☆ 4.5 Review

The role of exosomes in central nervous system tissue regeneration and repair

BIOMEDICAL MATERIALS (2023)

Related references

Note: Only part of the references are listed.

Article Chemistry, Multidisciplinary

Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia

Xue Zheng et al.

Summary: A synthetic sialic acid analogue was successfully used for exosome labeling, leading to the development of a resveratrol-loaded exosome formulation for multiple sclerosis treatment. The study demonstrated the feasibility and efficacy of engineered exosome administration as a potential therapeutic strategy for CNS diseases.

JOURNAL OF CONTROLLED RELEASE (2023)

Add to Collection

Review Cell Biology

Context-specific regulation of extracellular vesicle biogenesis and cargo selection

Andrew C. C. Dixson et al.

Summary: Cells communicate with each other by secreting molecules into the extracellular space, and the selection of these molecules for secretion has been a long-standing question in the field. Recently, extracellular vesicles (EVs) have been recognized as important mediators of intercellular communication, transporting various molecular components to recipient cells. Understanding the context-specific mechanisms of EV biogenesis and cargo sorting is crucial for deciphering the specificity of EV-mediated signaling.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2023)

Add to Collection

Article Biotechnology & Applied Microbiology

Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis

Yong Wang et al.

Summary: This study aimed to design and prepare anti-ferroptosis exosomes (ADSC-Exo) from adipose-derived mesenchymal stem cells for treating ischemic brain injury. It was found that IN administration of ADSC-Exo effectively improved the neurobehavior function and ferroptosis-related outcomes in mice after ischemia/reperfusion injury. The results also demonstrated that ADSC-Exo inhibited ferroptosis by targeting CHAC1 in neurons.

JOURNAL OF NANOBIOTECHNOLOGY (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson's Disease

Huan Peng et al.

Summary: The treatment of Parkinson's disease has been hindered by complex pathologies and membrane barriers. A self-oriented nanocarrier called PR-EXO/PP@Cur, combining stem cell-derived exosomes with curcumin, can overcome these barriers and achieve threepronged synergistic treatment for PD. PR-EXO/PP@Cur shows great prospects for the treatment of PD and other neurodegenerative diseases.

ACS NANO (2022)

Add to Collection

Article Clinical Neurology

Alzheimer disease in African American individuals: increased incidence or not enough data?

Lisa L. Barnes

Summary: Research on racial differences in Alzheimer disease has shown that older African American individuals bear a disproportionate burden of AD compared to non-Latino white individuals. Despite progress in understanding the neurobiological substrates of AD, challenges such as study participant recruitment and lack of biological data in the African American population have hindered a deeper understanding of the disease's drivers. Enhancing knowledge of AD in African American individuals is crucial for the development of effective interventions and treatments.

NATURE REVIEWS NEUROLOGY (2022)

Add to Collection

Review Nanoscience & Nanotechnology

Drug delivery to the central nervous system

Elizabeth Nance et al.

Summary: The central nervous system is protected by tightly regulated physiological barriers, making drug delivery into the brain and spinal cord very challenging. This Review discusses the pathophysiological changes that complicate drug delivery into the central nervous system and examines materials-based strategies to bypass or overcome these barriers for drug delivery.

NATURE REVIEWS MATERIALS (2022)

Add to Collection

Article Cell Biology

Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer’s disease mice model

Haining Liu et al.

Aging-US (2022)

Add to Collection

Review Biochemistry & Molecular Biology

The blood-brain barrier in aging and neurodegeneration

Emily G. Knox et al.

Summary: The blood-brain barrier is essential for maintaining brain homeostasis and preventing the entry of toxins into the brain. However, it deteriorates with age and plays a role in age-related disorders. Recent research suggests that microbial-derived metabolites may have the potential to protect and restore the blood-brain barrier. This review focuses on the components of the barrier, levels of disruption, current drugs and therapeutics, and the effects of microbial-derived metabolites.

MOLECULAR PSYCHIATRY (2022)

Add to Collection

Review Neurosciences

The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury

Zhe-Lun Yang et al.

