☆ 4.7 Article

Methods and biomarkers for early detection, prediction, and diagnosis of colorectal cancer

BIOMEDICINE & PHARMACOTHERAPY (2023)

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Size and macromolecule stabilizer-dependent performance of gold colloids in immuno-PCR

Mahdis Sadat Tabatabaei et al.

Summary: This study explores the role of size and surface chemistry of gold nanoparticles in immuno-PCR assay. The results show that smaller-sized gold nanoparticles exhibit higher sensitivity and better loading capacity for proteins and oligonucleotides. The signal-to-noise ratio of GNP probes is significantly improved through functionalization.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)

Add to Collection
Review Oncology

Genomic landscape of colorectal carcinogenesis

Jin Cheon Kim et al.

Summary: This study assessed the molecular pathogenesis of solid tumors, focusing specifically on colorectal cancer. Through a review of relevant literature, it was found that colorectal carcinogenesis mainly occurs through chromosomal instability, microsatellite instability, and serrated pathway. Familial colorectal cancers and genotype-phenotype correlations also play a role in colorectal carcinogenesis. The use of multi-gene panels has facilitated the detection of previously unidentified genes involved in colorectal carcinogenesis.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3-eIF3h interaction

Rui Zheng et al.

Summary: This comprehensive study highlights the potential of plasma exosomal circLPAR1 in CRC diagnosis and describes its biological regulation of colorectal tumorigenesis.

MOLECULAR CANCER (2022)

Add to Collection
Article Oncology

Age-related Differences in Recall of Information and Handling of Chemotherapy-related Side Effects in Cancer Patients: The ReCap Study

Cecilia Margareta Lund et al.

Summary: Older age and poor cognitive screening may impact patients' ability to understand and adequately handle chemotherapy-related side effects. Cognitive screening and focus on individual ways to give information including assessment of recall and handling are needed.

ONCOLOGIST (2022)

Add to Collection
Review Oncology

Use of Omics Technologies for the Detection of Colorectal Cancer Biomarkers

Marina Alorda-Clara et al.

Summary: Colorectal cancer (CRC) is a highly diagnosed cancer with significant mortality rates, and early detection is crucial for improving patient survival. Current CRC screening programs involve stool tests and colonoscopies, but the use of new biomarkers could enhance screening effectiveness. Omics technologies offer promise in detecting novel biomarkers for CRC across different sample types.

CANCERS (2022)

Add to Collection
Article Cell Biology

Spatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver, and Lung Metastasis

Guillermo Solis-Fernandez et al.

Summary: In this study, quantitative spatial proteomics analysis was used to investigate lymph nodes, liver, and lung metastasis in colorectal cancer (CRC). The results revealed dysregulation of protein abundance and localization in these metastatic sites, with proteins such as GLG1 and MUC5AC being associated with poor prognosis and diagnosis of CRC.

CELLS (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Research Progress in Predicting DNA Methylation Modifications and the Relation with Human Diseases

Chunyan Ao et al.

Summary: This review provides a systematic summary of DNA methylation and its relationship with related diseases, including DNA methylation databases, prediction tools, and machine learning algorithms. A deep understanding of DNA methylation mechanisms can contribute to accurate prediction and treatment of related diseases.

CURRENT MEDICINAL CHEMISTRY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer

Yang Yang et al.

Summary: This study reports a novel mechanism and target related to P53-induced drug resistance and provides corresponding interventional strategies for the precision treatment of colorectal cancer (CRC).

CELL DEATH AND DIFFERENTIATION (2022)

Add to Collection
Article Medical Laboratory Technology

Combination of serum CST4 and DR-70 contributes to early diagnosis of colorectal cancer

Liqing Cai et al.

Summary: This study found that serum CST4 and DR-70 have diagnostic value for early CRC patients, and the combination of the two can further improve early detection of CRC.

