FRONTIERS IN IMMUNOLOGY (2021)

Article Cell Biology

Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling

Juanjuan Yuan et al.

Summary: The study reveals the crucial role of LDLR in regulating the antitumor activity of CD8(+) T cells, including promoting T cell priming and clonal expansion, as well as regulating TCR signaling through interaction with the TCR complex. Moreover, the tumor microenvironment suppresses LDLR and TCR signaling in CD8(+) T cells via PCSK9, inhibiting the effector function of CTLs.

PROTEIN & CELL (2021)

Article Oncology

Key Markers Involved in the Anticolon Cancer Response of CD8+T Cells through the Regulation of Cholesterol Metabolism

Liang Dong et al.

Summary: Our study identified key genes involved in the anticolon cancer response of CD8+ T cells through the regulation of cholesterol metabolism, with APOE expression significantly impacting CRC patient prognosis and pathologic features. The distribution of CD8+ T cells was found to be related to APOE expression levels.

JOURNAL OF ONCOLOGY (2021)

Review Cell Biology

The MAMs Structure and Its Role in Cell Death

Nan Wang et al.

Summary: The cooperation and antagonism between organelles within the cell play a crucial role in maintaining cellular homeostasis. The signaling crosstalk between the endoplasmic reticulum (ER) and mitochondria influences cell fate. Mitochondria-associated membranes (MAMs) are pivotal in regulating lipid synthesis, calcium homeostasis, ER-mitochondrial coordination, and death signal transduction, contributing to cell death mechanisms such as apoptosis.

CELLS (2021)

Review Cell Biology

Targeting Mitochondrial Biogenesis with Polyphenol Compounds

Leila Chodari et al.

Summary: Appropriate mitochondrial physiology is crucial for health and survival, with polyphenols being considered effective components for treating various diseases by regulating mitochondrial biogenesis pathways.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Oncology

Influence of cholesterol on cancer progression and therapy

Shyamananda Singh Mayengbam et al.

Summary: Cholesterol plays a crucial role in maintaining cell structure and normal biological function, but is also linked to lifestyle-related diseases. Research has shown alterations in blood cholesterol levels in cancer patients compared to healthy individuals, highlighting its significance in cancer progression and therapy.

TRANSLATIONAL ONCOLOGY (2021)

Article Oncology

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling

Luwei He et al.

Summary: The study identified SQLE as highly upregulated in colorectal cancer patients and found that it promotes CRC growth by regulating the accumulation of calcitriol and stimulating CYP24A1-mediated MAPK signaling. Inhibition of SQLE reduced CRC cell proliferation, highlighting SQLE as a potential therapeutic target for CRC treatment.

CANCER COMMUNICATIONS (2021)

Article Medicine, Research & Experimental

Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer

Kai-Li Zhang et al.

Summary: This study identified a specific cholesterol metabolic pathway in colorectal cancer liver metastasis involving the activation of SREBP2-dependent cholesterol biosynthesis, which is essential for the growth and colonization of metastatic CRC cells in the liver. Targeting this pathway could be a promising treatment for CRC liver metastasis.

THERANOSTICS (2021)

Review Cell Biology

Mechanisms and regulation of cholesterol homeostasis

Jie Luo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Gastroenterology & Hepatology

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis

Alex J. Cornish et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Cell Biology

Mitophagy pathways in health and disease

Samuel A. Killackey et al.

JOURNAL OF CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

ER-Mitochondria Contact Sites Reporters: Strengths and Weaknesses of the Available Approaches

Flavia Giamogante et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery

Rong Yu et al.

EMBO JOURNAL (2019)

Review Biochemistry & Molecular Biology

Cholesterol biosensors: A review

Vinay Narwal et al.

STEROIDS (2019)

Article Cell Biology

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

Xingzhe Ma et al.

CELL METABOLISM (2019)

Review Chemistry, Analytical

Current analytical approaches in diagnosis of melanoma

Aziz Eftekhari et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

Review Cell Biology

ER-Mitochondria Communication in Cells of the Innate Immune System

Dmitry Namgaladze et al.

CELLS (2019)

Article Oncology

Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8+ T Cells

Katie E. Hurst et al.

CANCER IMMUNOLOGY RESEARCH (2019)

Editorial Material Oncology

AJCC 8th Edition: Colorectal Cancer

Martin R. Weiser

ANNALS OF SURGICAL ONCOLOGY (2018)

Article Nanoscience & Nanotechnology

Enhanced chemo-immunotherapy against melanoma by inhibition of cholesterol esterification in CD8+ T cells

Man Li et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Review Cell Biology

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Konstantinos Palikaras et al.

NATURE CELL BIOLOGY (2018)

Article Oncology

Secondary bile acid-induced dysbiosis promotes intestinal carcinogenesis

Hailong Cao et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

Review Immunology

Regulation of T cell signalling by membrane lipids

Wei Wu et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Different Susceptibilities between Apoe- and Ldlr-Deficient Mice to Inflammation-Associated Colorectal Carcinogenesis

Takuji Tanaka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Immunology

LXR-dependent and -independent effects of oxysterols on immunity and tumor growth

Catia Traversari et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2014)

Review Microbiology

The gut microbiota, bacterial metabolites and colorectal cancer

Petra Louis et al.

NATURE REVIEWS MICROBIOLOGY (2014)

Article Multidisciplinary Sciences

Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling

Ren Sheng et al.

NATURE COMMUNICATIONS (2014)

Review Immunology

Sterols and oxysterols in immune cell function

Nathanael J. Spann et al.

NATURE IMMUNOLOGY (2013)

Article Oncology

Dietary cholesterol intake and cancer

J. Hu et al.

ANNALS OF ONCOLOGY (2012)

Article Biochemistry & Molecular Biology

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

L. Bouman et al.

CELL DEATH AND DIFFERENTIATION (2011)

Article Biochemistry & Molecular Biology

Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes

S. Lucken-Ardjomande et al.

CELL DEATH AND DIFFERENTIATION (2008)

Article Cardiac & Cardiovascular Systems

Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome

Masafumi Myoishi et al.

CIRCULATION (2007)

Article Biochemical Research Methods

Detecting protein-protein interactions by far western blotting

Yuliang Wu et al.

NATURE PROTOCOLS (2007)

Article Biochemical Research Methods

Western blotting

BT Kurien et al.

METHODS (2006)