Summary: Spinal cord injury (SCI) has significant impacts on both patients' quality of life and their families. While cell therapy has made major breakthroughs in treating SCI, it also has disadvantages. In recent years, there has been growing interest in the potential therapeutic role of exosomes and exosomal ncRNAs in SCI treatment. They may be promising tools for treating spinal cord injury.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

Add to Collection

Article Cell Biology

Therapeutic Potential of a Combination of Electroacupuncture and Human iPSC-Derived Small Extracellular Vesicles for Ischemic Stroke

Peiying Deng et al.

Summary: This study investigated the effects and mechanisms of electroacupuncture (EA) combined with induced pluripotent stem cell-derived small extracellular vesicles (iPSC-EVs) on mice with ischemic stroke. The combination treatment improved neurological impairments, reduced infarct volume and neuronal apoptosis, and modulated immune responses. It also exerted neuroprotective effects by regulating the IL-33/ST2 axis and inhibiting microglia and astrocyte activation. These findings suggest that EA and iPSC-EVs have a synergistic neuroprotective effect and may be a promising therapy for ischemic stroke.

CELLS (2022)

Add to Collection

Article Cell Biology

Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides

Zhanchi Zhu et al.

Summary: The study demonstrates that engineered sEVs can effectively treat glioma by crossing the blood-brain barrier and specifically targeting brain tumors. The high targeting efficiency of these dual-modified sEVs for BBB and glioma was confirmed in vitro and in animal models.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Add to Collection

Article Engineering, Biomedical

A functionalized collagen-I scaffold delivers microRNA 21-loaded exosomes for spinal cord injury repair

Xingzhi Liu et al.

Summary: This study aims to develop genetically engineered miR21-loaded exosomes that can be stably tethered to a collagen-I scaffold, promoting the sustained release of miR21 and benefiting spinal cord injury repair.

ACTA BIOMATERIALIA (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Engineered Extracellular Vesicles with SHP2 High Expression Promote Mitophagy for Alzheimer's Disease Treatment

Fang Xu et al.

Summary: This study develops a platform for Alzheimer's disease (AD) therapy using nanosized mesenchymal-stem-cells-derived extracellular vesicles with high expression of tyrosine phosphatase-2 (SHP2). The platform demonstrates high blood-brain barrier penetration ability, delivers SHP2 to the brain, and induces significant mitophagy of neuronal cells, thereby alleviating mitochondrial damage, apoptosis, and neuroinflammation, leading to improved synaptic loss and cognitive decline in an AD mouse model.

ADVANCED MATERIALS (2022)

Add to Collection

Article Cell Biology

Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury

Liang Wen et al.

Summary: Exosomes derived from bone marrow mesenchymal stem cells can inhibit neuroinflammation by regulating microglial phenotypes and promoting nerve injury repair. This study found that these exosomes can promote the polarization of activated BV2 microglia to their anti-inflammatory phenotype and inhibit the expression of proinflammatory cytokines. Moreover, the exosomes reduced cell apoptosis and neuroinflammation, and promoted microglial transformation to the anti-inflammatory phenotype when injected into the tail vein. Additionally, miR181b was found to be actively involved in this process by regulating the interleukin 10/STAT3 pathway.

NEURAL REGENERATION RESEARCH (2022)

Add to Collection

Article Materials Science, Biomaterials

High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination

Yuanxin Zhai et al.

Summary: This study demonstrates the use of modified exosomes as carriers for brain-derived neurotrophic factor (BDNF), which promotes the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes. Through intranasal administration, this method shows significant therapeutic effects on remyelination and motor coordination in demyelination model mice. Thus, this strategy of delivering BDNF via engineered exosomes provides a new approach for the treatment of central nervous system diseases.

BIOMATERIALS SCIENCE (2022)

Add to Collection

Article Medicine, Research & Experimental

M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice

Yongfang Li et al.

Summary: Research suggests that extracellular vesicles (EVs) derived from M2 microglia can promote white matter repair after cerebral ischemia through the direct targeting of Olig3 by miR-23a-5p. This finding provides a novel therapeutic strategy for white matter repair in stroke and demyelinating diseases.

THERANOSTICS (2022)

Add to Collection

Article Clinical Neurology

2022 Alzheimer's disease facts and figures

Joseph Gaugler et al.