CLINICA CHIMICA ACTA (2022)

Add to Collection
Article Gastroenterology & Hepatology

Young-onset colorectal cancer: Insights from an English population-based study

Joshua Franklyn et al.

Summary: This study analyzed the demographics, clinicopathological features, and prognosis of young colorectal cancer (CRC) patients in England. The results showed that young patients had a higher prevalence of right-sided colon cancer and better overall and relative survival rates compared to older patients with CRC.

COLORECTAL DISEASE (2022)

Add to Collection
Article Biochemistry & Molecular Biology

miR-485-3p and miR-4728-5p as Tumor Suppressors in Pathogenesis of Colorectal Cancer

T. Gurer et al.

Summary: miR-485-3p and miR-4728-5p expression levels were significantly downregulated in CRC tissues, with lower expression of miR-485-3p in both rectum and colon and decreased miR-4728-5p expression associated with age. Bioinformatics analysis identified TFs associated with these miRNAs, suggesting a potential role in early diagnosis and treatment of CRC. Pathway enrichment analysis highlighted the involvement of Hippo signaling pathway in the regulation of miR-485-3p.

MOLECULAR BIOLOGY (2022)

Add to Collection
Article Plant Sciences

Modified Shenlingbaizhu Decoction represses the pluripotency of colorectal cancer stem cells by inhibiting TGF-β mediated EMT program

Yu Dai et al.

Summary: The Modified Shenlingbaizhu Decoction (MSD) has been found to inhibit the pluripotency of colorectal cancer stem cells (CSCs) and impede the epithelial-mesenchymal transition (EMT) program. MSD treatment significantly reduces tumor size and TGF-beta 1 content in mice, while also decreasing the expression of pluripotent factors and stem cells in tumor tissues.

PHYTOMEDICINE (2022)

Add to Collection
Article Oncology

Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer

Mihir Rajurkar et al.

Summary: Aberrant RNA expression of repetitive sequences and retrotransposition are common in colorectal cancer and can be targeted by the nucleoside reverse transcriptase inhibitor 3TC. The preferential effect of 3TC on p53-mutant cell lines is attributed to direct binding of p53 to repeat elements. Clinical trials have shown that single-agent 3TC treatment benefits a subset of metastatic colorectal cancer patients. 3TC induces the accumulation of immunogenic RNA:DNA hybrids, interferon response, and DNA damage response in colorectal cancer tumorspheres. Epigenetic and DNA-damaging agents enhance the cytotoxicity of 3TC. These findings highlight the therapeutic potential of targeting the viral mimicry of repeat elements in colorectal cancer.

CANCER DISCOVERY (2022)

Add to Collection
Review Oncology

Colorectal Cancer Diagnosis: The Obstacles We Face in Determining a Non-Invasive Test and Current Advances in Biomarker Detection

Faddy Kamel et al.

Summary: Colorectal cancer (CRC) is a commonly occurring cancer that originates from adenomatous polyps. Current detection methods, such as colonoscopy, are invasive and uncomfortable. While some molecular biomarkers have been approved for use, the development of non-invasive and highly specific biomarkers for early detection and screening is urgently needed. This review evaluates the current methods and availability of biomarkers, and discusses the potential of transcriptome analysis in discovering differential gene expression in CRC.

CANCERS (2022)

Add to Collection
Article Oncology

Tumor-Originated Exosomal hsa-miR-3937 as a Minimally Invasive Early Biomarker for Liquid Biopsy of Colorectal Cancer

Dan Qiao et al.

Summary: This study identified tumor-originated exosomal hsa-miR-3937 as a potential and effective liquid biopsy marker for colorectal cancer detection and therapy, and investigated its role and mechanism in CRC.

JOURNAL OF ONCOLOGY (2022)

Add to Collection
Article Oncology

Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

Hannah Shailes et al.

