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Nutrition & Dietetics
Laura Moschino et al.
Summary: NEC, a serious gastrointestinal disease in neonates, leads to SBS and requires early prevention. Nutritional practices are crucial for preventing NEC and supporting growth and intestinal function in preterm infants.
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Jordan T. Russell et al.
Summary: The use of antibiotics in neonates can affect the gut microbiome diversity, while different types of nutrition shape the early infant gut microbiome. The study discovered an association between Veillonella and the neurotransmitter gamma-aminobutyric acid (GABA).
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Nannan Sun et al.
Summary: The interaction between intestinal bacteria and the central nervous system, known as the gut-brain axis, plays a critical role in maintaining brain homeostasis. Depletion of gut microbiota led to increased blood-brain barrier permeability and migration of bone marrow-derived cells to specific brain regions involved in emotional behavior regulation.
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Xiaoning Liu et al.
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Biochemistry & Molecular Biology
Nathanael Yates et al.
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Michael G. Constantinides et al.
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FRONTIERS IN CELLULAR NEUROSCIENCE
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Chien-Chung Lee et al.
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FRONTIERS IN MICROBIOLOGY
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Microbiology
Yue-feng Li et al.
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Immunology
Qing Liu et al.
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BRAIN BEHAVIOR AND IMMUNITY
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Zinni Manuela et al.
Summary: Prematurity is a major cause of neonatal mortality and morbidity, with preterm infants at high risk of developing respiratory problems and other morbidities. Perinatal glucocorticosteroids, commonly used for prevention and treatment, have shown short-term benefits but may also be associated with abnormal brain development in infants born preterm. Neuroinflammation, particularly the role of microglia, has emerged as a significant factor for brain injury in preterm infants.
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Microbiology
Lesley Hoyles et al.
Summary: The study shows that methylamine substances can directly affect the integrity of the blood-brain barrier in mammals by improving its function through regulation of tight junction proteins. Long-term exposure to trimethylamine N-oxide helps protect cognitive function, reducing astrocyte and microglial reactivity in specific brain regions.
Article
Microbiology
Hongli Shi et al.
Summary: The study indicates that a diet lacking in fiber may lead to cognitive impairment, predominantly through altering the gut microbiota-hippocampal axis. These findings are crucial in highlighting the adverse effects of dietary fiber deficiency on brain function.
Article
Multidisciplinary Sciences
Bente Winkler et al.
Summary: The study reveals that macrophages can enter the brain during infections and autoimmune diseases, participating in pathogen elimination but also potentially causing tissue damage. Through a Drosophila model, it was found that the immune deficiency pathway plays a role in attracting and invading macrophages into the brain.
Review
Microbiology
Van A. Ortega et al.
Summary: This article discusses the biological and neuroendocrine networks regulating stress response, as well as the impact of gut microbiota on early-life development that may predispose individuals to various diseases later in life. Animal models have confirmed the influence of gut microbiota on HPA axis activity, stress reactivity, and brain development.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
David Seki et al.
Summary: The study found that premature infants with severe brain damage had suppressed maturation of electrocortical activity, elevated levels of gamma delta T cells, increased secretion of vascular endothelial growth factor by T cells, and reduced secretion of neuroprotectants. Klebsiella overgrowth in the gut was highly predictive of brain damage and associated with a pro-inflammatory immunological tone. These findings suggest that aberrant development of the gut-microbiota-immune-brain axis may drive or exacerbate brain injury in extremely premature neonates and could be a potential target for novel intervention strategies.
CELL HOST & MICROBE
(2021)
Article
Biochemistry & Molecular Biology
Chun Chen et al.
Summary: Inflammation activates C/EBP beta/delta-secretase and initiates AD-associated pathologies in the gut, which then spread to the brain via the vagus nerve. Inhibition of this signaling pathway may attenuate AD-like pathologies in both the gut and the brain, restoring cognitive function. This study suggests a potential therapeutic strategy for Alzheimer's disease by targeting the gut-brain axis.
Article
Immunology
Long Lu et al.
Summary: The study found that Vγ4 T cells play a crucial role in ischemic brain tissue damage by providing an early source of IL-17A in stroke. Additionally, CCL20 and IL-1β/IL-23 are deeply involved in amplifying inflammatory responses in the brain tissue.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Wei-Li Wu et al.
