CXCR4 to improve both T cell homing and function

In this issue of Blood, Biondi et al(1) show that enforcing CXCR4 expression on CD33-targeting chimeric antigen receptor (CAR) cytokine-induced killer (CIK) cells enhances their homing to the bone marrow (BM) and improves their activity against acute myeloid leukemia (AML).

Automated summary

The study found that enforcing CXCR4 expression on CD33-targeting CAR CIK cells enhances their homing to the bone marrow and improves their activity against AML.