☆ 4.7 Review

Cathepsins and SARS-CoV-2 infection: From pathogenic factors to potential therapeutic targets

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Related references

Note: Only part of the references are listed.

Review Microbiology

SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies

MacGregor Cox et al.

Summary: Monoclonal antibodies (mAbs) are an important treatment option for severe COVID-19, but the emergence of new SARS-CoV-2 variants has led to evasion of mAb-induced protection. Spike protein amino acid substitutions, both at epitope and non-epitope positions, play a role in resistance to mAb neutralization. Understanding the dynamics of viral evasion can inform surveillance and the development of novel mAb therapies.

NATURE REVIEWS MICROBIOLOGY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Potential protease inhibitors and their combinations to block SARS-CoV-2

Chandran S. Abhinand et al.

Summary: COVID-19, caused by SARS-coronavirus 2, has created a global public health emergency, requiring effective therapeutic strategies. This study suggests that existing anti-viral protease inhibitor drugs, particularly Ritonavir, may have the potential to treat COVID-19 by blocking viral replication.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Cathepsin B is a potential therapeutic target for coronavirus disease 2019 patients with lung adenocarcinoma

Xiaoyan Ding et al.

Summary: Hospitalization and mortality rates of lung cancer patients diagnosed with COVID-19 are higher than those of patients presenting with other cancers. The present study aims to identify the possible causes for disproportionately severe COVID-19 outcomes in lung adenocarcinoma (LUAD) patients and determine a therapeutic target. CTSB plays a vital role in the hyperinflammatory response in COVID-19 patients with LUAD and is a promising target for drug therapy.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

Add to Collection

Article Chemistry, Medicinal

Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

Anneliese S. Ashhurst et al.

Summary: The study identifies cathepsin L as a key protease used by coronaviruses for cell entry and a potential drug target for antiviral treatment against SARS-CoV-2. The researchers discovered that gallinamide A and synthetic analogues are potent inhibitors of cathepsin L, showing promising antiviral activity against SARS-CoV-2. The combination with a TMPRSS2 inhibitor further enhances the antiviral effect.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection

Article Genetics & Heredity

Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations

Luiz Gustavo de Almeida Chuffa et al.

Summary: The study revealed that genes such as FASLG, CTSW, CTSE, VCAM1, and BAG3 are upregulated in aged blood and associated with immune response, inflammation, and blood clots. These findings suggest that certain blood molecules may be related to the severe progression of COVID-19.

JOURNAL OF MOLECULAR MEDICINE-JMM (2022)

Add to Collection

Review Cell Biology

Mechanisms of SARS-CoV-2 entry into cells

Cody B. Jackson et al.

Summary: The entry of SARS-CoV-2 into host cells is facilitated by the interaction between the viral spike protein and ACE2, leading to virus-cell membrane fusion, which has been extensively studied at the structural and cellular levels worldwide. This understanding has paved the way for the development of effective vaccines in response to the COVID-19 pandemic, caused by the infection with SARS-CoV-2.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Add to Collection

Article Chemistry, Medicinal

MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L**

Xinyu R. Ma et al.

Summary: Inhibitors targeting the SARS-CoV-2 main protease have been developed, with some showing high potency in inhibiting cathepsins B/K/L. Among them, MPI8 displays the best selectivity towards cathepsin L, highlighting its potential for further investigation in treating COVID-19.

CHEMMEDCHEM (2022)

Add to Collection

Article Microbiology

Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L

Fei Yu et al.

Summary: The outbreak of COVID-19 has posed a serious threat to global public health. Finding effective treatments is crucial but hindered by limited understanding of the virus and lack of specific antiviral agents. This study reveals that teicoplanin can inhibit the cell entry of SARS-CoV-2 and prevent cellular infection. Teicoplanin shows potential as a universal intervention against coronaviruses.

FRONTIERS IN MICROBIOLOGY (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Nanoantibiotics to fight multidrug resistant infections by Gram-positive bacteria: hope or reality?

