Potential roles of exosomes in the initiation and metastatic progression of lung cancer

Review Biochemistry & Molecular Biology

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Martin Vokurka et al.

Summary: This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts, discussing their significance and therapeutic potential in the dialogue between cancer cells and the tumor microenvironment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Medicine, Research & Experimental

Overexpression of BACH1 mediated by IGF2 facilitates hepatocellular carcinoma growth and metastasis via IGF1R and PTK2

Meng Xie et al.

Summary: The study demonstrates that BACH1 plays a tumorigenic role in HCC and can serve as a biomarker for poor prognosis, suggesting a potential therapeutic strategy targeting IGF1R and PTK2 for HCC patients.

THERANOSTICS (2022)

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Article Biotechnology & Applied Microbiology

Therapeutic efficacy of the novel SHP2 degrader SHP2-D26, alone or in combination, against lung cancer is associated with modulation of p70S6K/S6, Bim and Mcl-1

Yunfu Deng et al.

Summary: This study evaluated the therapeutic potential of a novel SHP2 degrader, SHP2-D26, against non-small cell lung cancer (NSCLC) cells and found that it effectively inhibited cell growth and induced apoptosis. When combined with the third generation EGFR inhibitor, osimertinib, synergistic effects on decreasing cell survival were observed, suggesting promising efficacy in overcoming acquired resistance to osimertinib.

CANCER GENE THERAPY (2022)

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Article Oncology

Sulfonylurea receptor 1-expressing cancer cells induce cancer-associated fibroblasts to promote non-small cell lung cancer progression

Hongling Chen et al.

Summary: SUR1-expressing cancer cells induce the transformation of normal fibroblasts into cancer-associated fibroblasts (CAFs) in the tumor microenvironment and promote the progression of non-small cell lung carcinoma (NSCLC) by transferring less exosomal let-7a-5p. Glibenclamide targeting SUR1 is a promising anti-cancer drug, and the level of plasma exosomal let-7a-5p serves as a potential diagnostic biomarker for NSCLC patients.

CANCER LETTERS (2022)

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Article Toxicology

The MIR100HG/miR-29a-3p/Tab1 axis modulates TGF-131-induced fibrotic changes in type II alveolar epithelial cells BLM-caused lung fibrogenesis in mice

Shuhong Guan et al.

Summary: In this study, the researchers found that the long non-coding RNA MIR100HG is abnormally upregulated in pulmonary fibrosis. They demonstrated that MIR100HG plays a role in TGF-131-induced fibrotic changes in alveolar epithelial cells by regulating the expression of miR-29a-3p and Tab1. Therefore, MIR100HG may be a promising target for therapy in pulmonary fibrosis.

TOXICOLOGY LETTERS (2022)

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Article Medicine, General & Internal

Large Cell Neuroendocrine Carcinoma of the Lung: Current Understanding and Challenges

Elisa Andrini et al.

Summary: Large cell neuroendocrine carcinoma of the lung is a rare and aggressive type of lung cancer, with a poor prognosis. The introduction of molecular subtyping has provided new insights into the management and treatment of LCNEC.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Identification of PTK2 as an adverse prognostic biomarker in breast cancer by integrated bioinformatics and experimental analyses

Yanru Chen et al.

Summary: PTK2 is highly expressed in breast cancer and is associated with poor survival outcome and prognosis, suggesting its potential importance in breast cancer development.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Oncology

Mesenchymal stem/stromal cells in breast cancer development and management

Zhenbo Tu et al.

Summary: Mesenchymal stem/stromal cells (MSCs) are a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body and have the ability to differentiate into various connective tissue cells. They play critical regulatory roles in breast tumor development and progression, participating in multiple aspects of the process.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Medicine, Research & Experimental

Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy

Zaoqu Liu et al.

Summary: Chimeric antigen receptor (CAR)-T cell therapy is a significant advancement in personalized cancer treatment. Although it has achieved considerable success in hematological malignancies, its effectiveness is limited in solid tumors. Recent studies have shown that the tumor immune microenvironment (TIME) has a profound impact on immunotherapeutic response, with immunosuppressive components being a critical obstacle to CAR-T cell activity. However, research on immunosuppressive components also provides inspiration for reshaping the immune environment through engineered CARs.

