Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits

a-Mangostin (a-MG) is a natural xanthone obtained from the pericarps of mangosteen. It exhibits excellent po-tential, including anti-cancer, neuroprotective, antimicrobial, antioxidant, and anti-inflammatory properties, and induces apoptosis. a-MG controls cell proliferation by modulating signaling molecules, thus implicated in cancer therapy. It possesses incredible pharmacological features and modulates crucial cellular and molecular factors. Due to its lesser water solubility and pitiable target selectivity, a-MG has limited clinical application. As a known antioxidant, a-MG has gained significant attention from the scientific community, increasing interest in extensive technical and biomedical applications. Nanoparticle-based drug delivery systems were designed to improve the pharmacological features and efficiency of a-MG. This review is focused on recent developments on the thera-peutic potential of a-MG in managing cancer and neurological diseases, with a special focus on its mechanism of action. In addition, we highlighted biochemical and pharmacological features, metabolism, functions, anti-inflammatory, antioxidant effects and pre-clinical applications of a-MG.

Automated summary

a-MG is a natural xanthone obtained from the pericarps of mangosteen, possessing various beneficial properties like anticancer, neuroprotective, antimicrobial, antioxidant, and anti-inflammatory effects, and inducing apoptosis. It controls cell proliferation by modulating signaling molecules and shows potential in cancer therapy, but its limited clinical application is due to low water solubility and poor target selectivity. Nanoparticle-based drug delivery systems have been developed to improve the pharmacological features and efficiency of a-MG.