Francesca Berini et al.

Summary: The spread of antibiotic resistance poses a threat to human health, leading to increased research on alternative antibacterial treatments. This review surveys the use of nanoparticles as carriers for frontline antibiotics in combating multidrug-resistant Gram-positive pathogens, focusing on glycopeptide antibiotics and daptomycin. The study highlights the potential of nanoantibiotics in countering biofilm-associated infections and critically reviews the toxicity of these formulations.

BIOTECHNOLOGY ADVANCES (2022)

Add to Collection

Review Biochemistry & Molecular Biology

The Key Role of Lysosomal Protease Cathepsins in Viral Infections

Melania Scarcella et al.

Summary: Cathepsins are a family of proteases involved in protein degradation and turnover. Their dysregulation has been associated with various human diseases. In viral infections, cathepsins play crucial roles and their inhibitors have potential therapeutic applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Immunology

Spatial localization of cathepsins: Implications in immune activation and resolution during infections

Elsa Anes et al.

Summary: This review highlights the spatial localization of cathepsins and their implications in immune activation and resolution pathways during infection.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Cell Biology

Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies

Miao-Miao Zhao et al.

Summary: This study identifies two previously unidentified Cathepsin L (CTSL) cleavage sites in the spike protein of SARS-CoV-2. CTSL cleavage promotes the adoption of a specific conformation by the spike protein, facilitating receptor binding and membrane fusion. Inhibitors targeting CTSL not only block viral infection in cells, but also reduce live virus infection in lung tissues. CTSL-specific inhibitors show promising effects in preventing live virus infection in animal models. Inhibition of CTSL cleavage could be a potential strategy for developing mutation-resistant therapies.

CELL DISCOVERY (2022)

Add to Collection

Review Cell Biology

The pathogenesis of coronavirus-19 disease

Alain C. Borczuk et al.

Summary: COVID-19 is a systemic disease caused by SARS-CoV-2 virus, mainly resulting in severe consequences through its impact on the immune and circulatory systems.

JOURNAL OF BIOMEDICAL SCIENCE (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19

Xue Li et al.

Summary: This article comprehensively explores how SARS-CoV-2 manipulates various types of cell death and cell autophagy, aiming to understand the occurrence and progression of COVID-19 and provide a foundation for existing interventions and the development of new therapies.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy

Wei-Li Yang et al.

Summary: This study applied the deep neural network approach Chemprop to identify potential inhibitors for the CTSL protein, which plays a role in the replication of SARS-CoV-2. The researchers discovered several promising molecules, including an FDA-approved antibiotic, that showed significant inhibition of CTSL activity and the infection of the virus. This research provides insight into the potential treatment options for COVID-19.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

Add to Collection

Article Biochemistry & Molecular Biology

In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties

Erman Salih Istifli et al.

Summary: This study investigated the interactions between twenty-three phytochemicals belonging to different flavonoid subgroups and the spike glycoprotein of 2019-nCoV. The results showed that (-)-epicatechin gallate had strong interactions with all the proteins studied.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Add to Collection

Article Multidisciplinary Sciences

Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies

Amal Mahmoud et al.

Summary: Drug repurposing is an important approach to assigning approved drugs for new indications, saving time and lives by bypassing traditional drug approval steps. Telaprevir shows promising potential against SARS-CoV-2 and may be considered for therapeutic development based on in silico and in vitro studies.

HELIYON (2021)

Add to Collection

Article Biochemical Research Methods

Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach

Chandra Bhushan Mishra et al.

Summary: The study identified seven drugs that preferentially bind to target proteins of SARS-CoV-2, among which catechin showed effective binding to multiple target proteins with favorable molecular interactions. The molecular dynamics simulations revealed the potential of catechin as a multi-targeted agent against COVID-19.

BRIEFINGS IN BIOINFORMATICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Multi-organ proteomic landscape of COVID-19 autopsies

Xiu Nie et al.

