Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 167, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2023.115471
Keywords
COPD; Astaxanthin; Cigarette smoke; DNA damage; Apoptosis; ROS; Inflammation; Lung disease
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This study found that astaxanthin can attenuate DNA damage and apoptosis caused by cigarette smoke, and reduce the activation of Caspase-3. Astaxanthin can also decrease the production of intracellular reactive oxygen species by suppressing the expression of NOX4 and DUOX1.
Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease that is associated with environ-mental allergic component exposure. Cigarette smoke is an environmental toxicant that induces lung malfunction leading to various pulmonary diseases. Astaxanthin (AST) is a carotenoid that shows antioxidant and anti-inflammatory activities which might be a promising candidate for COPD therapy. In this study, we released that AST could attenuate cigarette smoke-induced DNA damage and apoptosis in vivo and in vitro. AST administration ameliorated cigarette smoke extract (CSE)-induced activation of Caspase-3 and apoptosis. Pre-treated mice with AST significantly decrease CSE-induced DNA damage which shows lower nuclear gamma-H2AX level. AST treatment also dramatically reduces the production of intracellular reactive oxygen species (ROS) by suppressing the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme 4 (NOX4) and dual oxidase 1 (DUOX1). Taken together, this study suggested that AST can decrease CSE-induced DNA damage and apoptosis by inhibiting NOX4/DUOX1 expression that promotes ROS generation. AST may be a potential protective agent against CSE-associated lung disease that is worth in-depth investigation.
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