4.7 Article

Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway

Related references

Note: Only part of the references are listed.
Editorial Material Urology & Nephrology

Cisplatin-Induced Kidney Injury: Delivering the Goods

Joshua N. Curry et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

Article Chemistry, Physical

Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment

Qingsi Wu et al.

Summary: The etiology of chronic kidney disease is complex, leading to outcomes such as glomerular sclerosis, endothelial dysfunction, and chronic inflammation. Traditional Chinese herb tripterygium wilfordii has shown efficacy in kidney disease treatment, with active ingredient celastrol being toxic. Targeted delivery systems like peptides coupled CLT-phospholipid lipid nanoparticles offer efficient drug delivery to alleviate inflammation and endothelial damage in CKD.

NANO RESEARCH (2022)

Article Pharmacology & Pharmacy

Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1

Piao Luo et al.

Summary: Celastrol exerts anti-fibrotic effects by inducing ferroptosis and promoting the production of ROS. It directly binds to PRDXs and HO-1, inhibiting their antioxidant activities and increasing ROS levels, thereby inducing ferroptosis.

ACTA PHARMACEUTICA SINICA B (2022)

Article Gastroenterology & Hepatology

Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis

Sha Huang et al.

Summary: This study demonstrates the important roles of apoptosis and ferroptosis in lipopolysaccharide/D-galactosamine-induced acute liver failure. The increase of transforming growth factor beta 1 is associated with acute liver failure, while liver-specific knockout of transforming growth factor beta receptor 1 can alleviate acute liver failure. The deficiency of liver transforming growth factor beta receptor 1 reduces apoptosis and ferroptosis by regulating the phosphorylation of glycogen synthase kinase 3 beta and nuclear factor erythroid 2-related factor 2, increasing the levels of glutathione peroxidase 4, glutamine antiporter xCT, dihydroorotate dehydrogenase, and ferroptosis suppressor protein 1, and decreasing the expression of transferrin receptor, prostaglandin-endoperoxide synthase, chaC glutathione specific gamma-glutamylcyclotransferase 1, and cytochrome P450 reductase.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Pharmacology & Pharmacy

Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway

Jianqiang Hu et al.

Summary: Evidence suggests that Nrf2 activation has renal protective effects on cisplatin-induced acute kidney injury, potentially by inhibiting lipid peroxide-mediated ferroptosis. Leonurine activates the Nrf2 pathway and protects against cisplatin-induced acute kidney injury by inhibiting ferroptosis.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling

Xue-Ting Li et al.

Summary: SIRT7 alleviates renal ferroptosis, lipid peroxidation, and partial EMT under hypertensive status by facilitating the KLF15/Nrf2 signaling, thereby mitigating renal fibrosis, injury, and dysfunction.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Review Biochemistry & Molecular Biology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

Summary: This review describes the key regulators of ferroptosis and provides an overview of metabolism, ROS biology, and iron biology. Additionally, it highlights the important concepts and unanswered questions in the field of ferroptosis. The future holds promise for further breakthroughs in understanding the mechanisms of ferroptosis and utilizing it for therapeutic purposes.
Article Cell Biology

Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis

Yue-bo Huang et al.

Summary: Acute kidney injury (AKI) is a clinical problem with unclear pathophysiology and lacking effective treatment. Ferroptosis, a novel form of regulated cell death, has been shown to play a vital role in AKI, while melatonin, an antioxidant, has therapeutic effects on AKI. This study reveals that melatonin prevents ferroptosis in AKI by acting on the NRF2/Slc7a11 axis.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Article Biochemistry & Molecular Biology

Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation

Yang Xu et al.

Summary: This study found that humans are exposed to ethyl carbamate (EC) through consumption of fermented food and beverages. EC triggers ferroptosis in liver cells, causing cell death. GSH depletion is the main cause of ferroptosis under EC exposure. EC blocks the activation of Nrf2, leading to the occurrence of ferroptosis.

REDOX BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes

Dong-Hyun Kim et al.

Summary: This study demonstrates that activated FXR regulates the transcription of ferroptosis-related genes and protects against cisplatin-induced AKI.

REDOX BIOLOGY (2022)

Article Chemistry, Multidisciplinary

Targeted delivery via albumin corona nanocomplex to renal tubules to alleviate acute kidney injury

Shuo Qin et al.

Summary: In this study, a high loading capacity nanocomplex core was developed with celastrol entrapped in D-alpha-tocopherol polyethylene glycol 1000 succinate. Bovine serum albumin was adsorbed onto the core surface to improve the targeting efficiency and stability. The nanocomplex showed good stability and renal tubule-specific distribution in in vitro and in vivo experiments. Pharmacodynamic studies demonstrated that the nanocomplex effectively alleviated acute kidney injury-induced injuries.

JOURNAL OF CONTROLLED RELEASE (2022)

Review Biochemistry & Molecular Biology

Signaling pathways of chronic kidney diseases, implications for therapeutics

Qian Yuan et al.

Summary: This article reviews the key signaling pathways involved in lipotoxicity, oxidative stress, inflammation, and myofibroblast activation in chronic kidney disease (CKD), and introduces targeted drugs based on the latest research. Understanding these signaling pathways and developing targeted therapies will advance basic and clinical research in CKD.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Multidisciplinary Sciences

Quercetin alleviates acute kidney injury by inhibiting ferroptosis

Yue Wang et al.

