Related references
Note: Only part of the references are listed.New drug approvals for 2021: Synthesis and clinical applications
Shuo Yuan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)
Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment
Chengliang Sun et al.
JOURNAL OF MEDICINAL CHEMISTRY (2023)
Discovery of novel tranylcypromine-based derivatives as LSD1 inhibitors for gastric cancer treatment
Qi-Sheng Ma et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)
Discovery of novel N-benzylarylamide-dithiocarbamate based derivatives as dual inhibitors of tubulin polymerization and LSD1 that inhibit gastric cancers
Xin-Ying Yuan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)
The dual FAK-HDAC inhibitor MY-1259 displays potent activities in gastric cancers in vitro and in vivo
Jian Song et al.
BIOORGANIC CHEMISTRY (2023)
Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities
Ya-Xin Sun et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents
Yong Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Cancer statistics in China and United States, 2022: profiles, trends, and determinants
Changfa Xia et al.
CHINESE MEDICAL JOURNAL (2022)
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles
Andrew J. Tao et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2022)
Cytotoxic screening and antibacterial activity of Withaferin A
Altevir Rossato Viana et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2022)
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins
Valentin Borshchevskiy et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2022)
Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities
Jian Song et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
Ammad Ahmad Farooqi et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond
Jianhong Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Therapeutic implications and clinical manifestations of thymoquinone
Manzar Alam et al.
PHYTOCHEMISTRY (2022)
Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway
Jian Song et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Subtilisin from Bacillus amyloliquefaciens induces apoptosis in breast cancer cells through ubiquitin-proteasome-mediated tubulin degradation
Nanda Singh et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)
Evaluating anticancer properties of Withaferin A-a potent phytochemical
Maushma Atteeq
FRONTIERS IN PHARMACOLOGY (2022)
An NMIDLINE HORIZONTAL ELLIPSISHMIDLINE HORIZONTAL ELLIPSISN low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction
Victoria N. Drago et al.
CHEMICAL SCIENCE (2022)
Targeted protein degradation: mechanisms, strategies and application
Lin Zhao et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)
Low barrier hydrogen bonds in protein structure and function
M. Trent Kemp et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2021)
Thymoquinone attenuates doxorubicin-cardiotoxicity in rats
Derya Karabulut et al.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)
Progress of tubulin polymerization activity detection methods
Ting Zhu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)
The Rise of Molecular Glues
Stuart L. Schreiber
CELL (2021)
Microtubule associated proteins as targets for anticancer drug development
Sadiya Khwaja et al.
BIOORGANIC CHEMISTRY (2021)
Natural Products Targeting the Mitochondria in Cancers
Yue Yang et al.
MOLECULES (2021)
Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas
Simona Corso et al.
CLINICAL CANCER RESEARCH (2021)
New drug approvals for 2020: Synthesis and clinical applications
Shuo Yuan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Nanomedicines for combating multidrug resistance of cancer
Ya-Xuan Zhu et al.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2021)
Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect
Jianhong Yang et al.
SCIENCE ADVANCES (2021)
Comparison of the inhibitory potential of benzyl isothiocyanate and phenethyl isothiocyanate on Shiga toxin-producing and enterotoxigenic Escherichia coli
Chun-Xue Yang et al.
LWT-FOOD SCIENCE AND TECHNOLOGY (2020)
Molecular glue concept solidifies
Kheewoong Baek et al.
NATURE CHEMICAL BIOLOGY (2020)
Prey for the Proteasome: Targeted Protein Degradation-A Medicinal Chemist's Perspective
Laura M. Luh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
Mechanisms of Multidrug Resistance in Cancer Chemotherapy
Karol Bukowski et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
Ivana Gasic et al.
CELLS (2020)
Prospecting for molecular glues
Willem den Besten et al.
NATURE CHEMICAL BIOLOGY (2020)
The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing
Jia Liang Sun-Wang et al.
AGEING RESEARCH REVIEWS (2020)
Covalent modification of Cys-239 in -tubulin by small molecules as a strategy to promote tubulin heterodimer degradation
Jianhong Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Advances in targeted degradation of endogenous proteins
Sascha Roth et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2019)
Targeting Tubulin-colchicine Site for Cancer Therapy: Inhibitors, Antibody-Drug Conjugates and Degradation Agents
Yongtao Duan et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)
Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat Diet
Wei-Ting Chuang et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)
Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization
Piman Pocasap et al.
BIOMOLECULES & THERAPEUTICS (2019)
Withaferin A Improves Nonalcoholic Steatohepatitis in Mice
Daxesh P. Patel et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)
Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms
Maamoun Fatfat et al.
LIFE SCIENCES (2019)
The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation
Jianhong Yang et al.
MOLECULAR PHARMACOLOGY (2019)
Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors
Dong-Jun Fu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy
Katarzyna Zientara-Rytter et al.
CELLS (2019)
Targeted protein degradation and the enzymology of degraders
Stewart L. Fisher et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2018)
The Neuroprotective Effects of Thymoquinone: A Review
Tahereh Farkhondeh et al.
DOSE-RESPONSE (2018)
Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site
Ling Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
The polypharmacology of natural products
Tu T. Ho et al.
FUTURE MEDICINAL CHEMISTRY (2018)
An Overview on Renoprotective Effects of Thymoquinone
Hanieh Shaterzadeh-Yazdi et al.
