Spatial transcriptomic profiling reveals the pathophysiology of early-stage hidradenitis suppurativa

Article Dermatology

Keratinocytes and immune cells in the epidermis are key drivers of inflammation in hidradenitis suppurativa providing a rationale for novel topical therapies

Stephanie L. Schell et al.

Summary: This study compares keratinocyte and immune cell-driven epidermal inflammation in HS patients and healthy controls. It demonstrates that interactions between keratinocytes and immune cells drive a broad inflammatory profile in HS epidermis. Ruxolitinib, a JAK inhibitor, mitigates inflammatory cytokine expression in HS lesional keratinocytes, suggesting its potential as a topical treatment for HS.

BRITISH JOURNAL OF DERMATOLOGY (2023)

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Article Biochemistry & Molecular Biology

Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions

Kacey L. Sachen et al.

Summary: This review highlights the cellular source of IL-36 cytokines, the effects of IL-36 signaling across cell types, and the association of IL-36 with a spectrum of inflammatory skin diseases.

CYTOKINE (2022)

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Article Dermatology

Histologic progression of acne inversa/hidradenitis suppurativa: Implications for future investigations and therapeutic intervention

Robert W. Dunstan et al.

Summary: The research on acne inversa found that it is an epithelial-driven disease, with inflammation mainly caused by cyst rupture. Ruptures often occur at depths beyond what punch biopsy samples can capture fully, potentially leading to an incomplete understanding of the disease.

EXPERIMENTAL DERMATOLOGY (2021)

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Article Allergy

Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa

Kristina Navrazhina et al.

Summary: The study found that tunnels in hidradenitis suppurativa (HS) play an immunologically active role in disease activity, showing inflammation characteristics and associated with increased infiltration of T cells, dendritic cells, and neutrophils. Treatment with medication reduced the size and draining of tunnels, indicating their involvement in disease inflammation.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Medicine, General & Internal