☆ 4.7 Article

Fluoxetine inactivates STAT3/NF-cB signaling and promotes sensitivity to cisplatin in bladder cancer

BIOMEDICINE & PHARMACOTHERAPY (2023)

Related references

Note: Only part of the references are listed.

Article Medicine, Research & Experimental

Hyperforin Suppresses Oncogenic Kinases and Induces Apoptosis in Colorectal Cancer Cells

Li-Cho Hsu et al.

Summary: This study found that hyperforin, an active constituent from Hypericum perforatum, suppresses the progression and transformation of colorectal cancer (CRC) by inhibiting the JAK/STAT3, ERK, and AKT signaling pathways, suggesting its therapeutic potential.

IN VIVO (2023)

Add to Collection

Review Medicine, Research & Experimental

The application of antidepressant drugs in cancer treatment

Yunxi Zheng et al.

Summary: Antidepressants are psychotropic drugs used to treat mental illness. They have been found to have anticarcinogenic effects, affecting various signaling pathways and the microenvironment. Mechanisms include apoptosis, antiproliferative effects, oxidative stress, DNA damage, immune response and inflammation, and inhibition of multidrug resistance. This review summarizes the impacts and mechanisms of 10 antidepressants in preventing cancer and discusses their potential drawbacks. Further research is needed for a full understanding and to explore new avenues for cancer prevention and treatment.

BIOMEDICINE & PHARMACOTHERAPY (2023)

Add to Collection

Article Cell Biology

Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4

Fan Yang et al.

Summary: According to recent studies, the tight junction protein occludin (OCLN) is highly expressed in bladder cancer tissues and is associated with a poor prognosis. Downregulation of OCLN inhibits tumor angiogenesis, while overexpression of OCLN has the opposite effect. Mechanistically, OCLN increases levels of interleukin-8 (IL8) and phosphorylated Signal Transducer and Activator of Transcription 3 (p-STAT3) to promote bladder cancer angiogenesis. OCLN regulates IL8 transcriptional activity through the transcription factor STAT4.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

DNA damage and NF-κB inactivation implicate glycyrrhizic acid-induced G1 phase arrest in hepatocellular carcinoma cells

Wei-Shu Wang et al.

Summary: Glycyrrhizic acid plays an important role in anti-HCC therapy by inducing DNA damage, apoptosis, and expression of cell cycle regulatory proteins to inhibit the growth of HCC cells. Moreover, it can induce G(1) phase arrest in HCC cells and suppress relevant signaling pathways.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

Add to Collection

Article Cell Biology

Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior

Monika Bijata et al.

Summary: This study investigates the impact of 5-HT7R/MMP-9 signaling and dendritic spine plasticity on major depressive disorder. The results show that activation of 5-HT7R and chronic stress both negatively affect dendritic spine elongation and density in the hippocampus, which are associated with depressive-like behavior.

CELL REPORTS (2022)

Add to Collection

Article Oncology

Magnolol Induces Apoptosis Through Extrinsic/intrinsic Pathways and Attenuates NF-?B/STAT3 Signaling in Non-small-cell Lung Cancer Cells

Yang-cheng Lee et al.

Summary: This study found that magnolol, a hydroxylated biphenyl isolated from Magnolia officinalis, has therapeutic effects on non-small-cell lung cancer (NSCLC) by inactivating NF-kappa B signaling and inducing cytotoxicity.

ANTICANCER RESEARCH (2022)

Add to Collection

Article Oncology

STAT3 Inactivation and Induction of Apoptosis Associate With Fluoxetine-inhibited Epithelial-mesenchymal Transition and Growth of Triple-negative Breast Cancer In Vivo

Pen-An Liao et al.

Summary: This study found that fluoxetine may inhibit the progression of triple-negative breast cancer by suppressing STAT3 signaling transduction and triggering the apoptotic pathway, suggesting its potential as an anti-tumor agent.

ANTICANCER RESEARCH (2022)

Add to Collection

Article Cell Biology

7-Epitaxol induces apoptosis in cisplatin-resistant head and neck squamous cell carcinoma via suppression of AKT and MAPK signalling

Hui-Ju Yang et al.