KIDNEY DISEASES (2018)
Short Carboxylic Acid-Carboxylate Hydrogen Bonds Can Have Fully Localized Protons
Jiusheng Lin et al.
BIOCHEMISTRY (2017)
Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion in vitro
Kuang-Chi Lai et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2017)
Proteasome Structure and Assembly
Lauren Budenholzer et al.
JOURNAL OF MOLECULAR BIOLOGY (2017)
Structure of Dynamic, Taxol-Stabilized, and GMPPCP-Stabilized Microtubule
Avi Ginsburg et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2017)
A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression
Wen-Tsan Chang et al.
MOLECULES (2017)
Targeted protein degradation by PROTACs
Taavi K. Neklesa et al.
PHARMACOLOGY & THERAPEUTICS (2017)
The Logic of the 26S Proteasome
Galen Andrew Collins et al.
CELL (2017)
Small-Molecule PROTACS: New Approaches to Protein Degradation
Momar Toure et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Microtubule and microtubule associated protein anomalies in psychiatric disease
Francesca Marchisella et al.
CYTOSKELETON (2016)
Obesity: will withaferin win the war?
Paul T. Pfluger et al.
NATURE MEDICINE (2016)
Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule
Jianhong Yang et al.
NATURE COMMUNICATIONS (2016)
Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies
Jane Kovalevich et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A
Andrea E. Prota et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Thymoquinone inhibits microtubule polymerization by tubulin binding and causes mitotic arrest following apoptosis in A549 cells
Bipul R. Acharya et al.
BIOCHIMIE (2014)
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
Gregory M. Alushin et al.
CELL (2014)
Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin
Marie L. Antony et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Transformation of taxol-stabilized microtubules into inverted tubulin tubules triggered by a tubulin conformation switch
Miguel A. Ojeda-Lopez et al.
NATURE MATERIALS (2014)
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
Andrea E. Prota et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts
Mahmoud Alhosin et al.
INVESTIGATIONAL NEW DRUGS (2012)
Crucial facts about health benefits of popular cruciferous vegetables
Shivapriya Manchali et al.
JOURNAL OF FUNCTIONAL FOODS (2012)
Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin
Katharina Effenberger-Neidnicht et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)
Allyl Isothiocyanate Arrests Cancer Cells in Mitosis, and Mitotic Arrest in Turn Leads to Apoptosis via Bcl-2 Protein Phosphorylation
Feng Geng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Characterization of the Covalent Binding of N-Phenyl-N′-(2-chloroethyl)ureas to β-Tubulin: Importance of Glu198 in Microtubule Stability
Sebastien Fortin et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Microtubule-Disrupting Chemotherapeutics Result in Enhanced Proteasome-Mediated Degradation and Disappearance of Tubulin in Neural Cells
Lyn M. Huff et al.
CANCER RESEARCH (2010)
Microtubule-binding agents: a dynamic field of cancer therapeutics
Charles Dumontet et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Microtubule-Binding Natural Products for Cancer Therapy
Qing-Xi Yue et al.
PLANTA MEDICA (2010)
The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulin
Gianni Harris et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
694 The Tubulin-Targeting Agent T0070907 Promotes Tubulin Degradation and Inactivates the Tubulin-Sequestering Protein Stathmin/Op18
Gianni Harris et al.
GASTROENTEROLOGY (2009)
Cancer Preventive Isothiocyanates Induce Selective Degradation of Cellular α- and β-Tubulins by Proteasomes
Lixin Mi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
TTI-237:: A novel microtubule-active compound with in vivo antitumor activity
Carl F. Beyer et al.
CANCER RESEARCH (2008)
Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo
Silvia D. Stan et al.
CANCER RESEARCH (2008)
Microtubule assembly dynamics: An attractive target for anticancer drugs
Parminder Singh et al.
IUBMB LIFE (2008)
Structure of the Human 26S Proteasome
Paula C. A. da Fonseca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Covalent binding to tubulin by isothiocyanates - A mechanism of cell growth arrest and apoptosis
Lixin Mi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
PPAR gamma Inhibitors as Novel Tubulin-Targeting Agents
Katherine L. Schaefer
PPAR RESEARCH (2008)
E3-independent monoubiquitination of ubiquitin-binding proteins
Daniela Hoeller et al.
MOLECULAR CELL (2007)
The tumor proteasome is a primary target for the natural anticancer compound withaferin a isolated from Indian Winter Cherry
Huanjie Yang et al.
MOLECULAR PHARMACOLOGY (2007)
PPARγ inhibitors reduce tubulin protein levels by a PPARγ, PPARδ and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells
Katherine L. Schaefer et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Mutations affecting β-tubulin folding and degradation
YQ Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Structural basis for the regulation of tubulin by vinblastine
B Gigant et al.
NATURE (2005)
Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax
D Xiao et al.
CLINICAL CANCER RESEARCH (2005)
Microtubules as a target for anticancer drugs
MA Jordan et al.
NATURE REVIEWS CANCER (2004)
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
RBG Ravelli et al.
NATURE (2004)
Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo
SK Srivastava et al.
CARCINOGENESIS (2003)
Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis
D Xiao et al.
CARCINOGENESIS (2003)
NMDA receptor stimulation induces temporary α-tubulin degradation signaled by nitric oxide-mediated tyrosine nitration in the nervous system of Sepia officinalis
A Palumbo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor α degradation
V Lallemand-Breitenbach et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)