The absence of immediate stimulation delays bone healing

Article Orthopedics

Is Immediate Weight-Bearing Safe After Single Implant Fixation of Elderly Distal Femur Fractures?

Charles M. Lieder et al.

Summary: The study results support the feasibility of immediately allowing carefully selected elderly patients to weight-bear after operative fixation of extra-articular distal femur fractures, regardless of implant choice.

JOURNAL OF ORTHOPAEDIC TRAUMA (2021)

Add to Collection

Article Critical Care Medicine

The role of mechanical stimulation in the enhancement of bone healing *

Peter Augat et al.

Summary: The biomechanical environment is crucial for fracture repair, regulating biological activities and tissue formation through mechanical signals. Manipulating mechanobiology at the fracture site through fracture fixation design and weight-bearing can influence the healing response. Parameters like fracture gap size, interfragmentary movement, strain, and deformation as well as externally applied movement play important roles in fracture repair process.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2021)

Add to Collection

Article Critical Care Medicine

The relation between fracture activity and bone healing with special reference to the early healing phase - A preclinical study

Markus Windolf et al.

Summary: The study found that early fracture activity, defined as the number of stimulatory events per time, had a positive effect on bone healing. There were strong correlations between fracture activity in the first and second weeks post-operation and the torsional strength of the healed bone, as well as the maximum callus area measured from X-rays. However, the role of fracture activity in the later timepoints was not significant. The findings suggest the importance of mechanical environment in the direct post-operative healing phase and may advocate for direct post-operative weight bearing, pending further clinical validation.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2021)

Add to Collection

Article Biophysics

Biphasic plating improves the mechanical performance of locked plating for distal femur fractures

Devakara R. Epari et al.

Summary: Biphasic plating offers greater flexibility in fracture motion and increased implant strength compared to standard locked plating. It provides more consistent interfragmentary movement over a wider loading range, supporting bone healing and early weight-bearing without sacrificing implant strength.

JOURNAL OF BIOMECHANICS (2021)

Add to Collection

Article Chemistry, Analytical

Programable Active Fixator System for Systematic In Vivo Investigation of Bone Healing Processes

Jan Barcik et al.

Summary: The programmable active bone fixator system introduced in this manuscript enables systematic investigation of bone healing processes in a sheep animal model by precisely controlling mechanical conditions and continuously monitoring healing progression. The system was validated in vivo, demonstrating feasibility for further preclinical studies on the influence of mechanical conditions on fracture healing.

SENSORS (2021)

Add to Collection

Article Biophysics

Tissue deformation controlling fracture healing

R. W. Hente et al.

Summary: Achieving optimal flexibility in biological internal fracture fixation requires clarifying the biomechanical parameters controlling healing and the associated boundary conditions. The level of strain applied appears to directly influence the occurrence of callus and osseous connection of the fragments. The relationship between interfragmentary strain and the quality of osseous bridging may define the upper limit for solid healing, highlighting the importance of considering fracture mobility in treatment planning.

JOURNAL OF BIOMECHANICS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?

Jan Barcik et al.

Summary: The local mechanical environment plays a crucial role in bone healing, with early mechanical stimulation being critical for optimal healing. Clinical practice often contradicts this, using non-weight-bearing approaches initially. Optimizing the mechanical environment throughout the healing process could significantly reduce fracture healing time.

BIOMEDICINES (2021)

Add to Collection

Article Geriatrics & Gerontology

Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Ai-Min Wu et al.

Summary: The global incidence, prevalence, and years lived with disability (YLDs) of fractures showed a slight decrease from 1990 to 2019, but the absolute counts increased substantially. Older individuals have a particularly high risk of fractures, highlighting the importance of injury prevention efforts and osteoporosis screening and treatment for reducing the overall burden.

LANCET HEALTHY LONGEVITY (2021)

Add to Collection

Article Orthopedics

Reverse Dynamization Accelerates Bone-Healing in a Large-Animal Osteotomy Model

Vaida Glatt et al.

Summary: The study demonstrated that tibial osteotomies treated with reverse dynamization healed faster, with better outcomes, and significantly stronger bones, indicating an accelerated healing and remodeling process.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2021)

Add to Collection

Article Critical Care Medicine