4.5 Article

SMAD signaling pathway is disrupted by BPA via the AMH receptor in bovine granulosa cells

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

Effects of BPA, BPS, and BPF on Oxidative Stress and Antioxidant Enzyme Expression in Bovine Oocytes and Spermatozoa

Mimi Nguyen et al.

Summary: Bisphenol A (BPA) and its analogs may impact fertility by altering oxidative stress pathways. BPA treatment leads to increased oxidative stress in oocytes, while BPS and BPF treatment decreases oxidative stress in sperm.

GENES (2022)

Article Environmental Sciences

Regulatory and academic studies to derive reference values for human health: The case of bisphenol S

Claire Beausoleil et al.

Summary: The study compared the similarities between BPS and BPA, revealing potential adverse effects of BPS on human health at lower doses. Inconsistencies in toxicity were found between academic and regulatory studies for BPS, suggesting the need to establish human reference values for exposure to BPS based on academic findings.

ENVIRONMENTAL RESEARCH (2022)

Article Cell Biology

BPA and its analogs increase oxidative stress levels in in vitro cultured granulosa cells by altering anti-oxidant enzymes expression

R. Sabry et al.

Summary: Research has found that Bisphenol A (BPA) and its analogs can induce oxidative stress within bovine granulosa cells, although not necessarily through common mechanisms. Therefore, the use of BPA analogs may need to be re-considered.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2022)

Review Endocrinology & Metabolism

Anti-Mullerian Hormone Signal Transduction involved in Mullerian Duct Regression

Richard L. Cate

Summary: This passage discusses the research on a new hormone related to male sexual development seventy years ago, AMH and AMHR2, and their roles in the regression of the Mullerian duct.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Biochemistry & Molecular Biology

BPA Decreases PDCD4 in Bovine Granulosa Cells Independently of miR-21 Inhibition

Reem Sabry et al.

Summary: This study investigates the regulation of miR-21 in bovine granulosa cells and its potential mechanisms. The research shows that miR-21 has anti-apoptotic effects and explains its impact on specific apoptotic targets. Additionally, the study confirms the influence of BPA on miR-21 expression and explores the temporal effects of BPA on miR-21 regulation. Furthermore, the research reveals that BPA induces upregulation of miR-21 expression by modulating upstream regulators. Overall, this study enhances our understanding of the function of miR-21 in granulosa cells and the mechanisms underlying BPA-induced reproductive impairment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Endocrinology & Metabolism

Molecular Mechanisms of AMH Signaling

James A. Howard et al.

Summary: Anti-Mullerian Hormone (AMH) plays critical roles in reproductive development and regulation, and its signaling mechanism differs from other members of the Transforming Growth Factor beta family. AMH has a unique receptor, AMHR2, which has potential implications for understanding its mechanism and therapeutic applications. Recent advancements have provided valuable insights into the molecular mechanisms of AMH signaling, although there are still many areas that remain unexplored.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Endocrinology & Metabolism

Bisphenols A and F, but not S, induce apoptosis in bovine granulosa cells via the intrinsic mitochondrial pathway

Emilia Kourmaeva et al.

Summary: This study investigates the effects of BPA, BPS, and BPF on bovine granulosa cell apoptosis and their potential impact on oocyte competence and overall fertility. The results suggest that BPA and BPF reduce cell viability through increased apoptosis, partially due to the induction of apoptotic genes in the intrinsic pathway. BPS may not act on the intrinsic mitochondrial apoptotic pathway in bovine granulosa cells.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Endocrinology & Metabolism

Genetics of anti-Mullerian hormone and its signaling pathway

Nathalie Josso et al.

Summary: Anti-Mullerian hormone (AMH) is a member of the TGF-beta family and is primarily produced by the supporting somatic cells of the testis. It plays a role in inhibiting the development of female internal organs and has other effects on germ cells. The signaling pathway of AMH is similar and different from other members of the TGF-beta family, and it has its own ligand-specific type 2 receptor, AMHR2, which distinguishes it from other family members. The relationship between AMH and AMHR2 is significant in the study of Persistent Mullerian Duct Syndrome.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Review Obstetrics & Gynecology

Environment, Lifestyle, and Female Infertility

Renu Bala et al.

