IL-34: a novel differentiation for AML?

In this issue of Blood, Xie et al(1) describe a novel role for interleukin 34 (IL-34) in promoting hematopoietic progenitor and myeloid leukemia differentiation by binding to a previously unrecognized receptor for IL-34, triggering receptor expressed on myeloid cells 2 (TREM2).

Automated summary

In this article, Xie et al(1) discovered a new role for interleukin 34 (IL-34) in promoting hematopoietic progenitor and myeloid leukemia differentiation through binding to the previously unrecognized IL-34 receptor, TREM2.