4.7 Article

Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism

Related references

Note: Only part of the references are listed.
Article Nutrition & Dietetics

Different Alterations in Gut Microbiota between Bifidobacterium longum and Fecal Microbiota Transplantation Treatments in Propionic Acid Rat Model of Autism

Turki S. Abujamel et al.

Summary: This study evaluated the effect of Bifidobacterium (BF) treatment and fecal microbiota transplantation (FT) on gut microbiota in a propionic acid (PPA) rat model of autism using 16S rRNA sequencing. The results demonstrated that BF and FT treatments have the ability to regulate gut microbiota and restore dysbiosis caused by autism.

NUTRIENTS (2022)

Review Medicine, General & Internal

Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS

Longsha Liu et al.

Summary: The gut microbiome plays a crucial role in the development of neurological diseases, and this article explores the complex interactions between the gut microbiome and neurological conditions. It discusses the transition from lab research to clinical application and the limitations of current approaches. The authors emphasize the need for therapeutic models that take into account the diverse gut bacteria to advance the treatment of neurological diseases.

EBIOMEDICINE (2022)

Article Biochemistry & Molecular Biology

Haploinsufficiency of a Circadian Clock Gene Bmal1 (Arntl or Mop3) Causes Brain-Wide mTOR Hyperactivation and Autism-like Behavioral Phenotypes in Mice

Rubal Singla et al.

Summary: Approximately 50-80% of children with autism spectrum disorders (ASDs) experience sleep problems, and the role of circadian clock dysfunction in ASD development is still unclear. This study found that the clock gene Bmal1 is associated with ASD, and its deletion in mice leads to autism-like behaviors. By partially deleting the Bmal1 gene, the study showed that mice exhibited similar autism-like behavioral changes. This research provides further evidence of disrupted clock gene expression in the development of ASD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Psychiatry

Maternal immune activation induces autism-like changes in behavior, neuroinflammatory profile and gut microbiota in mouse offspring of both sexes

Anna Maria Tartaglione et al.

Summary: Autism Spectrum Disorder (ASD) is a sex-biased neurodevelopmental disorder with deficits in social communication, interaction, and repetitive behaviors. Evidence suggests that maternal immune activation (MIA) may be a risk factor for ASD, impacting behavior, gut microbiota, and neuroinflammation in offspring.

TRANSLATIONAL PSYCHIATRY (2022)

Review Microbiology

The gut microbiota-brain axis in behaviour and brain disorders

Livia H. Morais et al.

Summary: This Review discusses the intricate and potentially important connections between the gut microbiota and the brain, involving bidirectional communication along the gut-brain axis. Emerging evidence suggests that disruptions in microbial communities may be implicated in neurological disorders, with animal models providing valuable insights into the pathways linking the gut and the brain which could have tangible impacts on human health.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Immunology

The Neuroprotective Effect of Short Chain Fatty Acids Against Sepsis-Associated Encephalopathy in Mice

Jiaming Liu et al.

Summary: The study found that SCFAs significantly alleviated behavioral impairments and neuronal degeneration in SAE mice, reduced levels of IL-1 beta and IL-6 in the brain, and modulated the expressions of TJ proteins, inflammatory factors, and phosphorylation of specific proteins in the brain, indicating a neuroprotective effect of SCFAs against SAE in mice.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Microbiota and Microglia Interactions in ASD

Marcela Davoli-Ferreira et al.

Summary: Environmental factors, particularly the gut microbiota, play a crucial role in influencing microglial cell behavior, potentially contributing to the development of autism spectrum disorders. Intestinal dysbiosis is commonly reported in ASD patients, and targeting the microbiome with therapies can alleviate behavioral symptoms. The intimate relationship between microglia and intestinal microbes suggests a key role in the etiology of ASD.

FRONTIERS IN IMMUNOLOGY (2021)

Review Gastroenterology & Hepatology

The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health

Ana Nogal et al.

Summary: Diet plays a crucial role in modulating gut microbiota composition and function, affecting the production of SCFAs which have beneficial effects on cardio-metabolic health. Targeting the gut microbiota through dietary strategies to increase SCFA production may be beneficial in improving cardio-metabolic outcomes.

GUT MICROBES (2021)

Article Biochemistry & Molecular Biology

Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders

Magdalena Gassowska-Dobrowolska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations

Zhi-Xiang Xu et al.

NATURE COMMUNICATIONS (2020)

Review Gastroenterology & Hepatology

The role of short-chain fatty acids in microbiota-gut-brain communication

Boushra Dalile et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Neurosciences

Neuron-Glia Signaling in Synapse Elimination

Daniel K. Wilton et al.

Annual Review of Neuroscience (2019)

Article Multidisciplinary Sciences

The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour

Nuria Dominguez-Iturza et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder

Simeng Liu et al.

SCIENTIFIC REPORTS (2019)

Review Neurosciences

The valproic acid-induced rodent model of autism

Chiara Nicolini et al.

EXPERIMENTAL NEUROLOGY (2018)

Review Biochemistry & Molecular Biology

The Impact of Carnitine on Dietary Fiber and Gut Bacteria Metabolism and Their Mutual Interaction in Monogastrics

Abdallah Ghonimy et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Increased circulation mobilization of endothelial progenitor cells in preterm infants with retinopathy of prematurity

Homa Babaei et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Review Clinical Neurology

The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders

Heather K. Hughes et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2018)

Article Immunology

Microglia priming by interleukin-6 signaling is enhanced in aged mice

Katherine M. Garner et al.

JOURNAL OF NEUROIMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Soyon Hong et al.

SCIENCE (2016)

Review Microbiology

Carnitine in bacterial physiology and metabolism

Jamie A. Meadows et al.

MICROBIOLOGY-SGM (2015)

Article Neurosciences

Host microbiota constantly control maturation and function of microglia in the CNS

Daniel Erny et al.

NATURE NEUROSCIENCE (2015)

Review Neurosciences

Microglia in the pathogenesis of autism spectrum disorders

Ryuta Koyama et al.

NEUROSCIENCE RESEARCH (2015)

Article Neurosciences

Altered Cytokine and BDNF Levels in Autism Spectrum Disorder

S. Ricci et al.

NEUROTOXICITY RESEARCH (2013)

Article Endocrinology & Metabolism

Acute management of propionic acidemia

Kimberly A. Chapman et al.

MOLECULAR GENETICS AND METABOLISM (2012)

Article Neurosciences

Neuroprotective Effects of Acetyl-L-carnitine on Neuropathic Pain and Apoptosis: A Role for the Nicotinic Receptor

Lorenzo Di Cesare Mannelli et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2009)

Article Psychology, Developmental

A new neurobehavioral model of autism in mice: Pre- and postnatal exposure to sodium valproate

George C. Wagner et al.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2006)

Article Neurosciences

Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism

T Schneider et al.

NEUROPSYCHOPHARMACOLOGY (2005)

Article Biochemistry & Molecular Biology

The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation

J Boren et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Nutrition & Dietetics

Regulation of short-chain fatty acid production

S Macfarlane et al.

PROCEEDINGS OF THE NUTRITION SOCIETY (2003)