4.7 Article

Dexmedetomidine attenuates sleep deprivation-induced inhibition of hippocampal neurogenesis via VEGF-VEGFR2 signaling and inhibits neuroinflammation

Related references

Note: Only part of the references are listed.
Review Neurosciences

The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases

Mobina Amanollahi et al.

Summary: Adult neurogenesis plays a critical role in various neurological disorders, and neuroinflammation is a key factor that can affect this process by regulating multiple steps of neurogenesis. Understanding the effects of immune components on adult neurogenesis can provide insights into potential therapeutic candidates for these disorders.

MOLECULAR NEUROBIOLOGY (2023)

Review Psychology

Understanding the Need for Sleep to Improve Cognition

Ruth L. F. Leong et al.

Summary: The restorative function of sleep is influenced by its duration, timing, continuity, subjective quality, and efficiency. Sleep recommendations based solely on self-reports may lack accuracy and important details. Sleep traits like duration, timing, and ability to withstand sleep deprivation can change with age and impact individual sleep prescription. Social norms, work, and relationships also affect sleep opportunity and quality. Restriction of sleep time can negatively impact behavior, brain activity, sleep structure, and cognitive function in late life. Enhancing sleep quality through slow oscillations and spindles is not consistently effective. Custom sleep recommendations could benefit from comprehensive objective sleep data integrated with behavioral and self-reported data.

ANNUAL REVIEW OF PSYCHOLOGY (2023)

Article Behavioral Sciences

Understanding neuron-glia crosstalk and biological clocks in insomnia

Catarina Carvalhas-Almeida et al.

Summary: According to the World Health Organization, insomnia symptoms affect about one-third of the population, with chronic insomnia affecting around 10-15% of individuals. Chronic sleep deprivation and insomnia can lead to disruption in the internal synchronisation of biological clocks, resulting in negative health impacts. Glial cells, particularly microglia and astrocytes, play a role in circadian rhythm regulation and sleep/circadian regulation and overall healthy brain function. Understanding the interplay between glial cells and neurons is crucial in addressing sleep disorders and maintaining brain health.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2023)

Article Medicine, Research & Experimental

Dexmedetomidine attenuates perioperative neurocognitive disorders by suppressing hippocampal neuroinflammation and HMGB1/RAGE/NF-κB signaling pathway

Jinxu Wang et al.

Summary: This study aimed to observe the neuroprotective effect of Dex pretreatment on postoperative cognitive change and explore the mechanisms involving hippocampal neuroinflammation, microglial polarization, and HMGB1/RAGE/NF-kappa B signaling pathway. The results showed that Dex pretreatment could improve postoperative short-term cognitive impairment by suppressing hippocampal neuroinflammation, regulating M1/M2 polarization, and inhibiting the HMGB1/RAGE/NF-kappa B signal transduction.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Biochemistry & Molecular Biology

Association between vascular endothelial growth factor-mediated blood-brain barrier dysfunction and stress-induced depression

Hitomi Matsuno et al.

Summary: Several lines of evidence suggest that stress-induced neurovascular dysfunction and increased blood-brain barrier permeability are important pathological links between stress and psychiatric disorders. This study demonstrates the crucial role of vascular endothelial growth factor in stress-induced blood-brain barrier dysfunction and depressive-like behavior development.

MOLECULAR PSYCHIATRY (2022)

Article Psychiatry

Intranasal Dexmedetomidine for the Treatment of Pre-operative Anxiety and Insomnia: A Prospective, Randomized, Controlled, and Clinical Trial

Wen Zeng et al.

Summary: Intranasal dexmedetomidine (DEX) is applicable in the treatment of pre-operative anxiety and insomnia, significantly improving sleep time and quality for patients and leading to higher treatment satisfaction.

FRONTIERS IN PSYCHIATRY (2022)

Review Immunology

Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease

Deepali Singh

Summary: Neuroinflammation is caused by the misfiring of immune cells in the central nervous system and can have both positive and negative effects on neurodevelopment and post-injury tissue. Chronic or uncontrolled inflammatory responses may lead to neurodegenerative diseases, while abnormal activation of glial cells can mediate neuroinflammation.

JOURNAL OF NEUROINFLAMMATION (2022)

Article Neurosciences

Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis

Na Duan et al.

Summary: This study reveals that chronic stress leads to depressive behaviors and increased levels of proinflammatory cytokines in the brain. Activation of the STING pathway enhances microglial phagocytosis and suppresses the release of proinflammatory cytokines, resulting in antidepressant effects.

NEUROBIOLOGY OF DISEASE (2022)

Review Pharmacology & Pharmacy

Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions

Silvia Squillace et al.

Summary: Toll-like receptors play important roles in immune responses and are also involved in brain functions. Increasing evidence suggests their involvement in aging and cognitive decline. These findings provide new potential targets for the development of drugs for the treatment of cognitive impairment.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

Article Clinical Neurology

Depriving Mice of Sleep also Deprives of Food

Nina Dukanovic et al.

Summary: The study found that sleep deprivation did not alter clock gene expression in the cortex of mice, and although food intake during sleep deprivation did not differ from baseline, mice lost weight and increased food intake during subsequent recovery. This suggests that the effects commonly attributed to sleep loss during sleep deprivation may actually be related to the resulting energy deficit from food deprivation.

CLOCKS & SLEEP (2022)

Article Immunology

Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor

Bin Mei et al.

Summary: Sepsis-associated encephalopathy (SAE) is a significant clinical issue associated with increased mortality and healthcare costs. Dexmedetomidine, an alpha 2 adrenoceptor agonist, has been shown to induce neuroprotection in septic mice by reducing systemic inflammation, neuroinflammation, blood-brain barrier injury, and cognitive dysfunction, possibly through activation of alpha 2A adrenoceptors in astrocytes.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Neurosciences

Electroacupuncture promotes the survival and synaptic plasticity of hippocampal neurons and improvement of sleep deprivation-induced spatial memory impairment

Wenya Pei et al.