Summary: This study identified a synthetic lethal relationship between APC mutations and statin treatment, which could potentially be used for the treatment of APC mutated cancers by decreasing Wnt signaling and reducing the expression of the anti-apoptotic protein Survivin.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection
Article Medicine, General & Internal

Role of MicroRNA-223 and MicroRNA-182 as Novel Biomarkers in Early Detection of Colorectal Cancer

Hala A. Mahmoud et al.

Summary: MiR-223 and miR-182 play crucial roles in early detection and prognosis evaluation of colorectal cancer.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

Add to Collection
Article Gastroenterology & Hepatology

Feasibility of quantification based on novel evaluation with stool DNA and fecal immunochemical test for colorectal cancer detection

Hongli Xu et al.

Summary: The study evaluated the performance of sDNA and FIT in CRC screening and monitoring in Hubei, China. The results showed that the novel evaluation had increased sensitivity for early CRC and AA detection. The dynamic changes of the comprehensive value after surgery were correlated with CRC treatment.

BMC GASTROENTEROLOGY (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited

Daniella C. N. Hall et al.

Summary: PIK3CA mutations are common in cancer and associated with resistance to treatment and low survival rates. Aspirin may benefit patients with PIK3CA mutations, especially in colorectal cancer. This review aims to summarize and analyze the mechanisms and targets behind aspirin sensitivity in PIK3CA-mutated cancers.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Add to Collection
Article Cell Biology

Diagnostic and prognostic biomarkers in colorectal cancer and the potential role of exosomes in drug delivery

Real Sumayya Abdul Sattar et al.

CELLULAR SIGNALLING (2022)

Add to Collection
Article Oncology

APC mutations as a predictive marker of endometrial cancer immunotherapy: a retrospective cohort study

Yiran Li et al.

LANCET ONCOLOGY (2022)

Add to Collection
Article Pathology

LncRNA SPINT1-AS1/miR-433-3p/E2F3 positive feedback loop promotes the KRAS-mutant colorectal cancer cell proliferation, migration and invasion

Xiujie Sui et al.

Summary: SPINT1-AS1 regulates the proliferation, migration, and invasion of CRC cells by interacting with miR-433-3p and E2F3.

PATHOLOGY RESEARCH AND PRACTICE (2022)

Add to Collection
Article Plant Sciences

Asperuloside inhibited epithelial-mesenchymal transition in colitis associated cancer via activation of vitamin D receptor

Yingyu Lu et al.

Summary: Asperuloside shows potential in preventing colorectal cancer by inhibiting epithelial-mesenchymal transition (EMT) development through regulation of VDR/Smad3 pathway. This natural compound exhibits significant anti-tumor effects and may serve as a promising therapeutic agent for colorectal cancer.

PHYTOMEDICINE (2022)

Add to Collection
Article Oncology

Identification of IMPA2 as the hub gene associated with colorectal cancer and liver metastasis by integrated bioinformatics analysis

Liuli Wang et al.

Summary: This study identifies and reports IMPA2 as a hub gene biomarker for the diagnosis and prognosis of CRC. IMPA2 expression is significantly decreased and correlates with poor prognosis. The gene may regulate CRC carcinogenesis and liver metastasis through the regulation of lipid metabolism, EMT, and DNA methylation.

TRANSLATIONAL ONCOLOGY (2022)

Add to Collection
Article Immunology

BEZ235 Prolongs Murine Cardiac Allograft Survival Through the Autophagy Pathway

Xiaolong Miao et al.

Summary: BEZ235 prolongs cardiac allograft survival through inducing autophagy and altering the expression of inflammatory factors.

TRANSPLANTATION PROCEEDINGS (2022)

Add to Collection
Review Biotechnology & Applied Microbiology

A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population

Hafeez Afolabi et al.

Summary: This study conducted a meta-analysis to investigate the prevalence of KRAS and BRAF mutations among CRC patients in Asia. The results showed that the overall prevalence of KRAS mutations was 36.3%, with major mutations occurring in codon 12, while the prevalence of BRAF mutations was 5.6%. There were variations in mutation prevalence among different geographical locations.

