4.6 Article

Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

The long non-coding RNA ASMTL-AS1 promotes hepatocellular carcinoma progression by sponging miR-1343-3p that suppresses LAMC1 (laminin subunit gamma 1)

Yanjie Mou et al.

Summary: This study found that ASMTL-AS1 plays a carcinogenic role in hepatocellular carcinoma (HCC) by interacting with miR-1343-3p and LAMC1 through the competing endogenous RNA (ceRNA) mechanism, thereby interfering with the malignant behavior of HCC cells.

BIOENGINEERED (2022)

Article Cell Biology

Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma

Yongchao Cai et al.

Summary: Microvascular invasion (MVI) is a high-risk factor for postoperative prognosis of hepatocellular carcinoma (HCC). By analyzing the STMN1 gene, a new protocol for MVI pathological diagnosis was established. The risk levels of MVI can be graded based on the expression levels of STMN1, which can predict recurrence rates and overall survival in early HCC patients. The STMN1-Microtubule-EMT axis plays a role in epithelial-mesenchymal transformation (EMT) of HCC cells. Inhibition of STMN1 expression reduces the lung metastatic ability of HCC cells in a mouse model.

CELL DEATH & DISEASE (2022)

Article Cell Biology

The circular RNA hsa_circ_0001394 promotes hepatocellular carcinoma progression by targeting the miR-527/UBE2A axis

Yu Yan et al.

Summary: This study identified hsa_circ_0001394 as a highly expressed circRNA in HCC. High expression of hsa_circ_0001394 was associated with poor survival and clinicopathological features in HCC patients. Mechanistically, hsa_circ_0001394 promoted HCC progression by regulating the miR-527/UBE2A pathway. Thus, hsa_circ_0001394 may serve as a potential therapeutic target and biomarker in HCC treatment.

CELL DEATH DISCOVERY (2022)

Article Oncology

Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma

Zhuochen Zhao et al.

Summary: In this study, it was found that LINC01559 plays a significant role in regulating the progression of LUAD, with high expression indicating lymph node metastasis and poor prognosis. By enhancing the autophagy signal pathway, LINC01559 promotes lung cancer cell proliferation and migration.

CANCER CELL INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

DAP3 Is Involved in Modulation of Cellular Radiation Response by RIG-I-Like Receptor Agonist in Human Lung Adenocarcinoma Cells

Yoshiaki Sato et al.

Summary: The RLR agonist Poly(I:C) was found to modulate the cellular radiation response of lung adenocarcinoma cells by downregulating DAP3 expression. Experimental results indicated that DAP3 is involved in the resistance of lung adenocarcinoma cells to IR-induced cell death.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin

Fengze Sun et al.

Summary: This study confirmed that DTYMK is significantly increased in HCC and is associated with poor prognosis. Further experiments demonstrated that DTYMK knockdown inhibited HCC growth and increased sensitivity to oxaliplatin, revealing a potential new therapeutic target for HCC. Additionally, DTYMK was found to competitively interact with miR-378a-3p to activate signaling pathways related to drug resistance and tumor progression, providing new insights into the role of mRNA in regulating tumor microenvironment.

CELL DEATH & DISEASE (2021)

Article Medical Laboratory Technology

Expression profiles of circular RNAs in colon biopsies from Crohn's disease patients by microarray analysis

Yu-an Hu et al.

Summary: The study identified that hsa_circ_0001666 and hsa_circ_0062142 were significantly upregulated in CD patients compared to UC patients and healthy controls, and exhibited good diagnostic value according to ROC curves. Bioinformatics analysis suggested that these circRNAs may be involved in the progression of CD.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

Article Cell Biology

DTYMK promote hepatocellular carcinoma proliferation by regulating cell cycle

Tianhao Zhou et al.

Summary: DTYMK is significantly upregulated in tumor tissue of HCC patients and is associated with worse overall survival. High expression of DTYMK correlates with poor relapse free survival and disease-specific survival, indicating its role in promoting tumor growth and proliferation through cell cycle regulation.

CELL CYCLE (2021)

Article Biotechnology & Applied Microbiology

RNF128 Promotes Malignant Behaviors via EGFR/MEK/ERK Pathway in Hepatocellular Carcinoma

Xue-Song Bai et al.

ONCOTARGETS AND THERAPY (2020)

Article Gastroenterology & Hepatology

Focal Adhesion Kinase and β-Catenin Cooperate to Induce Hepatocellular Carcinoma

Na Shang et al.

HEPATOLOGY (2019)

Article Biochemistry & Molecular Biology

Circbank: a comprehensive database for circRNA with standard nomenclature

Ming Liu et al.

RNA BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Ularcirc: visualization and enhanced analysis of circular RNAs via back and canonical forward splicing

David T. Humphreys et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

GBDTCDA: Predicting circRNA-disease Associations Based on Gradient Boosting Decision Tree with Multiple Biological Data Fusion

Xiujuan Lei et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

CSCD: a database for cancer-specific circular RNAs

Siyu Xia et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Biochemistry & Molecular Biology

Circular RNAs in cancer: opportunities and challenges in the field

L. S. Kristensen et al.

ONCOGENE (2018)

Article Gastroenterology & Hepatology

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma

Jian Yu et al.

JOURNAL OF HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET

Jacey J. Liu et al.

JOURNAL OF HEPATOLOGY (2018)

Article Multidisciplinary Sciences

miRWalk: An online resource for prediction of microRNA binding sites

Carsten Sticht et al.

PLOS ONE (2018)

Article Multidisciplinary Sciences

Recurrently deregulated lncRNAs in hepatocellular carcinoma

Yang Yang et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

CircNet: a database of circular RNAs derived from transcriptome sequencing data

Yu-Chen Liu et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma

Yi-Hsin Tseng et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Editorial Material Biotechnology & Applied Microbiology

The Expanding Repertoire of Circular RNAs

Paul N. Valdmanis et al.

MOLECULAR THERAPY (2013)

Article Biochemistry & Molecular Biology

Circular RNAs are abundant, conserved, and associated with ALU repeats

William R. Jeck et al.