Summary: Lifestyle and environmental factors have a significant impact on women's fertility, particularly with modern lifestyle choices and delayed childbearing age providing more opportunities for these factors to affect fertility. These factors mainly act through neuroendocrine pathways, leading to metabolic disturbances.

REPRODUCTIVE SCIENCES (2021)

Article Environmental Sciences

The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells

Junxia Shi et al.

Summary: The study demonstrates that exposure to environmentally relevant levels of BPA can disrupt steroid hormone synthesis in human ovarian granulosa cells, leading to decreased gene expression in hormone synthesis and inhibition of the FSHR/GS/AC signaling pathway.

ENVIRONMENTAL TOXICOLOGY (2021)

Article Reproductive Biology

Effects of bisphenol A and bisphenol S on microRNA expression during bovine (Bos taurus) oocyte maturation and early embryo development

Reem Sabry et al.

Summary: The study found that exposure to BPA led to significant changes in the expression of miR-21, miR-155, and miR-29a during oocyte maturation and embryo development, while BPS had no effects on these specific miRNAs examined. This suggests that BPA effects may be miRNA-specific, rather than a global effect on miRNA synthesis and processing mechanisms, and that BPS may not interfere with these miRNAs during bovine oocyte maturation.

REPRODUCTIVE TOXICOLOGY (2021)

Article Environmental Sciences

BPA and BPA alternatives BPS, BPAF, and TMBPF, induce cytotoxicity and apoptosis in rat and human stem cells

Kristen G. Harnett et al.

Summary: BPA alternatives such as BPS, BPAF, and TMBPF exhibit toxicity and potency in rat and human stem cells, with TMBPF being the most toxic, followed by BPA and then BPS. This highlights the need for better regulation, public awareness, and the development of safer alternatives.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Review Biochemistry & Molecular Biology

Effects of heavy metals on reproduction owing to infertility

Jitender K. Bhardwaj et al.

Summary: The reproductive performance of most species is adversely affected by hazardous heavy metals, which are released into the environment through natural and human activities. These metals alter various reproductive functions in both males and females, forming an important aspect of reproductive toxicology. This review summarizes the toxicity aspects of heavy metals on mammals and their mechanisms of action.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

Article Endocrinology & Metabolism

BPA and BPS affect the expression of anti-Mullerian hormone (AMH) and its receptor during bovine oocyte maturation and early embryo development

Angela Christina Saleh et al.

Summary: This study demonstrates that exposure to BPA significantly impairs in vitro oocyte maturation and early preimplantation embryo development, leading to decreased cleavage and blastocyst rates, increased developmental arrest, and elevated DNA fragmentation. Additionally, both BPA and BPS affect the expression of AMH and AMHRII, with BPA also skewing sex ratios towards female blastocysts.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

Bisphenol A: an emerging threat to female fertility

Claudia Pivonello et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2020)

Review Reproductive Biology

Long non-coding RNAs in ovarian granulosa cells

Jiajie Tu et al.

JOURNAL OF OVARIAN RESEARCH (2020)

Review Oncology

Carcinogenic effects of bisphenol A in breast and ovarian cancers

Mihai Cristian Dumitrascu et al.

ONCOLOGY LETTERS (2020)

Article Developmental Biology

Characterisation of the Hippo signalling pathway during bovine preimplantation embryo development

Jyoti Sharma et al.

REPRODUCTION FERTILITY AND DEVELOPMENT (2020)

Review Neurosciences

Neuro-toxic and Reproductive Effects of BPA

Antonietta Santoro et al.

CURRENT NEUROPHARMACOLOGY (2019)

Review Endocrinology & Metabolism

Application of Growth Hormone in in vitro Fertilization

Yue-Ming Xu et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Endocrinology & Metabolism

Comparing the role of anti-Mullerian hormone as a marker of FSH action in male and female fertility

Mariela Urrutia et al.

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2019)

Review Cell Biology

The role of FSH and TGF-ß superfamily in follicle atresia

Yu-Lan Chu et al.

AGING-US (2018)

Article Medical Laboratory Technology

Interfering effects of bisphenol A on in vitro growth of preantral follicles and maturation of oocyes

Xiyan Wang et al.