Summary: The study demonstrates that microbiome modulates neuronal activity in specific brain regions of male mice to regulate stress responses and social behaviors. Social deviations in germ-free or antibiotic-treated mice are associated with elevated corticosterone levels, primarily produced by activation of the hypothalamus-pituitary-adrenal (HPA) axis.
Article
Neurosciences
Jenkang Tao et al.
Summary: The study revealed seven molecularly distinct subtypes of motor neurons within the vagus nerve, with two of them exclusively innervating the glandular domain of the stomach and contacting enteric neurons releasing functionally opposing neurotransmitters. This discovery demonstrates a division of labor within the parasympathetic nervous system to control autonomic function.
Article
Neurosciences
Yunpeng Liu et al.
Summary: The study investigated the impact of subdiaphragmatic vagotomy on the anxiolytic effects of L.rhamnosus and found that the vagus nerve plays a crucial role in modulating immune changes associated with this effect. Vagotomy prevented the anxiolytic effects, immune cell increase, and altered microglia activation in the hippocampus, highlighting the importance of vagal signaling in the microbiota-gut-brain axis.
Review
Pharmacology & Pharmacy
Tongtong Ge et al.
Summary: Increasing evidence suggests that dysbiosis of gut microbiota may be involved in the physiological mechanisms of neuropsychiatric disorders, but the exact pathways are still unclear. The complex crosstalk between neuroendocrine and immunological regulation may underlie the mechanisms by which gut microbiota are associated with neuropsychiatric disorders.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Louise Dupraz et al.
Summary: The gut microbiota represses IL-17 production by gamma delta T cells through the production of metabolites, particularly propionate.
Article
Cell Biology
Laetitia Travier et al.
Summary: Neonates are more susceptible to Group B streptococcus meningitis due to the immature intestinal microbiota and age-dependent but microbiota-independent Wnt activity, leading to bacterial colonization and neuroinvasion. Interventions aimed at maturing the microbiota may help prevent neonatal meningitis.
Review
Microbiology
Pedro H. Papotto et al.
Summary: The interactions between microbiota and gamma delta T cells impact tissue homeostasis and disease pathology, with microbiota-induced IL-17-producing gamma delta T cells playing a role in various immunological processes. However, the reciprocal interactions between gamma delta T cells and microbiota remain to be fully elucidated.
NATURE MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kaitlyn Oliphant et al.
Summary: The study investigated the association between gut microbiome succession and head circumference growth in preterm infants, finding that depletion of Bacteroidota and Lachnospiraceae was associated with suboptimal neurodevelopment. Early integration of these core taxa is crucial for optimal neurodevelopment.
Review
Medicine, Research & Experimental
Michael D. Gershon et al.
Summary: Modern research has uncovered the complexities of gastrointestinal behavior, where the gut communicates bidirectionally with the brain and senses the environment within itself, while the microbiome within the gut also plays a significant role in this process. The microbiota-gut-brain connectome has emerged as a key aspect of this tripartite interaction, highlighting the roles of serotonin, Toll-like receptors, and macrophages in signaling.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Mingbang Wang et al.
Summary: This study utilized VFGM genes and IgA levels for a machine learning-based classification of ASD, finding that VFGM gene composition was associated with ASD phenotype and gene diversity was higher in children with ASD. The classification method using VFGM genes offers a novel early risk identification method for ASD, independent of sex and gastrointestinal symptoms.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Gastroenterology & Hepatology
Miriam Aguilar-Lopez et al.
Summary: Factors such as postnatal age, mode of delivery, antibiotic use, and human milk consumption have been found to have an impact on the gut microbiota of preterm infants. Limited evidence exists for associations with race, sex, use of different fortifiers, macronutrients, and other medications. Further studies with rich metadata are needed to explore the impact of the preterm exposome on microbiota development in this high-risk population.
Review
Nutrition & Dietetics
Radka Roubalova et al.
CLINICAL NUTRITION
(2020)
Article
Biochemistry & Molecular Biology
Liu L. Yang et al.