THERANOSTICS (2022)

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Article Respiratory System

Exosomes derived from adipose-derived stem cells alleviate cigarette smoke-induced lung inflammation and injury by inhibiting alveolar macrophages pyroptosis

Zhixing Zhu et al.

Summary: The study demonstrates that ADSCs-Exo can effectively alleviate cigarette smoke-induced lung inflammation and injury by inhibiting AMs pyroptosis. This suggests that ADSCs-Exo may be a promising cell-free therapeutic candidate for cigarette smoke-induced lung inflammation and injury.

RESPIRATORY RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications

Atefeh Amiri et al.

Summary: Exosomes, as novel biomarkers, have the potential to play a key role in the diagnosis of lung cancer.

CURRENT MEDICINAL CHEMISTRY (2021)

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Article Oncology

Apelin enhances biological functions in lung cancer A549 cells by downregulating exosomal miR-15a-5p

Jingjing Ran et al.

Summary: This study revealed that apelin may enhance the proliferation and invasion ability of lung cancer cells by inhibiting miR-15a-5p encapsulated in exosomes.

CARCINOGENESIS (2021)

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Article Oncology

CDCA4 suppresses epithelial-mesenchymal transtion (EMT) and metastasis in Non-small cell lung cancer through modulating autophagy

Chenxin Xu et al.

Summary: The study revealed that CDCA4 inhibits the EMT, migration, and invasion of NSCLC by interacting with CARM1 to regulate autophagy.

CANCER CELL INTERNATIONAL (2021)

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Article Biotechnology & Applied Microbiology

microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner

Shufeng Xu et al.

Summary: This study demonstrates the clinical significance of serum-derived exosomal miR-let-7e as a biomarker in metastasis of NSCLC. Lower expression of miR-let-7e and higher expression of SUV39H2 are associated with a lower survival rate in NSCLC patients. Exosomal miR-let-7e inhibits SUV39H2, leading to impaired cell viability, migration, invasion in vitro, and delayed tumor growth in vivo.

CANCER GENE THERAPY (2021)

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Article Chemistry, Multidisciplinary

Secretome of Activated Fibroblasts Induced by Exosomes for the Discovery of Biomarkers in Non-Small Cell Lung Cancer

Jian Zhang et al.

Summary: This study uses quantitative proteomics to identify diagnostic markers and a prognostic signature based on differential protein secretion by normal fibroblasts and exosome-activated fibroblasts affected by lung cancer cell-derived exosomes. These findings have the potential to distinguish tumor tissues from normal tissue and identify patients who may benefit from adjuvant therapy after surgical resection. Additionally, the secretome offers novel targets for clinical treatment.

SMALL (2021)

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Article Oncology

Exosomal miR-3180-3p inhibits proliferation and metastasis of non-small cell lung cancer by downregulating FOXP4

Tengfei Chen et al.

Summary: This study demonstrated that exosomal miR-3180-3p inhibits the progression of NSCLC by downregulating FOXP4 expression, indicating that miR-3180-3p may serve as a therapeutic target for NSCLC.

THORACIC CANCER (2021)

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Article Oncology

被撤回的出版物: Liver Kinase B1 (LKB1) Regulates Proliferation and Apoptosis of Non-Small Cell Lung Cancer A549 Cells via Targeting ERK Signaling Pathway (Retracted article. See vol. 14, pg. 3203, 2022)

Yirong Wang et al.

Summary: The study showed that overexpression of LKB1 can inhibit proliferation and promote apoptosis of NSCLC A549 cells, and this mechanism may be related to inhibition of the ERK signaling pathway.

CANCER MANAGEMENT AND RESEARCH (2021)

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Article Cell Biology

Exosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis

Xin Lv et al.

Aging-US (2021)

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Article Oncology

M2 macrophages-derived exosomal microRNA-501-3p promotes the progression of lung cancer via targeting WD repeat domain 82

Jie Lei et al.

Summary: Research suggests that exosomal miR-501-3p derived from M2 macrophages promotes the progression of lung cancer (LC) by downregulating WDR82. This study provides important insights into the molecular mechanisms underlying the development of LC.

CANCER CELL INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Shi-Wei Chen et al.

Summary: In human non-small cell lung cancer (NSCLC) tissues, high expression levels of circUSP7 are associated with poor clinical prognosis and dysfunction of CD8(+) T cells. CircUSP7 found in NSCLC patient plasma is mainly secreted by NSCLC cells via exosomes, inhibiting CD8(+) T cell function by upregulating SHP2 expression. Additionally, circUSP7 may contribute to resistance to anti-PD1 immunotherapy in NSCLC patients.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

Cancer-associated fibroblasts-derived exosomes promote lung cancer progression by OIP5-AS1/miR-142-5p/PD-L1 axis

Yun Jiang et al.

Summary: CAFs are key stromal cells in the tumor microenvironment, playing a crucial role in regulating lung cancer development. Through exosome-mediated miR-142-5p/ PD-L1 axis, CAFs promote tumor growth and suppress immune killing of lung cancer cells, providing potential opportunities for diagnosis and treatment of lung cancer.

MOLECULAR IMMUNOLOGY (2021)

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Article Cell Biology

Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway

Wen Tian et al.

Summary: This study evaluated the specific regulatory mechanisms of the exosomal miR-338-3p/CHL1/MAPK signaling pathway axis in non-small-cell lung cancer. The upregulation of CHL1 enhanced tumor cell proliferation and inhibited apoptosis, while miR-338-3p was found to mediate tumor cell progression by directly interacting with CHL1. Exosomal miR-338-3p suppressed tumor cell proliferation and metastasis by inhibiting the activation of the MAPK signaling pathway through downregulating CHL1 expression.

CELL DEATH & DISEASE (2021)

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Article Medicine, Research & Experimental

被撤回的出版物: MTTL3 upregulates microRNA-1246 to promote occurrence and progression of NSCLC via targeting paternally expressed gene 3 (Retracted Article)

Shaohong Huang et al.

Summary: In this study, it was found that METTL3 and miR-1246 were upregulated, while PEG3 was downregulated in NSCLC tissues. Furthermore, METTL3 affected the m6A modification of miR-1246, leading to the upregulation of miR-1246 and promotion of NSCLC progression by inhibiting PEG3.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Cell Biology

GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small-cell lung cancer

Jun-Wei Song et al.

Summary: This study found that overexpression of GOLPH3 in NSCLC patients is positively correlated with distal metastasis and related characteristics, potentially promoting metastasis and inducing a stem cell-like phenotype by activating the WNT/beta-catenin pathway. Through interaction with CKAP4, GOLPH3 enhances metastasis through exosome-mediated mechanisms, increasing secretion of WNT3A.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease

Ishita Choudhary et al.

Summary: This study revealed the impact of repetitive ozone exposure on exosomal, secretory, and cell-specific proteins and biological pathways in mice. Exosome-bound proteomic signatures and levels of soluble inflammatory mediators were influenced by ozone exposure differently between male and female mice. Enrichment of pro-inflammatory pathways and macrophage activation-related proteins were observed in exosomes from ozone-exposed mice, indicating a potential role in ozone-induced lung injury.

SCIENTIFIC REPORTS (2021)

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Article Astronomy & Astrophysics

Characterization of exosome release and extracellular vesicle-associated miRNAs for human bronchial epithelial cells irradiated with high charge and energy ions

Zhentian Li et al.

Summary: This study found that high-energy heavy ions can stimulate the release of exosomes from human bronchial epithelial cells, containing pro-inflammatory molecules and miRNAs associated with cancer progression. An over-represented set of miRNAs in cells irradiated with HZE ions showed significant association with nonsmall cell lung and other cancers.

LIFE SCIENCES IN SPACE RESEARCH (2021)

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Review Oncology

miR-21: a non-specific biomarker of all maladies

Ana E. Jenike et al.

Summary: miRNA-21 is considered as a specific predictive or prognostic biomarker for at least 29 diseases, but lacks specificity for any one disease, thus making it not an ideal candidate for a biomarker despite continued evaluation. This issue of non-specificity in biomarker designation is shared with other common, ubiquitous miRNAs and warrants concern for their use as biomarkers as well.

BIOMARKER RESEARCH (2021)

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Article Medicine, General & Internal

Defining CD4 T helper and T regulatory cell endotypes of progressive and remitting pulmonary sarcoidosis (BRITE): protocol for a US-based, multicentre, longitudinal observational bronchoscopy study

Laura L. Koth et al.

Summary: This study aims to investigate the longitudinal changes in adaptive immune response in patients with recently diagnosed sarcoidosis, and their relationship to progressive and non-progressive pulmonary outcomes.

BMJ OPEN (2021)

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Article Environmental Sciences

Ambient Ozone, PM1 and Female Lung Cancer Incidence in 436 Chinese Counties

Huagui Guo et al.

Summary: The study revealed positive associations between ozone and PM1 with the incidence rate of female lung cancer in China. Urban-rural division may modify the effect of PM1 on the incidence rate of female lung cancer. Further prevention and control measures are needed to address the situation of these two air pollutants.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Review Oncology

Exosomes: a new perspective in EGFR-mutated lung cancer

Amina Jouida et al.

Summary: Exosomes play a crucial role in cell to cell communication by transferring biological material, and have implications in tumor initiation, promotion, and progression. They are emerging as potential biomarkers for early detection, diagnosis, prognosis assessment, and therapeutic response prediction in EGFR-mutated lung cancer.

CANCER AND METASTASIS REVIEWS (2021)

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Article Oncology

The tumor microenvironment shapes the molecular characteristics of exhausted CD8+ T cells

Hongcheng Cheng et al.

Summary: Persistent antigen stimulation in chronic infections and cancer leads to CD8(+) T cell exhaustion, characterized by increased expression of co-inhibitory receptors, loss of effector function, and dysregulated metabolic activity. Understanding the molecular mechanisms and key factors shaping exhaustion features within the tumor microenvironment could improve cancer immunotherapy efficacy targeting exhausted T cells.

CANCER LETTERS (2021)

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Article Neurosciences

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model

Chunni Zhu et al.

Summary: Inhibition of nSMase2 was found to reduce brain EV/exosome production and proteopathic protein spread in a PD mouse model, offering a potential new approach for therapeutic development in neurodegenerative diseases.

MOLECULAR BRAIN (2021)

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Article Oncology

The value of combined detection of CEA, CYFRA21-1, SCC-Ag, and pro-GRP in the differential diagnosis of lung cancer

Jiezhou Li et al.

Summary: This study investigated the value of CEA, CYFRA21-1, SCC-Ag, and pro-GRP in the differential diagnosis of lung cancer. The results showed that the joint detection of these four markers has clinical value for the differential diagnosis of lung cancer. The AUC for the combined diagnosis was 0.9250, with a sensitivity of 93.29% and a specificity of 84.32%.

TRANSLATIONAL CANCER RESEARCH (2021)

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Article Oncology

Tumor-associated macrophages secret exosomal miR-155 and miR-196a-5p to promote metastasis of non-small-cell lung cancer

Xiang Li et al.

Summary: The study revealed that exosomal miR-155 and miR-196a-5p secreted by M2 TAMs promoted NSCLC metastasis by directly targeting RASSF4, offering a potential opportunity for diagnosis and treatment of NSCLC.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

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Article Cell Biology

MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells

Hongqing Wen et al.

Aging-US (2021)

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Article Oncology

Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2

Kaiyi Tao et al.

Summary: The study investigated the molecular mechanism of lung adenocarcinoma (LUAD) progression and the communication between cancer cells and vascular endothelial cells. The findings demonstrated that miR-30a-5p could be delivered from vascular endothelial cells to LUAD cells via exosomes to inhibit tumor progression.

CARCINOGENESIS (2021)

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Article Cell Biology

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming

Samantha M. Morrissey et al.

Summary: The study reveals that tumor-derived exosomes can polarize macrophages towards an immunosuppressive phenotype through NF-kB and glycolytic reprogramming, and are associated with lactate, GLUT-1, and YKT6 factors, further promoting tumor metastasis.