BIOMED RESEARCH INTERNATIONAL (2022)

Add to Collection
Article Pharmacology & Pharmacy

Coptidis Rhizoma Suppresses Metastatic Behavior by Inhibiting TGF-beta-Mediated Epithelial-Mesenchymal Transition in 5-FU-Resistant HCT116 Cells

Yong-Hwi Kang et al.

Summary: Colorectal cancer is the second most lethal malignancy worldwide, and its high mortality rate is largely due to cancer metastasis. Suppression of epithelial-to-mesenchymal transition (EMT) has emerged as a promising strategy for treating metastatic cancer. This study evaluated the antimetastatic effect of Coptidis Rhizoma, a traditional Chinese medicine, on drug-resistant colon cancer cells and found that it inhibits EMT through the TGF-beta signaling pathway.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection
Article Surgery

Rescue percutaneous transhepatic portal vein embolization after failed associated liver partition and portal vein ligation for staged hepatectomy in a patient with multiple liver metastases of rectal cancer: a case report

Hidenori Tomida et al.

Summary: ALPPS surgery is crucial for treating initially unresectable colorectal cancer liver metastasis; Resumption of portal venous blood flow through collateral vessels after ALPPS may interfere with residual liver hypertrophy; Consideration of remnant portal venous blood flow in surgical planning, early additional portal vein embolization could be effective.

SURGICAL CASE REPORTS (2022)

Add to Collection
Article Medicine, Research & Experimental

Comprehensive characterization of ubiquitinome of human colorectal cancer and identification of potential survival-related ubiquitination

Wei Zhang et al.

Summary: This study characterized the ubiquitinome of CRC cells and identified abnormal ubiquitination(s) potentially affecting patient survival. The findings shed light on the functions and pathways associated with ubiquitination in CRC, as well as the potential role of FOCAD mutations in RNA localization and translation. These findings offer new opportunities for clinical treatment.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

Add to Collection
Article Oncology

Correlation of miR-31 and miR-373 expression with KRAS mutations and its impact on prognosis in colorectal cancer

Hasan Ashoori et al.

Summary: This study investigated the role of miR-31 and miR-373 in the pathogenesis of CRC and their association with histopathological features. It also explored the prognostic value of these molecular markers in CRC patients with or without common KRAS mutations.

JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE (2022)

Add to Collection
Article Biochemistry & Molecular Biology

KRAS Mutation: Characterization and Its Impact on Survival Outcome of Patients with Metastatic Colorectal Cancer

Datul Damit et al.

Summary: This study determined the survival outcome of metastatic colorectal cancer (mCRC) in Brunei Darussalam and established the association with KRAS mutation. The results showed a significant difference in survival outcomes between wild-type KRAS and mutant KRAS mCRC patients in the Brunei population.

FRONTIERS IN BIOSCIENCE-LANDMARK (2022)

Add to Collection
Article Chemistry, Analytical

A Prussian blue nanoparticles-based fluorescent nanoprobe for monitoring microRNA-92a and microRNA-21

Yao Li et al.

Summary: A simple and sensitive fluorescent biosensor was developed for the detection of crucial biomarkers, miR-92a and miR-21, in colorectal cancer. The biosensor showed high sensitivity, specificity, and cost-effectiveness. This study lays a potential foundation for early diagnosis of cancer using the developed biosensor.

ANALYTICAL SCIENCES (2022)

Add to Collection
Article Gastroenterology & Hepatology

Evaluation of combined detection of multigene mutation and SDC2/SFRP2 methylation in stool specimens for colorectal cancer early diagnosis

Jie Lin et al.

Summary: The combined detection of fecal KRAS/BRAF/APC mutation and SFRP2/SDC2 methylation can serve as an auxiliary diagnostic approach for colorectal cancer and advanced adenoma, with high sensitivity and diagnostic specificity.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2022)

Add to Collection
Article Oncology

Applications of Artificial Intelligence in Screening, Diagnosis, Treatment, and Prognosis of Colorectal Cancer

Hang Qiu et al.

