4.4 Article

Development of Hyperpolarized NMR Molecular Probes for Biological Applications

Journal

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 96, Issue 9, Pages 995-1002

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20230161

Keywords

Molecular probe; Nuclear magnetic resonance; Hyperpolarization

Ask authors/readers for more resources

This article describes the research on the development of hyperpolarized molecular probes with long hyperpolarization lifetimes. Various hyperpolarized molecular probes have been successfully developed and applied for in vivo studies, based on the understanding of the relaxation mechanism of hyperpolarized spin states. In addition, the development of hyperpolarized molecular probes with remarkably long hyperpolarization lifetimes has been demonstrated.
Our bodies are composed of molecules. The dynamic activ-ity of molecules is the essence of living phenomena. Toward the analysis of this, the establishment of in vivo molecular imaging techniques has been sought. Hyperpolarized nuclear magnetic resonance (NMR) is a promising technique that enables in vivo molecular imaging using highly sensitive hyper polarized NMR molecular probes and is expected to be a next generation molecular imaging technology. However, a major challenge lies in the rapid relaxation of the hyperpolarized nuclear spin state of the molecule, i.e., a short lifetime of high sensitivity. We have made our efforts to address this critical issue. This award account mainly describes our research to develop hyperpolarized molecular probes with long hyper polarization lifetime. Based on the understanding of the relax-ation mechanism of hyperpolarized spin states, we successfully developed various hyperpolarized C-13 molecular probes, some of which were applied for in vivo studies. In addition, we demonstrated the development of hyperpolarized N-15 molecular probes with remarkably long hyperpolarization lifetimes. These results pave the way for the rational design of hyperpolarized molecular probes, which has been difficult to achieve so far.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available