JOURNAL OF NEUROCHEMISTRY
(2020)
Article
Neurosciences
Rebecca Sadler et al.
JOURNAL OF NEUROSCIENCE
(2020)
Review
Pediatrics
Ian H. Jones et al.
JOURNAL OF PEDIATRICS
(2020)
Review
Biochemistry & Molecular Biology
Jon D. Laman et al.
TRENDS IN MOLECULAR MEDICINE
(2020)
Article
Agriculture, Multidisciplinary
Beita Zhao et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Pediatrics
Vivien Yap et al.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2020)
Article
Nutrition & Dietetics
Cathelijne Heymans et al.
Review
Immunology
Monica Cappelletti et al.
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Heather Hulme et al.
Review
Neurosciences
Chuyue D. Yu et al.
CURRENT OPINION IN NEUROBIOLOGY
(2020)
Article
Chemistry, Medicinal
Evan M. Alexander et al.
ACS INFECTIOUS DISEASES
(2020)
Review
Immunology
Eduardo Villamor-Martinez et al.
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Nam Su Oh et al.
Review
Immunology
Alexander Humberg et al.
SEMINARS IN IMMUNOPATHOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Ayoze Gonzalez-Santana et al.
TRENDS IN MOLECULAR MEDICINE
(2020)
Review
Neurosciences
Brittany D. Needham et al.
NATURE REVIEWS NEUROSCIENCE
(2020)
Article
Pediatrics
Claire Howarth et al.
Article
Microbiology
Anaamika Campeau et al.
Article
Agriculture, Multidisciplinary
Jiaming Liu et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Billel Benmimoun et al.
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Anne-Katrin Probstel et al.
SCIENCE IMMUNOLOGY
(2020)
Review
Immunology
Maria Papadopoulou et al.
IMMUNOLOGICAL REVIEWS
(2020)
Article
Multidisciplinary Sciences
Zachary Fitzpatrick et al.
Article
Neurosciences
Christopher D. Smyser et al.
Article
Clinical Neurology
Jun-Xi Pan et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2019)
Review
Physiology
Frank van Bel et al.
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Peng Zheng et al.
Article
Immunology
George Biouss et al.
JOURNAL OF NEUROINFLAMMATION
(2019)
Review
Gastroenterology & Hepatology
Boushra Dalile et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2019)
Review
Immunology
Jannie G. E. Henderickx et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Immunology
Emma Murray et al.
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Neurosciences
Sangjune Kim et al.
Article
Immunology
Miguel Ribeiro et al.
SCIENCE IMMUNOLOGY
(2019)
Article
Cell Biology
Renqiang Yu et al.
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Neurosciences
Martina Sgritta et al.
Article
Medicine, General & Internal
Joanne E. Sordillo et al.
Article
Pediatrics
Hendrik J. Niemarkt et al.
Review
Immunology
J. J. Worthington et al.
MUCOSAL IMMUNOLOGY
(2018)
Article
Obstetrics & Gynecology
Joshua P. Vogel et al.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2018)
Article
Immunology
Matthew G. Frank et al.
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Review
Clinical Neurology
Margie A. Ream et al.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2018)
Review
Endocrinology & Metabolism
Sofia Cussotto et al.
FRONTIERS IN NEUROENDOCRINOLOGY
(2018)
Article
Immunology
Yin Pang et al.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Review
Clinical Neurology
Aitak Farzi et al.
Article
Endocrinology & Metabolism
Mari L. Lund et al.
MOLECULAR METABOLISM
(2018)
Article
Multidisciplinary Sciences
Melanie Maya Kaelberer et al.
Article
Cell Biology
Diego F. Nino et al.
SCIENCE TRANSLATIONAL MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Jay Vornhagen et al.
TRENDS IN MICROBIOLOGY
(2017)
Review
Clinical Neurology
Stephen A. Back
ACTA NEUROPATHOLOGICA
(2017)
Article
Immunology
Melissa H. Bloodworth et al.
INFECTION AND IMMUNITY
(2016)
Review
Obstetrics & Gynecology
Chong Jai Kim et al.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Review
Infectious Diseases
Tobias Strunk et al.
LANCET INFECTIOUS DISEASES
(2014)