Summary: This study used proteomic analysis to reveal the molecular mechanisms of multi-organ injuries in COVID-19 patients. The data showed significant upregulation of cathepsin L1 in the lung, instead of ACE2. Systemic hyperinflammation, dysregulation of glucose and fatty acid metabolism were detected in multiple organs.

CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage

Kun Wang et al.

Summary: Compound 8a showed broad-spectrum anti-coronavirus effects by potentially inhibiting host cathepsin B activity to block the late stage of viral entry. Additionally, it could reduce the release of multiple inflammatory cytokines, contributing to the suppression of cytokine storm.

BIOORGANIC CHEMISTRY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells

Mart M. Lamers et al.

Summary: This study describes a human 2D air-liquid interface culture system for studying interactions between SARS-CoV-2 and host cells, showing potential as an experimental model and drug screening tool. The system is characterized by the infection of alveolar cells and induction of interferon response, with interferon lambda 1 treatment reducing viral replication.

EMBO JOURNAL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

Elisa Costanzi et al.

Summary: The COVID-19 pandemic continues to afflict people globally, emphasizing the need for multiple antiviral strategies. Research on the binding mode of MG-132 to SARS-CoV-2 main protease and human Cathepsin-L suggests a potential scaffold for double-inhibitors. Inhibitory effects of MG-132 on both enzymes indicate the possibility of a promising dual-acting drug development approach.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2

Andre Fischer et al.

Summary: Research assessed the selectivity of 33 reported non-covalent inhibitors of SARS-CoV-2 M-pro against eight proteases and 16 anti-targets, revealing off-target binding of some compounds to multiple proteases and anti-targets, with a high risk especially in chymase and cathepsin G.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Multidisciplinary Sciences

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

Yunkai Zhu et al.

Summary: The SARS-CoV-2 spike protein contains a multi-basic cleavage site that affects virus entry and transmission, as shown in hamster models. Host factors affecting virus entry were identified through a genome-wide CRISPR screen.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Chemistry, Medicinal

Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19

Kas Steuten et al.

Summary: Two proteases produced by the SARS-CoV-2 virus play essential roles in viral replication, but inhibitors may also affect host cells; careful assessment of the selectivity of protease inhibitors is needed during drug development to avoid unnecessary interference with redundant pathways for viral entry.

ACS INFECTIOUS DISEASES (2021)

Add to Collection

Article Chemistry, Medicinal

Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses

Yanmei Hu et al.

Summary: The study identified four SARS-CoV-2 main protease inhibitors with potent antiviral activity and dual mechanism of action, targeting viral M-pro and host cathepsin L. These compounds showed broad-spectrum antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV, and human coronaviruses 229E, OC43, and NL63. Additionally, the research demonstrated additive antiviral effect when these compounds were combined with remdesivir, suggesting their potential as promising starting points for further development against existing and emerging coronaviruses.

ACS INFECTIOUS DISEASES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells

Drake M. Mellott et al.

Summary: K777, an irreversible inactivator of cysteine proteases, has shown reduction in the infectivity of SARS-CoV-2 in various host cells. By inhibiting the activity of host cathepsin L, this drug prevents the processing of viral spike protein, thereby reducing viral infectivity.

ACS CHEMICAL BIOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells

Rina Hashimoto et al.

Summary: This study investigated the roles of neuropilin-1, basigin, TMPRSSs, and CTSs in SARS-CoV-2 infection using the CRISPR interference system and ACE2-expressing human iPS cells. Double knockdown of TMPRSS2 and CTSB significantly reduced the viral load. Combination of CTPB and TMPRSS2 inhibitors showed highly efficient antiviral effects against various SARS-CoV-2 variants, independent of gender.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Add to Collection

Review Virology

Targeting the viral-entry facilitators of SARS-CoV-2 as a therapeutic strategy in COVID-19

Shibi Muralidar et al.

