4.6 Article

Dietary intakes of methionine, threonine, lysine, arginine and histidine increased risk of type 2 diabetes in Chinese population: does the mediation effect of obesity exist?

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies

Jakub Morze et al.

Summary: Based on this updated systematic review and meta-analysis, several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with the risk of type 2 diabetes.

DIABETES CARE (2022)

Article Multidisciplinary Sciences

Targeted metabolomics analysis of amino acids and acylcarnitines as risk markers for diabetes by LC-MS/MS technique

Shaghayegh Hosseinkhani et al.

Summary: The study aimed to evaluate the association between the levels of amino acids and acylcarnitines and diabetes in order to develop predictive models. The results showed that some amino acids and acylcarnitines were positively associated with diabetes, while others showed a reverse trend. These findings provide insights into the disturbances in metabolic pathways among the diabetic population and can be targeted for prevention, diagnosis, and treatment of diabetes.

SCIENTIFIC REPORTS (2022)

Article Biochemistry & Molecular Biology

Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity

Ming Liu et al.

Summary: Obesity is associated with altered amino acid metabolism, and restricting branched-chain amino acids in a high-fat diet can prevent obesity and insulin resistance.

METABOLITES (2022)

Article Nutrition & Dietetics

The Dietary Branched-Chain Amino Acids Transition and Risk of Type 2 Diabetes Among Chinese Adults From 1997 to 2015: Based on Seven Cross-Sectional Studies and a Prospective Cohort Study

Lianlong Yu et al.

Summary: Based on the data from China Health and Nutrition Survey and China Nutrition and Health Survey, the intake of BCAAs among Chinese adults has shown a decreasing trend from 1997 to 2015, and the consumption of BCAAs declines after the age of 40. Higher BCAAs intake is associated with a higher risk of T2D, with this relationship being more stable among males and middle-aged and elderly individuals.

FRONTIERS IN NUTRITION (2022)

Article Endocrinology & Metabolism

Longitudinal Branched-Chain Amino Acids, Lifestyle Intervention, and Type 2 Diabetes in the Finnish Diabetes Prevention Study

Jemina Kivela et al.

Summary: This study examines the interaction between lifestyle intervention and the association between circulating branched-chain amino acids (BCAAs) and the risk of type 2 diabetes (T2D). The findings show that lifestyle intervention modifies the association of baseline BCAA concentration and BCAA trajectories with the incidence of T2D.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Article Multidisciplinary Sciences

Branched-chain and aromatic amino acid levels response to an oral glucose load associated with gestational diabetes mellitus

BeiBei Gao et al.

Summary: Serum levels of branched chain amino acids (BCAAs) and aromatic amino acids (AAAs) in women with gestational diabetes mellitus (GDM) were investigated, and their changes in response to an oral glucose tolerance test (OGTT) were examined. The study found that the differences in BCAA and AAA levels between GDM women and controls, which were not evident during fasting, could be provoked by performing an OGTT.

SCIENTIFIC REPORTS (2022)

Review Endocrinology & Metabolism

Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes

Froukje Vanweert et al.

Summary: The catabolism of branched-chain amino acids (BCAA) is believed to play an important role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D). However, there is limited understanding of tissue-specific BCAA catabolism in humans. Studies suggest that enhancing BCAA catabolism may improve glucose homeostasis in metabolic disorders like obesity and T2D, making it a potential future treatment strategy for insulin resistance and T2D.

NUTRITION & DIABETES (2022)

Article Medicine, Research & Experimental

Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity

Thomas Grenier-Larouche et al.

Summary: This study found that increased levels of BCKA in the blood and hepatic expression of BCKDK are associated with the presence and severity of NAFLD/NASH in humans. SREBP1 has been identified as a transcriptional regulator of BCKDK.

JCI INSIGHT (2022)

Article Endocrinology & Metabolism

Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies

Jakub Morze et al.

Summary: An updated systematic review and meta-analysis found that several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with type 2 diabetes risk. However, there were substantial heterogeneity observed for some of the metabolites, indicating the need for further research in this area.

DIABETES CARE (2022)

Article Medicine, General & Internal

Metabolite profiles and the risk of metabolic syndrome in early childhood: a case-control study

Sandi M. Azab et al.