Summary: The study showed that electroacupuncture attenuated the loss of hippocampal neurons and synapses, stimulated hippocampal neurogenesis, and improved learning and memory in rats under sleep deprivation by upregulating BDNF and increasing the phosphorylation of TrkB and Erk. In cultured hippocampal neurons, exogenous BDNF enhanced synaptic plasticity through TrkB/Erk signaling, while this effect was reversed by treatment with the TrkB inhibitor K252a.

CNS NEUROSCIENCE & THERAPEUTICS (2021)

Article Multidisciplinary Sciences

IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis

Jinqiang Zhang et al.

Summary: IL4-driven microglia expressing Arg1 in the hippocampus play a crucial role in maintaining neurogenesis and enhancing stress resilience. Modulating the expression of these microglia through IL4 signaling can restore neurogenesis and resilience. Additionally, BDNF is necessary for the proneurogenesis effects of these microglia.

SCIENCE ADVANCES (2021)

Article Nutrition & Dietetics

Efficacy of a Multi-Component m-Health Diet, Physical Activity, and Sleep Intervention on Dietary Intake in Adults with Overweight and Obesity: A Randomised Controlled Trial

Sasha Fenton et al.

Summary: This three-arm randomised controlled trial found that a multi-component weight loss intervention could effectively reduce total energy and sodium intake and increase fruit intake in adults at six months. However, at twelve months, the enhanced intervention group showed significant improvements in dietary intake compared to the traditional group.

NUTRIENTS (2021)

Article Medicine, General & Internal

The evolving clinical use of dexmedetomidine

Federico Bilotta et al.

LANCET (2020)

Article Integrative & Complementary Medicine

Effect of Electroacupuncture at GV20 on Sleep Deprivation-Induced Depression-Like Behavior in Mice

Xiaohong Xu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

Review Cell & Tissue Engineering

Adult Neurogenesis, Glia, and the Extracellular Matrix

Elise C. Cope et al.

CELL STEM CELL (2019)

Article Chemistry, Medicinal

Dexmedetomidine Promotes Hippocampal Neurogenesis and Improves Spatial Learning and Memory in Neonatal Rats

Yahan Zhang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

Review Neurosciences

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

Lijuan Zhang et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Article Neurosciences

Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex

Michele Bellesi et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior

P. De Rossi et al.

MOLECULAR PSYCHIATRY (2016)

Review Immunology

Astrocytes: Key Regulators of Neuroinflammation

Emanuela Colombo et al.

TRENDS IN IMMUNOLOGY (2016)

Review Psychology

Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective

Michael R. Irwin

ANNUAL REVIEW OF PSYCHOLOGY, VOL 66 (2015)

Article Multidisciplinary Sciences

Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF

Elizabeth D. Kirby et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Immunology

Control of autoimmune CNS inflammation by astrocytes

Veit Rothhammer et al.

SEMINARS IN IMMUNOPATHOLOGY (2015)

Review Neurosciences

Detrimental role of prolonged sleep deprivation on adult neurogenesis

Carina Femandes et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Review Biochemistry & Molecular Biology

Delineating multiple functions of VEGF-A in the adult brain

Tamar Licht et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Review Biochemistry & Molecular Biology

VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration

Peter Carmeliet et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Review Oncology

VEGF targets the tumour cell

Hira Lal Goel et al.

NATURE REVIEWS CANCER (2013)

Article Clinical Neurology

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

Chuanyu Li et al.

Current Alzheimer Research (2011)

Review Cardiac & Cardiovascular Systems

Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies

Francesco P. Cappuccio et al.

EUROPEAN HEART JOURNAL (2011)

Article Multidisciplinary Sciences

Reversible modulations of neuronal plasticity by VEGF

Tamar Licht et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Developmental Biology

VEGF is required for dendritogenesis of newly born olfactory bulb interneurons

Tamar Licht et al.

DEVELOPMENT (2010)

Review Biochemistry & Molecular Biology

Adult hippocampal neurogenesis and related neurotrophic factors

Eugene Lee et al.

BMB REPORTS (2009)

Review Physiology

Role and Therapeutic Potential of VEGF in the Nervous System

Carmen Ruiz De Almodovar et al.

PHYSIOLOGICAL REVIEWS (2009)

Article Multidisciplinary Sciences

Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus

Eri Segi-Nishida et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Multidisciplinary Sciences

Pathophysiological consequences of VEGF-induced vascular permeability

SM Weis et al.

NATURE (2005)

Review Biotechnology & Applied Microbiology

The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease

DIR Holmes et al.

GENOME BIOLOGY (2005)

Article Genetics & Heredity

VEGF links hippocampal activity with neurogenesis, learning and memory

L Cao et al.

NATURE GENETICS (2004)

Article Multidisciplinary Sciences

Inflammatory blockade restores adult hippocampal neurogenesis

ML Monje et al.

SCIENCE (2003)

Review Neurosciences

Adult neurogenesis and neural stem cells of the central nervous system in mammals

P Taupin et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2002)

Article Multidisciplinary Sciences

Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

KL Jin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Astroglia induce neurogenesis from adult neural stem cells

SH Song et al.

NATURE (2002)

Article Multidisciplinary Sciences

Opiates inhibit neurogenesis in the adult rat hippocampus

AJ Eisch et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Developmental Biology

Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain

OO Ogunshola et al.

DEVELOPMENTAL BRAIN RESEARCH (2000)