Summary: SARS-CoV-2 is the causative agent of COVID-19, and targeting key steps of viral entry like the interaction between S-protein and ACE2 is crucial for developing effective therapeutics. Studies have shown the importance of cell surface heparan sulfate, TMPRSS2, and CatB/L in mediating SARS-CoV-2 entry, providing potential targets for drug development.

JOURNAL OF MEDICAL VIROLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V

Keval Bollavaram et al.

Summary: This study identifies the crucial role of proteases, particularly cathepsins B, K, L, S, and V, in SARS-CoV-2 infection and proposes methodologies to identify other proteases involved in viral entry. It emphasizes the importance of considering additional proteases in COVID-19 research, especially in cases of exacerbated damage in inflammatory conditions where these proteases are upregulated.

PROTEIN SCIENCE (2021)

Add to Collection

Article Multidisciplinary Sciences

Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestations

Kartikay Prasad et al.

Summary: Lysosomal cathepsins, especially cathepsins B/L, play a crucial role in the entry of SARS-CoV-2 into host cells and may be involved in neurological manifestations linked to COVID-19. Through network-based drug repurposing analyses, cyclosporine, phenytoin, and paclitaxel were identified as potential drugs with binding ability to cathepsins B/L. Molecular docking and molecular dynamics simulations showed strong and stable binding of these drugs with cathepsins B/L.

HELIYON (2021)

Add to Collection

Article Pharmacology & Pharmacy

Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen

Jordi Rodon et al.

Summary: This study identified potential antiviral drugs for the treatment of COVID-19 by screening existing drugs approved for human use. Among the 72 antivirals tested, only 18% showed effective inhibition of viral replication, with Plitidepsin being the most promising candidate. Drug combinations showed no particular synergy, but did not reduce antiviral activity, potentially decreasing the emergence of resistant viruses.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Article Pharmacology & Pharmacy

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

Stephen P. H. Alexander et al.

Summary: The Concise Guide to PHARMACOLOGY 2021/22 provides concise overviews of nearly 1900 human drug targets, with an emphasis on selective pharmacology, linking to an open access knowledgebase for more detailed information. Produced in collaboration with NC-IUPHAR, it offers official IUPHAR classification and nomenclature for human drug targets.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Add to Collection

Article Pharmacology & Pharmacy

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

Stephen P. H. Alexander et al.

Summary: The Concise Guide to PHARMACOLOGY 2021/22 provides concise overviews of nearly 1900 human drug targets, with emphasis on selective pharmacology. It also includes links to an open access knowledgebase for more detailed information. Additionally, the guide discusses six main areas of focus for drug targets and pharmacological tools.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Add to Collection

Article Pharmacology & Pharmacy

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

Stephen P. H. Alexander et al.

Summary: The Concise Guide to PHARMACOLOGY 2021/22 presents concise overviews of nearly 1900 human drug targets with an emphasis on selective pharmacology, along with links to a more detailed knowledgebase. It serves as a permanent, citable record for researchers, providing useful information in the field of pharmacology.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Add to Collection

Review Gastroenterology & Hepatology

The multifaceted role of cathepsins in liver disease

Paloma Ruiz-Blazquez et al.

Summary: Proteases, as the most abundant enzyme gene family in vertebrates, play essential roles in maintaining important functions in living organisms. Lysosomal protease cathepsins, especially, play key roles in liver disease, participating in controlling processes such as apoptosis, extracellular matrix remodeling, and hepatocellular carcinoma.

JOURNAL OF HEPATOLOGY (2021)

Add to Collection

Review Neurosciences

A Review on SARS-CoV-2-Induced Neuroinflammation, Neurodevelopmental Complications, and Recent Updates on the Vaccine Development

Medha Karnik et al.

Summary: COVID-19 caused by SARS-CoV-2 is a devastating viral infection with higher mortality in older individuals and those with preexisting conditions. Understanding the virus entry mechanism and its impact on different organ systems is crucial for developing effective therapeutic strategies.

MOLECULAR NEUROBIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of Cysteine Proteases by 6,6′-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea

Kamran Waidha et al.