CLINICA CHIMICA ACTA (2018)

Article Agriculture, Dairy & Animal Science

The impact of bisphenol S on bovine granulosa and theca cells

K. A. Campen et al.

REPRODUCTION IN DOMESTIC ANIMALS (2018)

Review Reproductive Biology

Effects of bisphenol A and its analogs on reproductive health: A mini review

Jacob Steven Siracusa et al.

REPRODUCTIVE TOXICOLOGY (2018)

Review Food Science & Technology

Bisphenol A: Food Exposure and Impact on Human Health

Susana Almeida et al.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2018)

Article Agriculture, Dairy & Animal Science

Systemic and local anti-Mullerian hormone reflects differences in the reproduction potential of Zebu and European type cattle

Anja Stojsin-Carter et al.

ANIMAL REPRODUCTION SCIENCE (2016)

Review Obstetrics & Gynecology

Bisphenol A and ovarian steroidogenesis

Michael S. Bloom et al.

FERTILITY AND STERILITY (2016)

Article Cell Biology

TGF-β Signaling from Receptors to Smads

Akiko Hata et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Article Endocrinology & Metabolism

Role of Anti-Mullerian Hormone in pathophysiology, diagnosis and treatment of Polycystic Ovary Syndrome: a review

Agathe Dumont et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2015)

Review Endocrinology & Metabolism

Bisphenol A: Targeting metabolic tissues

Nicolas Chevalier et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2015)

Review Obstetrics & Gynecology

The physiology and clinical utility of anti-Mllerian hormone in women

Didier Dewailly et al.

HUMAN REPRODUCTION UPDATE (2014)

Review Environmental Sciences

Bisphenol-A: Epigenetic Reprogramming and Effects on Reproduction and Behavior

Guergana Mileva et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2014)

Article Endocrinology & Metabolism

Selective Smad4 Knockout in Ovarian Preovulatory Follicles Results in Multiple Defects in Ovulation

Chao Yu et al.

MOLECULAR ENDOCRINOLOGY (2013)

Article Endocrinology & Metabolism

The Role of Anti-Mullerian Hormone (AMH) During Follicle Development in a Monovulatory Species (Sheep)

Bruce K. Campbell et al.

ENDOCRINOLOGY (2012)

Article Obstetrics & Gynecology

Anti-Mullerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells

Laura Pellatt et al.

FERTILITY AND STERILITY (2011)

Review Biochemistry & Molecular Biology

Endocrine disrupting chemicals and disease susceptibility

Thaddeus T. Schug et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2011)

Article Endocrinology & Metabolism

Anti-Mullerian hormone (AMH): Regulator and marker of ovarian function

E. L. A. F. van Houten et al.

ANNALES D ENDOCRINOLOGIE (2010)

Article Obstetrics & Gynecology

Does estrogen directly modulate anti-mullerian hormone secretion in women?

Gad Liberty et al.

FERTILITY AND STERILITY (2010)

Article Obstetrics & Gynecology

Concentrations of AMH and inhibin-B in relation to follicular diameter in normal human small antral follicles

Claus Yding Andersen et al.

HUMAN REPRODUCTION (2010)

Article Biochemistry & Molecular Biology

Bisphenol A Impairs Estradiol-induced Protective Effects Against DLD-1 Colon Cancer Cell Growth

Alessandro Bolli et al.

IUBMB LIFE (2010)

Article Nursing

Bisphenol A Exposure: Human Risk and Health Policy

Cheryl Erler et al.

JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES (2010)

Article Obstetrics & Gynecology

Roles for Transforming Growth Factor Beta Superfamily Proteins in Early Folliculogenesis

Daniel J. Trombly et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2009)

Review Endocrinology & Metabolism

Smad signalling in the ovary

Noora Kaivo-oja et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2006)

Article Biochemistry & Molecular Biology

Suppression of UV-induced apoptosis by the human DNA repair protein XPG

V Clément et al.

CELL DEATH AND DIFFERENTIATION (2006)

Article Cell Biology

Anti-Mullerian hormone and folliculogenesis

JA Visser et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2005)

Article Cell Biology

AMH signaling: from receptor to target gene

JA Visser

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2003)

Article Endocrinology & Metabolism

Thyroid hormone action is disrupted by bisphenol A as an antagonist

K Moriyama et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)

Article Cell Biology

The origins of protein phosphorylation

P Cohen

NATURE CELL BIOLOGY (2002)