CELL METABOLISM (2021)

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Article Environmental Sciences

Identification of exosome miRNAs in bronchial epithelial cells after PM2.5 chronic exposure

Yunxia Wang et al.

Summary: Chronic exposure to PM2.5 induces bronchial epithelial cell atypical hyperplasia and EMT event in vivo, and leads to expression differences of exosome-miRNAs in vitro. The identified exosome-miRNAs may partially contribute to lung cancer tumorigenesis induced by chronic PM2.5 exposure.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Environmental Sciences

Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice

Milu Li et al.

Summary: This study revealed that embryonic exposure to propylparaben (PrP) led to adverse effects on ovarian function in adult mice, including accelerated ovarian aging, decreased follicle pool size, and increased follicular atresia, potentially through oxidative stress, inflammation, and fibrosis pathways.

ENVIRONMENTAL POLLUTION (2021)

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Article Immunology

Cigarette smoke extract-treated airway epithelial cells-derived exosomes promote M1 macrophage polarization in chronic obstructive pulmonary disease

Lijing Wang et al.

Summary: In this study, it was found that exosomes derived from cigarette smoke extract-treated mouse airway epithelial cells promoted M1 macrophage polarization by upregulating TREM-1 expression, thereby aggravating the development of COPD.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion

Xin Yang et al.

Summary: This study identified the mechanism of GPC5 in lung cancer, showing that it enhances the expression of CTDSP1 and miR-26b, inhibiting the proliferation of lung cancer cells and affecting the function of lymphatic endothelial cells. The findings suggest that GPC5 functions as a tumor suppressor in human lung cancer.

ONCOGENE (2021)

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Review Pharmacology & Pharmacy

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

Paolo Spagnolo et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause that is age-related, with current treatments focusing on slowing disease progression and providing a growing portfolio of treatment options.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Toxicology

CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis

Jun Bai et al.

Summary: The study revealed that circRNA_0026344 is involved in the aberrant epithelium-fibroblast cross-talk induced by cigarette smoke through regulation of miR-21 and Smad7 expression. These findings are important for the discovery of early biomarkers and therapeutic targets for smoking-induced pulmonary fibrosis.

TOXICOLOGY LETTERS (2021)

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Article Cell Biology

Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2

Dong Ha Kim et al.

Summary: Exosomal miR-1260b promotes angiogenesis in HUVECs and metastasis in NSCLC by targeting HIPK2, and may serve as a potential prognostic marker for lung cancer.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

TGF-β1-mediated exosomal lnc-MMP2-2 increases blood-brain barrier permeability via the miRNA-1207-5p/EPB41L5 axis to promote non-small cell lung cancer brain metastasis

Dongming Wu et al.

Summary: The study revealed that TGF-beta 1-mediated exosomal lnc-MMP2-2 increases BBB permeability to promote NSCLC brain metastasis by modulating miR-1207-5p and EPB41L5. Thus, exosomal lnc-MMP2-2 may serve as a potential therapeutic target for lung cancer brain metastasis.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer

Zijian Ma et al.

Summary: miR-3157-3p transferred via exosomes from NSCLC cells to vascular endothelial cells is involved in the formation of pre-metastatic niche before tumor metastasis, and may serve as a blood-based biomarker for NSCLC metastasis. Exosome miR-3157-3p regulates VEGF/MMP2/MMP9 and occludin expression in endothelial cells by targeting TIMP/KLF2, promoting angiogenesis and increasing vascular permeability, as well as enhancing NSCLC metastasis in vivo.

CELL DEATH & DISEASE (2021)

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Article Oncology

Exosome-derived microRNA-433 inhibits tumorigenesis through incremental infiltration of CD4 and CD8 cells in non-small cell lung cancer

Boyang Liu et al.

Summary: Tumor-derived exosomal microRNAs, especially miR-433, play a vital role in tumorigenesis and development of NSCLC. MiR-433 inhibits tumor growth by promoting apoptosis, blocking the cell cycle, and regulating DNA damage. Moreover, miR-433 is associated with a poor prognosis in NSCLC patients.

ONCOLOGY LETTERS (2021)

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Article Multidisciplinary Sciences

Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit

Theodora Katopodi et al.

Summary: This study investigates the role of oncogenic Kras signaling in circRNA-related immunosuppression and its involvement in tumoral chemoresistance. The findings reveal that M2 macrophages drive Kras immunosuppressive chemoresistance by myeloid differentiation through circHIPK3/PTK2 enrichment, representing a potential therapeutic target for metastatic lung cancer.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Exosomal miR-375-3p breaks vascular barrier and promotes small cell lung cancer metastasis by targeting claudin-1

Shuangshuang Mao et al.

Summary: This study identified the crucial role of exosomal miRNA-375-3p in regulating vascular endothelial barrier integrity and SCLC metastasis. miRNA-375-3p has the potential to serve as a novel biomarker for monitoring metastasis and guiding clinical therapeutics in SCLC patients.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Role and Mechanism of Exosome-Derived Long Noncoding RNA HOTAIR in Lung Cancer

Lanlan Chen et al.

Summary: The study identified that HOTAIR is highly expressed in tumor tissues, serum, and serum exosomes of NSCLC patients, and its expression is significantly correlated with lymphatic metastasis and TNM staging. Exosomes may promote NSCLC proliferation and migration through HOTAIR transport.

ACS OMEGA (2021)

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Article Oncology

Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway

Jing Chen et al.

Summary: The research revealed that LUAD cells induced M2 polarization of TAMs by transporting miR-19b-3p via exosomes, activating STAT3 pathway to promote tumor metastasis. The interactive communication between LUAD cells and TAMs through exchange of exosomal miR-19b-3p and LINC00273 was elucidated, proving the pro-metastatic effect of this interchange. These findings offer a new perspective for developing LUAD treatment.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Physiology

Ozone-induced changes in the murine lung extracellular vesicle small RNA landscape

Gregory J. Smith et al.

Summary: The study revealed that exposure to ozone can impact the transfer of microRNAs between cells and the release of extracellular vesicles, particularly affecting airway macrophages.

PHYSIOLOGICAL REPORTS (2021)

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Article Oncology

Tumor-derived Exosome Promotes Metastasis via Altering its Phenotype and Inclusions

Yu Zhou et al.

Summary: The study revealed significant differences in inclusions and functions between early and late exosomes of the same tumor, with late tumor exosomes showing a greater ability to promote cell migration. These findings emphasize the importance of exosomes in cancer metastasis and suggest their potential as biomarkers and therapeutic targets for cancer metastasis.

JOURNAL OF CANCER (2021)

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Review Oncology

Oncogenic driver mutations in non-small cell lung cancer: Past, present and future

Mathieu Chevallier et al.

Summary: Lung cancer, particularly non-small cell lung cancer, is the leading cause of cancer related-death globally, with alterations in oncogenic drivers playing a key role in cancer development. There are over fifteen targeted agents approved for treatment of non-small cell lung cancer, emphasizing the importance of understanding the biology and resistance mechanisms associated with each driver mutation for developing optimal treatment strategies.

WORLD JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Oncology

Long Noncoding RNA FGD5-AS1 Knockdown Decrease Viability, Migration, and Invasion of Non-Small Cell Lung Cancer (NSCLC) Cells by Regulating the MicroRNA-944/MACC1 Axis

Jian Lv et al.

Summary: FGD5-AS1 regulates the viability, migration, and invasion of NSCLC cells by modulating the miR-944/MACC1 axis, serving as a potential therapeutic target for NSCLC. Knockdown of FGD5-AS1 not only reduces tumorigenesis in NSCLC cells, but also suppresses M2 polarization of macrophages and eliminates the promoting effects of exosomes on NSCLC cell migration and invasion.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

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Article Biotechnology & Applied Microbiology

Tumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX)

Wulong Wang et al.

Summary: The study showed that miRNA-141 in exosomes from lung cancer serum promoted tumor cell migration, invasion, proliferation, and angiogenesis by targeting GAX. These findings suggest a potential treatment strategy for lung cancer.