Summary: The study demonstrated the specificity of inhibition by 6,6'-dihydroxythiobinupharidine (DTBN) on cysteine proteases, with different levels of inhibition among the tested enzymes. The lack of reactivity of DTBN against SARS-CoV-2 M-pro suggests a potential mismatch in binding conformation. This research indicates a potential alternative strategy for developing derivatives of nupharidine against COVID-19.

MOLECULES (2021)

Add to Collection

Article Multidisciplinary Sciences

Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L

Kartikay Prasad et al.

Summary: Genomic analysis and drug screening identified estradiol and retinoic acid as potential agents for treating SARS-CoV-2. These drugs interact with human proteins, suggesting the therapeutic benefits of targeting the virus entry pathways.

PLOS ONE (2021)

Add to Collection

Review Immunology

Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity

Hylemariam Mihiretie Mengist et al.

Summary: COVID-19, caused by SARS-CoV-2, has resulted in over 4.9 million deaths and is having devastating effects on the global healthcare system. Understanding the impact of viral mutations on vaccines and immunity is crucial for designing effective strategies to combat emerging variants.

SEMINARS IN IMMUNOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Miao-Miao Zhao et al.

Summary: CTSL plays a crucial role in COVID-19 patients, with its levels positively correlated with disease severity. Research showed that CTSL promotes SARS-CoV-2 virus entry into cells, and the CTSL inhibitor amantadine can inhibit this process, providing a direction for the development of new anti-COVID-19 drugs.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection

Article Biology

Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols

Erman Salih Istifli et al.

Summary: The study found that robinin and gossypetin have significant binding capacity to the targets of the novel coronavirus and could be potential therapeutic agents. However, further verification of their inhibitory effects on cytochromes and minimizing adverse effects on cellular energy metabolism through molecular modifications are necessary.

TURKISH JOURNAL OF BIOLOGY (2021)

Add to Collection

Article Virology

Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376

Gang Ye et al.

VIRUSES-BASEL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

Qihui Wang et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

Add to Collection

Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Article Multidisciplinary Sciences

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Xiuyuan Ou et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

Add to Collection

Article Biochemistry & Molecular Biology

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Markus Hoffmann et al.

MOLECULAR CELL (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Chemistry and Biology of SARS-CoV-2

Alexander Domling et al.

CHEM (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

Shaobo Shi et al.

JAMA CARDIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural basis of receptor recognition by SARS-CoV-2

Jian Shang et al.

NATURE (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart

Hanning Liu et al.

CARDIOVASCULAR RESEARCH (2020)

Add to Collection

Article Cell Biology

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

Chunlong Ma et al.

CELL RESEARCH (2020)

Add to Collection

Article Infectious Diseases

In silico study of azithromycin, chloroquine and hydroxychloroquine and their potential mechanisms of action against SARS-CoV-2 infection

Helyson Lucas Bezerra Braz et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells

Rolando Cannalire et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Immunology

Severe COVID-19: NLRP3 Inflammasome Dysregulated

Daan F. van den Berg et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Review Cell Biology

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management

Tulasi Yadati et al.

CELLS (2020)

Add to Collection

Article Multidisciplinary Sciences

Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site

Javier A. Jaimes et al.

ISCIENCE (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

SARS-CoV-2 infects and induces cytotoxic effacts in human cardiomyocytes

Denisa Bojkova et al.

CARDIOVASCULAR RESEARCH (2020)

Add to Collection

Article Biochemistry & Molecular Biology

In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection

R. P. Vivek-Ananth et al.

MOLECULES (2020)

Add to Collection

Article Multidisciplinary Sciences

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

Hanjun Zhao et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Review Immunology

Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics

Caio P. Gomes et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Potential clinical drugs as covalent inhibitors of the priming proteases of the spike protein of SARS-CoV-2

Qizhang Li et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2

Jie Hu et al.

GENES & DISEASES (2020)

Add to Collection

Article Multidisciplinary Sciences

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L

Michael Dominic Sacco et al.