Summary: This article reviews the research progress and clinical application value of artificial intelligence technologies in the screening, diagnosis, treatment, and prognosis of colorectal cancer. The limitations and challenges in the clinical implementation of AI are also discussed.

CURRENT ONCOLOGY (2022)

Add to Collection
Article Biotechnology & Applied Microbiology

A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population

Hafeez Afolabi et al.

Summary: KRAS and BRAF mutations play a crucial role in the pathogenesis of colorectal carcinoma, leading to treatment failure and poor prognosis. The prevalence of KRAS mutations among CRC patients in Asia was found to be 36.3%, while that of BRAF mutations was 5.6%.

BIOMED RESEARCH INTERNATIONAL (2022)

Add to Collection
Review Biotechnology & Applied Microbiology

Novel Genetic and Epigenetic Biomarkers of Prognostic and Predictive Significance in Stage II/III Colorectal Cancer

Xiao-Jing Luo et al.

Summary: The therapeutic strategies for stage II/III colorectal cancer patients post-surgery are still debated, with the need for better biomarkers to stratify patients for adjuvant chemotherapy. Recent advances in sequencing and high-throughput technologies have led to the discovery of novel genetic and epigenetic biomarkers that could aid in prognosis and treatment responses in CRC.

MOLECULAR THERAPY (2021)

Add to Collection
Article Multidisciplinary Sciences

Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

Pauline A. J. Mendelaar et al.

Summary: The genomic landscape of metastatic colorectal cancers (mCRC) shows distinct changes compared to primary CRC, influenced by prior treatments, and contains features with potential clinical relevance. Specific genes are associated with treatment response, such as LINC00672 mutations correlating with general response and FBXW7 mutations predicting poor response to EGFR-targeted treatment.

NATURE COMMUNICATIONS (2021)

Add to Collection
Review Chemistry, Medicinal

A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors

Manjinder Singh Phull et al.

Summary: Colorectal cancer is a major cause of carcinogenic mortality, with mutations in the APC gene playing a key role. Current research is focused on developing new anti-colorectal cancer drugs by targeting essential cellular components.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection
Article Oncology

Global colorectal cancer burden in 2020 and projections to 2040

Yue Xi et al.

Summary: Colorectal cancer is a major global public health challenge with higher incidence rates in developed countries and increasing trends in middle- and low-income countries. The rise of early-onset colorectal cancer is also seen. Increasing awareness, promoting healthy lifestyle choices, and implementing global screening programs are crucial in reducing the morbidity and mortality of colorectal cancer in the future.

TRANSLATIONAL ONCOLOGY (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis

Alessio Ardizzone et al.

Summary: Cancer is a multifactorial disease with high mortality often linked to late diagnosis. The discovery of miRNAs has been crucial for cancer research, with miR-19a playing a key role in tumor growth, invasion, and prognosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Review Oncology

Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer

Maria Radanova et al.

Summary: Recent studies have highlighted the potential of circRNAs as new diagnostic and prognostic biomarkers in colorectal cancer (CRC), with a focus on their clinical significance and diagnostic potential. The reliability of circRNAs as non-invasive biomarkers and the challenges of finding more reliable biomarkers for early diagnosis and predicting metastasis and resistance to therapies have been discussed. There is a growing understanding of the role of oncogenic circRNAs in CRC pathogenesis and the potential for using them as new drug targets in personalized treatment.

CANCERS (2021)

Add to Collection
Review Immunology

The inflammatory pathogenesis of colorectal cancer

Mark Schmitt et al.

Summary: The research on colorectal cancer indicates the importance of an inflammatory microenvironment for tumorigenesis, which influences the activation of immune cells and stromal cells, as well as the role of intestinal microbiome in tumor development. Chronic inflammation can initiate tumorigenesis, and tumor-elicited and therapy-induced inflammation are also implicated in promoting colorectal cancer.