BIOENGINEERED (2021)

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Review Oncology

The role of SOX family members in solid tumours and metastasis

Daniela Grimm et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers

Falin Chen et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Review Cell Biology

The many functions of ESCRTs

Marina Vietri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Oncology

Upregulation of E-cadherin in bronchoalveolar lavage fluid-derived exosomes in patients with lung cancer

Ying Zhang et al.

THORACIC CANCER (2020)

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Article Respiratory System

Lung Cancer Pathology Current Concepts

William D. Travis

CLINICS IN CHEST MEDICINE (2020)

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Article Respiratory System

Lung Cancer 2020 Epidemiology, Etiology, and Prevention

Brett C. Bade et al.

CLINICS IN CHEST MEDICINE (2020)

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Article Cell Biology

Exosome-mediated transfer of miR-1260b promotes cell invasion through Wnt/β-catenin signaling pathway in lung adenocarcinoma

Yang Xia et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Biochemistry & Molecular Biology

EGFR E746-A750 deletion in lung cancer represses antitumor immunity through the exosome-mediated inhibition of dendritic cells

Shaorong Yu et al.

ONCOGENE (2020)

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Article Biophysics

High-sensitive and multiplex biosensing assay of NSCLC-derived exosomes via different recognition sites based on SPRi array

Yunpeng Fan et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Review Biochemistry & Molecular Biology

Non-Coding RNAs in Lung Tumor Initiation and Progression

Ruben Mercado Santos et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Critical Care Medicine

Small Cell Lung Cancer: Advances in Diagnosis and Management

Ayushi F. Chauhan et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Pharmacology & Pharmacy

Kruppel-like factor 2 disturb non-small cell lung cancer energy metabolism by inhibited glutamine consumption

Song Xiao et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)

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Article Cell Biology

Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression

Xueyan Zang et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage Polarization

Alexandra Pritchard et al.

CELLS (2020)

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Article Oncology

Modulation of the PD-1/PD-L1 immune checkpoint axis during inflammation-associated lung tumorigenesis

Sreekanth Chanickal Narayanapillai et al.

CARCINOGENESIS (2020)

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Article Cell Biology

MiR-210 in exosomes derived from CAFs promotes non-small cell lung cancer migration and invasion through PTEN/PI3K/AKT pathway

Fang Yang et al.

CELLULAR SIGNALLING (2020)

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Article Pathology

Enhanced expression of lncRNA ZXF1 promotes cisplatin resistance in lung cancer cell via MAPK axis

Ting Yu et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2020)

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Article Oncology

Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression

Manman Liang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

The potential roles of exosomes in pancreatic cancer initiation and metastasis

Wei Sun et al.

MOLECULAR CANCER (2020)

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Article Oncology

Diagnosis Value of Combined Detection of Serum SF, CEA and CRP in Non-Small Cell Lung Cancer

Jing Zhou et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Potential diagnostic and therapeutic roles of exosomes in pancreatic cancer

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Extracellular Vesicles: Messengers of p53 in Tumor-Stroma Communication and Cancer Metastasis

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miR-224, miR-147b and miR-31 associated with lymph node metastasis and prognosis for lung adenocarcinoma by regulating PRPF4B, WDR82 or NR3C2

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The Tumor Microenvironment-A Metabolic Obstacle to NK Cells' Activity

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Cdh1 functions as an oncogene by inducing self-renewal of lung cancer stem-like cells via oncogenic pathways

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Monitoring HSP70 exosomes in cancer patients' follow up: a clinical prospective pilot study

Gaetan Chanteloup et al.

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Public Understanding of Cigarette Smoke Chemicals: Longitudinal Study of US Adults and Adolescents

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Tumor-derived exosomal lncRNA GAS5 as a biomarker for early-stage non-small-cell lung cancer diagnosis

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p53/miR-30a-5p/SOX4 feedback loop mediates cellular proliferation, apoptosis, and migration of non-small-cell lung cancer

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Snail1-dependent cancer-associated fibroblasts induce epithelial-mesenchymal transition in lung cancer cells via exosomes

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Bronchoalveolar Lavage Fluid-Derived Exosomes: A Novel Role Contributing to Lung Cancer Growth

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microRNA-328 in exosomes derived from M2 macrophages exerts a promotive effect on the progression of pulmonary fibrosis via FAM13A in a rat model

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Glibenclamide Targets Sulfonylurea Receptor 1 to Inhibit p70S6K Activity and Upregulate KLF4 Expression to Suppress Non-Small Cell Lung Carcinoma

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Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells

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lncRNA LEF1-AS1 Promotes Malignancy in Non-Small-Cell Lung Cancer by Modulating the miR-489/SOX4 Axis

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Exosomal Leucine-Rich-Alpha2-Glycoprotein 1 Derived from Non-Small-Cell Lung Cancer Cells Promotes Angiogenesis via TGF-β Signal Pathway

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The release of tryptase from mast cells promote tumor cell metastasis via exosomes

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Effects of chronic PM2.5 exposure on pulmonary epithelia: Transcriptome analysis of mRNA-exosomal miRNA interactions

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EV-associated miRNAs from pleural lavage as potential diagnostic biomarkers in lung cancer

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Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

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Upregulated circRNA ARHGAP10 Predicts an Unfavorable Prognosis in NSCLC through Regulation of the miR-150-5p/GLUT-1 Axis

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Clinicopathologic Features and Prognostic Implications of Golgi Phosphoprotein 3 in Non-small Cell Lung Cancer: A Meta-analysis

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Icotinib-resistant HCC827 cells produce exosomes with mRNA MET oncogenes and mediate the migration and invasion of NSCLC

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Exosomes in lung cancer diagnosis and treatment. From the translating research into future clinical practice

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Exosomes from asbestos-exposed cells modulate gene expression in mesothelial cells

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CircRNF13 regulates the invasion and metastasis in lung adenocarcinoma by targeting miR-93-5p

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Tumor exosomes block dendritic cells maturation to decrease the T cell immune response

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Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression

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Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN

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Tumor-derived exosomes antagonize innate antiviral immunity

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Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

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Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis

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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

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Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics

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The Potential Roles of Extracellular Vesicles in Cigarette Smoke-Associated Diseases

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Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

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Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants

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Lipids in exosomes: Current knowledge and the way forward

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IL-6 and TNF-α promote metastasis of lung cancer by inducing epithelial-mesenchymal transition

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Molecular mechanisms governing microRNA-125a expression in human hepatocellular carcinoma cells

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Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression

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Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non-Small Cell Lung Cancer Using Next-Generation Sequencing

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Serum long non coding RNA MALAT-1 protected by exosomes is up-regulated and promotes cell proliferation and migration in non-small cell lung cancer

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Ceramide-C16 Is a Versatile Modulator of Phosphatidylethanolamine Polymorphism

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Exosomal formulation of anthocyanidins against multiple cancer types

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Silencing stem cell factor attenuates stemness and inhibits migration of cancer stem cells derived from Lewis lung carcinoma cells

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The regulation of cancer cell migration by lung cancer cell-derived exosomes through TGF-β and IL-10

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STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells

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Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway

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Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)

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The prognostic role of tissue and serum MMP-1 and TIMP-1 expression in patients with non-small cell lung cancer

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Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a

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Structural and functional characterization of endothelial microparticles released by cigarette smoke

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Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis

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Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction

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FOXP4 modulates tumor growth and independently associates with miR-138 in non-small cell lung cancer cells

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Progenitor-like cells derived from mouse kidney protect against renal fibrosis in a remnant kidney model via decreased endothelial mesenchymal transition

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Androgen Pathway Manipulation and Survival in Patients with Lung Cancer

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EGFR Regulates the Development and Microarchitecture of Intratumoral Angiogenic Vasculature Capable of Sustaining Cancer Cell Intravasation

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Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis

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Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

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MET Amplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib

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Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

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The regulation of exosome secretion: a novel function of the p53 protein

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TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway

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Tumor markers (CEA, CA 125, CYFRA 21-1, SCC and NSE) in patients with non-small cell lung cancer as an aid in histological diagnosis and prognosis - Comparison with the main clinical and pathological prognostic factors

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TUMOR BIOLOGY (2003)

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Potential roles of exosomes in the initiation and metastatic progression of lung cancer

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