SCIENCE ADVANCES (2020)

Add to Collection

Review Microbiology

The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

Anja Pislar et al.

PLOS PATHOGENS (2020)

Add to Collection

Article Immunology

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Yong Xiong et al.

EMERGING MICROBES & INFECTIONS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond

Matej Vizovisek et al.

MATRIX BIOLOGY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Proteases: History, discovery, and roles in health and disease

Judith S. Bond

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Add to Collection

Review Virology

Ebola Virus Entry: From Molecular Characterization to Drug Discovery

Cristiano Salata et al.

VIRUSES-BASEL (2019)

Add to Collection

Article Computer Science, Information Systems

Novel Computational Approach to Predict Off-Target Interactions for Small Molecules

Mohan S. Rao et al.

FRONTIERS IN BIG DATA (2019)

Add to Collection

Article Chemistry, Medicinal

Cathepsin B and L inhibitors: a patent review (2010-present)

Yu-Yao Li et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2017)

Add to Collection

Review Cell Biology

Human gut microbiota: the links with dementia development

Rashad Alkasir et al.

PROTEIN & CELL (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury

Jingjing Cai et al.

MOLECULAR MEDICINE (2017)

Add to Collection

Review Cell Biology

The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease

Pasquale Cocchiaro et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

Nan Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Add to Collection

Review Dentistry, Oral Surgery & Medicine

Oral inflammation and infection, and chronic medical diseases: implications for the elderly

Frank A. Scannapieco et al.

PERIODONTOLOGY 2000 (2016)

Add to Collection

Article Microbiology

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

Yunjeong Kim et al.

PLOS PATHOGENS (2016)

Add to Collection

Article Physiology

Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats

Tsubasa Shibaguchi et al.

PHYSIOLOGICAL REPORTS (2016)

Add to Collection

Article Cell Biology

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

Juergen Brojatsch et al.

CELL CYCLE (2015)

Add to Collection

Article Immunology

Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

Gregory M. Orlowski et al.

JOURNAL OF IMMUNOLOGY (2015)

Add to Collection

Article Biotechnology & Applied Microbiology

An analysis of the attrition of drug candidates from four major pharmaceutical companies

Michael J. Waring et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Add to Collection

Article Toxicology

OpenVirtualToxLab-A platform for generating and exchanging in silico toxicity data

Angelo Vedani et al.

TOXICOLOGY LETTERS (2015)

Add to Collection

Article Cell Biology

Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting

Sandra Markmann et al.

TRAFFIC (2015)

Add to Collection

Review Geriatrics & Gerontology

Microglial cell dysregulation in brain aging and neurodegeneration

Rommy von Bernhardi et al.

FRONTIERS IN AGING NEUROSCIENCE (2015)

Add to Collection

Review Oncology

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response

Oakley C. Olson et al.

NATURE REVIEWS CANCER (2015)

Add to Collection

Article Biochemistry & Molecular Biology

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

Neil D. Rawlings et al.

NUCLEIC ACIDS RESEARCH (2014)

Add to Collection

Review Pharmacology & Pharmacy

Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

Graham Simmons et al.

ANTIVIRAL RESEARCH (2013)

Add to Collection

Article Virology

Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Entry That Act by Three Distinct Mechanisms

Adeyemi O. Adedeji et al.

JOURNAL OF VIROLOGY (2013)

Add to Collection

Article Multidisciplinary Sciences

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

Yoshinori Hayashi et al.

SCIENTIFIC REPORTS (2013)

Add to Collection

Article Endocrinology & Metabolism

Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt

Dawit A. P. Goncalves et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Add to Collection

Review Biochemistry & Molecular Biology

Cysteine cathepsins: From structure, function and regulation to new frontiers

Vito Turk et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2012)

Add to Collection

Article Virology

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

Miyuki Kawase et al.

JOURNAL OF VIROLOGY (2012)

Add to Collection

Article Biotechnology & Applied Microbiology

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

Joanne Bowes et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Add to Collection

Article Virology

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

Ilona Glowacka et al.

