4.5 Article

SAR study of niclosamide derivatives for neuroprotective function in SH-SY5Y neuroblastoma

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 96, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2023.129498

Keywords

Niclosamide; Drug discovery; Neurodegeneration; Neuroprotection; Protein ubiquitination; Apoptosis

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Neurodegenerative diseases are severe and incurable conditions that affect millions of people worldwide. Recent research has found that the anthelmintic drug niclosamide shows potential as a neuroprotective agent, preventing neuronal cell toxicity and enhancing autophagy. The structure-activity relationship of niclosamide derivatives has also been investigated, providing guidance for the development of new drugs for neurodegenerative diseases.
Neurodegenerative disease is a debilitating and incurable condition that affects millions of people around the world. The loss of functions or malfunctions of neural cells are the causes of mortality. A proteosome inhibitor, MG132, is well known to cause neurodegeneration in vitro when model neuronal-derived cell lines are exposed to it. Niclosamide, an anthelmintic drug, which has been used to treat tapeworm infections for more than 50 years, has recently attracted renewed attention in drug repurposing because it has been found to be a good candidate in many drug development screenings. We recently found that all markers of MG132-induced neuronal cell toxicity, including the accumulation of ubiquitinated proteins, were prevented by the presence of niclosamide. In addition, niclosamide was shown to enhance autophagy induced by MG132. There results suggested that niclosamide could act as a neuroprotective agent. In the present study, niclosamide derivatives were synthesized, and the structure-activity relationship (SAR) were determined with respect to protein ubiquitination induced by MG132 and effect on cell survival signaling pathways for neuroprotective function. Our results indicate that phenol OH plays a significant role in neuroprotective activity while the niclosamide derivatives without Cl (5- or 2 '-Cl) showed almost the same neuroprotective effect. 4 '-NO2 can be replaced by N3 or CF3 whereas NH2 significantly decreased activity. These findings provide guidance for the development of new niclosamide analogues against neurodegenerative diseases including Parkinson's disease.

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