NATURE REVIEWS IMMUNOLOGY (2021)

Add to Collection
Article Gastroenterology & Hepatology

Long-term colorectal cancer incidence after adenoma removal and the effects of surveillance on incidence: a multicentre, retrospective, cohort study

Amanda J. Cross et al.

GUT (2020)

Add to Collection
Review Oncology

Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges

Eric Koncina et al.

CANCERS (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Proteomic Profiling of Colon Cancer Tissues: Discovery of New Candidate Biomarkers

Miriam Buttacavoli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection
Article Oncology

Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis

Francesca Tavano et al.

FRONTIERS IN ONCOLOGY (2020)

Add to Collection
Article Oncology

The relationship between KRAS gene mutation and intestinal flora in tumor tissues of colorectal cancer patients

Xinke Sui et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

Add to Collection
Review Biochemistry & Molecular Biology

The Liquid Biopsy in the Management of Colorectal Cancer: An Overview

Marco Vacante et al.

BIOMEDICINES (2020)

Add to Collection
Article Medicine, General & Internal

miR-485-3p suppresses colorectal cancer via targeting TPX2

K. Taherdangkoo et al.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY (2020)

Add to Collection
Review Oncology

Clinical diagnostic value of long non-coding RNAs in Colorectal Cancer: A systematic review and meta-analysis

Bi Chen et al.

JOURNAL OF CANCER (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives

Amirsaeed Sabeti Aghabozorgi et al.

BIOCHIMIE (2019)

Add to Collection
Article Genetics & Heredity

A panel of seven-miRNA signature in plasma as potential biomarker for colorectal cancer diagnosis

Huo Zhang et al.

GENE (2019)

Add to Collection
Article Oncology

Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines

Pietro Paolo Vitiello et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Add to Collection
Article Oncology

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

Winifred Lo et al.

CANCER IMMUNOLOGY RESEARCH (2019)

Add to Collection
Review Biochemistry & Molecular Biology

Epidrugs: targeting epigenetic marks in cancer treatment

Cristiana Libardi Miranda Furtado et al.

EPIGENETICS (2019)

Add to Collection
Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

Lasse S. Kristensen et al.

NATURE REVIEWS GENETICS (2019)

Add to Collection
Review Medicine, General & Internal

Colorectal cancer

Evelien Dekker et al.

LANCET (2019)

Add to Collection
Article Medicine, General & Internal

A Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis

Oscar Rapado-Gonzalez et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Add to Collection
Article Biochemistry & Molecular Biology

RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers

Hanchen Xu et al.

MOLECULAR CANCER (2019)

Add to Collection
Article Multidisciplinary Sciences

Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer

Ariadna Martin-Blazquez et al.

SCIENTIFIC REPORTS (2019)

Add to Collection
Article Chemistry, Physical

The structural basis for Ras activation of PI3Kα lipid kinase

Mingzhen Zhang et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2019)

Add to Collection
Review Biochemical Research Methods

Proteomics for early detection of colorectal cancer: recent updates

Abdo Alnabulsi et al.

EXPERT REVIEW OF PROTEOMICS (2018)

Add to Collection
Article Cell Biology

MicroRNA-506-3p inhibits osteosarcoma cell proliferation and metastasis by suppressing RAB3D expression

Wang Jiashi et al.

AGING-US (2018)

Add to Collection
Article Oncology

SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients

Zhu Mei et al.

BMC CANCER (2018)

Add to Collection
Article Biochemistry & Molecular Biology

The role of TGF-beta/SMAD4 signaling in cancer

Ming Zhao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Add to Collection
Article Medicine, General & Internal

The IARC Perspective on Colorectal Cancer Screening

Beatrice Lauby-Secretan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Add to Collection
Article Multidisciplinary Sciences

Metabolomic approach for a rapid identification of natural products with cytotoxic activity against human colorectal cancer cells

Vittoria Graziani et al.