JOURNAL OF VIROLOGY (2011)

Add to Collection

Article Chemistry, Medicinal

Novel Peptidyl Aryl Vinyl Sulfones as Highly Potent and Selective Inhibitors of Cathepsins L and B

Laura Mendieta et al.

CHEMMEDCHEM (2010)

Add to Collection

Article Biochemistry & Molecular Biology

Heparin Enhances Serpin Inhibition of the Cysteine Protease Cathepsin L

Wayne J. Higgins et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Add to Collection

Article Neurosciences

Low-dose dexamethasone prevents endotoxaemia-induced muscle protein loss and impairment of carbohydrate oxidation in rat skeletal muscle

Hannah Crossland et al.

JOURNAL OF PHYSIOLOGY-LONDON (2010)

Add to Collection

Article Pharmacology & Pharmacy

A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells

Parag P. Shah et al.

MOLECULAR PHARMACOLOGY (2010)

Add to Collection

Article Microbiology

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

Asuka Nanbo et al.

PLOS PATHOGENS (2010)

Add to Collection

Review Clinical Neurology

Brain Extracellular Matrix in Neurodegeneration

Dafna Bonneh-Barkay et al.

BRAIN PATHOLOGY (2009)

Add to Collection

Article Virology

Simulating Henipavirus Multicycle Replication in a Screening Assay Leads to Identification of a Promising Candidate for Therapy

Matteo Porotto et al.

JOURNAL OF VIROLOGY (2009)

Add to Collection

Article Chemistry, Medicinal

Molecular docking of cathepsin L inhibitors in the binding site of papain

Mary Pat Beavers et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)

Add to Collection

Review Immunology

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

Hiroshi Takayanagi

NATURE REVIEWS IMMUNOLOGY (2007)

Add to Collection

Article Biochemistry & Molecular Biology

SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells

IC Huang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Add to Collection

Review Biotechnology & Applied Microbiology

Targeting proteases: successes, failures and future prospects

Boris Turk

NATURE REVIEWS DRUG DISCOVERY (2006)

Add to Collection

Article Multidisciplinary Sciences

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

G Simmons et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Add to Collection

Article Multidisciplinary Sciences

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

K Chandran et al.

SCIENCE (2005)

Add to Collection

Article Immunology

Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo

C Beers et al.

JOURNAL OF IMMUNOLOGY (2005)

Add to Collection

Review Biochemistry & Molecular Biology

Cathepsin S supports acid-independent infection by some reoviruses

JW Golden et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Add to Collection

Article Biochemistry & Molecular Biology

Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of bid by multiple papain-like lysosomal cathepsins

T Cirman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Add to Collection

Article Cell Biology

Neuronal and microglial cathepsins in aging and age-related diseases

H Nakanishi

AGEING RESEARCH REVIEWS (2003)

Add to Collection

Article Biochemistry & Molecular Biology

Functional involvement of cathepsin W in the cytotoxic activity of NK-92 cells

T Wex et al.

FEBS LETTERS (2003)

Add to Collection

Review Immunology

Lysosomal cysteine proteases regulate antigen presentation

K Honey et al.

NATURE REVIEWS IMMUNOLOGY (2003)

Add to Collection

Article Immunology

Differential regulation of cathepsin S and cathepsin L in interferon γ-treated macrophages

C Beers et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

Add to Collection

Article Virology

Addition of exogenous protease facilitates reovirus infection in many restrictive cells

JW Golden et al.

JOURNAL OF VIROLOGY (2002)

Add to Collection

Article Biochemistry & Molecular Biology

Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells

DH Ebert et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Add to Collection

Article Immunology

Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain:: A role in the generation of positively selecting peptide ligands

K Honey et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

Add to Collection

Article Biochemistry & Molecular Biology

Lysosomal protease pathways to apoptosis -: Cleavage of Bid, not pro-caspases, is the most likely route

V Stoka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.