Two-Dimensional Population Receptive Field Mapping of Human Primary Somatosensory Cortex

Functional magnetic resonance imaging can provide detailed maps of how sensory space is mapped in the human brain. Here, we use a novel 16 stimulator setup (a 4 x 4 grid) to measure two-dimensional sensory maps of between and within-digit (D2-D4) space using high spatial-resolution (1.25 mm isotropic) imaging at 7 Tesla together with population receptive field (pRF) mapping in 10 participants. Using a 2D Gaussian pRF model, we capture maps of the coverage of digits D2-D5 across Brodmann areas and estimate pRF size and shape. In addition, we compare results to previous studies that used fewer stimulators by constraining pRF models to a 1D Gaussian Between Digit or 1D Gaussian Within Digit model. We show that pRFs across somatosensory areas tend to have a strong preference to cover the within-digit axis. We show an increase in pRF size moving from D2-D5. We quantify pRF shapes in Brodmann area (BA) 3b, 3a, 1, 2 and show differences in pRF size in Brodmann areas 3a-2, with larger estimates for BA2. Generally, the 2D Gaussian pRF model better represents pRF coverage maps generated by our data, which itself is produced from a 2D stimulation grid.

Automated summary

Functional magnetic resonance imaging with high spatial resolution was used to map the sensory space in the human brain. Results showed that the pRFs in somatosensory areas had a strong preference for the within-digit axis. The 2D Gaussian pRF model better represented the pRF coverage generated by the data obtained from the 2D stimulation grid.