Summary: This article discusses the impact of Alzheimer's disease on public health, including its incidence, prevalence, mortality and morbidity rates, healthcare costs and caregivers' burden. It also addresses the perspectives of consumers and primary care physicians on mild cognitive impairment (MCI) and the need for improved awareness, diagnosis, and treatment. The article emphasizes the increasing number of individuals living with Alzheimer's and the challenges faced by caregivers and healthcare providers, particularly during the COVID-19 pandemic.

ALZHEIMERS & DEMENTIA (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Add to Collection

Review Neurosciences

Blood-Brain Barrier Dynamics to Maintain Brain Homeostasis

Marta Segarra et al.

Summary: The blood-brain barrier (BBB) is a critical gatekeeper between the blood and the brain parenchyma, maintaining brain homeostasis by dynamically adjusting its tightness. BBB integrity is adjusted at critical stages in life and can be influenced by stressors such as nutrition, environment, and psychological stress.

TRENDS IN NEUROSCIENCES (2021)

Add to Collection

Review Biotechnology & Applied Microbiology

Strategies for delivering therapeutics across the blood-brain barrier

Georg C. Terstappen et al.

Summary: The blood-brain barrier presents a challenge for delivering therapeutics to the central nervous system, particularly for biopharmaceuticals. Non-invasive approaches have been developed to help overcome this challenge, with increasing research efforts focusing on technologies to deliver therapeutics to the CNS, some of which have entered clinical testing. Developing effective strategies for crossing the blood-brain barrier is crucial for treating CNS disorders, with a particular emphasis on non-invasive methods such as receptor-mediated transcytosis and the use of neurotropic viruses, nanoparticles, and exosomes.

NATURE REVIEWS DRUG DISCOVERY (2021)

Add to Collection

Article Cell & Tissue Engineering

Exosomes derived from human placental mesenchymal stem cells enhanced the recovery of spinal cord injury by activating endogenous neurogenesis

Wenshu Zhou et al.

Summary: This study demonstrates that the use of hpMSC-derived exosomes may constitute a promising therapeutic strategy for the treatment of SCI, significantly improving locomotor activity and bladder dysfunction in experimental animals. The exosomes promoted the activation of endogenous neural stem/progenitor cells and significantly increased neurogenesis.

STEM CELL RESEARCH & THERAPY (2021)

Add to Collection

Article Clinical Neurology

Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease

Lauren A. Apodaca et al.

Summary: The study demonstrated the regenerative potential of EVs derived from human neural stem cells in mitigating neurocognitive and neuropathologic hallmarks of Alzheimer's disease. The EV treatment showed neuroprotective effects in restoring fear extinction memory, reducing anxiety, decreasing amyloid plaque accumulation, and protecting against synaptic loss in the AD brain. MiRNA analysis of the EV cargo revealed promising candidates targeting neuroinflammation and synaptic function.

ALZHEIMERS RESEARCH & THERAPY (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Improvement of Cerebral Ischemia-Reperfusion Injury via Regulation of Apoptosis by Exosomes Derived from BDNF-Overexpressing HEK293

Lizong Wang et al.

Summary: Studies have shown that exosomes containing BDNF have neuroprotective effects on cerebral ischemia-reperfusion injury by reducing apoptosis through inhibition of oxidative stress and calcium ion levels.

BIOMED RESEARCH INTERNATIONAL (2021)

Add to Collection

Review Engineering, Chemical

Overview and Update on Methods for Cargo Loading into Extracellular Vesicles

Yohan Han et al.

Summary: Extracellular vesicles (EVs) have great potential to serve as effective drug carriers, as they can deliver drugs efficiently and overcome some limitations of traditional drugs.

PROCESSES (2021)

Add to Collection

Review Pharmacology & Pharmacy

Extracellular vesicles for the treatment of central nervous system diseases

Viridiane Gratpain et al.

Summary: Extracellular vesicles (EVs) have gained increasing interest over the past decade for their roles in the pathogenesis of central nervous system diseases (CNS) and their therapeutic properties; they can potentially be used as therapeutic agents for CNS diseases due to their ability to cross the blood-brain barrier.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Article Cell Biology

Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour

Chaoxiang Chen et al.

