Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma

Article Biotechnology & Applied Microbiology

Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9

Junqi Liu et al.

Summary: The study found that lncRNA DIO3OS upregulates the expression of PAX9 by binding to miR-130b, ultimately promoting the radiosensitivity of esophageal squamous cell carcinoma (ESCC).

CANCER GENE THERAPY (2022)

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Article Cell Biology

Long non-coding RNA DIO3OS/let-7d/NF-κB2 axis regulates cells proliferation and metastasis of thyroid cancer cells

Mingming Wang et al.

Summary: DIO3OS, a highly expressed lncRNA in thyroid cancer, is associated with poorer overall survival in patients. Inhibiting DIO3OS affects cancer cell viability and invasion, potentially through its regulation of NF-kappa B2 and let-7d. Further in vivo and clinical investigation is needed for the clinical application of this axis.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2021)

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Article Oncology

TNK2-AS1 upregulated by YY1 boosts the course of osteosarcoma through targeting miR-4319/WDR1

Weitao Yao et al.

Summary: The study revealed that TNK2-AS1 can elevate WDR1 expression in OS cells by 'sponging' miR-4319, thereby promoting the development of OS.

CANCER SCIENCE (2021)

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Article Biophysics

Dual electrochemical genosensor for early diagnosis of prostate cancer through lncRNAs detection

Raquel Sanchez-Salcedo et al.

Summary: A sandwich-type hybridization assay has been developed for detecting prostate cancer by simultaneously measuring prostate cancer antigen 3 and PSA mRNA. This method improves the sensitivity of long noncoding RNA detection and shows good performance in PCa diagnosis without significant cross-talk in the dual configuration.

BIOSENSORS & BIOELECTRONICS (2021)

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Review Medicine, General & Internal

New Horizons in the Treatment of Osteosarcoma

Paul S. Meltzer et al.

Summary: Osteosarcoma is a common malignant tumor that primarily affects individuals aged 10 to 30, and is usually treated with surgery and chemotherapy. While whole-genome sequencing can detect genetic alterations, it has not yet resulted in improved treatment outcomes.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Genetics & Heredity

The Missing Link Between Cancer-Associated Variants and LncRNAs

Claire Wilson et al.

Summary: This study speculates on the potential role of variants of lncRNAs in cancer development by drawing upon emerging research findings.

TRENDS IN GENETICS (2021)

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Review Biochemistry & Molecular Biology

Diagnostic, prognostic, and therapeutic significance of long non-coding RNA MALAT1 in cancer

Bela Goyal et al.

Summary: MALAT1 is a widely studied lncRNA in cancer, playing an important role in tumorigenesis and development, localized in the periphery of nuclear speckles. Molecular tools have shown its diagnostic, prognostic, and therapeutic potential in various cancers.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Oncology

DNA-methylation-induced silencing of DIO3OS drives non-small cell lung cancer progression via activating hnRNPK-MYC-CDC25A axis

Meichun Zhang et al.

Summary: The study identified DIO3OS as an important protective factor against NSCLC by modulating the hnRNPK-MYC-CDC25A axis. DIO3OS is downregulated in NSCLC, and its overexpression can suppress NSCLC cell growth and motility while promoting apoptosis. Additionally, DIO3OS exerts its effects through competitive binding with hnRNPK.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Review Oncology

Advancing therapy for osteosarcoma

Jonathan Gill et al.

Summary: Osteosarcoma, the most common primary bone cancer in children and young adults, presents challenges in treatment due to its rarity and molecular heterogeneity. Collaborative efforts in biological discoveries, technologies, and therapeutic approaches are expected to advance osteosarcoma treatment and improve patient outcomes. The increasing feasibility of molecular profiling, along with the creation of robust model systems and large tissue banks, has enhanced understanding of osteosarcoma biology.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology