4.7 Review

The RAGE signaling in osteoporosis

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

HMGB1 Positive Feedback Loop Between Cancer Cells and Tumor-Associated Macrophages Promotes Osteosarcoma Migration and Invasion

Changhe Hou et al.

Summary: This study found that high mobility group box 1 (HMGB1) is overexpressed in osteosarcoma tissues and is positively correlated with AJCC III and IV stages, lymph node metastasis, and distant metastasis. HMGB1 regulates macrophage polarization through the receptor RAGE. Polarized M2 macrophages induce osteosarcoma migration and invasion, activating HMGB1 expression in osteosarcoma cells to form a positive feedback regulation.

LABORATORY INVESTIGATION (2023)

Review Endocrinology & Metabolism

Contributors to impaired bone health in type 2 diabetes

Angela Sheu et al.

Summary: Type 2 diabetes is associated with an increased risk of fragility fractures, even in individuals with normal bone mineral density and higher body mass index. Current fracture risk calculators underestimate fracture risk in individuals with type 2 diabetes. Several diabetes-related factors, such as insulin therapy, vascular complications, and poor glycemic control, contribute to increased fracture risk, but their independent contributions are not well-studied. Understanding the complex mechanisms underlying impaired bone health in type 2 diabetes is crucial for effective management of these patients.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2023)

Article Hematology

Effects of AGEs, sRAGE and HMGB1 on Clinical Outcomes in Multiple MyelomaIn the PDF, in Header of all pages, Journal title should be abbreviated as Indian J Hematol Blood Transfus.

Ayfer Geduk et al.

Summary: This study found a significant elevation of serum HMGB1 level in MM patients. In addition, the positive effects of RAGE ligands on treatment response and prognosis were determined.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION (2023)

Article Respiratory System

Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia

Jing Lei et al.

Summary: This study investigates the efficiency of RAGE and OSM as new prognosis biomarkers in severe pneumonia patients. The results suggest that RAGE and OSM may serve as new biomarkers for poor prognosis in pneumonia patients.

CANADIAN RESPIRATORY JOURNAL (2022)

Article Endocrinology & Metabolism

AGEs/RAGE Promote Osteogenic Differentiation in Rat Bone Marrow-Derived Endothelial Progenitor Cells via MAPK Signaling

Yuping Wang et al.

Summary: Systemic vascular impairment is a common complication of diabetes, which can be worsened by advanced glycation end products (AGEs) affecting the intima and media. This study demonstrated that AGEs and their receptor RAGE could induce differentiation of EPCs into osteoblasts, promoting accelerated atherosclerosis. The underlying mechanism involves p38MAPK and JNK signaling pathways, but not the ERK signaling pathway.

JOURNAL OF DIABETES RESEARCH (2022)

Article Endocrinology & Metabolism

Receptors of Advanced Glycation End Product (RAGE) Suppression Associated With a Preserved Osteogenic Differentiation in Patients With Prediabetes

Mattabhorn Phimphilai et al.

Summary: This study found that prediabetic individuals still have preserved osteogenic differentiation ability in PBMC, and these cells show both suppression of cellular AGE receptors and apoptotic-related signals. Serum pentosidine is an independent risk factor for cellular AGE receptor expression and can be used as a good predictor for AGE receptor suppression in prediabetic individuals.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Biotechnology & Applied Microbiology

Integrated Analysis of Crucial Genes and miRNAs Associated with Osteoporotic Fracture of Type 2 Diabetes

Liang Mo et al.

Summary: This study aims to explore the pathological mechanisms of bone fragility in type 2 diabetes mellitus (T2DM) patients. By analyzing differentially expressed genes and miRNAs, as well as performing enrichment analysis, the study revealed the important roles of the PI3K-Akt signaling pathway and AGE-RAGE signaling pathway in diabetic osteoporosis.

BIOMED RESEARCH INTERNATIONAL (2022)

Article Endocrinology & Metabolism

Methylglyoxal-an advanced glycation end products (AGEs) precursor-Inhibits differentiation of human MSC-derived osteoblasts in vitro independently of receptor for AGEs (RAGE)

Komal Waqas et al.

Summary: Treatment with MG negatively influences collagen metabolism and differentiation of BMSC-derived osteoblasts, resulting in decreased cell viability, reduced ALP activity and mineralization, with downregulation of genes involved in osteogenic differentiation.
Article Cell Biology

Age-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis

Jingshen Zhuang et al.

Summary: Accumulation of AOPPs is associated with enhanced osteoclastogenesis and deterioration of bone microstructure in aged mice. In vitro experiments showed that AOPPs directly induce osteoclastogenesis by activating various signaling pathways, leading bone marrow monocytes to differentiate into mature osteoclasts.

CELL DEATH & DISEASE (2021)

Article Oncology

The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone

Tatsuo Okui et al.