Summary: Extracellular vesicles have unique advantages as nanocarriers for drug delivery, but their cargo encapsulation efficiency is often below expectations, especially for hydrophilic chemotherapeutic drugs. This study introduced a new method named SEAL, which significantly enhances drug encapsulation efficiency of EVs, and single-particle analysis techniques were used to uncover the encapsulation heterogeneity of EVs.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Add to Collection

Review Neurosciences

Microglial Exosomes in Neurodegenerative Disease

Min Guo et al.

Summary: Microglia play a crucial role in neurodegenerative diseases, impacting pathological changes, neurogenesis, neuronal cell death, and synaptic interactions. Additionally, microglial exosomes have been found to contribute significantly to CNS diseases, serving as potential biomarkers for disease monitoring and as drug delivery vehicles for treating disorders.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Add to Collection

Article Pharmacology & Pharmacy

Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Amin Mirzaaghasi et al.

Summary: Exosomes have potential as drug delivery vehicles due to their ability to selectively deliver therapeutic cargoes to disease sites. The in vivo behaviors of exosomes are affected by pathophysiological conditions, and exosomes exhibit specific behaviors in sepsis mice compared to liposomes. This suggests that exosome-based therapeutics may be effective in managing sepsis and septic shock.

PHARMACEUTICS (2021)

Add to Collection

Article Cell Biology

Astrocyte-derived exosomes protect hippocampal neurons after traumatic brain injury by suppressing mitochondrial oxidative stress and apoptosis

Wenqian Zhang et al.

Aging-US (2021)

Add to Collection

Article Engineering, Biomedical

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

Jun Wang et al.

Summary: NEs-Exos system exhibits neutrophil-like chemotactic function and BBB penetration capability, efficiently suppressing tumor growth and prolonging survival time in a glioma mouse model.

BIOMATERIALS (2021)

Add to Collection

Review Immunology

Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes

Maedeh Arabpour et al.

Summary: MSC-derived exosomes have the potential to polarize M2 macrophages and modulate inflammation in various diseases and conditions like CNS diseases, autoimmune diseases, inflammatory bowel disease, and cardiomyopathy.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Add to Collection

Article Chemistry, Medicinal

Strategies for Structural Modification of Small Molecules to Improve Blood-Brain Barrier Penetration: A Recent Perspective

Baichen Xiong et al.

Summary: The blood-brain barrier poses challenges in delivering drugs to the brain, with small molecule drugs dominating current CNS medication. Medicinal chemists have been working on enhancing the penetration of small molecules by improving diffusion, reducing efflux, and activating carrier transporters, aiming to provide insights for future development of small molecule CNS drugs.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation

Ying Xu et al.

Summary: Lovastatin alleviates sevoflurane-induced cognitive deficiency in aged rats by promoting Aβ degradation and reducing Aβ production.

NEUROCHEMISTRY INTERNATIONAL (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Development of Novel Therapeutics Targeting the Blood-Brain Barrier: From Barrier to Carrier

Jia Li et al.

Summary: The blood-brain barrier is a crucial neurovascular unit that prevents harmful substances from entering the brain and maintains normal neuronal function. Disruption of BBB in diseases can contribute to disease progression, while restoration of BBB integrity is a biomarker for better clinical outcomes. The BBB also plays a role in facilitating communication between neuronal and circulatory systems, showing promising results for brain-targeted drug delivery.

ADVANCED SCIENCE (2021)

Add to Collection

Article Medicine, Research & Experimental

Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

Allaura S. Cone et al.

Summary: Research has shown that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have potential therapeutic effects for Alzheimer's disease, slowing down disease progression and improving cognitive function when administered intranasally in mice.

THERANOSTICS (2021)

Add to Collection

Article Medicine, Research & Experimental

Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis

Dong Zhong et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Add to Collection

Review Medicine, General & Internal

Diagnosis and Treatment of Parkinson Disease A Review

Melissa J. Armstrong et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Add to Collection

Article Immunology

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

Wei Liu et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Add to Collection

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Add to Collection

Article Chemistry, Multidisciplinary

The Regulatory Functionality of Exosomes Derived from hUMSCs in 3D Culture for Alzheimer's Disease Therapy

Lingyan Yang et al.

