4.7 Article

Deficiency of HtrA4 in BeWo cells downregulates angiogenesis through IL-6/JAK/STAT3 signaling

Related references

Note: Only part of the references are listed.
Article Cell Biology

Cellular Functions of High-Temperature Requirement Factor A4 in Placenta

Chang-Zhu Pei et al.

Summary: The expression of High-temperature requirement factor A4 (HtrA4) mRNA is lower in patients with recurrent pregnancy loss (RPL) compared to the control group. Knockout BeWo cells with reduced invasion and fusion capacity and increased proliferation and migration were created using the CRISPR/Cas9 system. Depletion of HtrA4 in JEG3 cells resulted in decreased invasion capacity but increased migration capacity. The findings suggest that HtrA4 may be associated with placental dysfunction in RPL patients.

CELLS (2023)

Article Obstetrics & Gynecology

First trimester HtrA1 maternal plasma level and spontaneous preterm birth

Stefano Raffaele Giannubilo et al.

Summary: The objective of this study was to determine whether the concentration of HtrA1 in maternal plasma can be used to identify women at risk for spontaneous preterm birth (SPTB). The results showed that HtrA1 concentration was significantly associated with SPTB, and BMI before pregnancy and physical activity were also found to affect the probability of SPTB.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

Review Cell Biology

Human placental development and function

Tereza Cindrova-Davies et al.

Summary: The placenta plays a critical role in the health of the fetus and its mother. However, our understanding of placental development is limited due to ethical restrictions and lack of suitable models. This review discusses current knowledge of early human placental development, emphasizing the role of the maternal endometrium and fetal-maternal dialogue, and introduces the latest cell models.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2022)

Article Pharmacology & Pharmacy

Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts

Kanoko Yoshida et al.

Summary: This study found that ER stress influences the pathogenesis of HDP by inhibiting EVT invasion through HTRA1, leading to the development of HDP.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

Review Public, Environmental & Occupational Health

The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis

Samantha Lapehn et al.

Summary: Placental epigenomics provides insights into the developmental origins of health and disease hypothesis by evaluating the impact of prenatal exposures on gene expression and DNA methylation in the placenta. Recent studies have connected various prenatal exposures to placental epigenetic changes, as well as health outcomes in infants and children.

CURRENT ENVIRONMENTAL HEALTH REPORTS (2022)

Article Biochemical Research Methods

Computer-aided prediction and design of IL-6 inducing peptides: IL-6 plays a crucial role in COVID-19

Anjali Dhall et al.

Summary: IL-6 plays a crucial role in the progression of COVID-19, and a method for predicting IL-6 inducing peptides has been developed using machine learning techniques. By identifying IL-6 inducing peptides in different proteins of SARS-CoV-2, the study offers new insights for designing vaccines against COVID-19.

BRIEFINGS IN BIOINFORMATICS (2021)

Review Oncology

IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy

Alvaro Teijeira et al.

Summary: High levels of IL8 in cancer patients can accurately predict non-response to immunotherapy, as IL8 plays a key role in attracting and modulating neutrophils and macrophages to promote cancer progression and metastasis. Blocking IL8 or its receptors is being investigated as a potential therapeutic strategy in combination with immunotherapy.

CLINICAL CANCER RESEARCH (2021)

Article Medicine, Research & Experimental

Interleukin-6 released by oral lichen planus myofibroblasts promotes angiogenesis

Xiao-Heng Xu et al.

Summary: Oral lichen planus (OLP) is a chronic inflammatory disease with a potential for malignant transformation. OLP-associated fibroblasts play a role in promoting OLP angiogenesis through the secretion of IL-6, which can be inhibited by anti-IL-6 receptor antibody to suppress disease progression.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Biochemistry & Molecular Biology

Estrogens Regulate Placental Angiogenesis in Horses

Shingo Haneda et al.

Summary: The development and expansion of the placental vascular network in horses is regulated by estrogen, as demonstrated through a study that showed that estrogen suppression led to impaired placental vascular network. This suggests a potential estrogen-dependent vasculogenesis in equine chorionic and allantoic regions during the first trimester of pregnancy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Molecular Pathways of Cellular Senescence and Placental Aging in Late Fetal Growth Restriction and Stillbirth

Anna Kajdy et al.

Summary: Accelerated placental senescence is crucial in pregnancy pathologies, leading to fetal growth restriction and stillbirth. Aging of the placenta results in decreased cell function and accumulation of senescent cells in mitotic tissues.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts

Kanoko Yoshida et al.

Summary: The study demonstrates that A1AT regulates inflammatory cytokine expression and HTRA1-induced trophoblast invasion by inducing ER stress, which may lead to abnormal placental development at the maternal-fetal interface.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Placental mitochondrial function as a driver of angiogenesis and placental dysfunction

Yolanda Correia et al.

Summary: Placental dysfunction can lead to pregnancy complications such as stillbirth, preeclampsia, and intrauterine growth restriction. Mitochondrial function and adaptations play a crucial role in placental angiogenesis and dysfunction. Increased levels of the anti-angiogenic factor sFlt-1 have been linked to different preeclamptic phenotypes and can dysregulate mitochondrial function.

BIOLOGICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

MicroRNAs targeting VEGF are related to vascular dysfunction in preeclampsia

Isabel Witvrouwen et al.

Summary: In preeclampsia, lower levels of circulating miR-16 are associated with impaired vascular function, while higher levels of miR-200c are linked to increased arterial stiffness. These miRNAs may serve as potential diagnostic biomarkers for preeclampsia.

BIOSCIENCE REPORTS (2021)

Article Integrative & Complementary Medicine

Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway

Yunchao Xin et al.

Summary: The study revealed that low expression of TFF3 in thyroid cancer is associated with lymph node metastasis and poorer prognosis. TFF3 not only enhances cell motility, but also inhibits cell apoptosis. These effects are mediated through the IL-6/JAK/STAT3 signaling pathway.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

Review Biochemistry & Molecular Biology

Angiogenic Properties of Placenta-Derived Extracellular Vesicles in Normal Pregnancy and in Preeclampsia

Natalia Gebara et al.

Summary: Angiogenesis, regulated by extracellular vesicles (EVs) from gestational tissues, plays a crucial role in healthy pregnancy and is dysregulated in pregnancy-related diseases like preeclampsia. The use of EVs from placental stem cells shows promise in clinical applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Medicine, General & Internal

Pre-eclampsia

Lucy C. Chappell et al.

Summary: Pre-eclampsia is a pregnancy disorder characterized by placental malperfusion, leading to hypertension and multi-organ injury, with potential fetal growth restriction and stillbirth. While prophylactic low-dose aspirin can reduce the risk of preterm pre-eclampsia, there are currently no curative treatments once pre-eclampsia is diagnosed except for delivery. Ongoing studies are evaluating various strategies and drugs to prevent and manage pre-eclampsia.

LANCET (2021)

Review Nutrition & Dietetics

Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients

Zihao Huang et al.

Summary: Normal placental development and proper angiogenesis are crucial for fetal growth during pregnancy, with factors like VEGF, DLL4, Wnt, and Hedgehog playing key roles in the process. Cell proliferation, migration, and differentiation are affected by the synthesis and secretion of metabolites, as well as coordination or inhibition in signaling pathways.

ADVANCES IN NUTRITION (2021)

Review Genetics & Heredity

Novel Technologies for Target Delivery of Therapeutics to the Placenta during Pregnancy: A Review

Gerald J. Pepe et al.

Summary: Uterine spiral artery remodeling is crucial for placental perfusion and fetal growth, with impaired function leading to placental ischemia and complications in pregnancy. Current research is focused on developing gene therapy technologies for targeted delivery of payloads to the placenta, aiming to provide more effective treatment options for adverse pregnancies.

GENES (2021)

Article Biochemistry & Molecular Biology

Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway

Chengjun Hu et al.

Summary: The study reveals that Nox2 deficiency facilitates angiogenesis by inhibiting the VEGF-A and STAT3 pathway, and reducing VEGF-A expression through inducing ROS production in pigs' vascular endothelial cells. The findings suggest that Nox2 could be a potential therapeutic target for increasing VEGF-A expression to promote angiogenesis, and also serve as a prognostic indicator for fetus with IUGR.

REDOX BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Interleukin-6-mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors

Mangala Hegde et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Obstetrics & Gynecology

Association between first trimester plasma htra1 level and subsequent preeclampsia: A possible early marker?

Rosaria Gesuita et al.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2019)

Article Immunology

Type I interferons instigate fetal demise after Zika virus infection

Laura J. Yockey et al.

SCIENCE IMMUNOLOGY (2018)

Review Biotechnology & Applied Microbiology

Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling

Robyn D. Pereira et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Review Immunology

Interleukin-6 in pregnancy and gestational disorders

Jelmer R. Prins et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2012)

Article Developmental Biology

Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia

A. Inagaki et al.

PLACENTA (2012)

Article Endocrinology & Metabolism

Effect of tocopherol supplementation during last trimester of pregnancy on mRNA abundances of interleukins and angiogenesis in ovine placenta and uterus

Ramanathan K. Kasimanickam et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2012)

Review Biochemistry & Molecular Biology

IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

Markus F. Neurath et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2011)

Article Immunology

IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway

Lin Wang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

Article Obstetrics & Gynecology

Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion

Funminiyi Ajayi et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2008)

Editorial Material Developmental Biology

Prediction of preeclampsia - A workshop report

N. G. Than et al.

PLACENTA (2008)

Review Oncology

The role of IL-6 and STAT3 in inflammation and cancer

DR Hodge et al.

EUROPEAN JOURNAL OF CANCER (2005)

Article Biochemistry & Molecular Biology

Expression of angiogenesis- and apoptosis-related genes in chorionic villi derived from recurrent pregnancy loss patients

HK Choi et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2003)

Article Developmental Biology

Comparison of gene expression at the feto-maternal interface between normal and recurrent pregnancy loss patients

KH Baek et al.

REPRODUCTION FERTILITY AND DEVELOPMENT (2002)