Summary: Bone pain caused by breast cancer metastasis is a common complication and a major factor in increased mortality. Studies suggest that HMGB1 secreted by breast cancer cells induces BCABP through binding to RAGE on sensory neurons.

JOURNAL OF BONE ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment

Yuteng Weng et al.

Summary: Periodontitis is the sixth most prevalent disease globally, closely related to systemic diseases and impacting overall health. It is characterized by irreversible alveolar bone loss and activated osteoclastogenic process, which may be linked to the activation of intracellular reactive oxygen species (ROS) in osteoclasts.

REDOX BIOLOGY (2021)

Article Biochemistry & Molecular Biology

S100 Calcium-Binding Protein P Secreted from Megakaryocytes Promotes Osteoclast Maturation

Seung-Hoon Lee et al.

Summary: Megakaryocytes (MKs) secrete S100P, which promotes osteoclast differentiation and activity, suggesting an indirect regulatory role of MKs in osteoclast function through paracrine action.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

The Development of Molecular Biology of Osteoporosis

Yongguang Gao et al.

Summary: Osteoporosis is a major bone disorder affecting both men and women, primarily due to an imbalance in bone remodeling. Understanding the effects of molecules produced by different cells on bone can help identify new therapeutic targets and approaches for preventing and treating bone disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Endocrinology & Metabolism

Age-Influenced Receptors of Advanced Glycation End Product Overexpression Associated With Osteogenic Differentiation Impairment in Patients With Type 2 Diabetes

Mattabhorn Phimphilai et al.

Summary: This study revealed impaired osteogenic differentiation in approximately half of PBMC derived from type 2 diabetic patients receiving metformin monotherapy. Overexpression of both AGER and BAX/BCL2 was only demonstrated in PBMC isolated from diabetic patients with poor osteogenic differentiation. Age was shown to have a positive impact on RAGE overexpression, and both age and RAGE overexpression were identified as independent risk factors influencing osteogenic differentiation potential in PBMC isolated from T2DM.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Medicine, General & Internal

Effects of Advanced Glycation End Products on Differentiation and Function of Osteoblasts and Osteoclasts

So Young Park et al.

Summary: Advanced glycation end products (AGEs) suppress the differentiation and function of osteoclasts and osteoblasts, potentially leading to decreased bone quality and turnover.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

Article Cell Biology

Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure

Katelyn Arnold et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Endocrinology & Metabolism

A broader strategy for osteoporosis interventions

Ian R. Reid

NATURE REVIEWS ENDOCRINOLOGY (2020)

Article Biochemistry & Molecular Biology

High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4

Yumi Sakamoto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis

Ji-Yoon Noh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, Research & Experimental

A beta 40 Promotes the Osteoblastic Differentiation of Aortic Valve Interstitial Cells through the RAGE Pathway

Bo Wang et al.

CURRENT MEDICAL SCIENCE (2020)

Review Cell Biology

Is there any evidence that AGE/sRAGE is a universal biomarker/risk marker for diseases?

Kailash Prasad

MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)

Article Nutrition & Dietetics

Divergent Changes in Plasma AGEs and sRAGE Isoforms Following an Overnight Fast in T1DM

Edwin R. Miranda et al.

NUTRIENTS (2019)

Review Endocrinology & Metabolism

RAGE Signaling in Skeletal Biology

Lilian I. Plotkin et al.

CURRENT OSTEOPOROSIS REPORTS (2019)

Article Biochemistry & Molecular Biology

High mobility group box 1 protein regulates osteoclastogenesis through direct actions on osteocytes and osteoclasts in vitro

Hannah M. Davis et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Review Agriculture, Multidisciplinary

Comparison of Free and Bound Advanced Glycation End Products in Food: A Review on the Possible Influence on Human Health

Di Zhao et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

sRAGE prolonged stem cell survival and suppressed RAGE-related inflammatory cell and T lymphocyte accumulations in an Alzheimer's disease model

Seyeon Oh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Medical Laboratory Technology

The bone remodelling cycle

J. S. Kenkre et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2018)

Article Endocrinology & Metabolism

Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men

Lydia S. Lamb et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Article Multidisciplinary Sciences

S100A12 facilitates osteoclast differentiation from human monocytes

Miwa Nishida et al.

PLOS ONE (2018)

Article Endocrinology & Metabolism

Impaired osteogenic differentiation and enhanced cellular receptor of advanced glycation end products sensitivity in patients with type 2 diabetes

Mattabhorn Phimphilai et al.

JOURNAL OF BONE AND MINERAL METABOLISM (2017)

Article Chemistry, Medicinal

Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective

Salvatore Bongarzone et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Public, Environmental & Occupational Health

PREVALENCE AND RISK FACTORS OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES MELLITUS

Ivan Raska et al.

CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH (2017)

Article Biochemistry & Molecular Biology

Extracellular S100A4 negatively regulates osteoblast function by activating the NF-κB pathway

Haemin Kim et al.

BMB REPORTS (2017)

Article Biochemistry & Molecular Biology

AGEs Induce Apoptosis in Rat Osteoblast Cells by Activating the Caspase-3 Signaling Pathway Under a High-Glucose Environment In Vitro

Jiaqiang Liu et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2016)

Article Medicine, Research & Experimental

Signaling pathways involved in the effects of HMGB1 on mesenchymal stem cell migration and osteoblastic differentiation

Feng Lin et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Change in the Molecular Dimension of a RAGE-Ligand Complex Triggers RAGE Signaling

Jing Xue et al.

STRUCTURE (2016)

Article Biochemistry & Molecular Biology

The S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells

Melania E. Mercado-Pimentel et al.

FEBS LETTERS (2015)

Article Endocrinology & Metabolism

Sarco-Osteoporosis: Prevalence and Association with Frailty in Chinese Community-Dwelling Older Adults

Yan-Jiao Wang et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2015)

Review Biotechnology & Applied Microbiology

Soluble Receptor for Advanced Glycation End Product: A Biomarker for Acute Coronary Syndrome

Louise J. N. Jensen et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Hematology

Functional Role of Soluble Receptor for Advanced Glycation End Products in Stroke

Sung-Chun Tang et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

Review Biochemistry & Molecular Biology

RAGE in tissue homeostasis, repair and regeneration

Guglielmo Sorci et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Biochemistry & Molecular Biology

Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function

Malin C. Erlandsson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Biochemistry & Molecular Biology

Signaling of High Mobility Group Box 1 (HMGB1) through Toll-like Receptor 4 in Macrophages Requires CD14

Sodam Kim et al.

MOLECULAR MEDICINE (2013)

Article Biochemistry & Molecular Biology

Receptor for advanced glycation end products inhibits proliferation in osteoblast through suppression of Wnt, PI3K and ERK signaling

Guofeng Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Letter Critical Care Medicine

Expression of HMGB1 and RAGE in rat and human brains after traumatic brain injury

Philip F. Stahel

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2012)

Article Endocrinology & Metabolism

APPswe/Aβ Regulation of Osteoclast Activation and RAGE Expression in an Age-Dependent Manner

Shun Cui et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2011)

Article Pharmacology & Pharmacy

Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging

Shi Fang Yan et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

Homodimerization Is Essential for the Receptor for Advanced Glycation End Products (RAGE)-mediated Signal Transduction

Hongliang Zong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer's disease animal model

H. J. Cho et al.

FASEB JOURNAL (2009)

Article Biochemistry & Molecular Biology

Direct Inhibitory and Indirect Stimulatory Effects of RAGE Ligand S100 on sRANKL-Induced Osteoclastogenesis

Tomohiko Yoshida et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Article Endocrinology & Metabolism

Metformin reverts deleterious effects of advanced glycation end-products (AGEs) on osteoblastic cells

L. Schurman et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2008)

Article Biochemistry & Molecular Biology

Identification, classification, and expression of RAGE gene splice variants

Barry I. Hudson et al.

FASEB JOURNAL (2008)

Article Biochemistry & Molecular Biology

Structural basis for pattern recognition by the receptor for advanced glycation end products (RAGE)

Jingjing Xie et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Endocrinology & Metabolism

HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE

Zheng Zhou et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2008)

Article Neurosciences

Site-specific blockade of RAGE-Vd prevents amyloid-β oligomer neurotoxicity

Emmanuel Sturchler et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Cell Biology

Regulation of advanced glycation end product (AGE) receptors and apoptosis by AGEs in osteoblast-like cells

Natalia Mercer et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Structural and functional insights into RAGE activation by multimeric S100B

Thorsten Ostendorp et al.

EMBO JOURNAL (2007)

Review Medicine, Research & Experimental

RAGE: A single receptor for several ligands and different cellular responses: The case of certain S100 proteins

Rosario Donato

CURRENT MOLECULAR MEDICINE (2007)

Article Immunology

Regulation of osteoclast function and bone mass by RAGE

Z Zhou et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Review Medical Laboratory Technology

Glycation endproducts in osteoporosis - Is there a pathophysiologic importance?

Gert E. Hein

CLINICA CHIMICA ACTA (2006)

Review Genetics & Heredity

Understanding RAGE, the receptor for advanced glycation end products

A Bierhaus et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2005)

Article Biochemistry & Molecular Biology

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

R Deane et al.

NATURE MEDICINE (2003)

Article Endocrinology & Metabolism

S100A4: A novel negative regulator of mineralization and osteoblast differentiation

WR Duarte et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2003)

Article Multidisciplinary Sciences

Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases

A Taguchi et al.

NATURE (2000)