Journal
BIOMETALS
Volume -, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1007/s10534-023-00538-1
Keywords
Bacterial microcompartments; Metal-binding peptides; Protein shells
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In this study, the functionalization of bacterial microcompartment (BMC) shell lumens was demonstrated to significantly increase the loading capacity of iron and cobalt. This suggests the possibility of passive flow of cobalt and iron atoms across the BMC shell.
Bacterial microcompartments (BMCs) are prokaryotic organelles involved in several biochemical processes in bacterial cells. These cellular substructures consist of an icosahedral shell and an encapsulated enzymatic core. The outer shells of BMCs have been proposed as an attractive platform for the creation of novel nanomaterials, nanocages, and nanoreactors. In this study, we present a method for functionalizing recombinant GRM2-type BMC shell lumens with short cysteine-containing sequences and demonstrate that the iron and cobalt loading capacity of such modified shells is markedly increased. These results also imply that a passive flow of cobalt and iron atoms across the BMC shell could be possible.
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