☆ 4.7 Article

Divergent androgenic modulation of SARS-CoV-2 infection cooperates with dysregulated immune response to dictate worse COVID-19 outcomes in men

BRAIN BEHAVIOR AND IMMUNITY (2023)

Related references

Note: Only part of the references are listed.

Article Immunology

The turning point of COVID-19 severity is associated with a unique circulating neutrophil gene signature

Carlos A. Fuzo et al.

Summary: COVID-19 patients exhibit a wide range of clinical manifestations due to the heterogeneity of the host immune response. By analyzing blood transcriptome, demographic data, clinical aspects, and laboratory findings, we identified perturbations in the blood-leukocyte transcriptional profile that are associated with COVID-19 aggravation and stratify patients according to disease severity. These molecular changes involve processes that inhibit lymphocyte activation and promote neutrophil activation, and the central genes of this unique neutrophil signature are S100A9, ANXA3, CEACAM6, VNN1, OLFM4, IL1R2, TCN1, and CD177.

IMMUNOLOGY (2023)

Add to Collection

Review Virology

Testosterone and Covid-19: An update

Aksam Yassin et al.

Summary: This article reviews the current epidemiological and biological evidence on the role of testosterone in SARS-CoV-2 infection and Covid-19 severity and discusses its potential as a biomarker for risk stratification and as a treatment or preventative therapy for Covid-19.

REVIEWS IN MEDICAL VIROLOGY (2023)

Add to Collection

Article Andrology

Testosterone in males with COVID-19: a 12-month cohort study

Andrea Salonia et al.

Summary: Total testosterone levels gradually increase in men after recovery from COVID-19. However, nearly 30% of men still have low testosterone levels suggestive of hypogonadism during a minimum 12-month follow-up period.

ANDROLOGY (2023)

Add to Collection

Article Urology & Nephrology

Implications of testicular ACE2 and the renin-angiotensin system for SARS-CoV-2 on testis function

R. Clayton Edenfield et al.

Summary: Early studies have suggested that SARS-CoV-2 might access the reproductive system and affect male fertility. Research on the mechanisms of infection of reproductive cells and the potential for testicular dysfunction in patients who have had COVID-19 is crucial for understanding the impact of the virus on male fertility.

NATURE REVIEWS UROLOGY (2022)

Add to Collection

Article Andrology

Testosterone in males with COVID-19: A 7-month cohort study

Andrea Salonia et al.

Summary: Although total testosterone levels increased over time after COVID-19, more than 50% of men who recovered from the disease still had circulating testosterone levels suggestive for a condition of hypogonadism at 7-month follow-up. In as many as 10% of cases, testosterone levels even further decreased. Of clinical relevance, the higher the burden of comorbid conditions at presentation, the lower the probability of testosterone levels recovery over time.

ANDROLOGY (2022)

Add to Collection

Editorial Material Endocrinology & Metabolism

Sexual dimorphism in COVID-19: potential clinical and public health implications

Nicole Bechmann et al.

Summary: Current evidence shows that COVID-19 severity and mortality are higher in men compared to women, while women may be at a higher risk of reinfection and long-term COVID-19 development. Differences between sexes have also been observed in other infectious diseases and vaccine responses. This could be explained by sex-specific expression patterns of proteins involved in virus binding and entry, as well as divergent reactions of the immune and endocrine systems to acute stress. Understanding the role of sex hormones, comorbidities, and sex chromosome complement in COVID-19 could have implications for disease treatment, public health measures, and follow-up of patients predisposed to long COVID. Considering sex differences in future pandemic surveillance and COVID-19 patient treatment may lead to better disease stratification and improved outcomes.

LANCET DIABETES & ENDOCRINOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Detection of Male Hypogonadism in Patients with Post COVID-19 Condition

Yukichika Yamamoto et al.

Summary: The pathogenesis and prognosis of post COVID-19 condition are still unclear. A study found a relatively high incidence of late-onset hypogonadism (LOH) in male patients, even young ones, with post COVID-19. Symptoms such as fatigue, anxiety, cough, and hair loss were more frequent in the LOH group than in the non-LOH group.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Article Endocrinology & Metabolism

Associations between COVID-19 infection and sex steroid hormones

Zixin Cai et al.

Summary: This study summarizes the correlation between sex hormone levels and COVID-19. The findings suggest that COVID-19 patients have lower levels of T/LH, FSH/LH, and SHBG, and higher levels of LH and E-2/T. These findings may be helpful in evaluating the severity of COVID-19.

FRONTIERS IN ENDOCRINOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Late-Onset Hypogonadism in a Male Patient with Long COVID Diagnosed by Exclusion of ME/CFS

Yoshiaki Soejima et al.

Summary: After acute COVID-19 infection, some patients may experience persistent symptoms, including general fatigue. This article reports the case of a 36-year-old man who developed post-COVID fatigue and was found to have late-onset hypogonadism (LOH) syndrome. Treatment with herbal medicine resulted in significant improvement of the patient's symptoms. The study emphasizes the possibility of LOH syndrome as an underlying cause of fatigue in patients with post-COVID-19 conditions.

MEDICINA-LITHUANIA (2022)

Add to Collection

Letter Medical Laboratory Technology

Testicular Changes Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Abdallah Flaifel et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2021)

Add to Collection

Letter Immunology

Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients

Xixiang Ma et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Add to Collection

Article Andrology

Severely low testosterone in males with COVID-19: A case-control study

Andrea Salonia et al.

