Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 6, Pages 1066-1069Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc05639f
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Funding
- Principle Investigator grant from Science Foundation Ireland
- Programme for Research in Third Level Institutions (PRTLI) Cycle 4
- European Regional Development Fund (ERDF), European Union Structural Funds Programme
- Irish Research Council
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Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2-4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.
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