Journal
BIOSENSORS & BIOELECTRONICS
Volume 238, Issue -, Pages -Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2023.115571
Keywords
Carbon nanotube; Glucose; Microneedle; Phenylboronic acid; Sensing material
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In this study, a microneedle sensor coated with a glucose-responsive composite material was proposed for measuring glucose concentrations in interstitial fluid. The composite material was prepared by blending a polymer containing glucose-responsive moieties with conductive carbon nanotubes. The sensor showed accurate measurements of glucose concentrations in animal models, comparable to a clinical glucometer.
A microneedle (MN) sensor coated with a sensing composite material was proposed for measuring glucose concentrations in interstitial fluid (ISF). The sensing composite material was prepared by blending a polymer containing glucose-responsive phenylboronic acid (PBA) moieties (i.e., polystyrene-block-poly(acrylic acid-coacrylamidophenylboronic acid)) with conductive carbon nanotubes (CNTs). The polymer exhibited reversible swelling behavior in response to glucose concentrations, which influenced the distribution of the embedded CNTs, resulting in sensitive variations in electrical percolation, even when coated onto a confined surface of the MN in the sensor. We varied the ratio of PBA moieties and the loading amount of CNTs in the sensing composite material of the MN sensor and tested them in vitro using an ISF-mimicking gel with physiological glucose concentrations to determine the optimal sensitivity conditions. When tested in animal models with varying blood glucose concentrations, the MN sensor coated with the selected sensing material exhibited a strong correlation between the measured electrical currents and blood glucose concentrations, showing accuracy comparable to that of a glucometer in clinical use.
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