4.6 Article

Src tyrosine kinase promotes cardiac remodeling induced by chronic sympathetic activation

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Adipocyte Thyroid Hormone β Receptor-Mediated Hormone Action Fine-tunes Intracellular Glucose and Lipid Metabolism and Systemic Homeostasis

Yiruo Ma et al.

Summary: Thyroid hormone (TH) plays a crucial role in energy metabolism and systemic homeostasis by regulating adipose tissues. The active form of TH, triiodothyronine (T3), affects inguinal white adipose tissue (iWAT) and whole-body metabolism. Through the study of mice lacking adipocyte TH receptors (TR) alpha or TR beta, it was found that TR beta is the major mediator of T3's effects on iWAT, influencing metabolic pathways related to glucose uptake and use, fatty acid synthesis, and thermogenesis. Adipocyte TR beta deficiency in mice leads to susceptibility to diet-induced obesity and metabolic dysregulation, highlighting its potential as a target for metabolic diseases.

DIABETES (2023)

Article Cardiac & Cardiovascular Systems

Chronic isoprenaline/phenylephrine vs. exclusive isoprenaline stimulation in mice: critical contribution of alpha1-adrenoceptors to early cardiac stress responses

Matthias Dewenter et al.

Summary: Hyperactivity of the sympathetic nervous system can lead to cardiac remodeling, and the relative contribution of alpha(1)-adrenoceptors (ARs) to cardiac stress responses is not well-understood. This study used a mouse model and treated mice with either the beta-AR agonist isoprenaline (ISO) or a combination of ISO and the stable alpha(1)-AR agonist phenylephrine (ISO/PE). The results showed that ISO/PE treatment resulted in limited cardiomyocyte growth and increased cardiac collagen deposition. Transcriptome analysis revealed upregulation of genes related to extracellular matrix and fiber organization, along with downregulation of genes involved in metabolic processes, muscle adaptation, and cardiac electrophysiology.

BASIC RESEARCH IN CARDIOLOGY (2022)

Article Biochemistry & Molecular Biology

GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision

Wesley B. Asher et al.

Summary: Beta-arrestins are strongly autoinhibited in their basal state but can be activated by phosphorylated receptors and receptor agonism, releasing the beta-arrestin tail and allowing it to assume different conformations. The rate and efficiency of beta-arrestin activation depend on the phosphorylation pattern of the receptor and agonist-promoted receptor activation.
Article Cardiac & Cardiovascular Systems

The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy

Jiayi Liu et al.

Summary: The study found a close correlation between Trim16 expression and hypertrophy-related heart failure in both humans and mice. Trim16 deficiency exacerbated cardiomyocyte enlargement, while Trim16 overexpression attenuated cardiac hypertrophy and remodeling. Mechanistically, Prdx1 is an essential target of Trim16 in cardiac hypertrophy, and the Trim16-Prdx1 axis represents a promising therapeutic strategy for hypertrophy-related heart failure.

CIRCULATION RESEARCH (2022)

Article Cardiac & Cardiovascular Systems

Restoring Sinus Rhythm Reverses Cardiac Remodeling and Reduces Valvular Regurgitation in Patients With Atrial Fibrillation

Laurie Soulat-Dufour et al.

Summary: Restoration of sinus rhythm in atrial fibrillation patients can improve cardiac cavity remodeling and functional regurgitation, reducing the severity of regurgitation.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

Article Multidisciplinary Sciences

Early SRC activation skews cell fate from apoptosis to senescence

Carlos Anerillas et al.

Summary: This study analyzed the response of human fibroblasts to different doses of the genotoxin etoposide and found that SRC is a crucial kinase in determining whether the cells undergo apoptosis or senescence. SRC is activated by low levels of DNA damage, leading to cell survival and senescence, but not by high levels, resulting in apoptosis. Inhibition of SRC prevents the accumulation of senescent cells in tissues exposed to DNA damage, suggesting that targeting SRC could improve health outcomes by promoting apoptosis over senescence.

SCIENCE ADVANCES (2022)

Article Multidisciplinary Sciences

How Carvedilol activates β2-adrenoceptors

Tobias Benkel et al.

Summary: This study provides an alternative mechanism for carvedilol's cellular signaling, demonstrating that G proteins drive all detectable signals through beta(2)-adrenoceptors.

NATURE COMMUNICATIONS (2022)

Article Cell Biology

Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2

Tian-You Cheng et al.

Summary: BTLA is an immune checkpoint molecule that is expressed across a broad range of tumor cells, and its overexpression inhibits tumor cell proliferation and colony formation. In contrast, the depletion of BTLA promotes cell growth. The coordination of BTLA and its ligand HVEM inhibits the ERK1/2 signaling pathway, thus preventing tumor cell growth.

CELLS (2022)

Article Pharmacology & Pharmacy

Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis

Yunzhao Yang et al.

Summary: Ciprofol protects the heart against ISO-induced myocardial infarction by reducing cardiac oxidative stress, the inflammatory response, and cardiomyocyte apoptosis.

FRONTIERS IN PHARMACOLOGY (2022)

Review Physiology

G PROTEIN-COUPLED RECEPTOR-G PROTEIN INTERACTIONS: A SINGLE-MOLECULE PERSPECTIVE

Davide Calebiro et al.

Summary: Recent research has revealed transient interactions between GPCRs and G proteins in living cells, resulting in short-lived signaling nanodomains that may confer rapidity and specificity to signal transduction. These findings could potentially offer new strategies for modulating GPCR function and pave the way for innovative drug development for common diseases like diabetes or heart failure.

PHYSIOLOGICAL REVIEWS (2021)

Review Cardiac & Cardiovascular Systems

Immune Cells and Immunotherapy for Cardiac Injury and Repair

Joel G. Rurik et al.