SMALL (2020)

Add to Collection

Article Cell & Tissue Engineering

Human Pluripotent Stem Cell-Derived Extracellular Vesicles: Characteristics and Applications

Richard Jeske et al.

TISSUE ENGINEERING PART B-REVIEWS (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

Li Yang et al.

CIRCULATION (2020)

Add to Collection

Article Cell Biology

Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy

Hong-Xu Chen et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Review Cell Biology

Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

Julien Saint-Pol et al.

CELLS (2020)

Add to Collection

Article Cell Biology

Extracellular Vesicles as Drug Carriers for Enzyme Replacement Therapy to Treat CLN2 Batten Disease: Optimization of Drug Administration Routes

Matthew J. Haney et al.

CELLS (2020)

Add to Collection

Review Clinical Neurology

The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics

Sarah A. Kent et al.

ACTA NEUROPATHOLOGICA (2020)

Add to Collection

Review Medicine, General & Internal

Treatment of Multiple Sclerosis: A Review

Stephen L. Hauser et al.

AMERICAN JOURNAL OF MEDICINE (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

Raghavendra Upadhya et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection

Article Cell Biology

MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat

Yunfei Chen et al.

Aging-US (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage

Pavle Andjus et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Cell Biology

Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

Alisa A. Shaimardanova et al.

NEURAL REGENERATION RESEARCH (2020)

Add to Collection

Article Cell Biology

Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties

Raghavendra Upadhya et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

Add to Collection

Review Clinical Neurology

Exosomes-beyond stem cells for restorative therapy in stroke and neurological injury

Zheng Gang Zhang et al.

NATURE REVIEWS NEUROLOGY (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

Huixin Zhang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

Milad Riazifar et al.

ACS NANO (2019)

Add to Collection

Article Geriatrics & Gerontology

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's disease

Guo-hong Cui et al.

IMMUNITY & AGEING (2019)

Add to Collection

Review Medicine, Research & Experimental

Exosomes in Pathogenesis, Diagnosis, and Treatment of Alzheimer's Disease

Liqun Jiang et al.

MEDICAL SCIENCE MONITOR (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Exosomes

D. Michiel Pegtel et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

Add to Collection

Article Medicine, Research & Experimental

Real-Time Monitoring of Exosome Enveloped-MV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain

Nicola Salvatore Orefice et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2019)

Add to Collection

Article Cell Biology

Insulin-like growth factor-1 enhances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism

Ke Ma et al.

AGING-US (2019)

Add to Collection

Review Clinical Neurology

Multiple sclerosis - a review

R. Dobson et al.

EUROPEAN JOURNAL OF NEUROLOGY (2019)

Add to Collection

Review Cell Biology

Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury

Yana O. Mukhamedshina et al.

NEURAL REGENERATION RESEARCH (2019)

Add to Collection

Article Materials Science, Biomaterials

Exosomes from LPS-stimulated macrophages induce neuroprotection and functional improvement after ischemic stroke by modulating microglial polarization

Yan Zheng et al.

BIOMATERIALS SCIENCE (2019)

Add to Collection

Article Clinical Neurology

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

Robin L. Webb et al.

TRANSLATIONAL STROKE RESEARCH (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

Guo-Hong Cui et al.

FASEB JOURNAL (2018)

Add to Collection

Article Multidisciplinary Sciences

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson's disease treatment

Ryosuke Kojima et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Neurosciences

Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery

Elvira R. Akhmetzyanova et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Add to Collection

Review Immunology

Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer's disease

Lee Chuen Liew et al.

INTERNATIONAL IMMUNOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

Yalin Zhang et al.

NATURE (2017)

Add to Collection

Article Multidisciplinary Sciences

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

Qianfa Long et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection

Review Neurosciences

Biomarkers for Parkinson's Disease: Recent Advancement

Sharvari Lotankar et al.