Summary: The study demonstrated that quercetin (QCT), a natural flavonoid, inhibited ferroptosis in renal proximal tubular epithelial cells by reducing lipid ROS levels and increasing glutathione (GSH) levels. QCT also ameliorated acute kidney injury induced by ischemia-reperfusion (I/R) or folic acid (FA). Furthermore, RNA-sequence analysis revealed ATF3 as a key factor in QCT's inhibition of ferroptosis. Additionally, QCT inhibited the recruitment of pro-inflammatory macrophages in AKI.

JOURNAL OF ADVANCED RESEARCH (2021)

Article Cell Biology

Involvement of GPX4 in irisin's protection against ischemia reperfusion-induced acute kidney injury

Jia Zhang et al.

Summary: Irisin attenuates I/R-induced AKI by upregulating GPX4, improving renal injury, and inhibiting inflammatory response and oxidative stress.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Pharmacology & Pharmacy

Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury

Lianxia Guo et al.

Summary: The study showed that Rev-erb-alpha and Rev-erb-beta play crucial roles in regulating AKI and ferroptosis, and targeted inhibition of these molecules can alleviate AKI. Misregulation of circadian clock components may contribute to the occurrence of ferroptosis, exacerbating the severity of AKI.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Cell Biology

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

Chuan'ai Chen et al.

Summary: The study demonstrates that deficiency of legumain attenuates acute renal tubular injury, inflammation, and ferroptosis in acute kidney injury models induced by ischemia-reperfusion injury or folic acid. Legumain deficiency prevents chaperone-mediated autophagy of GPX4, dampening ferroptosis induced by hypoxia or erastin. The results suggest that legumain promotes tubular ferroptosis in acute kidney injury by promoting chaperone-mediated autophagy of GPX4.

CELL DEATH & DISEASE (2021)

Article Medicine, Research & Experimental

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

Jiucui Li et al.

Summary: Panaxydol (PX) isolated from Panax ginseng roots attenuates ferroptosis against LPS-induced ALI via the Keap1-Nrf2/HO-1 pathway, showing promising therapeutic potential for ALI treatment.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Review Pharmacology & Pharmacy

Celastrol in metabolic diseases: Progress and application prospects

Shaohua Xu et al.

Summary: Celastrol, as an active ingredient derived from plants, has shown great potential in the treatment of metabolic diseases. Its anti-obesity effect is achieved through regulating various aspects, and it also shows effects on diseases like diabetes, atherosclerosis, and osteoporosis.

PHARMACOLOGICAL RESEARCH (2021)

Review Oncology

Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations

Kristen Renee McSweeney et al.

Summary: This article summarizes the characteristics of nephrotoxicity in cisplatin treatment, the pathophysiological mechanisms of kidney injury, and the current research on pharmacological treatment options to reduce AKI. Despite years of research, interventions, and clinical trials, there is still a lack of consistent pharmacological treatment options for cisplatin-induced acute kidney injury.

CANCERS (2021)

Article Multidisciplinary Sciences

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Wulf Tonnus et al.

Summary: This study demonstrates the role of ferroptosis in acute kidney injury and how dysfunction of Gpx4 can hypersensitize mice to tubular damage. The researchers developed a dual inhibitor targeting RIPK1 and ferroptosis, which improved survival rates in mouse models of acute kidney injury.

NATURE COMMUNICATIONS (2021)

Review Medicine, Research & Experimental

Ferroptosis as a novel therapeutic target for cardiovascular disease

Xiaoguang Wu et al.

Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.

THERANOSTICS (2021)

Review Chemistry, Medicinal

Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone-methide triterpenoid celastrol

Yun Lu et al.

Summary: Celastrol, a quinone-methide triterpenoid, has shown potential in anticancer, anti-inflammatory, and antiobesity activities. Studies on its chemical structure and biosynthesis have advanced, but its clinical applications are limited due to toxic effects. Structural modifications have been explored to improve its pharmacological properties for future research.

MEDICINAL RESEARCH REVIEWS (2021)

Review Urology & Nephrology

AKI!Now Initiative: Recommendations for Awareness, Recognition, and Management of AKI

Kathleen D. Liu et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

Article Multidisciplinary Sciences

Ferroptosis as a target for protection against cardiomyopathy

Xuexian Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Medicine, Research & Experimental

Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule

Fei Deng et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Urology & Nephrology

Global epidemiology and outcomes of acute kidney injury

Eric A. J. Hoste et al.

NATURE REVIEWS NEPHROLOGY (2018)

Review Biochemistry & Molecular Biology

Mechanisms of ferroptosis

Jennifer Yinuo Cao et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Urology & Nephrology

Biomarkers of AKI: A Review of Mechanistic Relevance and Potential Therapeutic Implications

Joseph L. Alge et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Review Urology & Nephrology

Regulated Cell Death in AKI

Andreas Linkermann et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Review Oncology

Targeting apoptosis pathways in cancer by Chinese medicine

Min Li-Weber

CANCER LETTERS (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Review Urology & Nephrology

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

N. Pabla et al.

KIDNEY INTERNATIONAL (2008)

Article Biochemistry & Molecular Biology

Molecular understanding and modern application of traditional medicines: Triumphs and trials

Timothy W. Corson et al.