Summary: The study identified a distinct metabolic signature of pediatric MetS in children as young as 5 years old through comprehensive metabolite profiling, with the quantitative MetS risk score being more powerful in consistently detecting this signature than the dichotomous outcome.

BMC MEDICINE (2021)

Article Endocrinology & Metabolism

Mid-Arm Muscle and Subcutaneous Fat Associated with All-Cause Mortality Independent of BMI: A Prospective Cohort Study

Liyun He et al.

Summary: The study systematically evaluated the association between triceps skinfold thickness, mid-arm muscle circumference, mid-upper arm circumference, and all-cause mortality. Results revealed an inverse association between mid-arm muscle and subcutaneous fat with all-cause mortality, independent of BMI, extending beyond the elderly population. Both mid-arm muscle and subcutaneous fat made comparable contributions and had positive joint effects on all-cause mortality.

OBESITY (2021)

Article Endocrinology & Metabolism

Habitual intake of dietary L-arginine in relation to risk of type 2 diabetes: a prospective study

Parvin Mirmiran et al.

Summary: The study found that higher dietary levels of L-arginine may increase the risk of T2DM and could have an independent role in the development of T2DM.

BMC ENDOCRINE DISORDERS (2021)

Review Endocrinology & Metabolism

Metabolomics Signatures in Type 2 Diabetes: A Systematic Review and Integrative Analysis

Yue Sun et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Review Nutrition & Dietetics

Dietary protein intake and risk of type 2 diabetes: a dose-response meta-analysis of prospective studies

Long-Gang Zhao et al.

EUROPEAN JOURNAL OF NUTRITION (2019)

Review Endocrinology & Metabolism

Type 2 diabetes: a multifaceted disease

Ewan R. Pearson

DIABETOLOGIA (2019)

Review Endocrinology & Metabolism

Biomarkers for type 2 diabetes

Markku Laakso

MOLECULAR METABOLISM (2019)

Review Biology

Regulation of glucose and lipid metabolism in health and disease

Ligong Chen et al.

SCIENCE CHINA-LIFE SCIENCES (2019)

Review Endocrinology & Metabolism

The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes)

Michael Halim et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2019)

Article Endocrinology & Metabolism

Fasting serum amino acids concentration is associated with insulin resistance and pro-inflammatory cytokines

Sang-Guk Lee et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Article Biochemistry & Molecular Biology

Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism

Long Ding et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

Ara Koh et al.

Article Environmental Sciences

Gender Stratified Analyses of the Association of Skinfold Thickness with Hypertension: A Cross-Sectional Study in General Northeastern Chinese Residents

Yuyan Liu et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Article Computer Science, Interdisciplinary Applications

flexsurv: A Platform for Parametric Survival Modeling in R

Christopher H. Jackson

JOURNAL OF STATISTICAL SOFTWARE (2016)

Article Biochemistry & Molecular Biology

In Vivo NMR Studies of the Brain with Hereditary or Acquired Metabolic Disorders

Erica B. Sherry et al.

NEUROCHEMICAL RESEARCH (2015)

Article Endocrinology & Metabolism

Lower BMI Cutoffs to Define Overweight and Obesity in China

Wei He et al.

OBESITY (2015)

Review Endocrinology & Metabolism

The China Health and Nutrition Survey, 1989-2011

B. Zhang et al.

OBESITY REVIEWS (2014)

Article Gastroenterology & Hepatology

Solute Carrier Family 2 Member 1 Is Involved in the Development of Nonalcoholic Fatty Liver Disease

Mercedes Vazquez-Chantada et al.

HEPATOLOGY (2013)

Article Public, Environmental & Occupational Health

Cohort Profile: The China Health and Nutrition Survey-monitoring and understanding socio-economic and health change in China, 1989-2011

Barry M. Popkin et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2010)

Review Biochemistry & Molecular Biology

Amino acids: metabolism, functions, and nutrition

Guoyao Wu

AMINO ACIDS (2009)

Article Nutrition & Dietetics

Mechanisms and kinetics of citrulline uptake in a model of human intestinal epithelial cells

Senda Bahri et al.

CLINICAL NUTRITION (2008)

Article Medicine, Research & Experimental

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization

K Kotani et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)