4.6 Review

DNA damage and repair dependencies of ionising radiation modalities

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The ATR Inhibitor VE-821 Enhances the Radiosensitivity and Suppresses DNA Repair Mechanisms of Human Chondrosarcoma Cells

Birgit Lohberger et al.

Summary: To overcome resistance to radiotherapy in chondrosarcomas, the combined treatment of DNA repair inhibitors (VE-821) with particle irradiation was investigated. The study showed that this combined treatment increased the radiosensitivity of chondrosarcoma cells and suppressed efficient DNA repair mechanisms, thus improving the efficiency of radiotherapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Review Biochemistry & Molecular Biology

The Cellular Response to Complex DNA Damage Induced by Ionising Radiation

Beth Wilkinson et al.

Summary: Radiotherapy using ionising radiation is a common treatment for many cancers, as it damages the DNA of cancer cells. Complex DNA damage (CDD), which is difficult to repair, is a key contributor to the cell-killing effects of radiotherapy. The level and complexity of CDD increase with higher ionisation density of the radiation. Detecting and measuring IR-induced CDD in cells and tissues poses challenges, and there are uncertainties regarding the specific DNA repair mechanisms involved. However, advancements are being made in these areas to improve understanding of cellular responses to CDD and explore targeted therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Biology

Targeted Inhibition of DNA-PKcs, ATM, ATR, PARP, and Rad51 Modulate Response to X Rays and Protons

Scott J. Bright et al.

Summary: Small molecule inhibitors targeting DNA repair and DNA damage response pathways show potential for treating certain cancers, especially those with genetic alterations. Combining these inhibitors with radiotherapy may have additive or synergistic effects. However, the genetic defects in cancer cells and the impact on normal cells should be considered when selecting the optimal inhibitor for combination treatment.

RADIATION RESEARCH (2022)

Review Oncology

A Review of Boron Neutron Capture Therapy: Its History and Current Challenges

Will H. Jin et al.

Summary: Boron neutron capture therapy (BNCT) is a radiation therapy technique that selectively destroys malignant cells while sparing normal tissue. Recent developments have revived interest in BNCT and offer prospects for overcoming previous limitations.

INTERNATIONAL JOURNAL OF PARTICLE THERAPY (2022)

Article Biology

Strong Shift to ATR-Dependent Regulation of the G2-Checkpoint after Exposure to High-LET Radiation

Veronika Mladenova et al.

Summary: The utilization of high linear-energy-transfer (LET) ionizing radiation modalities is rapidly growing globally, with potential for cancer therapy but also increased health risks in space missions. Understanding the biological effects of high-LET IR is essential for improving therapy and human protection during space travel. High-LET IR induces complex DNA double-strand breaks, leading to enhanced cell killing and potential utility for ATR inhibitors in high-LET radiation therapy.

LIFE-BASEL (2021)

Article Oncology

Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining

Qin Zhou et al.

Summary: This study investigated whether targeting the DNA damage response could enhance vulnerability to the distinct damage induced by proton Bragg peak irradiation, and found that ATM inhibitor could sensitize cells to more densely ionizing proton Bragg peak irradiation.

CANCER RESEARCH (2021)

Article Multidisciplinary Sciences

DNA repair inhibitors sensitize cells differently to high and low LET radiation

Kristina Bannik et al.

Summary: This study aimed to investigate the effects of high LET alpha-radiation combined with DDR inhibitors and compare it with the radiosensitizing effect of low LET X-ray radiation. The results showed that the inhibitors sensitized different cancer cell lines to radiation, with sensitization enhancement ratios ranging from 1.6 to 1.85. ATMi preferentially sensitized cancer cells and normal HEK293 cells to alpha-radiation, while DNA-PKi and ATMi could sensitize cancer cells to X-ray depending on the cancer cell type.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Checkpoint Kinase 1 (CHK1) Inhibition Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Proton Irradiation via Rad51 Downregulation

Changhoon Choi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Base excision repair and its implications to cancer therapy

Gabrielle J. Grundy et al.

GUARDIANS OF THE GENOME: DNA DAMAGE AND REPAIR (2020)

Review Biochemistry & Molecular Biology

FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy

Jonathan R. Hughes et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells

Stefan J. Roobol et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biotechnology & Applied Microbiology

The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks

Lei Zhao et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Review Biochemistry & Molecular Biology

Immunomodulatory Effects of Radiotherapy

Sharda Kumari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Oncology

Characterisation of Deubiquitylating Enzymes in the Cellular Response to High-LET Ionizing Radiation and Complex DNA Damage

Rachel J. Carter et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2019)

Editorial Material Oncology

Relative Biological Effect/Linear Energy Transfer in Proton Beam Therapy: A Primer

S. L. Gulliford et al.

CLINICAL ONCOLOGY (2019)

Article Oncology

Treatment of a first patient with FLASH-radiotherapy

Jean Bourhis et al.

RADIOTHERAPY AND ONCOLOGY (2019)

Article Oncology

Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation

Mathieu Cesaire et al.

JOURNAL OF BONE ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

Nicholas R. Pannunzio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biology

DNA damage induced by boron neutron capture therapy is partially repaired by DNA ligase IV

Natsuko Kondo et al.

RADIATION AND ENVIRONMENTAL BIOPHYSICS (2016)

Review Biochemistry & Molecular Biology

Base Excision Repair, a Pathway Regulated by Posttranslational Modifications

Rachel J. Carter et al.

MOLECULAR AND CELLULAR BIOLOGY (2016)

Article Oncology

Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation

Andrea O. Fontana et al.

RADIOTHERAPY AND ONCOLOGY (2015)

Review Oncology

Proton Radiobiology

Francesco Tommasino et al.

CANCERS (2015)

Article Oncology

Deficiency in Homologous Recombination Renders Mammalian Cells More Sensitive to Proton Versus Photon Irradiation

Nicole Grosse et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2014)

Article Oncology

Induction and Persistence of Large γH2AX Foci by High Linear Energy Transfer Radiation in DNA-Dependent protein kinase-Deficient Cells

Candelaria Bracalente et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2013)

Review Biology

Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?

Alexandros G. Georgakilas et al.

RADIATION RESEARCH (2013)

Review Oncology

Clinical evidence of particle beam therapy (carbon)

Tadashi Kamada

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2012)

Review Medicine, General & Internal

Cancer and Radiation Therapy: Current Advances and Future Directions

Rajamanickam Baskar et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2012)

Article Genetics & Heredity

DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis

Jiafeng Gu et al.

DNA REPAIR (2010)

Review Oncology

Charged particles in radiation oncology

Marco Durante et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

Article Environmental Sciences

Energy deposition stochastics and track structure: What about the target?

Dudley T. Goodhead

RADIATION PROTECTION DOSIMETRY (2006)

Article Environmental Sciences

Modelling of DNA damage induced by energetic electrons (100 eV to 100 keV)

H Nikjoo et al.

RADIATION PROTECTION DOSIMETRY (2002)