NEUROSCIENCE BULLETIN (2017)

Add to Collection

Article Multidisciplinary Sciences

Chromatographically isolated CD63+ CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

Dong-ki Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Exosomes as drug delivery vehicles for Parkinson's disease therapy

Matthew J. Haney et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection

Article Neurosciences

Chronic Oligodendrogenesis and Remyelination after Spinal Cord Injury in Mice and Rats

Zoe C. Hesp et al.

JOURNAL OF NEUROSCIENCE (2015)

Add to Collection

Article Cell Biology

The Blood-Brain Barrier

Richard Daneman et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Add to Collection

Article Clinical Neurology

Microglial and macrophage polarization -new prospects for brain repair

Xiaoming Hu et al.

NATURE REVIEWS NEUROLOGY (2015)

Add to Collection

Article Cell Biology

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Oscar P. B. Wiklander et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Add to Collection

Review Immunology

Immunopathology of multiple sclerosis

Calliope A. Dendrou et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

Kohei Yuyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Add to Collection

Article Neurosciences

Long-Distance Axonal Growth from Human Induced Pluripotent Stem Cells after Spinal Cord Injury

Paul Lu et al.

NEURON (2014)

Add to Collection

Article Biology

Astroglial connexin 43 sustains glutamatergic synaptic efficacy

Oana Chever et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Add to Collection

Article Cell & Tissue Engineering

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

Hongqi Xin et al.

STEM CELLS (2013)

Add to Collection

Article Neurosciences

Extracellular microvesicles from astrocytes contain functional glutamate transporters: regulation by protein kinase C and cell activation

Romain-Daniel Gosselin et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2013)

Add to Collection

Article Clinical Neurology

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment A Pilot Clinical Trial

Suzanne Craft et al.

ARCHIVES OF NEUROLOGY (2012)

Add to Collection

Review Biochemistry & Molecular Biology

Alzheimer Mechanisms and Therapeutic Strategies

Yadong Huang et al.

CELL (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

Paul Lu et al.

CELL (2012)

Add to Collection

Article Cell & Tissue Engineering

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

Hongqi Xin et al.

STEM CELLS (2012)

Add to Collection

Article Neurosciences

Synapsin I Is an Oligomannose-Carrying Glycoprotein, Acts As an Oligomannose-Binding Lectin, and Promotes Neurite Outgrowth and Neuronal Survival When Released via Glia-Derived Exosomes

Shiwei Wang et al.

JOURNAL OF NEUROSCIENCE (2011)

Add to Collection

Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

Add to Collection

Article Neurosciences

NG2 Glia Generate New Oligodendrocytes But Few Astrocytes in a Murine Experimental Autoimmune Encephalomyelitis Model of Demyelinating Disease

Richa B. Tripathi et al.

JOURNAL OF NEUROSCIENCE (2010)

Add to Collection

Review Chemistry, Medicinal

Intranasal Delivery to the Central Nervous System: Mechanisms and Experimental Considerations

Shyeilla V. Dhuria et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2010)

Add to Collection

Article Neurosciences

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

Shin H. Kang et al.

NEURON (2010)

Add to Collection

Article Multidisciplinary Sciences

Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease

Kwasi G. Mawuenyega et al.

SCIENCE (2010)

Add to Collection

Article Cell & Tissue Engineering

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Ruenn Chai Lai et al.

STEM CELL RESEARCH (2010)

Add to Collection

Article Urology & Nephrology

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

Stefania Bruno et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Add to Collection

Article Biochemical Research Methods

Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins:: Trophic support for axons?

Eva-Maria Kraemer-Albers et al.

PROTEOMICS CLINICAL APPLICATIONS (2007)

Add to Collection

Article Cell Biology

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi et al.

NATURE CELL BIOLOGY (2007)

Add to Collection

Review Immunology

Exosomes:: Composition, biogenesis and function

C Théry et al.

NATURE REVIEWS IMMUNOLOGY (2002)

Add to Collection

Article Anatomy & Morphology

Astrocyte-endothelial interactions and blood-brain barrier permeability

NJ Abbott

JOURNAL OF ANATOMY (2002)

Add to Collection

Review Pharmacology & Pharmacy

Transport of drugs from the nasal cavity to the central nervous system

L Illum

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.