Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 4, Pages 792-795Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08915d
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Funding
- NSF of China [21136002, 21376039, 21422601, 21421005, 21104008]
- National Basic Research Program of China [2013CB733702]
- Ministry of Education [NCET-12-0080]
- Fundamental Research Funds for the Central University [DUT14ZD214]
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The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be a promising molecular tool for guiding tumor resection during surgery.
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