Are we on track for diagnosing high-grade urothelial carcinoma with a minimum quantity of five malignant cells in lower tract specimens? Critical analysis of The Paris System Quantitation Criteria

Article Pathology

Application of the Paris Reporting System for Urine Cytology: The Three-Year Experience of a Single Tertiary Care Institute in Thailand

Bantita Phruttinarakorn et al.

Summary: Urothelial carcinoma is a common human cancer and urine cytology is a screening tool used to detect it. The Paris System for Reporting Urinary Cytology (TPSRUC) provides reliable results and is helpful in detecting high-grade urothelial carcinoma.

ACTA CYTOLOGICA (2022)

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Article Oncology

Digital image analysis of high-grade urothelial carcinoma in urine cytology confirms chromasia heterogeneity and reveals a subset with hypochromatic nuclei and another with extremely dark or India ink nuclei

Patrick J. McIntire et al.

Summary: The study evaluated high-grade urothelial carcinoma (HGUC) using digital image analysis and found significant variations in chromasia between cases, including a subset with hypochromasia and another subset with extremely dark or India ink nuclei. There was also heterogeneity in chromasia within a single sample.

CANCER CYTOPATHOLOGY (2022)

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Article Health Care Sciences & Services

The Paris System for Reporting Urinary Cytology: A Meta-Analysis

Ilias P. Nikas et al.

Summary: The Paris System is a standardized reporting system for urinary cytology that provides diagnostic accuracy by assigning samples into seven diagnostic categories and calculating the risk of high-grade malignancy. It guides clinical management and has an overall good diagnostic performance.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Article

Urothelial Carcinoma

Jatin Gandhi et al.

Surgical Pathology Clinics (2022)

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Article

Perceptions of Paris: an international survey in preparation for The Paris System for Reporting Urinary Cytology 2.0 (TPS 2.0)

Daniel F.I. Kurtycz et al.

Journal of the American Society of Cytopathology (2022)

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Article Cell Biology

Quantitative cytomorphological comparison of SurePath and ThinPrep liquid-based cytology using high-grade urothelial carcinoma cells

Chihiro Okuda et al.

Summary: The study confirmed the rationality of using the N:C ratio as the main criterion for TPS on both SurePath and ThinPrep slides, with an N:C ratio cut-off of 0.7 suitable for identifying HGUC cells. However, the severity of hyperchromasia and irregular nuclear borders differed between the processing methods.

CYTOPATHOLOGY (2021)

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Article Cell Biology

Comparison of conventional and liquid-based cytology using The Paris System for Reporting Urinary Cytology

Dimitris Goutas et al.

Summary: There were no significant differences found in terms of sensitivity and specificity between cytospin and ThinPrep when applying TPS criteria. TPS is a reliable classification scheme for conventional/cytospin or liquid-based cytology, or their combination. Interobserver reproducibility and repeatability were high for both methods.

CYTOPATHOLOGY (2021)

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Article Medical Laboratory Technology

Nuclear hypochromasia: Shedding light on the lightness of high-grade urothelial carcinoma

Evan S. Stern et al.

Summary: The study investigated the incidence of nuclear hypochromasia in high-grade urothelial carcinoma, identifying it in 10.2% of cases. Hypochromasia was present in 5% or more of tumor cells, suggesting it as a potential feature of high-grade urothelial carcinoma.

DIAGNOSTIC CYTOPATHOLOGY (2021)

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Article Economics