SCIENTIFIC REPORTS (2018)

Add to Collection
Article Genetics & Heredity

The Circular RNA Profiles of Colorectal Tumor Metastatic Cells

Weiqin Jiang et al.

FRONTIERS IN GENETICS (2018)

Add to Collection
Article Oncology

Five serum-based miRNAs were identified as potential diagnostic biomarkers in gastric cardia adenocarcinoma

Juan Wang et al.

CANCER BIOMARKERS (2018)

Add to Collection
Article Biochemistry & Molecular Biology

MicroRNA485-3p negatively regulates the transcriptional co-repressor CtBP1 to control the oncogenic process in osteosarcoma cells

Kaili Du et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Add to Collection
Review Oncology

Function and clinical significance of circRNAs in solid tumors

Yiting Geng et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Add to Collection
Review Biochemistry & Molecular Biology

Cancer-Associated PIK3CA Mutations in Overgrowth Disorders

Ralitsa R. Madsen et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Add to Collection
Article Multidisciplinary Sciences

Metabolomics and 16S rRNA sequencing of human colorectal cancers and adjacent mucosa

Mun Fai Loke et al.

PLOS ONE (2018)

Add to Collection
Article Cell Biology

Comprehensive Analysis of the Relationship Between RAS and RAF Mutations and MSI Status of Colorectal Cancer in Northeastern China

Wenqi Li et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Add to Collection
Article Oncology

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

David Barras et al.

CLINICAL CANCER RESEARCH (2017)

Add to Collection
Review Genetics & Heredity

The role of miRNA-223 in cancer: Function, diagnosis and therapy

Yunliang Gao et al.

GENE (2017)

Add to Collection
Article Oncology

Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells

Qiaoyan Cai et al.

TUMOR BIOLOGY (2017)

Add to Collection
Article Oncology

Effect of KRAS and BRAF Mutations on Survival of Metastatic Colorectal Cancer After Liver Resection: A Systematic Review and Meta-Analysis

Federica Tosi et al.

CLINICAL COLORECTAL CANCER (2017)

Add to Collection
Review Medical Laboratory Technology

Waste, Leaks, and Failures in the Biomarker Pipeline

John P. A. Ioannidis et al.

CLINICAL CHEMISTRY (2017)

Add to Collection
Review Medicine, General & Internal

Screening for Colorectal Cancer Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Jennifer S. Lin et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Add to Collection
Review Medicine, General & Internal

Screening for Colorectal Cancer US Preventive Services Task Force Recommendation Statement

Kirsten Bibbins-Domingo et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Add to Collection
Review Geriatrics & Gerontology

Colorectal cancer development and advances in screening

Karen Simon

CLINICAL INTERVENTIONS IN AGING (2016)

Add to Collection
Article Oncology

MiR-4728-3p could act as a marker of HER2 status

Hai Li et al.

CANCER BIOMARKERS (2015)

Add to Collection
Letter Cell Biology

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

Yan Li et al.

CELL RESEARCH (2015)

Add to Collection
Article Oncology

Serum miR-21, miR-29a, and miR-125b Are Promising Biomarkers for the Early Detection of Colorectal Neoplasia

Atsushi Yamada et al.

CLINICAL CANCER RESEARCH (2015)

Add to Collection
Review Cell Biology

Regulation of RAF protein kinases in ERK signalling

Hugo Lavoie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Add to Collection
Article Biology

Serum expression levels of miR-17, miR-21, and miR-92 as potential biomarkers for recurrence after adjuvant chemotherapy in colon cancer patients

Nikolay V. Conev et al.

BIOSCIENCE TRENDS (2015)

Add to Collection
Review Oncology

Colonoscopy in Colorectal Cancer Screening: Current Aspects

John K. Triantafillidis et al.