Summary: This study investigated the anticancer efficacy of a major paclitaxel metabolite called 7-Epitaxol in cisplatin-resistant HNSCC and found that it exhibits cytotoxic effects by inducing cell cycle arrest and apoptotic pathways. The study also revealed that 7-Epitaxol can suppress AKT and MAPK signaling pathways to induce cancer cell apoptosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Add to Collection

Review Medicine, Research & Experimental

NF-KB inhibitors gifted by nature: The anticancer promise of polyphenol compounds

Chengcheng Guan et al.

Summary: Polyphenol compounds, as natural antioxidants, have anti-inflammatory and antioxidant properties, and are believed to have various medicinal benefits for improving human health. Their anticancer effect is mainly attributed to their strong antioxidant and immunomodulatory effects. By targeting NF-KB, polyphenol compounds can exert antioxidant and immunomodulatory effects, hindering the occurrence and development of tumors. They have advantages over conventional anticancer therapies as they have minimal side effects and can attenuate the toxic effects of other treatments, showing great potential in cancer prevention and treatment.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Review Medicine, Research & Experimental

Pre-clinical investigation of STAT3 pathway in bladder cancer: Paving the way for clinical translation

Sepideh Mirzaei et al.

Summary: Effective cancer therapy requires the identification of signaling networks, with STAT3 playing a significant role in promoting proliferation, invasion, chemoresistance, and metastasis in bladder cancer cells. Inhibiting STAT3 may enhance chemotherapy efficacy by overcoming chemoresistance in BC. Multiple molecular pathways and non-coding RNAs act as upstream regulators of STAT3 in BC cells.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Oncology

Soluble PD-L1 in Serum and Urine in Urinary Bladder Cancer Patients

Anders Vikerfors et al.

Summary: The study found that high serum PD-L1 levels are associated with aggressive disease and development of metastatic disease in BC patients, but no significant difference was found in urine sPD-L1 levels in BC patients.

CANCERS (2021)

Add to Collection

Article Oncology

Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

Po-Fu Yueh et al.

Summary: The study found that imipramine effectively induces apoptosis of NSCLC cells by suppressing the EGFR/PKC-d/NF-κB pathway, leading to increased DNA damage and decreased invasion and migration potential. In both in vitro and in vivo models, imipramine demonstrated tumor growth inhibition similar to the standard therapy erlotinib (EGFR inhibitor). Non-obvious body weight loss and liver pathology changes were observed in mice treated with imipramine.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Article Environmental Sciences

In vitro antimetastatic activity of Momordica balsamina crude acetone extract in HT-29 human colon cancer cells

Karabo Serala et al.

Summary: The study demonstrated that the crude acetone extract of Momordica balsamina (MBE) inhibited the metastatic ability of HT-29 colorectal cancer (CRC) cells in vitro. MBE consists of a mixture of compounds with cytotoxic effects against HT-29 cells and can suppress reactive oxygen species formation, cell invasion, migration, and adhesion. The antimetastatic effects of MBE were associated with the regulation of various proteins related to cancer metastasis.

ENVIRONMENTAL TOXICOLOGY (2021)

Add to Collection

Article Environmental Sciences

Benzyl isothiocyanate promotes miR-99a expression through ERK/AP-1-dependent pathway in bladder cancer cells

Te-Fu Tsai et al.

ENVIRONMENTAL TOXICOLOGY (2020)

Add to Collection

Article Oncology

Antihelminthic Niclosamide Induces Autophagy and Delayed Apoptosis in Human Non-small Lung Cancer Cells In Vitro and In Vivo

Woei-Horng Chai et al.

ANTICANCER RESEARCH (2020)

Add to Collection

Article Oncology

The Association between Selective Serotonin Reuptake Inhibitors (SSRIs) Use and the Risk of Bladder Cancer: A Nationwide Population-Based Cohort Study

Yi-Chun Liu et al.

CANCERS (2020)

Add to Collection

Article Environmental Sciences

Regorefenib induces extrinsic/intrinsic apoptosis and inhibits MAPK/NF-κB-modulated tumor progression in bladder cancer in vitro and in vivo

Chih-Hung Chiang et al.