Summary: This study revealed that male patients with COVID-19 had lower levels of androgens, particularly testosterone, upon hospital admission, indicating a high prevalence of hypogonadism. Furthermore, the research showed an independent association between SARS-CoV-2 infection and decreased testosterone levels, as well as a higher risk of hypogonadism. Lower testosterone levels were also linked to increased risk of ICU admission and death outcomes.

ANDROLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19

Sandeep Dhindsa et al.

Summary: This study found that lower testosterone concentrations in male COVID-19 patients were associated with increased disease severity and inflammation. Estradiol and IGF-1 concentrations were not associated with COVID-19 severity in men. Changes in hormone signaling pathways in monocytes may not correspond to the severity of the disease in COVID-19 patients.

JAMA NETWORK OPEN (2021)

Add to Collection

Article Immunology

High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study

Maria Schroeder et al.

Summary: The study found significantly elevated estradiol levels and reduced testosterone levels in critically ill male COVID-19 patients compared to control cohorts. No statistically significant differences in sex hormone levels were detected in critically ill female COVID-19 patients, albeit similar trends towards elevated estradiol levels were observed. Furthermore, high estradiol levels in male COVID-19 patients were associated with a higher likelihood of receiving ECMO treatment.

EMERGING MICROBES & INFECTIONS (2021)

Add to Collection

Article Medicine, General & Internal

Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial

Jesper D. Gunst et al.

Summary: This study evaluated the efficacy and safety of the TMPRSS2 inhibitor camostat mesilate in Covid-19 patients through a randomized controlled trial. The results showed that camostat mesilate treatment did not prolong time to clinical improvement and did not increase the occurrence of adverse events.

ECLINICALMEDICINE (2021)

Add to Collection

Review Endocrinology & Metabolism

Sex differences in COVID-19: the role of androgens in disease severity and progression

Mohamed S. Mohamed et al.

Summary: Men are more affected by COVID-19, with androgen sensitivity potentially playing a crucial role in determining disease severity and predicting patient outcomes.

ENDOCRINE (2021)

Add to Collection

Article Multidisciplinary Sciences

A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity

Ruozhu Zhao et al.

NATURE (2020)

Add to Collection

Article Respiratory System

Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis

Wei-jie Guan et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Add to Collection

Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

Add to Collection

Article Biochemistry & Molecular Biology

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Markus Hoffmann et al.

MOLECULAR CELL (2020)

Add to Collection

Article Endocrinology & Metabolism

Effect of serum total testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease 2019 (COVID-19) in SARS-CoV-2 infected male patients: a cohort study

Selahittin Cayan et al.

AGING MALE (2020)

Add to Collection

Article Multidisciplinary Sciences

Factors associated with COVID-19-related death using OpenSAFELY

Elizabeth J. Williamson et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

Add to Collection

Article Obstetrics & Gynecology

Age-related changes in human Leydig cell status

Valentina Mularoni et al.

HUMAN REPRODUCTION (2020)

Add to Collection

Article Multidisciplinary Sciences

Sex differences in immune responses that underlie COVID-19 disease outcomes

Takehiro Takahashi et al.

NATURE (2020)

Add to Collection

Article Andrology

COVID-19 pneumonia causes lower testosterone levels

Sezgin Okcelik

ANDROLOGIA (2020)

Add to Collection

Article Cell & Tissue Engineering

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

Ryan M. Samuel et al.

CELL STEM CELL (2020)

Add to Collection

Review Endocrinology & Metabolism

Aging and the Male Reproductive System

Jean-Marc Kaufman et al.

ENDOCRINE REVIEWS (2019)

Add to Collection

Review Immunology

Obesity and metabolic syndrome associated with systemic inflammation and the impact on the male reproductive system

Kristian Leisegang et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Estrogen receptor α contributes to T cell-mediated autoimmune inflammation by promoting T cell activation and proliferation

Imran Mohammad et al.

SCIENCE SIGNALING (2018)

Add to Collection

Article Multidisciplinary Sciences

Testosterone is an endogenous regulator of BAFF and splenic B cell number

Anna S. Wilhelmson et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Estrogen receptor α contributes to T cell-mediated autoimmune inflammation by promoting T cell activation and proliferation

Imran Mohammad et al.

SCIENCE SIGNALING (2018)

Add to Collection

Article Medicine, Research & Experimental

Androgen Signaling in Prostate Cancer

Charles Dai et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)

Add to Collection

Article Geriatrics & Gerontology

Bioavailable Testosterone Linearly Declines Over A Wide Age Spectrum in Men and Women From The Baltimore Longitudinal Study of Aging

Elisa Fabbri et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov et al.

NUCLEIC ACIDS RESEARCH (2016)

Add to Collection

Article Endocrinology & Metabolism

Predictive value of serum testosterone for type 2 diabetes risk assessment in men

Evan Atlantis et al.

BMC ENDOCRINE DISORDERS (2016)

Add to Collection

Article Public, Environmental & Occupational Health

Severe Influenza in 33 US Hospitals, 2013-2014: Complications and Risk Factors for Death in 507 Patients

Nirav S. Shah et al.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2015)

Add to Collection

Article Biochemical Research Methods

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Edward Y. Chen et al.

BMC BIOINFORMATICS (2013)

Add to Collection

Article Endocrinology & Metabolism

The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men

Kishore M. Lakshman et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)

Add to Collection

Article Cell Biology

Leydig cells: From stem cells to aging

Haolin Chen et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)

Add to Collection

Article Virology

Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human Leydig cells

R Le Goffic et al.

JOURNAL OF VIROLOGY (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.