INDIAN JOURNAL OF SURGICAL ONCOLOGY (2015)

Add to Collection
Article Oncology

A panel of genes methylated with high frequency in colorectal cancer

Susan M. Mitchell et al.

BMC CANCER (2014)

Add to Collection
Article Multidisciplinary Sciences

miR-18a Inhibits CDC42 and Plays a Tumour Suppressor Role in Colorectal Cancer Cells

Karen J. Humphreys et al.

PLOS ONE (2014)

Add to Collection
Article Medicine, Research & Experimental

Comparing Bioinformatic Gene Expression Profiling Methods: Microarray and RNA-Seq

Kirk J. Mantione et al.

MEDICAL SCIENCE MONITOR BASIC RESEARCH (2014)

Add to Collection
Article Multidisciplinary Sciences

PIK3CA Activating Mutation in Colorectal Carcinoma: Associations with Molecular Features and Survival

Christophe Rosty et al.

PLOS ONE (2013)

Add to Collection
Article Biochemistry & Molecular Biology

Proteomic profiling of tumor-initiating cells in HT-29 human colorectal cancer cells

Han-Na Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Add to Collection
Article Gastroenterology & Hepatology

Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas

David A. Ahlquist et al.

GASTROENTEROLOGY (2012)

Add to Collection
Article Oncology

Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial

Esther M. Stoop et al.

LANCET ONCOLOGY (2012)

Add to Collection
Article Multidisciplinary Sciences

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

Anirudh Prahallad et al.

NATURE (2012)

Add to Collection
Article Anatomy & Morphology

Relationship Between Expression of ras p21 Oncoprotein and Mutation Status of the K-ras Gene in Sporadic Colorectal Cancer Patients in Tunisia

Souraya Sammoud et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2012)

Add to Collection
Article Oncology

Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer

Zhaohui Huang et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

Add to Collection
Article Gastroenterology & Hepatology

The quality of screening colonoscopies in an office-based endoscopy clinic

Douglas Bair et al.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2009)

Add to Collection
Review Medicine, General & Internal

Molecular Origins of Cancer: Molecular Basis of Colorectal Cancer.

Sanford D. Markowitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Add to Collection
Article Biochemical Research Methods

Quantitative and temporal proteome analysis of butyrate-treated colorectal cancer cells

Hwee Tong Tan et al.

MOLECULAR & CELLULAR PROTEOMICS (2008)

Add to Collection
Article Multidisciplinary Sciences

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer

Lanlan Shen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Add to Collection
Review Oncology

MicroRNA signatures in human cancers

George A. Calin et al.

NATURE REVIEWS CANCER (2006)

Add to Collection
Article Gastroenterology & Hepatology

Review in depth and meta-analysis of controlled trials on colorectal cancer screening by faecal occult blood test

Denis Heresbach et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2006)

Add to Collection
Article Oncology

The TP53 Colorectal Cancer International Collaborative Study on the prognostic and predictive significance of p53 mutation:: Influence of tumor site, type of mutation, and adjuvant treatment

A Russo et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

Add to Collection
Review Oncology

Raf: A strategic target for therapeutic development against cancer

M Beeram et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

Add to Collection
Article Cell Biology

p53 isoforms can regulate p53 transcriptional activity

JC Bourdon et al.

GENES & DEVELOPMENT (2005)

Add to Collection
Article Oncology

Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene

WD Chen et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)

Add to Collection
Article Oncology

Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers

WS Samowitz et al.

CANCER RESEARCH (2005)

Add to Collection
Article Oncology

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

Y Samuels et al.

CANCER CELL (2005)

Add to Collection
Review Cell Biology

MicroRNAs: a developing story

AE Pasquinelli et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2005)

Add to Collection
Review Biochemistry & Molecular Biology

MicroRNAs: Genomics, biogenesis, mechanism, and function

DP Bartel

CELL (2004)

Add to Collection
Article Multidisciplinary Sciences

Finishing the euchromatic sequence of the human genome

FS Collins et al.

NATURE (2004)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.