ENVIRONMENTAL TOXICOLOGY (2019)

Add to Collection

Article Integrative & Complementary Medicine

Proliferation and Migration of Lung Cancer Could be Inhibited by Oxymatrine through the Regulation for miR-520/VEGF

Wen Zhou et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2019)

Add to Collection

Article Medicine, Research & Experimental

Apoptosis induction and AKT/NF-κB inactivation are associated with regroafenib-inhibited tumor progression in non-small cell lung cancer in vitro and in vivo

Mao-Chi Weng et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Add to Collection

Review Medicine, Research & Experimental

Targeting STAT3 inhibition to reverse cisplatin resistance

Chao-Yue Sung et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Add to Collection

Article Oncology

p85α Inactivates MMP-2 and Suppresses Bladder Cancer Invasion by Inhibiting MMP-14 Transcription and TIMP-2 Degradation

Jingjing Wang et al.

NEOPLASIA (2019)

Add to Collection

Article Cell Biology

Anticancer activity of paroxetine in human colon cancer cells: Involvement of MET and ERBB3

Won-Jun Jang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Add to Collection

Article Medicine, Research & Experimental

Hyperforin Induces Apoptosis Through Extrinsic/Intrinsic Pathways and Inhibits NF-κB-modulated Survival and Invasion Potential in Bladder Cancer

Yu-Chang Liu et al.

IN VIVO (2019)

Add to Collection

Article Medicine, Research & Experimental

Synergistic antitumour effects of triptolide plus gemcitabine in bladder cancer

Ying Yang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Article Oncology

Impact of Psychiatric Illness on Decreased Survival in Elderly Patients With Bladder Cancer in the United States

Usama Jazzar et al.

CANCER (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Apoptosis: A Target for Anticancer Therapy

Claire M. Pfeffer et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Article Oncology

Nuclear Factor-κB Promotes Urothelial Tumorigenesis and Cancer Progression via Cooperation with Androgen Receptor Signaling

Satoshi Inoue et al.

MOLECULAR CANCER THERAPEUTICS (2018)

Add to Collection

Article Multidisciplinary Sciences

STAT3 expression is a prognostic marker in upper urinary tract urothelial carcinoma

Kyosuke Matsuzaki et al.

PLOS ONE (2018)

Add to Collection

Article Oncology

Preadmission antidepressant use and bladder cancer: a population-based cohort study of stage at diagnosis, time to surgery, and surgical outcomes

Ellen Hollands Steffensen et al.

BMC CANCER (2018)

Add to Collection

Article

Prognostic role of matrix metalloproteinases in bladder carcinoma: a systematic review and meta-analysis

Chenkui Miao et al.

Oncotarget (2017)

Add to Collection

Article Oncology

Fluoxetine regulates cell growth inhibition of interferon-α

Yu-Min Lin et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2016)

Add to Collection

Review Chemistry, Multidisciplinary

Emerging antibody-based therapeutic strategies for bladder cancer: A systematic review

Rita Azevedo et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection

Article Cell Biology

Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner

W. Guo et al.

CELL DEATH & DISEASE (2015)

Add to Collection

Article Multidisciplinary Sciences

Cancer Mortality in People Treated with Antidepressants before Cancer Diagnosis: A Population Based Cohort Study

Yuelian Sun et al.

PLOS ONE (2015)

Add to Collection

Article Pharmacology & Pharmacy

MCL-1 dependency of cisplatin-resistant cancer cells

Judith Michels et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Add to Collection

Article Environmental Sciences

Crude Extract of Rheum Palmatum L Induced cell Death in LS1034 Human Colon Cancer Cells acts through the Caspase-Dependent and -Independent Pathways

Yi-Shih Ma et al.

ENVIRONMENTAL TOXICOLOGY (2014)

Add to Collection

Article Urology & Nephrology

The Role of c-FLIP in Cisplatin Resistance of Human Bladder Cancer Cells

Sangchul Lee et al.

JOURNAL OF UROLOGY (2013)

Add to Collection

Article Oncology

Role of Diffusion-Weighted Magnetic Resonance Imaging in Predicting Sensitivity to Chemoradiotherapy in Muscle-Invasive Bladder Cancer

Soichiro Yoshida et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2012)

Add to Collection

Article Medicine, General & Internal

XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer

Li Ming et al.

CHINESE MEDICAL JOURNAL (2007)

Add to Collection

Article Urology & Nephrology

c-FLIP expression in bladder urothelial carcinomas: Its role in resistance to FAS-mediated apoptosis and clinicopathologic correlations

P Korkolopoulou et al.

UROLOGY (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.