Summary: Cardiac injury remains a major cause of morbidity and mortality worldwide, with a lack of understanding on why the heart fails to fully recover function after acute injury and why progressive heart failure frequently ensues. Recent studies have brought to light the significant contributions of the immune system to normal cardiac function and response to injury, offering promise for new treatment avenues for cardiac disease through immune modifying therapies.

CIRCULATION RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Heart failure drug titration, discontinuation, mortality and heart failure hospitalization risk: a multinational observational study (US, UK and Sweden)

Gianluigi Savarese et al.

Summary: Despite the high risk of clinical events following heart failure hospitalization, new initiation of guideline-directed medical therapy (GDMT) was accompanied by consistent patterns of low up-titration and early discontinuation in three countries with different healthcare and economies.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

Article Cell Biology

P2X7 Receptor Deficiency Ameliorates STZ-induced Cardiac Damage and Remodeling Through PKCβ and ERK

Shanjun Huang et al.

Summary: The study showed that P2X7R plays an important role in the pathogenesis of STZ-induced diabetic cardiac damage and remodeling through the PKC beta/ERK axis. These findings suggest that P2X7R might be a potential target in the treatment of diabetic cardiomyopathy.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src

Xian Xiao et al.

Summary: Research has shown that small extracellular vesicles play a crucial role in mitigating endothelial cell senescence and stimulating angiogenesis through the miR-146a/Src mechanism.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Cell Biology

Developmental Pathways of Cardiac Fibroblasts

Michelle D. Tallquist

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis

Julia Ritterhoff et al.

CIRCULATION RESEARCH (2020)

Review Cell Biology

ERK signalling: a master regulator of cell behaviour, life and fate

Hugo Lavoie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes

Natalia Pakharukova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Review Cardiac & Cardiovascular Systems

Inflammation and fibrosis in murine models of heart failure

Lucas Bacmeister et al.

BASIC RESEARCH IN CARDIOLOGY (2019)

Review Biochemistry & Molecular Biology

ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy

Simona Gallo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Peripheral Vascular Disease

Three Generations of β-blockers: History, Class Differences and Clinical Applicability

Gabriel T. do Vale et al.

CURRENT HYPERTENSION REVIEWS (2019)

Article Biochemistry & Molecular Biology

Attenuation of Na/K-ATPase/Src/ROS amplification signal pathway with pNaktide ameliorates myocardial ischemia-reperfusion injury

Hua Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Review Cardiac & Cardiovascular Systems

Therapeutic approaches for cardiac regeneration and repair

Hisayuki Hashimoto et al.

NATURE REVIEWS CARDIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Metabolic remodelling in heart failure

Edoardo Bertero et al.

NATURE REVIEWS CARDIOLOGY (2018)

Article Multidisciplinary Sciences

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

Sahil Gulati et al.

NATURE COMMUNICATIONS (2018)

Review Cardiac & Cardiovascular Systems

Hypertrophic Cardiomyopathy

Jeffrey B. Geske et al.

JACC-HEART FAILURE (2018)

Editorial Material Cardiac & Cardiovascular Systems

Beta1-Adrenergic Receptor Regulation Revisited The Role of the Extracellular N-Terminus

Susan F. Steinberg

CIRCULATION RESEARCH (2018)

Review Medicine, General & Internal

Carvedilol versus traditional, non-selective beta-blockers for adults with cirrhosis and gastroesophageal varices

Antony P. Zacharias et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2018)

Review Pharmacology & Pharmacy

Antihypertensive drugs

Stephane Laurent

PHARMACOLOGICAL RESEARCH (2017)

Article Multidisciplinary Sciences

LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis

Elaine Ngan et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

Alex R. B. Thomsen et al.

Review Cardiac & Cardiovascular Systems

The Biological Basis for Cardiac Repair After Myocardial Infarction From Inflammation to Fibrosis

Sumanth D. Prabhu et al.

CIRCULATION RESEARCH (2016)

Article Cell Biology

Myocardial plasticity: cardiac development, regeneration and disease

Joshua Bloomekatz et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2016)

Article Cardiac & Cardiovascular Systems

Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems

Jason Pellman et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

Review Biochemistry & Molecular Biology

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

Yu Sun et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2015)

Review Cardiac & Cardiovascular Systems

Effects of Beta-Blocker Withdrawal in Acute Decompensated Heart Failure A Systematic Review and Meta-Analysis

Kurt W. Prins et al.

JACC-HEART FAILURE (2015)

Article Biochemistry & Molecular Biology

HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway

Ning Liu et al.

MOLECULAR BIOSYSTEMS (2014)

Review Genetics & Heredity

The RASopathies

Katherine A. Rauen

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 14 (2013)

Review Biochemistry & Molecular Biology

Angiotensin II and Oxidative Stress in the Failing Heart

Daniela Zablocki et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Medicine, Research & Experimental

Expression and distribution of Src in the nucleus of myocytes in cardiac hypertrophy

Ping Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

Article Biochemistry & Molecular Biology

c-Src Links a RANK/αvβ3 Integrin Complex to the Osteoclast Cytoskeleton

Takashi Izawa et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Nebivolol The Somewhat-Different β-Adrenergic Receptor Blocker

Thomas Muenzel et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)

Review Cell Biology

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system

Puja K. Mehta et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin

J Melendez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Physiology

Cardiac hypertrophy: The good, the bad and the ugly

N Frey et al.

ANNUAL REVIEW OF PHYSIOLOGY (2003)

Review Endocrinology & Metabolism

Activation of MAPK cascades by G-protein-coupled receptors: The case of gonadotropin-releasing hormone receptor

Z Naor et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2000)